Article ; Online: LC-MS/MS and GC-MS based phytochemical perspectives and antimicrobial effects of endophytic fungus Chaetomium ovatoascomatis isolated from Euphorbia milii.
2022 Volume 204, Issue 11, Page(s) 661
Abstract: The antimicrobial activity of endophytic fungi isolated from Euphorbia milii was evaluated against Gram-positive, Gram-negative bacteria, unicellular yeast, and filamentous fungi. Chaetomium ovatoascomatis NRC was identified morphologically and ... ...
| Abstract | The antimicrobial activity of endophytic fungi isolated from Euphorbia milii was evaluated against Gram-positive, Gram-negative bacteria, unicellular yeast, and filamentous fungi. Chaetomium ovatoascomatis NRC was identified morphologically and genetically as the most active strain. The total ethyl acetate extract of C. ovatoascomatis NRC demonstrated significant antimicrobial activity against Gram-negative; Escherichia coli, Salmonella enteric, and fungi; Aspergillus niger with MIC of 62.5 ug/ml. Whereas n-hexane fraction demonstrated broader activity against Gram-positive; Bacillus subtilis, Lactobacillus cereus, Gram-negative; Escherichia coli and Salmonella enteric, fungi; Candida albicans and F. solani. LC-MS/MS analysis of ethyl acetate strain extract and GC-MS analysis of the n-hexane fraction were used to identify the metabolites of the strain extract. LC-MS/MS determined three major metabolites with potential antimicrobial activities including grevilline B, aflatoxin G2 and apigenin. GC-MS analysis of n-hexane fraction tentatively identified 30 compounds, where 9,12-octadecadienoic acid methyl ester was the major compound. |
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| MeSH term(s) | Acetates ; Anti-Infective Agents/metabolism ; Anti-Infective Agents/pharmacology ; Apigenin/metabolism ; Apigenin/pharmacology ; Bacillus subtilis ; Chaetomium ; Chromatography, Liquid ; Endophytes ; Escherichia coli ; Esters/metabolism ; Euphorbia ; Gas Chromatography-Mass Spectrometry ; Gram-Negative Bacteria ; Hexanes ; Linoleic Acid/metabolism ; Linoleic Acid/pharmacology ; Microbial Sensitivity Tests ; Phytochemicals/pharmacology ; Tandem Mass Spectrometry |
| Chemical Substances | Acetates ; Anti-Infective Agents ; Esters ; Hexanes ; Phytochemicals ; n-hexane (2DDG612ED8) ; ethyl acetate (76845O8NMZ) ; Apigenin (7V515PI7F6) ; Linoleic Acid (9KJL21T0QJ) |
| Language | English |
| Publishing date | 2022-10-04 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 124824-8 |
| ISSN | 1432-072X ; 0302-8933 |
| ISSN (online) | 1432-072X |
| ISSN | 0302-8933 |
| DOI | 10.1007/s00203-022-03262-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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