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  1. Article ; Online: Hepatitis B Virus DNA Integration Drives Carcinogenesis and Provides a New Biomarker for HBV-related HCC.

    Yeh, Shiou-Hwei / Li, Chiao-Ling / Lin, You-Yu / Ho, Ming-Chih / Wang, Ya-Chun / Tseng, Sheng-Tai / Chen, Pei-Jer

    Cellular and molecular gastroenterology and hepatology

    2023  Volume 15, Issue 4, Page(s) 921–929

    Abstract: Hepatitis B virus (HBV) DNA integration is an incidental event in the virus replication cycle and occurs in less than 1% of infected hepatocytes during viral infection. However, HBV DNA is present in the genome of approximately 90% of HBV-related HCCs ... ...

    Abstract Hepatitis B virus (HBV) DNA integration is an incidental event in the virus replication cycle and occurs in less than 1% of infected hepatocytes during viral infection. However, HBV DNA is present in the genome of approximately 90% of HBV-related HCCs and is the most common somatic mutation. Whole genome sequencing of liver tissues from chronic hepatitis B patients showed integration occurring at random positions in human chromosomes; however, in the genomes of HBV-related HCC patients, there are integration hotspots. Both the enrichment of the HBV-integration proportion in HCC and the emergence of integration hotspots suggested a strong positive selection of HBV-integrated hepatocytes to progress to HCC. The activation of HBV integration hotspot genes, such as telomerase (TERT) or histone methyltransferase (MLL4/KMT2B), resembles insertional mutagenesis by oncogenic animal retroviruses. These candidate oncogenic genes might shed new light on HBV-related HCC biology and become targets for new cancer therapies. Finally, the HBV integrations in individual HCC contain unique sequences at the junctions, such as virus-host chimera DNA (vh-DNA) presumably being a signature molecule for individual HCC. HBV integration may thus provide a new cell-free tumor DNA biomarker to monitor residual HCC after curative therapies or to track the development of de novo HCC.
    MeSH term(s) Humans ; Hepatitis B virus/genetics ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/genetics ; Carcinogenesis/genetics ; DNA, Viral/genetics
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2023.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Secure the availability of labor: Extension of annual paid leave settlement between healthcare workers and employers is good for post COVID-19 recovery.

    Wang, Chiao-Ling / Hung, Chung-Yu / Lin, Fang-Jiun / Hsiao, Shih-Huai

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2020  Volume 119, Issue 12, Page(s) 1881–1883

    MeSH term(s) Betacoronavirus ; COVID-19 ; Contracts ; Coronavirus Infections ; Health Personnel/economics ; Health Personnel/psychology ; Health Workforce/economics ; Humans ; Pandemics/economics ; Pneumonia, Viral ; SARS-CoV-2 ; Salaries and Fringe Benefits/economics ; Taiwan
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country Singapore
    Document type Letter
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2020.06.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1041: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Secure the availability of labor

    Chiao-Ling Wang / Chung-Yu Hung / Fang-Jiun Lin / Shih-Huai Hsiao

    Journal of the Formosan Medical Association, Vol 119, Iss 12, Pp 1881-

    Extension of annual paid leave settlement between healthcare workers and employers is good for post COVID-19 recovery

    2020  Volume 1883

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Competing Risk Analysis of Outcomes of Unresectable Pancreatic Cancer Patients Undergoing Definitive Radiotherapy.

    Chen, Yi-Lun / Tsai, Chiao-Ling / Cheng, Jason Chia-Hsien / Wang, Chun-Wei / Yang, Shih-Hung / Tien, Yu-Wen / Kuo, Sung-Hsin

    Frontiers in oncology

    2022  Volume 11, Page(s) 730646

    Abstract: Purpose: We investigated potential factors, including clinicopathological features, treatment modalities, neutrophil-to-lymphocyte ratio (NLR), carbohydrate antigen (CA) 19-9 level, tumor responses correlating with overall survival (OS), local ... ...

    Abstract Purpose: We investigated potential factors, including clinicopathological features, treatment modalities, neutrophil-to-lymphocyte ratio (NLR), carbohydrate antigen (CA) 19-9 level, tumor responses correlating with overall survival (OS), local progression (LP), and distant metastases (DMs), in patients with locally advanced pancreatic cancer (LAPC) who received definitive radiotherapy (RT).
    Methods: We retrospectively analyzed demographic characteristics; biologically effective doses (BED
    Results: A median BED
    Conclusion: Our results indicate that pre-RT NLR and post-RT monitoring of CA19-9 and tumor size reduction can help identify whether patients belong to the good or poor prognostic group of LAPC. The incorporation of new systemic treatments during and after a higher BED
    Language English
    Publishing date 2022-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.730646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The correlation between professional quality of life and mental health outcomes among hospital personnel during the Covid-19 pandemic in Taiwan.

    Su, Po-An / Lo, Mu-Chen / Wang, Chiao-Ling / Yang, Ping-Chen / Chang, Chiao-I / Huang, Meng-Chuan / Huang, Ming-Kuo / Cheng, Kuang-I

    Journal of multidisciplinary healthcare

    2021  Volume 14, Page(s) 3485–3495

    Abstract: Purpose: This study investigated the association between professional quality of life, working context, and mental health outcomes among hospital personnel in Taiwan during the worldwide upsurge in COVID-19 cases.: Patients and methods: We recruited ... ...

    Abstract Purpose: This study investigated the association between professional quality of life, working context, and mental health outcomes among hospital personnel in Taiwan during the worldwide upsurge in COVID-19 cases.
    Patients and methods: We recruited 503 hospital personnel to whom we administered online questionnaires containing items from the Professional Quality of Life (ProQoL) scale, which covers compassion satisfaction (CS), burnout (BO) and compassion fatigue (CF), the Depression, Anxiety and Stress Scale (DASS-21) and questions on work-related variables. Data were collected from 13 July to 19 August 2020.
    Results: The participants generally reported moderate CS and BO and low CF. Overall prevalence of mild-to-extremely-severe stress, anxiety and depression was 24.5%, 39.6% and 31.2%, respectively. Multiple logistic regression revealed that moderate-to-high BO and CF correlated with increased risks of mild-to-extremely-severe stress (OR = 4.17 and 2.23, respectively), anxiety (OR = 4.86 and 2.81, respectively) and depression (OR = 5.83 and 3.01, respectively), while moderate-to-high CS correlated with reduced risks of stress (OR = 0.53) and depression (OR = 0.45) only. There were CS and BO differences in groups categorized by marital status and profession. Anxiety increased linearly by seniority <10, 10-19 and ≥20 years (p for trend <0.05).
    Conclusion: In conclusion, the subscales of ProQOL, BO and CF appeared to be associated with increased risks of stress, anxiety and depression among hospital personnel during the COVID-19 epidemic. A long-term contingency program may be needed to adjust work context variables and support emotional well-being of these workers.
    Language English
    Publishing date 2021-12-21
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2453343-9
    ISSN 1178-2390
    ISSN 1178-2390
    DOI 10.2147/JMDH.S330533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Secure the availability of labor: Extension of annual paid leave settlement between healthcare workers and employers is good for post COVID-19 recovery

    Wang, Chiao-Ling / Hung, Chung-Yu / Lin, Fang-Jiun / Hsiao, Shih-Huai

    J. Formos. Med. Assoc

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #628028
    Database COVID19

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  7. Article: HBV DNA Integration into Telomerase or MLL4 Genes and TERT Promoter Point Mutation as Three Independent Signatures in Subgrouping HBV-Related HCC with Distinct Features.

    Li, Chiao-Ling / Hsu, Chia-Lang / Lin, You-Yu / Ho, Ming-Chih / Hu, Ray-Heng / Chen, Chi-Ling / Ho, Tung-Ching / Lin, Yung-Feng / Tsai, Shih-Feng / Tzeng, Sheng-Tai / Huang, Chin-Fang / Wang, Ya-Chun / Yeh, Shiou-Hwei / Chen, Pei-Jer

    Liver cancer

    2023  Volume 13, Issue 1, Page(s) 41–55

    Abstract: Introduction: A set of genetic mutations to classify hepatocellular carcinoma (HCC) useful to clinical studies is an unmet need. Hepatitis B virus-related HCC (HBV-HCC) harbors a unique genetic mutation, namely, the HBV integration, among other somatic ... ...

    Abstract Introduction: A set of genetic mutations to classify hepatocellular carcinoma (HCC) useful to clinical studies is an unmet need. Hepatitis B virus-related HCC (HBV-HCC) harbors a unique genetic mutation, namely, the HBV integration, among other somatic endogenous gene mutations. We explored a combination of HBV DNA integrations and common somatic mutations to classify HBV-HCC by using a capture-sequencing platform.
    Methods: A total of 153 HBV-HCCs after surgical resection were subjected to capture sequencing to identify HBV integrations and three common somatic mutations in genomes. Three mutually exclusive mutations, HBV DNA integration into the TERT promoter, HBV DNA integration into MLL4, or TERT promoter point mutation, were identified in HBV-HCC.
    Results: They were used to classify HBV-HCCs into four groups: G1 with HBV-TERT integration (25.5%); G2 with HBV-MLL4 integration (10.5%); G3 with TERT promoter mutation (30.1%); and G4 without these three mutations (34.0%). Clinically, G3 has the highest male-to-female ratio, cirrhosis rate, and associated with higher early recurrence and mortality after resection, but G4 has the best outcome. Transcriptomic analysis revealed a grouping different from the published ones and G2 with an active immune profile related to immune checkpoint inhibitor response. Analysis of integrated HBV DNA provided clues for HBV genotype and variants in carcinogenesis of different HCC subgroup. This new classification was also validated in another independent cohort.
    Conclusion: A simple and robust genetic classification was developed to aid in understanding HBV-HCC and in harmonizing clinical studies.
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2666925-0
    ISSN 1664-5553 ; 2235-1795
    ISSN (online) 1664-5553
    ISSN 2235-1795
    DOI 10.1159/000530699
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  8. Article ; Online: Secure the availability of labor

    Wang, Chiao-Ling / Hung, Chung-Yu / Lin, Fang-Jiun / Hsiao, Shih-Huai

    Journal of the Formosan Medical Association ; ISSN 0929-6646

    Extension of annual paid leave settlement between healthcare workers and employers is good for post COVID-19 recovery

    2020  

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.jfma.2020.06.027
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage.

    Cheng, Ya-Wen / Chao, Tai-Ling / Li, Chiao-Ling / Wang, Sheng-Han / Kao, Han-Chieh / Tsai, Ya-Min / Wang, Hurng-Yi / Hsieh, Chi-Ling / Lin, You-Yu / Chen, Pei-Jer / Chang, Sui-Yuan / Yeh, Shiou-Hwei

    mBio

    2021  Volume 12, Issue 4, Page(s) e0058721

    Abstract: Since the D614G substitution in the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, the variant strain has undergone a rapid expansion to become the most abundant strain worldwide. Therefore, this substitution ... ...

    Abstract Since the D614G substitution in the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, the variant strain has undergone a rapid expansion to become the most abundant strain worldwide. Therefore, this substitution may provide an advantage for viral spreading. To explore the mechanism, we analyzed 18 viral isolates containing S proteins with either G614 or D614 (S-G614 and S-D614, respectively). The plaque assay showed a significantly higher virus titer in S-G614 than in S-D614 isolates. We further found increased cleavage of the S protein at the furin substrate site, a key event that promotes syncytium formation, in S-G614 isolates. The enhancement of the D614G substitution in the cleavage of the S protein and in syncytium formation has been validated in cells expressing S protein. The effect on the syncytium was abolished by furin inhibitor treatment and mutation of the furin cleavage site, suggesting its dependence on cleavage by furin. Our study pointed to the impact of the D614G substitution on syncytium formation through enhanced furin-mediated S cleavage, which might increase the transmissibility and infectivity of SARS-CoV-2 strains containing S-G614.
    MeSH term(s) Amino Acid Substitution/genetics ; Animals ; COVID-19/pathology ; COVID-19/transmission ; Cell Line ; Chlorocebus aethiops ; Furin/antagonists & inhibitors ; Furin/metabolism ; Genetic Fitness/genetics ; Genome, Viral/genetics ; Giant Cells/virology ; HEK293 Cells ; Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/genetics ; Vero Cells ; Viral Load/genetics ; Virus Replication/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; FURIN protein, human (EC 3.4.21.75) ; Furin (EC 3.4.21.75)
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00587-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Responses of a common tropical epiphyte,

    Chen, Xiao-Zhen / Hogan, J Aaron / Wang, Chiao-Ping / Wang, Pei-Ling / Lin, Teng-Chiu

    AoB PLANTS

    2023  Volume 15, Issue 6, Page(s) plad076

    Abstract: Epiphytes are highly dependent on atmospheric inputs of water and nutrients. Reductions in water availability associated with warming and climate change and continual atmospheric nitrogen (N) deposition can affect plant growth but few studies have ... ...

    Abstract Epiphytes are highly dependent on atmospheric inputs of water and nutrients. Reductions in water availability associated with warming and climate change and continual atmospheric nitrogen (N) deposition can affect plant growth but few studies have evaluated the effects of changes in both water and nutrient availabilities on epiphytes. We experimentally tested whether epiphyte growth is more water- or nutrient-limited, if nutrient limitation was stronger for nitrogen or phosphorus, and whether nutrient limitation interacts with water availability. We applied watering (high and low) and nutrient addition (control, +N, +P, +N+P) treatments to greenhouse-grown
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2555823-7
    ISSN 2041-2851
    ISSN 2041-2851
    DOI 10.1093/aobpla/plad076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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