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  1. Article ; Online: Patient/Family Involvement Leads to Successful Outcomes Following Lower Extremity Arthroplasties.

    James, Bonnie / Odicio, Nilsy / Baldwin, Kathleen M / Johnson, Tracey

    Orthopedic nursing

    2021  Volume 40, Issue 5, Page(s) 307–313

    MeSH term(s) Arthroplasty, Replacement, Hip ; Humans ; Lower Extremity/surgery ; Retrospective Studies
    Language English
    Publishing date 2021-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632639-0
    ISSN 1542-538X ; 0744-6020
    ISSN (online) 1542-538X
    ISSN 0744-6020
    DOI 10.1097/NOR.0000000000000791
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2822: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Helping others enhances graduate student wellness and mental health.

    Hermanstyne, Tracey O / Johnson, Lauren / Wylie, Kristine M / Skeath, James B

    Nature biotechnology

    2022  Volume 40, Issue 4, Page(s) 618–619

    MeSH term(s) Humans ; Mental Health ; Students, Medical/psychology
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-022-01275-5
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    Zs.A 2167: Show issues Location:
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    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

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  3. Article ; Online: Development of a cationic polyethyleneimine-poly(lactic-

    Tracey, Shannon R / Smyth, Peter / Herron, Una M / Burrows, James F / Porter, Andrew J / Barelle, Caroline J / Scott, Christopher J

    RSC advances

    2023  Volume 13, Issue 48, Page(s) 33721–33735

    Abstract: Intracellular delivery of proteins, peptides and biologics is an emerging field which has the potential to provide novel opportunities to target intracellular proteins, previously deemed 'undruggable'. However, the delivery of proteins intracellularly ... ...

    Abstract Intracellular delivery of proteins, peptides and biologics is an emerging field which has the potential to provide novel opportunities to target intracellular proteins, previously deemed 'undruggable'. However, the delivery of proteins intracellularly remains a challenge. Here, we present a cationic nanoparticle delivery system for enhanced cellular delivery of proteins through use of a polyethyleneimine and poly-(lactic-
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra06050k
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  4. Article: Models in Pancreatic Neuroendocrine Neoplasms: Current Perspectives and Future Directions.

    Forsythe, Steven D / Pu, Tracey / Andrews, Stephen G / Madigan, James P / Sadowski, Samira M

    Cancers

    2023  Volume 15, Issue 15

    Abstract: Pancreatic neuroendocrine neoplasms (pNENs) are a heterogeneous group of tumors derived from multiple neuroendocrine origin cell subtypes. Incidence rates for pNENs have steadily risen over the last decade, and outcomes continue to vary widely due to ... ...

    Abstract Pancreatic neuroendocrine neoplasms (pNENs) are a heterogeneous group of tumors derived from multiple neuroendocrine origin cell subtypes. Incidence rates for pNENs have steadily risen over the last decade, and outcomes continue to vary widely due to inability to properly screen. These tumors encompass a wide range of functional and non-functional subtypes, with their rarity and slow growth making therapeutic development difficult as most clinically used therapeutics are derived from retrospective analyses. Improved molecular understanding of these cancers has increased our knowledge of the tumor biology for pNENs. Despite these advances in our understanding of pNENs, there remains a dearth of models for further investigation. In this review, we will cover the current field of pNEN models, which include established cell lines, animal models such as mice and zebrafish, and three-dimensional (3D) cell models, and compare their uses in modeling various disease aspects. While no study model is a complete representation of pNEN biology, each has advantages which allow for new scientific understanding of these rare tumors. Future efforts and advancements in technology will continue to create new options in modeling these cancers.
    Language English
    Publishing date 2023-07-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15153756
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  5. Article ; Online: Secondary and tertiary treatments for multiple sclerosis patients with urinary symptoms.

    Tracey, James M / Stoffel, John T

    Investigative and clinical urology

    2016  Volume 57, Issue 6, Page(s) 377–383

    Abstract: Multiple sclerosis patients with refractory urinary symptoms after treatment with behavioral therapy and medications still have treatment options. Prior to starting treatments, baseline symptoms should be assessed and treatment goals thoroughly discussed. ...

    Abstract Multiple sclerosis patients with refractory urinary symptoms after treatment with behavioral therapy and medications still have treatment options. Prior to starting treatments, baseline symptoms should be assessed and treatment goals thoroughly discussed. Catheterization, botulinum toxin, and reconstructive surgery all can play a role in improving both safety and quality of life for these patients. Newer modalities, such as neuromodulation, may also have an increasing role in the future as more data develop regarding efficacy. Risks need to be weighed against any perceived benefit and disease status before more aggressive therapy is initiated.
    Language English
    Publishing date 2016-11
    Publishing country Korea (South)
    Document type Review ; Journal Article
    ZDB-ID 2923014-7
    ISSN 2466-054X ; 2466-0493
    ISSN (online) 2466-054X
    ISSN 2466-0493
    DOI 10.4111/icu.2016.57.6.377
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  6. Article ; Online: Teaching the Neurological Examination in a Rapidly Evolving Clinical Climate.

    Hillis, James M / Milligan, Tracey A

    Seminars in neurology

    2018  Volume 38, Issue 4, Page(s) 428–440

    Abstract: The neurological examination remains the essence of neurology. It allows symptoms to be assessed, diagnoses to be made, and dynamic functions to be followed. Skill in the neurological examination has faced increasing challenges from the encroachment of ... ...

    Abstract The neurological examination remains the essence of neurology. It allows symptoms to be assessed, diagnoses to be made, and dynamic functions to be followed. Skill in the neurological examination has faced increasing challenges from the encroachment of diagnostic imaging, but has maintained its clinical utility. It has also encountered the battle for the precious time within a medical curriculum. This review considers how the neurological examination can best be taught into the future. It does so by considering factors related to the examination, the learner, the teacher, and the modern clinical environment.
    MeSH term(s) Curriculum/standards ; Education, Medical/methods ; Education, Medical/standards ; Humans ; Neurologic Examination/methods ; Neurologic Examination/standards ; Neurology/education
    Language English
    Publishing date 2018-08-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0038-1667135
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1737: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Bioengineered small extracellular vesicles deliver multiple SARS-CoV-2 antigenic fragments and drive a broad immunological response.

    Jackson, Hannah K / Long, Heather M / Yam-Puc, Juan Carlos / Palmulli, Roberta / Haigh, Tracey A / Gerber, Pehuén Pereyra / Lee, Jin S / Matheson, Nicholas J / Young, Lesley / Trowsdale, John / Lo, Mathew / Taylor, Graham S / Thaventhiran, James E / Edgar, James R

    Journal of extracellular vesicles

    2024  Volume 13, Issue 2, Page(s) e12412

    Abstract: The COVID-19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing several efficacious vaccines which were expedited by the global need for vaccines. The emergence ... ...

    Abstract The COVID-19 pandemic highlighted the clear risk that zoonotic viruses pose to global health and economies. The scientific community responded by developing several efficacious vaccines which were expedited by the global need for vaccines. The emergence of SARS-CoV-2 breakthrough infections highlights the need for additional vaccine modalities to provide stronger, long-lived protective immunity. Here we report the design and preclinical testing of small extracellular vesicles (sEVs) as a multi-subunit vaccine. Cell lines were engineered to produce sEVs containing either the SARS-CoV-2 Spike receptor-binding domain, or an antigenic region from SARS-CoV-2 Nucleocapsid, or both in combination, and we tested their ability to evoke immune responses in vitro and in vivo. B cells incubated with bioengineered sEVs were potent activators of antigen-specific T cell clones. Mice immunised with sEVs containing both sRBD and Nucleocapsid antigens generated sRBD-specific IgGs, nucleocapsid-specific IgGs, which neutralised SARS-CoV-2 infection. sEV-based vaccines allow multiple antigens to be delivered simultaneously resulting in potent, broad immunity, and provide a quick, cheap, and reliable method to test vaccine candidates.
    MeSH term(s) Animals ; Humans ; Mice ; SARS-CoV-2 ; Pandemics ; COVID-19 ; Extracellular Vesicles ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2683797-3
    ISSN 2001-3078 ; 2001-3078
    ISSN (online) 2001-3078
    ISSN 2001-3078
    DOI 10.1002/jev2.12412
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  8. Article ; Online: Transurethral Bipolar Enucleation of the Prostate Is an Effective Treatment Option for Men With Urinary Retention.

    Tracey, James M / Warner, Jonathan N

    Urology

    2016  Volume 87, Page(s) 166–171

    Abstract: Objective: To evaluate outcomes of transurethral bipolar enucleation (TuBE) of the prostate in patients with refractory lower urinary tract symptoms.: Materials and methods: A retrospective analysis was performed on patients who underwent TuBE from ... ...

    Abstract Objective: To evaluate outcomes of transurethral bipolar enucleation (TuBE) of the prostate in patients with refractory lower urinary tract symptoms.
    Materials and methods: A retrospective analysis was performed on patients who underwent TuBE from July 2014 to March 2015. Perioperative factors evaluated included International Prostate Symptom Score, Sexual Health Inventory for Men score, prostate-specific antigen, postvoid residual volume, transrectal ultrasound volume measurement, estimated blood loss, operative time, pathologic weight, and complications. Postoperative evaluation was performed at 6 weeks and 3 months.
    Results: Forty-nine patients were identified. Mean age was 67 years and mean follow-up was 4.4 months. Twenty-eight patients (57%) were in retention. Preoperative, 6-week, and 3-month mean postvoid residual volumes were 278 mL, 66 mL, and 87 mL (P < .01); mean International Prostate Symptom Scores were 22, 9, and 8 (P  <  .01); mean quality of life scores were 5.0, 1.9, and 1.9; and Sexual Health Inventory for Men scores were 7.1, 8.4, and 7.0 (P = .35), respectively. Twenty-eight patients (57%) were able to have erections preoperatively and were still able to postoperatively. All (100%) of the patients in retention were able to void postoperatively. Mean operative time was 93 minutes, estimated blood loss was 49 mL, and pathologic weight was 18 g. Urinary tract infection occurred in 3 patients (6%), urethral stricture in 1 (2%), and bladder neck contracture in 2 (4%). Mean prostate-specific antigen decreased from 3.2 ng/dL to 0.9 ng/dL at 3 months (P < .01).
    Conclusion: TuBE is an effective operation for refractory urinary tract symptoms including those who are in urinary retention.
    MeSH term(s) Aged ; Aged, 80 and over ; Endosonography ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prostatic Hyperplasia/complications ; Prostatic Hyperplasia/diagnostic imaging ; Prostatic Hyperplasia/surgery ; Quality of Life ; Rectum ; Retrospective Studies ; Severity of Illness Index ; Time Factors ; Transurethral Resection of Prostate/methods ; Treatment Outcome ; Urinary Bladder Neck Obstruction/complications ; Urinary Bladder Neck Obstruction/surgery ; Urinary Retention/etiology ; Urinary Retention/physiopathology ; Urinary Retention/surgery ; Urination/physiology
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2015.10.011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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  9. Article ; Online: Exploring Bismuth Coordination Complexes as Visible-Light Absorbers: Synthesis, Characterization, and Photophysical Properties.

    Bhatia, Harsh / Guo, Junjun / Savory, Christopher N / Rush, Martyn / James, David Ian / Dey, Avishek / Chen, Charles / Bučar, Dejan-Krešimir / Clarke, Tracey M / Scanlon, David O / Palgrave, Robert G / Schroeder, Bob C

    Inorganic chemistry

    2023  Volume 63, Issue 1, Page(s) 416–430

    Abstract: Bismuth-based coordination complexes are advantageous over other metal complexes, as bismuth is the heaviest nontoxic element with high spin-orbit coupling and potential optoelectronics applications. Herein, four bismuth halide-based coordination ... ...

    Abstract Bismuth-based coordination complexes are advantageous over other metal complexes, as bismuth is the heaviest nontoxic element with high spin-orbit coupling and potential optoelectronics applications. Herein, four bismuth halide-based coordination complexes [Bi
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c03290
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  10. Article ; Online: Computer-aided diagnostic screen for Congenital Central Hypoventilation Syndrome with facial phenotype.

    Slattery, Susan M / Wilkinson, James / Mittal, Angeli / Zheng, Charlie / Easton, Nicholas / Singh, Saumya / Baker, Joshua J / Rand, Casey M / Khaytin, Ilya / Stewart, Tracey M / Demeter, David / Weese-Mayer, Debra E

    Pediatric research

    2024  

    Abstract: Background: Congenital Central Hypoventilation Syndrome (CCHS) has devastating consequences if not diagnosed promptly. Despite identification of the disease-defining gene PHOX2B and a facial phenotype, CCHS remains underdiagnosed. This study aimed to ... ...

    Abstract Background: Congenital Central Hypoventilation Syndrome (CCHS) has devastating consequences if not diagnosed promptly. Despite identification of the disease-defining gene PHOX2B and a facial phenotype, CCHS remains underdiagnosed. This study aimed to incorporate automated techniques on facial photos to screen for CCHS in a diverse pediatric cohort to improve early case identification and assess a facial phenotype-PHOX2B genotype relationship.
    Methods: Facial photos of children and young adults with CCHS were control-matched by age, sex, race/ethnicity. After validating landmarks, principal component analysis (PCA) was applied with logistic regression (LR) for feature attribution and machine learning models for subject classification and assessment by PHOX2B pathovariant.
    Results: Gradient-based feature attribution confirmed a subtle facial phenotype and models were successful in classifying CCHS: neural network performed best (median sensitivity 90% (IQR 84%, 95%)) on 179 clinical photos (versus LR and XGBoost, both 85% (IQR 75-76%, 90%)). Outcomes were comparable stratified by PHOX2B genotype and with the addition of publicly available CCHS photos (n = 104) using PCA and LR (sensitivity 83-89% (IQR 67-76%, 92-100%).
    Conclusions: Utilizing facial features, findings suggest an automated, accessible classifier may be used to screen for CCHS in children with the phenotype and support providers to seek PHOX2B testing to improve the diagnostics.
    Impact: Facial landmarking and principal component analysis on a diverse pediatric and young adult cohort with PHOX2B pathovariants delineated a distinct, subtle CCHS facial phenotype. Automated, low-cost machine learning models can detect a CCHS facial phenotype with a high sensitivity in screening to ultimately refer for disease-defining PHOX2B testing, potentially addressing gaps in disease underdiagnosis and allow for critical, timely intervention.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02990-8
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    Zs.MO 373: Show issues

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