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  1. Article ; Online: Regulatory Roles of Non-Coding RNAs in Cancer.

    Silva-Cázares, Macrina B / Pérez-Plasencia, Carlos / López-Camarillo, César

    Cells

    2023  Volume 12, Issue 9

    Abstract: For several decades, scientific research in cancer biology has focused mainly on the involvement of protein-coding genes [ ... ]. ...

    Abstract For several decades, scientific research in cancer biology has focused mainly on the involvement of protein-coding genes [...].
    MeSH term(s) Humans ; Neoplasms/genetics ; Biology
    Language English
    Publishing date 2023-05-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12091298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Regulatory Roles of Non-Coding RNAs in Cancer

    Macrina B. Silva-Cázares / Carlos Pérez-Plasencia / César López-Camarillo

    Cells, Vol 12, Iss 1298, p

    2023  Volume 1298

    Abstract: For several decades, scientific research in cancer biology has focused mainly on the involvement of protein-coding genes [.] ...

    Abstract For several decades, scientific research in cancer biology has focused mainly on the involvement of protein-coding genes [.]
    Keywords n/a ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article: Editorial: Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets.

    Pessoa, João / Martins, Marta / Casimiro, Sandra / Pérez-Plasencia, Carlos / Shoshan-Barmatz, Varda

    Frontiers in oncology

    2022  Volume 12, Page(s) 949139

    Language English
    Publishing date 2022-06-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.949139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Altered expression of proteins in cancer: function and potential therapeutic targets, volume II.

    Pessoa, João / Valenti, Maria Teresa / Bellance, Nadège / Chiarella, Paula / Abebe, Tamrat / Gerratana, Lorenzo / Pérez-Plasencia, Carlos / Kzhyshkowska, Julia

    Frontiers in oncology

    2023  Volume 13, Page(s) 1242855

    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1242855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genomic profiling in GIST: Implications in clinical outcome and future challenges.

    Calderillo-Ruíz, German / Pérez-Yepez, Eloy Andrés / García-Gámez, María Alejandra / Millan-Catalan, Oliver / Díaz-Romero, Consuelo / Ugalde-Silva, Paul / Salas-Benavides, Rodrigo / Pérez-Plasencia, Carlos / Carbajal-López, Berenice

    Neoplasia (New York, N.Y.)

    2024  Volume 48, Page(s) 100959

    Abstract: Gastrointestinal Stromal Tumors (GIST) are the most frequent mesenchymal neoplasia of the digestive tract. Genomic alterations in KIT, PDFGRA, SDH, and BRAF genes are essential in GIST oncogenesis. Therefore, the mutations in these genes have ... ...

    Abstract Gastrointestinal Stromal Tumors (GIST) are the most frequent mesenchymal neoplasia of the digestive tract. Genomic alterations in KIT, PDFGRA, SDH, and BRAF genes are essential in GIST oncogenesis. Therefore, the mutations in these genes have demonstrated clinical implications. Tumors with deletions in KIT-exon 11 or duplications in exon 9 are associated with a worse prognosis. In contrast, KIT-exon 11 substitutions and duplications are associated with a better clinical outcome. Moreover, mutations in Kit exon 9 and 11 are actionable, due to their response to imatinib, while mutations in PDGFRA respond to sunitinib and/or avapritinib. Although, molecular testing on tissue samples is effective; it is invasive, requires adequate amounts of tissue, and a long experimental process is needed for results. In contrast, liquid biopsy has been proposed as a simple and non-invasive method to test biomarkers in cancer. The most common molecule analyzed by liquid biopsy is circulating tumor DNA (ctDNA). GISTs ctDNA testing has been demonstrated to be effective in identifying known and novel KIT mutations that were not detected using traditional tissue DNA testing and have been useful in determining progression risk and response to TKI therapy. This allows the clinician to have an accurate picture of the genetic changes of the tumor over time. In this work, we aimed to discuss the implications of mutational testing in clinical outcomes, the methods to test ctDNA and the future challenges in the establishment of alternatives of personalized medicine.
    MeSH term(s) Humans ; Gastrointestinal Stromal Tumors/diagnosis ; Gastrointestinal Stromal Tumors/drug therapy ; Gastrointestinal Stromal Tumors/genetics ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Sunitinib/therapeutic use ; Prognosis ; Mutation ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/therapeutic use ; Receptor, Platelet-Derived Growth Factor alpha/genetics
    Chemical Substances Imatinib Mesylate (8A1O1M485B) ; Sunitinib (V99T50803M) ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1483840-0
    ISSN 1476-5586 ; 1522-8002
    ISSN (online) 1476-5586
    ISSN 1522-8002
    DOI 10.1016/j.neo.2023.100959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5203: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Factors Associated with Parametrial Involvement in Endometrial Carcinoma in Patients Treated with Radical Hysterectomy.

    Barquet-Muñoz, Salim / Bandala-Jaques, Antonio / Perez-Montiel, Ma Delia / Prada, Diddier / Martínez-Flores, Marithe / Salcedo-Hernández, Rosa A / Pérez-Plasencia, Carlos / Gonzalez-Enciso, Aaron / Leon, David Cantu-de

    International journal of surgical pathology

    2024  , Page(s) 10668969231225773

    Abstract: Introduction: Describe factors associated with parametrial involvement, and how these factors modify the prognosis of patients with endometrial carcinoma treated with radical hysterectomy.: Methods: Observational study in which categorized patients ... ...

    Abstract Introduction: Describe factors associated with parametrial involvement, and how these factors modify the prognosis of patients with endometrial carcinoma treated with radical hysterectomy.
    Methods: Observational study in which categorized patients according to those with and without parametrial involvement. A descriptive analysis and comparative analysis were performed for associations between parametrial spread and clinical, surgical, and pathology variables.
    Results: We analyzed 85 patients, which 18 (21%) had parametrial involvement. Pathology factors associated with parametrial involvement were the endometrioid subtype, grade 3, and variants of poor prognosis (odds ratio (OR) 3.41, 95% CI 1.09-10.64;
    Conclusion: Factors associated with parametrial involvement were histologies of poor prognosis, tumors affecting uterine serosa, cervix, or spread beyond the uterus. Additionally, parametrial involvement directly affects prognosis by reducing overall survival, disease-free survival and increasing odds for recurrence.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969231225773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4500: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Editorial: Tumor Cell Metabolism and Autophagy as Therapeutic Targets.

    Jacobo-Herrera, Nadia / Gomez-Quiroz, Luis / Pérez-Plasencia, Carlos

    Frontiers in oncology

    2020  Volume 10, Page(s) 573343

    Language English
    Publishing date 2020-12-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.573343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Repurposed Drugs Targeting Cancer Signaling Pathways: Dissecting New Mechanism of Action Through

    López-Urrutia, Eduardo / Padilla-Benavides, Teresita / Pérez-Plasencia, Carlos / Campos-Parra, Alma D

    Frontiers in oncology

    2021  Volume 11, Page(s) 773429

    Language English
    Publishing date 2021-10-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.773429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Editorial: Repurposed Drugs Targeting Cancer Signaling Pathways: Clinical Insights to Improve Oncologic Therapies.

    Pérez-Plasencia, Carlos / Padilla-Benavides, Teresita / López-Urrutia, Eduardo / Campos-Parra, Alma D

    Frontiers in oncology

    2021  Volume 11, Page(s) 713040

    Language English
    Publishing date 2021-06-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.713040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Laherradurin Inhibits Tumor Growth in an Azoxymethane/Dextran Sulfate Sodium Colorectal Cancer Model In Vivo.

    Rendón-Barrón, Michael Joshue / Pérez-Arteaga, Eduardo / Delgado-Waldo, Izamary / Coronel-Hernández, Jossimar / Pérez-Plasencia, Carlos / Rodríguez-Izquierdo, Frida / Linares, Rosa / González-Esquinca, Alma Rosa / Álvarez-González, Isela / Madrigal-Bujaidar, Eduardo / Jacobo-Herrera, Nadia Judith

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Colorectal cancer (CRC) is the third most common neoplasia in the world. Its mortality rate is high due to the lack of specific and effective treatments, metastasis, and resistance to chemotherapy, among other factors. The natural products in cancer are ... ...

    Abstract Colorectal cancer (CRC) is the third most common neoplasia in the world. Its mortality rate is high due to the lack of specific and effective treatments, metastasis, and resistance to chemotherapy, among other factors. The natural products in cancer are a primary source of bioactive molecules. In this research, we evaluated the antitumor activity of an acetogenin (ACG), laherradurin (LH), isolated from the Mexican medicinal plant
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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