Article ; Online: Annulate lamellae and intracellular pathogens.
2021 Volume 23, Issue 8, Page(s) e13328
Abstract: Annulate lamellae (AL) have been observed many times over the years on electron micrographs of rapidly dividing cells, but little is known about these unusual organelles consisting of stacked sheets of endoplasmic reticulum-derived membranes with nuclear ...
Abstract | Annulate lamellae (AL) have been observed many times over the years on electron micrographs of rapidly dividing cells, but little is known about these unusual organelles consisting of stacked sheets of endoplasmic reticulum-derived membranes with nuclear pore complexes (NPCs). Evidence is growing for a role of AL in viral infection. AL have been observed early in the life cycles of the hepatitis C virus (HCV) and, more recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), suggesting a specific induction of mechanisms potentially useful to these pathogens. Like other positive-strand RNA viruses, these viruses induce host cells membranes rearrangements. The NPCs of AL could potentially mediate exchanges between these partially sealed compartments and the cytoplasm. AL may also be involved in regulating Ca |
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MeSH term(s) | Animals ; COVID-19 ; Cytoplasm/virology ; Endoplasmic Reticulum/microbiology ; Endoplasmic Reticulum/parasitology ; Endoplasmic Reticulum/ultrastructure ; Endoplasmic Reticulum/virology ; Host-Pathogen Interactions/physiology ; Humans ; Organelles/microbiology ; Organelles/parasitology ; Organelles/ultrastructure ; Organelles/virology ; SARS-CoV-2/physiology |
Language | English |
Publishing date | 2021-03-25 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ZDB-ID | 1468320-9 |
ISSN | 1462-5822 ; 1462-5814 |
ISSN (online) | 1462-5822 |
ISSN | 1462-5814 |
DOI | 10.1111/cmi.13328 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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