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  1. Article ; Online: Targeting IL-1 Receptor Signaling in AKI.

    Steiger, Stefanie

    Journal of the American Society of Nephrology : JASN

    2023  Volume 34, Issue 10, Page(s) 1601–1603

    MeSH term(s) Humans ; Receptors, Interleukin-1 ; Kidney ; Signal Transduction ; Acute Kidney Injury
    Chemical Substances Receptors, Interleukin-1
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Interferon blockade in lupus: effects on antiviral immunity.

    Steiger, Stefanie / Anders, Hans-Joachim

    Nature reviews. Nephrology

    2022  Volume 18, Issue 7, Page(s) 415–416

    MeSH term(s) Antiviral Agents/therapeutic use ; Humans ; Immunity, Innate ; Interferon Type I ; Lupus Erythematosus, Systemic/drug therapy
    Chemical Substances Antiviral Agents ; Interferon Type I
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-022-00581-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Lösliche Harnsäure bei akuter Gicht und chronischer Niereninsuffizienz

    Steiger, Stefanie [Verfasser]

    2021  

    Author's details Stefanie Steiger
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article: Asymptomatic hyperuricaemia in chronic kidney disease: mechanisms and clinical implications.

    Anders, Hans-Joachim / Li, Qiubo / Steiger, Stefanie

    Clinical kidney journal

    2023  Volume 16, Issue 6, Page(s) 928–938

    Abstract: Asymptomatic hyperuricaemia (HU) is considered a pathogenic factor in multiple disease contexts, but a causative role is only proven for the crystalline form of uric acid in gouty arthritis and urate nephropathy. Epidemiological studies document a robust ...

    Abstract Asymptomatic hyperuricaemia (HU) is considered a pathogenic factor in multiple disease contexts, but a causative role is only proven for the crystalline form of uric acid in gouty arthritis and urate nephropathy. Epidemiological studies document a robust association of HU with hypertension, cardiovascular disease (CVD) and CKD progression, but CKD-related impaired uric acid (UA) clearance and the use of diuretics that further impair UA clearance likely accounts for these associations. Interpreting the available trial evidence is further complicated by referring to xanthine oxidase inhibitors as urate-lowering treatment, although these drugs inhibit other substrates, so attributing their effects only to HU is problematic. In this review we provide new mechanistic insights into the biological effects of soluble and crystalline UA and discuss clinical evidence on the role of asymptomatic HU in CKD, CVD and sterile inflammation. We identify research areas with gaps in experimental and clinical evidence, specifically on infectious complications that represent the second common cause of death in CKD patients, referred to as secondary immunodeficiency related to kidney disease. In addition, we address potential therapeutic approaches on how and when to treat asymptomatic HU in patients with kidney disease and where further interventional studies are required.
    Language English
    Publishing date 2023-01-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sensitive Positron Emission Tomography Imaging of PD-L1 Expression in Human Breast and Lung Carcinoma Xenografts Using the Radiometalated Peptide Ga-68-TRAP-WL12.

    Quigley, Neil Gerard / Steiger, Katja / Färber, Stefanie Felicitas / Richter, Frauke / Weichert, Wilko / Notni, Johannes

    Molecular pharmaceutics

    2024  

    Abstract: Noninvasive imaging of the immune checkpoint protein programmed death ligand 1 (PD-L1; synonyms: CD274, B7-H1) holds great promise to improve patient selection and, thus, response rates for immune checkpoint therapy (ICT) with monoclonal antibodies ... ...

    Abstract Noninvasive imaging of the immune checkpoint protein programmed death ligand 1 (PD-L1; synonyms: CD274, B7-H1) holds great promise to improve patient selection and, thus, response rates for immune checkpoint therapy (ICT) with monoclonal antibodies targeting the PD1/PD-L1 axis. The PD-L1 specific peptide WL12 (cyclo(AcY-(
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c01128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Die Rolle der Makrophagen bei der chronischen Uratnephropathie

    Sellmayr, Markus [Verfasser] / Steiger, Stefanie [Akademischer Betreuer]

    2023  

    Author's details Markus Sellmayr ; Betreuer: Stefanie Steiger
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: Biological drugs for systemic lupus erythematosus or active lupus nephritis and rates of infectious complications. Evidence from large clinical trials.

    Steiger, Stefanie / Ehreiser, Louisa / Anders, Juliane / Anders, Hans-Joachim

    Frontiers in immunology

    2022  Volume 13, Page(s) 999704

    Abstract: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that frequently affects the kidneys, known as lupus nephritis (LN). Such patients are treated with antimalarials, corticosteroids or immunosuppressive drugs, and more recently, ... ...

    Abstract Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that frequently affects the kidneys, known as lupus nephritis (LN). Such patients are treated with antimalarials, corticosteroids or immunosuppressive drugs, and more recently, target-specific biological drugs. Although efficacy of these therapies improved SLE-related outcomes, SLE remains associated with higher rates of infections. Here, we performed a comprehensive systemic review of infectious complications in clinical trials covering drug interventions for SLE or specifically for active LN. Our search in 15 online registries yielded a total of 1477 studies of which 14 matched our prespecified criteria. These covered the biological drugs anifrolumab, belimumab, and rituximab that were tested in patients with non-renal SLE and active LN.The available safety data from the SLE trials indicated that infectious complications such as herpes zoster, upper respiratory tract infection, nasopharyngitis, bronchitis, and urinary tract infection in patients receiving placebo were quite prevalent especially in the EXPLORER (rituximab) trial. Infections occurred mostly during the first year of LN therapy. Serious adverse events and infectious complications occurred more frequently in placebo-treated patients with active LN, especially in the BLISS-LN (belimumab) and LUNAR (rituximab) trials. Anifrolumab and rituximab increased the number of clinically relevant episodes of herpes zoster compared to belimumab in patients with active LN. Anifrolumab displayed a similar trend for influenza infections, which is consistent with the specific mechanisms-of-action of anifrolumab; highlighting drug-specific effects on infectious complications. In addition, standard-of-care therapy, e.g., MMF and immunosuppressants, as well as a longer SLE duration may also affect the incidence of serious adverse events and certain infectious complications in SLE patients with active LN.Infectious complications are common in SLE but even more common in patients with active LN, especially herpes zoster is strongly associated with active LN and anifrolumab therapy (OR 2.8, 95% CI 1.18 to 6.66, p = 0.018). Immunotherapy seems to impose unspecific and specific risks for infections. The latter may imply specific precautions such as preemptive vaccination and individual risk-benefit assessments.
    MeSH term(s) Biological Products/adverse effects ; Clinical Trials as Topic ; Herpes Zoster ; Humans ; Immunosuppressive Agents/adverse effects ; Infections/epidemiology ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Nephritis/drug therapy ; Rituximab/adverse effects
    Chemical Substances Biological Products ; Immunosuppressive Agents ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.999704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The case for evidence-based medicine for the association between hyperuricaemia and CKD.

    Steiger, Stefanie / Ma, Qiuyue / Anders, Hans-Joachim

    Nature reviews. Nephrology

    2020  Volume 16, Issue 7, Page(s) 422

    MeSH term(s) Evidence-Based Medicine ; Humans ; Hyperuricemia ; Renal Insufficiency, Chronic ; Uric Acid
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2020-04-20
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-020-0288-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: The pathogenesis of chronic uric acid crystal nephropathy

    Hernández Petzsche, Moritz Roman [Verfasser] / Steiger, Stefanie [Akademischer Betreuer]

    2021  

    Author's details Moritz Roman Hernández Petzsche ; Betreuer: Stefanie Steiger
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Secondary Immunodeficiency Related to Kidney Disease (SIDKD)-Definition, Unmet Need, and Mechanisms.

    Steiger, Stefanie / Rossaint, Jan / Zarbock, Alexander / Anders, Hans-Joachim

    Journal of the American Society of Nephrology : JASN

    2021  Volume 33, Issue 2, Page(s) 259–278

    Abstract: Kidney disease is a known risk factor for poor outcomes of COVID-19 and many other serious infections. Conversely, infection is the second most common cause of death in patients with kidney disease. However, little is known about the underlying secondary ...

    Abstract Kidney disease is a known risk factor for poor outcomes of COVID-19 and many other serious infections. Conversely, infection is the second most common cause of death in patients with kidney disease. However, little is known about the underlying secondary immunodeficiency related to kidney disease (SIDKD). In contrast to cardiovascular disease related to kidney disease, which has triggered countless epidemiologic, clinical, and experimental research activities or interventional trials, investments in tracing, understanding, and therapeutically targeting SIDKD have been sparse. As a call for more awareness of SIDKD as an imminent unmet medical need that requires rigorous research activities at all levels, we review the epidemiology of SIDKD and the numerous aspects of the abnormal immunophenotype of patients with kidney disease. We propose a definition of SIDKD and discuss the pathogenic mechanisms of SIDKD known thus far, including more recent insights into the unexpected immunoregulatory roles of elevated levels of FGF23 and hyperuricemia and shifts in the secretome of the intestinal microbiota in kidney disease. As an ultimate goal, we should aim to develop therapeutics that can reduce mortality due to infections in patients with kidney disease by normalizing host defense to pathogens and immune responses to vaccines.
    MeSH term(s) Adaptive Immunity ; Blood Platelets/immunology ; COVID-19/etiology ; COVID-19/immunology ; COVID-19 Vaccines/immunology ; Gastrointestinal Microbiome/immunology ; Humans ; Immunity, Innate ; Immunologic Deficiency Syndromes/etiology ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/prevention & control ; Immunophenotyping ; Models, Immunological ; Pandemics ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/immunology ; Risk Factors ; SARS-CoV-2 ; Seroconversion
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-12-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021091257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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