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Book ; Online: Talous, sääntely, ohjaus

Wacker, Jani / Rönkkö, Jaakko / Kihn, Lili-Anne / Oulasvirta, Lasses / Ruohonen, Janne

2019

Abstract: This edited book (Finance, Regulation, Steering - Current Topics of Audit and Control) provides original research about various current auditing and evaluation topics. Over the past decade, the field of auditing has experienced substantial changes. The ... ...

Abstract	This edited book (Finance, Regulation, Steering - Current Topics of Audit and Control) provides original research about various current auditing and evaluation topics. Over the past decade, the field of auditing has experienced substantial changes. The articles cover, for instance, such topics as audit quality and price of auditing, performance of internal auditing, XBRL and the debt costs, risk management in local governments and ownership steering of government-owned-enterprises. This book will be of value to practitioners, students and academics interested in contemporary aspects of external and internal auditing, evaluation and oversight of service providers and evaluation
Keywords	Economic theory. Demography
Size	1 electronic resource (309 pages)
Publisher	Tampere University Press
Document type	Book ; Online
Note	Finnish ; Open Access
HBZ-ID	HT020310390
ISBN	9789523590045 ; 9523590049
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Sociodemographic Differences in Health Awareness and Oral Health in Pregnant Women.

Kühle, Anna-Maria / Wacker, Jürgen

Geburtshilfe und Frauenheilkunde

2020 Volume 80, Issue 8, Page(s) 834–843

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2020-08-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80111-2
ISSN	1438-8804 ; 0016-5751 ; 1615-3359
ISSN (online)	1438-8804
ISSN	0016-5751 ; 1615-3359
DOI	10.1055/a-1205-0601
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Book ; Online: Tarkastus, arviointi ja valvonta murroksessa

Kihn, Lili-Anne / Oulasvirta, Lasse / Ruohonen, Janne / Rönkkö, Jaakko / Urpilainen, Matti / Wacker, Jani

2021

Keywords	Management accounting & bookkeeping ; audit of the accounts, auditing, private sector, public sector, municipalities, quality, enterprises, businesses, control, inspection, evaluation, legal regulation, standards, accountants, auditors, financial statements, appeal boards, audit reports, tilintarkastus, yksityinen sektori, yritykset, yhtiöt, julkinen sektori, kunnat, tietokoneavusteisuus, laatu, valvonta, tarkastus, sisäinen tarkastus, arviointi, oikeudellinen sääntely, standardit, tilintarkastajat, tarkastuslautakunnat, tilintarkastuskertomukset, tilinpäätös
Size	1 electronic resource (305 pages)
Publisher	Tampere University Press
Publishing place	Tampere
Document type	Book ; Online
Note	Finnish ; Open Access
HBZ-ID	HT021232265
ISBN	9789523590335 ; 9523590332
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: NMR characterization and ligand binding site of the stem loop 2 motif (s2m) from the Delta variant of SARS-CoV-2.

Matzel, Tobias / Wirtz Martin, Maria / Herr, Alexander / Wacker, Anna / Richter, Christian / Sreeramulu, Sridhar / Schwalbe, Harald

RNA (New York, N.Y.)

2024

Abstract: The stem loop 2 motif (s2m) in SARS-CoV-2 (SCoV-2) is located in the 3'-UTR. Although s2m has been reported to display characteristics of a mobile genomic element that might lead to an evolutionary advantage, its function has remained unknown. The ... ...

Abstract	The stem loop 2 motif (s2m) in SARS-CoV-2 (SCoV-2) is located in the 3'-UTR. Although s2m has been reported to display characteristics of a mobile genomic element that might lead to an evolutionary advantage, its function has remained unknown. The secondary structure of the original SCoV-2 RNA sequence (Wuhan-Hu-1) was determined by NMR in late 2020, delineating the base pairing pattern and revealing substantial differences in secondary structure compared to SARS-CoV-1 (SCoV-1). The existence of a single G29742-A29756 mismatch in the upper stem of s2m leads to its destabilization and impedes a complete NMR analysis. With Delta, a variant of concern has evolved with one mutation compared to the original sequence that replaces G29742 by U29742. We show here that this mutation results in a more defined structure at ambient temperature accompanied by a rise in melting temperature. Consequently, we were able to identify over 90 % of the relevant NMR resonances using a combination of selective RNA labeling and filtered 2D NOESY as well as 4D NMR experiments. We present a comprehensive NMR analysis of the secondary structure, (sub-) nanosecond dynamics and ribose conformation of s2m Delta based on heteronuclear 13C NOE and T1 measurements and ribose carbon chemical shift-derived canonical coordinates. We further show that the G29742U mutation in Delta has no influence on the druggability of s2m compared to the Wuhan-Hu-1 sequence. With the assignment at hand, we identify the flexible regions of s2m as primary site for small molecule binding.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1241540-6
ISSN	1469-9001 ; 1355-8382
ISSN (online)	1469-9001
ISSN	1355-8382
DOI	10.1261/rna.079902.123
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Article ; Online: Cell-free transcription-translation system: a dual read-out assay to characterize riboswitch function.

Bains, Jasleen Kaur / Qureshi, Nusrat Shahin / Ceylan, Betül / Wacker, Anna / Schwalbe, Harald

Nucleic acids research

2023 Volume 51, Issue 15, Page(s) e82

Abstract: Cell-free protein synthesis assays have become a valuable tool to understand transcriptional and translational processes. Here, we established a fluorescence-based coupled in vitro transcription-translation assay as a read-out system to simultaneously ... ...

Abstract	Cell-free protein synthesis assays have become a valuable tool to understand transcriptional and translational processes. Here, we established a fluorescence-based coupled in vitro transcription-translation assay as a read-out system to simultaneously quantify mRNA and protein levels. We utilized the well-established quantification of the expression of shifted green fluorescent protein (sGFP) as a read-out of protein levels. In addition, we determined mRNA quantities using a fluorogenic Mango-(IV) RNA aptamer that becomes fluorescent upon binding to the fluorophore thiazole orange (TO). We utilized a Mango-(IV) RNA aptamer system comprising four subsequent Mango-(IV) RNA aptamer elements with improved sensitivity by building Mango arrays. The design of this reporter assay resulted in a sensitive read-out with a high signal-to-noise ratio, allowing us to monitor transcription and translation time courses in cell-free assays with continuous monitoring of fluorescence changes as well as snapshots of the reaction. Furthermore, we applied this dual read-out assay to investigate the function of thiamine-sensing riboswitches thiM and thiC from Escherichia coli and the adenine-sensing riboswitch ASW from Vibrio vulnificus and pbuE from Bacillus subtilis, which represent transcriptional and translational on- and off-riboswitches, respectively. This approach enabled a microplate-based application, a valuable addition to the toolbox for high-throughput screening of riboswitch function.
MeSH term(s)	Adenine/chemistry ; Aptamers, Nucleotide/genetics ; Aptamers, Nucleotide/metabolism ; Fluorescence ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Nucleic Acid Conformation ; Riboswitch ; Cell-Free System
Chemical Substances	Adenine (JAC85A2161) ; Aptamers, Nucleotide ; Green Fluorescent Proteins (147336-22-9) ; Riboswitch
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad574
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Article ; Online: Characterization of Structure and Dynamics of the Guanidine-II Riboswitch from Escherichia coli by NMR Spectroscopy and Small-Angle X-ray Scattering (SAXS).

Schamber, Tatjana / Binas, Oliver / Schlundt, Andreas / Wacker, Anna / Schwalbe, Harald

Chembiochem : a European journal of chemical biology

2021 Volume 23, Issue 3, Page(s) e202100564

Abstract: Riboswitches are regulatory RNA elements that undergo functionally important allosteric conformational switching upon binding of specific ligands. The here investigated guanidine-II riboswitch binds the small cation, guanidinium, and forms a kissing loop- ...

Abstract	Riboswitches are regulatory RNA elements that undergo functionally important allosteric conformational switching upon binding of specific ligands. The here investigated guanidine-II riboswitch binds the small cation, guanidinium, and forms a kissing loop-loop interaction between its P1 and P2 hairpins. We investigated the structural changes to support previous studies regarding the binding mechanism. Using NMR spectroscopy, we confirmed the structure as observed in crystal structures and we characterized the kissing loop interaction upon addition of Mg
MeSH term(s)	Escherichia coli/chemistry ; Guanidine/chemistry ; Guanidine/metabolism ; Magnetic Resonance Spectroscopy ; Riboswitch ; Scattering, Small Angle ; X-Ray Diffraction
Chemical Substances	Riboswitch ; Guanidine (JU58VJ6Y3B)
Language	English
Publishing date	2021-12-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202100564
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NMR

Hymon, Daniel / Martins, Jason / Richter, Christian / Sreeramulu, Sridhar / Wacker, Anna / Ferner, Jan / Patwardhan, Neeraj N / Hargrove, Amanda E / Schwalbe, Harald

RSC medicinal chemistry

2023 Volume 15, Issue 1, Page(s) 165–177

Abstract: Development of new antiviral medication against the beta-coronavirus SARS-CoV-2 (SCoV2) is actively being pursued. Both NMR spectroscopy and crystallography as structural screening technologies have been utilised to screen the viral proteome for binding ... ...

Abstract	Development of new antiviral medication against the beta-coronavirus SARS-CoV-2 (SCoV2) is actively being pursued. Both NMR spectroscopy and crystallography as structural screening technologies have been utilised to screen the viral proteome for binding to fragment libraries. Here, we report on NMR screening of elements of the viral RNA genome with two different ligand libraries using
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article
ISSN	2632-8682
ISSN (online)	2632-8682
DOI	10.1039/d3md00322a
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Article ; Online: Chemosaturation for primary and secondary liver malignancies: A comprehensive update of current evidence.

Vogel, Arndt / Ochsenreither, Sebastian / Zager, Jonathan S / Wacker, Frank / Saborowski, Anna

Cancer treatment reviews

2022 Volume 113, Page(s) 102501

Abstract: Regional therapies for primary and secondary liver tumors have garnered interest in recent years and several types of treatment approaches have been pursued to control disease, palliate symptoms, and extend survival. Chemosaturation is an innovative way ... ...

Abstract	Regional therapies for primary and secondary liver tumors have garnered interest in recent years and several types of treatment approaches have been pursued to control disease, palliate symptoms, and extend survival. Chemosaturation is an innovative way to deliver high-dose chemotherapy to the liver via the hepatic artery. Within the last decade, "isolated hepatic perfusion" (IHP) has evolved from an open surgical approach to a minimally invasive procedure, now termed "chemosaturation" (CS) with "percutaneous hepatic perfusion (PHP)". The most conclusive data on CS-PHP is currently available for patients with hepatic metastases from uveal melanoma (UM) - a rare but devastating disease with a poor long-term survival rate. A global phase-3 study and several cohort studies have provided compelling evidence that CS-PHP is an effective salvage treatment for liver-dominant metastatic UM in institutions with appropriate expertise. In this review we provide an overview on the technique, available clinical data, including safety and efficacy, and potential indications for CS-PHP.
MeSH term(s)	Humans ; Melphalan ; Antineoplastic Agents, Alkylating/therapeutic use ; Chemotherapy, Cancer, Regional Perfusion/methods ; Liver Neoplasms/pathology
Chemical Substances	Melphalan (Q41OR9510P) ; Antineoplastic Agents, Alkylating
Language	English
Publishing date	2022-12-24
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2022.102501
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Article: Sociodemographic Differences in Health Awareness and Oral Health in Pregnant Women

Kühle, Anna-Maria / Wacker, Jürgen

Geburtshilfe und Frauenheilkunde

2020 Volume 80, Issue 08, Page(s) 834–843

Abstract: Objective: The aim of this study was to determine the present oral health status of pregnant women depending on selected sociodemographic differences and deduce any resulting consequences for health prevention.: Methods: The participantsʼ data of ... ...

Abstract	Objective: The aim of this study was to determine the present oral health status of pregnant women depending on selected sociodemographic differences and deduce any resulting consequences for health prevention. Methods: The participantsʼ data of relevance to the study such as age, school leaving qualification, migration background, smoking habits or last dentist visit were recorded using a questionnaire. The subsequent dental check-up concentrated on open carious lesions, any initiated root canal treatments and missing teeth. Finally, the Periodontal Screening Index was recorded to diagnose the presence of any gingivitis or periodontitis. The subsequent biometric evaluation comprised descriptive data analysis, χ 2 test and logistical regression. Results: The higher the school leaving qualification, the lower the probability that a pregnant woman smoked prior to pregnancy (OR 0.291; 95% CI 0.114 – 0.743) and that tartar was diagnosed (OR 0.424; 95% CI 0.185 – 0.973). Regular dentist visits (OR 4.026; 95% CI 1.613 – 10.049) increase with the attained school leaving qualification. There is a greater chance that women born in Germany taking part in the study were aware of dental risks in pregnancy (OR 2.652; 95% CI 1.285 – 5.472) and attended the dentist during pregnancy (OR 2.507; 95% CI 1.281 – 4.907). Conclusion: The rate of awareness of the risks and consequences of pregnancy for oral health must be increased. The main aim for primary prophylaxis should be a reduction in the periodontal bacteria and caries of the mother and father. ; Fragestellung: Ziel dieser Studie ist es, einen aktuellen Status der Mundgesundheit von Schwangeren in Abhängigkeit ausgewählter soziodemografischer Unterschiede zu ermitteln und gegebenenfalls daraus Konsequenzen für die Gesundheitsprävention abzuleiten. Methoden: Anhand eines Fragebogens wurden zunächst die studienrelevanten Daten der Teilnehmerinnen wie das Alter, der Schulabschluss, der Migrationshintergrund, das Rauchverhalten oder der letzte Zahnarztbesuch erfasst. Eine anschließende zahnärztliche Kontrolluntersuchung konzentrierte sich auf offene kariöse Läsionen, begonnene Wurzelkanalbehandlungen und fehlende Zähne. Um eine eventuell vorliegende Gingivitis oder Parodontitis zu diagnostizieren, ermittelte man abschließend den Parodontalen Screening Index. Deskriptive Datenanalyse, χ 2 -Test und logistische Regression in der anschließenden biometrischen Auswertung. Ergebnisse: Je höher der Schulabschluss, desto geringer ist die Wahrscheinlichkeit, dass eine Schwangere vor der Schwangerschaft geraucht hat (OR 0,291; 95%-KI 0,114 – 0,743) und Zahnstein diagnostizierbar ist (OR 0,424; 95%-KI 0,185 – 0,973). Regelmäßige Zahnarztbesuche (OR 4,026; 95%-KI 1,613 – 10,049) nehmen mit der Höhe des Schulabschlusses zu. Bei den in Deutschland geborenen Frauen ist die Chance größer, dass eine Studienteilnehmerin eine Aufklärung über zahnärztliche Risiken in der Schwangerschaft erhalten hat (OR 2,652; 95%-KI 1,285 – 5,472) und während der Schwangerschaft beim Zahnarzt war (OR 2,507; 95%-KI 1,281 – 4,907). Schlussfolgerung: Die Aufklärungsrate über Risiken und Folgen einer Schwangerschaft für die Mundgesundheit muss erhöht werden. Hauptziel im Sinne einer Primärprophylaxe sollte die parodontale Keim- und Kariesreduktion von Mutter und Vater sein.
Keywords	bacterial infection ; gestational diabetes ; premature birth ; screening ; bakterielle Infektion ; Gestationsdiabetes ; Frühgeburt ; Vorsorge
Language	English
Publishing date	2020-08-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80111-2
ISSN	1438-8804 ; 0016-5751 ; 1615-3359
ISSN (online)	1438-8804
ISSN	0016-5751 ; 1615-3359
DOI	10.1055/a-1205-0601
Database	Thieme publisher's database

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Article ; Online: PREFUL MRI for Monitoring Perfusion and Ventilation Changes after Elexacaftor-Tezacaftor-Ivacaftor Therapy for Cystic Fibrosis: A Feasibility Study.

Dohna, Martha / Voskrebenzev, Andreas / Klimeš, Filip / Kaireit, Till F / Glandorf, Julian / Pallenberg, Sophia T / Ringshausen, Felix C / Hansen, Gesine / Renz, Diane Miriam / Wacker, Frank / Dittrich, Anna-Maria / Vogel-Claussen, Jens

Radiology. Cardiothoracic imaging

2024 Volume 6, Issue 2, Page(s) e230104

Abstract: Purpose To assess the feasibility of monitoring the effects of elexacaftor-tezacaftor-ivacaftor (ETI) therapy on lung ventilation and perfusion in people with cystic fibrosis (CF), using phase-resolved functional lung (PREFUL) MRI. Materials and Methods ... ...

Abstract	Purpose To assess the feasibility of monitoring the effects of elexacaftor-tezacaftor-ivacaftor (ETI) therapy on lung ventilation and perfusion in people with cystic fibrosis (CF), using phase-resolved functional lung (PREFUL) MRI. Materials and Methods This secondary analysis of a multicenter prospective study was carried out between August 2020 and March 2021 and included participants 12 years or older with CF who underwent PREFUL MRI, spirometry, sweat chloride test, and lung clearance index assessment before and 8-16 weeks after ETI therapy. For PREFUL-derived ventilation and perfusion parameter extraction, two-dimensional coronal dynamic gradient-echo MR images were evaluated with an automated quantitative pipeline. T1- and T2-weighted MR images and PREFUL perfusion maps were visually assessed for semiquantitative Eichinger scores. Wilcoxon signed rank test compared clinical parameters and PREFUL values before and after ETI therapy. Correlation of parameters was calculated as Spearman ρ correlation coefficient. Results Twenty-three participants (median age, 18 years [IQR: 14-24.5 years]; 13 female) were included. Quantitative PREFUL parameters, Eichinger score, and clinical parameters (lung clearance index = 21) showed significant improvement after ETI therapy. Ventilation defect percentage of regional ventilation decreased from 18% (IQR: 14%-25%) to 9% (IQR: 6%-17%) (
MeSH term(s)	Adolescent ; Female ; Humans ; Aminophenols ; Benzodioxoles ; Cystic Fibrosis/diagnostic imaging ; Feasibility Studies ; Indoles ; Lung/diagnostic imaging ; Magnetic Resonance Imaging ; Perfusion ; Prospective Studies ; Pyrazoles ; Pyridines ; Pyrrolidines ; Quinolones ; Respiration ; Male ; Young Adult
Chemical Substances	Aminophenols ; Benzodioxoles ; elexacaftor (RRN67GMB0V) ; Indoles ; ivacaftor (1Y740ILL1Z) ; Pyrazoles ; Pyridines ; Pyrrolidines ; Quinolones ; tezacaftor
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ISSN	2638-6135
ISSN (online)	2638-6135
DOI	10.1148/ryct.230104
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