LIVIVO - Search results -

Search results

Result 1 - 10 of total 53

Search options

Article ; Online: Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants.

Moriyama, Miyu / Lucas, Carolina / Monteiro, Valter Silva / Iwasaki, Akiko

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 16, Page(s) e2221652120

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) possess mutations that confer resistance to neutralizing antibodies within the Spike protein and are associated with breakthrough infection and reinfection. By ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) possess mutations that confer resistance to neutralizing antibodies within the Spike protein and are associated with breakthrough infection and reinfection. By contrast, less is known about the escape from CD8+ T cell-mediated immunity by VOC. Here, we demonstrated that all SARS-CoV-2 VOCs possess the ability to suppress major histocompatibility complex class I (MHC-I) expression. We identified several viral genes that contribute to the suppression of MHC I expression. Notably, MHC-I upregulation was strongly inhibited after SARS-CoV-2 but not influenza virus infection in vivo. While earlier VOCs possess similar capacity as the ancestral strain to suppress MHC-I, the Omicron subvariants exhibited a greater ability to suppress surface MHC-I expression. We identified a common mutation in the E protein of Omicron that further suppressed MHC-I expression. Collectively, our data suggest that in addition to escaping from neutralizing antibodies, the success of Omicron subvariants to cause breakthrough infection and reinfection may in part be due to its optimized evasion from T cell recognition.
MeSH term(s)	Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; Breakthrough Infections ; COVID-19/genetics ; Reinfection ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2221652120
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: SARS-CoV-2 variants do not evolve to promote further escape from MHC-I recognition.

Moriyama, Miyu / Lucas, Carolina / Monteiro, Valter Silva / Iwasaki, Akiko

bioRxiv : the preprint server for biology

2022

Abstract: ... By contrast, less is known about the escape from CD8 : Summary: Moriyama et al. demonstrate that SARS-CoV-2 ...

Abstract	SARS-CoV-2 variants of concern (VOCs) possess mutations that confer resistance to neutralizing antibodies within the Spike protein and are associated with breakthrough infection and reinfection. By contrast, less is known about the escape from CD8 Summary: Moriyama et al. demonstrate that SARS-CoV-2 variants of concern retain similar MHC-I downregulation capacity compared to the ancestral virus. The results suggest that MHC-I evasion capacity is optimized in the ancestral virus and thus further adaptation was not observed.
Language	English
Publishing date	2022-05-16
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.05.04.490614
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Lactate dehydrogenase A inhibition prevents RANKL-induced osteoclastogenesis by reducing enhanced glycolysis.

Nishioku, Tsuyoshi / Anzai, Rumi / Hiramatsu, Sami / Terazono, Ayaka / Nakao, Mamiko / Moriyama, Miyu

Journal of pharmacological sciences

2023 Volume 153, Issue 4, Page(s) 197–207

Abstract: Osteoclasts are multinucleated, specializes bone-resorbing cells that are derived from the monocyte/macrophage lineage. Excessive resorbing activities of osteoclasts are involved in destructive bone diseases. The detailed mechanism of acidification at ... ...

Abstract	Osteoclasts are multinucleated, specializes bone-resorbing cells that are derived from the monocyte/macrophage lineage. Excessive resorbing activities of osteoclasts are involved in destructive bone diseases. The detailed mechanism of acidification at the bone adhesion surface during the bone resorption process of osteoclasts remains to be defined. During glycolysis, pyruvate proceeds to the tricarboxylic cycle under aerobic conditions and pyruvate is converted to lactate via lactate dehydrogenase A (LDHA) under anaerobic conditions. However, tumor cells produce ATP during aerobic glycolysis and large amounts of pyruvate are converted to lactate and H
MeSH term(s)	Humans ; Osteogenesis ; Lactate Dehydrogenase 5/metabolism ; Osteoclasts/physiology ; Bone Resorption/prevention & control ; Bone Resorption/metabolism ; Lactates/metabolism ; Glycolysis ; Pyruvates/metabolism ; L-Lactate Dehydrogenase/metabolism
Chemical Substances	Lactate Dehydrogenase 5 (EC 1.1.1.27.-) ; Lactates ; Pyruvates ; L-Lactate Dehydrogenase (EC 1.1.1.27)
Language	English
Publishing date	2023-09-27
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1016/j.jphs.2023.09.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 237: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Oral Bacteria Combined with an Intranasal Vaccine Protect from Influenza A Virus and SARS-CoV-2 Infection.

Nagai, Minami / Moriyama, Miyu / Ichinohe, Takeshi

mBio

2021 Volume 12, Issue 4, Page(s) e0159821

Abstract: The gut microbiota plays a critical role in the induction of adaptive immune responses to influenza virus infection. However, the role of nasal bacteria in the induction of the virus-specific adaptive immunity is less clear. Here, we found that ... ...

Abstract	The gut microbiota plays a critical role in the induction of adaptive immune responses to influenza virus infection. However, the role of nasal bacteria in the induction of the virus-specific adaptive immunity is less clear. Here, we found that disruption of nasal bacteria by intranasal application of antibiotics before influenza virus infection enhanced the virus-specific antibody response in a MyD88-dependent manner. Similarly, disruption of nasal bacteria by lysozyme enhanced antibody responses to intranasally administered influenza virus hemagglutinin (HA) vaccine in a MyD88-dependent manner, suggesting that intranasal application of antibiotics or lysozyme could release bacterial pathogen-associated molecular patterns (PAMPs) from disrupted nasal bacteria that act as mucosal adjuvants by activating the MyD88 signaling pathway. Since commensal bacteria in the nasal mucosal surface were significantly lower than those in the oral cavity, intranasal administration of HA vaccine alone was insufficient to induce the vaccine-specific antibody response. However, intranasal supplementation of cultured oral bacteria from a healthy human volunteer enhanced antibody responses to an intranasally administered HA vaccine. Finally, we demonstrated that oral bacteria combined with an intranasal vaccine protect from influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our results reveal the role of nasal bacteria in the induction of the virus-specific adaptive immunity and provide clues for developing better intranasal vaccines.
MeSH term(s)	Adaptive Immunity/immunology ; Adjuvants, Immunologic ; Administration, Intranasal ; Animals ; Antibodies, Viral/immunology ; Bacteria/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Cell Line ; Chlorocebus aethiops ; Dogs ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Immunity, Mucosal/immunology ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza Vaccines/immunology ; Madin Darby Canine Kidney Cells ; Mice ; Mice, Inbred BALB C ; Myeloid Differentiation Factor 88/metabolism ; Nasal Mucosa/immunology ; Nasal Mucosa/microbiology ; Orthomyxoviridae Infections/prevention & control ; Pathogen-Associated Molecular Pattern Molecules/immunology ; SARS-CoV-2/immunology ; Vaccination/methods ; Vero Cells
Chemical Substances	Adjuvants, Immunologic ; Antibodies, Viral ; COVID-19 Vaccines ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza Vaccines ; Myeloid Differentiation Factor 88 ; Pathogen-Associated Molecular Pattern Molecules
Language	English
Publishing date	2021-08-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.01598-21
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: High ambient temperature dampens adaptive immune responses to influenza A virus infection.

Moriyama, Miyu / Ichinohe, Takeshi

Proceedings of the National Academy of Sciences of the United States of America

2019 Volume 116, Issue 8, Page(s) 3118–3125

Abstract: Although climate change may expand the geographical distribution of several vector-borne diseases, the effects of environmental temperature in host defense to viral infection in vivo are unknown. Here, we demonstrate that exposure of mice to the high ... ...

Abstract	Although climate change may expand the geographical distribution of several vector-borne diseases, the effects of environmental temperature in host defense to viral infection in vivo are unknown. Here, we demonstrate that exposure of mice to the high ambient temperature of 36 °C impaired adaptive immune responses against infection with viral pathogens, influenza, Zika, and severe fever with thrombocytopenia syndrome phlebovirus. Following influenza virus infection, the high heat-exposed mice failed to stimulate inflammasome-dependent cytokine secretion and respiratory dendritic cell migration to lymph nodes. Although commensal microbiota composition remained intact, the high heat-exposed mice decreased their food intake and increased autophagy in lung tissue. Induction of autophagy in room temperature-exposed mice severely impaired virus-specific CD8 T cells and antibody responses following respiratory influenza virus infection. In addition, we found that administration of glucose or dietary short-chain fatty acids restored influenza virus-specific adaptive immune responses in high heat-exposed mice. These findings uncover an unexpected mechanism by which ambient temperature and nutritional status control virus-specific adaptive immune responses.
MeSH term(s)	Adaptive Immunity/immunology ; Animals ; CD8-Positive T-Lymphocytes/immunology ; Hot Temperature ; Humans ; Inflammasomes/immunology ; Influenza A virus/immunology ; Influenza A virus/pathogenicity ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Lung/immunology ; Lung/virology ; Mice ; Phlebovirus/immunology ; Phlebovirus/pathogenicity ; Zika Virus/immunology ; Zika Virus/pathogenicity ; Zika Virus Infection
Chemical Substances	Inflammasomes
Language	English
Publishing date	2019-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1815029116
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [113th Scientific Meeting of the Japanese Society of Internal Medicine: Symposium: Microbiota and Influenza].

Ichinohe, Takeshi / Moriyama, Miyu

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

2018 Volume 105, Issue 9, Page(s) 1701–1705

MeSH term(s)	Animals ; Humans ; Influenza Vaccines/immunology ; Influenza Vaccines/therapeutic use ; Influenza, Human/prevention & control ; Internal Medicine ; Japan ; Microbiota ; Orthomyxoviridae/immunology ; Societies, Medical
Chemical Substances	Influenza Vaccines
Language	Japanese
Publishing date	2018-10-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	952816-7
ISSN	1883-2083 ; 0021-5384
ISSN (online)	1883-2083
ISSN	0021-5384
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 594: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19.

Yap, Jeremy K Y / Moriyama, Miyu / Iwasaki, Akiko

Journal of immunology (Baltimore, Md. : 1950)

2020 Volume 205, Issue 2, Page(s) 307–312

Abstract: The inflammatory response to severe acute respiratory syndrome-related coronavirus 2 infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients. Of the many innate immune pathways that are engaged by severe acute ... ...

Abstract	The inflammatory response to severe acute respiratory syndrome-related coronavirus 2 infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients. Of the many innate immune pathways that are engaged by severe acute respiratory syndrome-related coronavirus 2, we highlight the importance of the inflammasome pathway. We discuss available pharmaceutical agents that target a critical component of inflammasome activation, signaling leading to cellular pyroptosis, and the downstream cytokines as a promising target for the treatment of severe coronavirus disease 2019-associated diseases.
MeSH term(s)	Animals ; Antiviral Agents/immunology ; Antiviral Agents/pharmacology ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Humans ; Immunity, Innate ; Inflammasomes/drug effects ; Intercellular Signaling Peptides and Proteins/metabolism ; Macrophages, Alveolar/pathology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pyroptosis/drug effects ; Severe acute respiratory syndrome-related coronavirus/physiology ; SARS-CoV-2 ; Signal Transduction ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Inflammasomes ; Intercellular Signaling Peptides and Proteins ; NLRC3 protein, human
Keywords	covid19
Language	English
Publishing date	2020-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2000513
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q.

Moriyama, Shogo / Mae, Miyu / Shibata, Daiki / Yamakoshi, Hiroyuki / Kajimoto, Shinji / Nakabayashi, Takakazu / Ishimoto, Takayoshi / Mogi, Kaiki / Sajiki, Hironao / Akai, Shuji / Sawama, Yoshinari

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 81, Page(s) 12100–12103

Abstract: All aromatic C-H bonds of triphenylphosphine ( ... ...

Abstract	All aromatic C-H bonds of triphenylphosphine (PPh
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc04410f
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Seasonality of Respiratory Viral Infections.

Moriyama, Miyu / Hugentobler, Walter J / Iwasaki, Akiko

Annual review of virology

2020 Volume 7, Issue 1, Page(s) 83–101

Abstract: The seasonal cycle of respiratory viral diseases has been widely recognized for thousands of years, as annual epidemics of the common cold and influenza disease hit the human population like clockwork in the winter season in temperate regions. Moreover, ... ...

Abstract	The seasonal cycle of respiratory viral diseases has been widely recognized for thousands of years, as annual epidemics of the common cold and influenza disease hit the human population like clockwork in the winter season in temperate regions. Moreover, epidemics caused by viruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and the newly emerging SARS-CoV-2 occur during the winter months. The mechanisms underlying the seasonal nature of respiratory viral infections have been examined and debated for many years. The two major contributing factors are the changes in environmental parameters and human behavior. Studies have revealed the effect of temperature and humidity on respiratory virus stability and transmission rates. More recent research highlights the importance of the environmental factors, especially temperature and humidity, in modulating host intrinsic, innate, and adaptive immune responses to viral infections in the respiratory tract. Here we review evidence of how outdoor and indoor climates are linked to the seasonality of viral respiratory infections. We further discuss determinants of host response in the seasonality of respiratory viruses by highlighting recent studies in the field.
MeSH term(s)	Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Humidity ; Infectious Disease Incubation Period ; Influenza, Human/epidemiology ; Influenza, Human/transmission ; Influenza, Human/virology ; Orthomyxoviridae/pathogenicity ; Orthomyxoviridae/physiology ; Pandemics ; Picornaviridae Infections/epidemiology ; Picornaviridae Infections/transmission ; Picornaviridae Infections/virology ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/transmission ; Respiratory Tract Infections/virology ; Rhinovirus/pathogenicity ; Rhinovirus/physiology ; SARS Virus/pathogenicity ; SARS Virus/physiology ; SARS-CoV-2 ; Seasons ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/transmission ; Severe Acute Respiratory Syndrome/virology ; Severity of Illness Index ; Temperature
Keywords	covid19
Language	English
Publishing date	2020-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2764224-0
ISSN	2327-0578 ; 2327-056X
ISSN (online)	2327-0578
ISSN	2327-056X
DOI	10.1146/annurev-virology-012420-022445
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

Miyu Moriyama / Takumi Koshiba / Takeshi Ichinohe

Nature Communications, Vol 10, Iss 1, Pp 1-

2019 Volume 14

Abstract: Cytosolic mitochondrial DNA (mtDNA) plays a role in innate antiviral immunity but how this is triggered during infection remains unclear. Here, the authors provide evidence that the Influenza virus protein M2 stimulates translocation of mtDNA into the ... ...

Abstract	Cytosolic mitochondrial DNA (mtDNA) plays a role in innate antiviral immunity but how this is triggered during infection remains unclear. Here, the authors provide evidence that the Influenza virus protein M2 stimulates translocation of mtDNA into the cytosol in a MAVS-dependent manner.
Keywords	Science ; Q
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED