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  1. Article ; Online: Complete genomic analysis of

    Manohar, Prasanth / Young, Ry

    Microbiology resource announcements

    2023  Volume 13, Issue 1, Page(s) e0096323

    Abstract: Escherichia ... ...

    Abstract Escherichia fergusonii
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00963-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Phage-antibiotic combinations in various treatment modalities to manage MRSA infections.

    Loganathan, Archana / Bozdogan, Bulent / Manohar, Prasanth / Nachimuthu, Ramesh

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1356179

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1356179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Phage-antibiotic combinations to control Pseudomonas aeruginosa-Candida two-species biofilms.

    Manohar, Prasanth / Loh, Belinda / Nachimuthu, Ramesh / Leptihn, Sebastian

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9354

    Abstract: Phage-antibiotic combinations to treat bacterial infections are gaining increased attention due to the synergistic effects often observed when applying both components together. Most studies however focus on a single pathogen, although in many clinical ... ...

    Abstract Phage-antibiotic combinations to treat bacterial infections are gaining increased attention due to the synergistic effects often observed when applying both components together. Most studies however focus on a single pathogen, although in many clinical cases multiple species are present at the site of infection. The aim of this study was to investigate the anti-biofilm activity of phage-antibiotic/antifungal combinations on single- and dual-species biofilms formed by P. aeruginosa and the fungal pathogen Candida albicans. The Pseudomonas phage Motto in combination with ciprofloxacin had significant anti-biofilm activity. We then compared biofilms formed by P. aeruginosa alone with the dual-species biofilms formed by bacteria and C. albicans. Here, we found that the phage together with the antifungal fluconazole was active against 6-h-old dual-species biofilms but showed only negligible activity against 24-h-old biofilms. This study lays the first foundation for potential therapeutic approaches to treat co-infections caused by bacteria and fungi using phage-antibiotic combinations.
    MeSH term(s) Biofilms/drug effects ; Biofilms/growth & development ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/physiology ; Pseudomonas aeruginosa/virology ; Antifungal Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Pseudomonas Phages/physiology ; Candida albicans/drug effects ; Candida albicans/physiology ; Ciprofloxacin/pharmacology ; Fluconazole/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents ; Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U) ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59444-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: In vitro

    Manohar, Prasanth / Loh, Belinda / Turner, Dann / Tamizhselvi, Ramasamy / Mathankumar, Marimuthu / Elangovan, Namasivayam / Nachimuthu, Ramesh / Leptihn, Sebastian

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1344962

    Abstract: Infections caused ... ...

    Abstract Infections caused by
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1344962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Will the Overuse of Antibiotics During the Coronavirus Pandemic Accelerate Antimicrobial Resistance of Bacteria?

    Manohar, Prasanth / Loh, Belinda / Leptihn, Sebastian

    Infectious microbes & diseases

    2020  Volume 2, Issue 3, Page(s) 87–88

    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Editorial
    ISSN 2641-5917
    ISSN (online) 2641-5917
    DOI 10.1097/IM9.0000000000000034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Complete Genome Sequence of Pseudomonas Phage Motto.

    Manohar, Prasanth / Loganathan, Archana / Nachimuthu, Ramesh / Loh, Belinda / Ma, Long / Turner, Dann / Leptihn, Sebastian

    Microbiology resource announcements

    2022  Volume 11, Issue 11, Page(s) e0074022

    Abstract: We describe the complete genome sequence of bacteriophage Motto, which infects clinical strains of Pseudomonas aeruginosa. Motto is a T1-like siphovirus related to members of the ... ...

    Abstract We describe the complete genome sequence of bacteriophage Motto, which infects clinical strains of Pseudomonas aeruginosa. Motto is a T1-like siphovirus related to members of the family
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00740-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Improved lyophilization conditions for long-term storage of bacteriophages

    Prasanth Manohar / Nachimuthu Ramesh

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: Abstract Phage therapy is one of the promising alternatives to combat the increasing problem of antibiotic resistance. Lyophilization is used for the preparation of pharmaceutical products to improve their stability in long-term storage. The aim of this ... ...

    Abstract Abstract Phage therapy is one of the promising alternatives to combat the increasing problem of antibiotic resistance. Lyophilization is used for the preparation of pharmaceutical products to improve their stability in long-term storage. The aim of this study was to improve the stability of lyophilized bacteriophages using different excipients. Three lytic bacteriophages Escherichia phage ECP311, Klebsiella phage KPP235 and Enterobacter phage ELP140 were subjected to lyophilization using six different excipients: glucose, sucrose, gelatin, mannitol, polyethylene glycol and sorbitol. The lyophilized phages were stored at 4 °C and 37 °C and rehydrated using biological saline to test their viability at 5 months interval up to 20 months. The results showed that the use of sucrose, gelatin and their combination was beneficial in maintaining the viability of phages post-lyophilization. When lyophilized phages were stored at 4 °C, their viability was maintained up to 20 months, but at 37 °C there was a reduction in activity after 10 months. This is one of the few studies to report the lyophilization of phage cocktails to have viability for up to 10 months. Our study identified promising lyophilization excipients to effectively lyophilize bacteriophages for pharmaceutical applications and long-term storage.
    Keywords Medicine ; R ; Science ; Q
    Subject code 500
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: The applications of animal models in phage therapy: An update.

    Mehmood Khan, Fazal / Manohar, Prasanth / Singh Gondil, Vijay / Mehra, Nancy / Kayode Oyejobi, Greater / Odiwuor, Nelson / Ahmad, Tauseef / Huang, Guangtao

    Human vaccines & immunotherapeutics

    2023  Volume 19, Issue 1, Page(s) 2175519

    Abstract: The rapid increase in antibiotic resistance presents a dire situation necessitating the need for alternative therapeutic agents. Among the current alternative therapies, phage therapy (PT) is promising. This review extensively summarizes preclinical PT ... ...

    Abstract The rapid increase in antibiotic resistance presents a dire situation necessitating the need for alternative therapeutic agents. Among the current alternative therapies, phage therapy (PT) is promising. This review extensively summarizes preclinical PT approaches in various
    MeSH term(s) Animals ; Humans ; Phage Therapy/methods ; Bacterial Infections/drug therapy ; Bacteriophages/physiology ; Drug Resistance, Multiple, Bacterial ; Models, Animal ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-19
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2023.2175519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Synergistic Effects of Phage-Antibiotic Combinations against

    Manohar, Prasanth / Madurantakam Royam, Madhav / Loh, Belinda / Bozdogan, Bulent / Nachimuthu, Ramesh / Leptihn, Sebastian

    ACS infectious diseases

    2022  Volume 8, Issue 1, Page(s) 59–65

    Abstract: Non-antibiotic alternative treatments to combat the increasing number of infections caused by multidrug resistant bacteria are urgently needed. In recent years, bacteriophages have reemerged to potentially replace or complement the role of antibiotics, ... ...

    Abstract Non-antibiotic alternative treatments to combat the increasing number of infections caused by multidrug resistant bacteria are urgently needed. In recent years, bacteriophages have reemerged to potentially replace or complement the role of antibiotics, as bacterial viruses have the ability to inactivate pathogens. This study aimed to evaluate the synergy of phage-antibiotic combinations. A
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteriophages ; Citrobacter ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.1c00117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Improved lyophilization conditions for long-term storage of bacteriophages.

    Manohar, Prasanth / Ramesh, Nachimuthu

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 15242

    Abstract: Phage therapy is one of the promising alternatives to combat the increasing problem of antibiotic resistance. Lyophilization is used for the preparation of pharmaceutical products to improve their stability in long-term storage. The aim of this study was ...

    Abstract Phage therapy is one of the promising alternatives to combat the increasing problem of antibiotic resistance. Lyophilization is used for the preparation of pharmaceutical products to improve their stability in long-term storage. The aim of this study was to improve the stability of lyophilized bacteriophages using different excipients. Three lytic bacteriophages Escherichia phage ECP311, Klebsiella phage KPP235 and Enterobacter phage ELP140 were subjected to lyophilization using six different excipients: glucose, sucrose, gelatin, mannitol, polyethylene glycol and sorbitol. The lyophilized phages were stored at 4 °C and 37 °C and rehydrated using biological saline to test their viability at 5 months interval up to 20 months. The results showed that the use of sucrose, gelatin and their combination was beneficial in maintaining the viability of phages post-lyophilization. When lyophilized phages were stored at 4 °C, their viability was maintained up to 20 months, but at 37 °C there was a reduction in activity after 10 months. This is one of the few studies to report the lyophilization of phage cocktails to have viability for up to 10 months. Our study identified promising lyophilization excipients to effectively lyophilize bacteriophages for pharmaceutical applications and long-term storage.
    MeSH term(s) Bacteriophages/physiology ; Coliphages/physiology ; Enterobacter/virology ; Excipients/chemistry ; Freeze Drying/methods ; Humans ; Klebsiella/virology ; Phage Therapy ; Temperature
    Chemical Substances Excipients
    Language English
    Publishing date 2019-10-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-51742-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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