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Article ; Online: Top tips on endoscopy in post-bariatric surgery patients.

Jirapinyo, Pichamol

2024 Volume 99, Issue 5, Page(s) 809–813

Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2024.01.011
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Article ; Online: Development of a novel endoscopic suturing simulator: validation and impact on clinical learning curve (with video).

Jirapinyo, Pichamol / Thompson, Christopher C

Gastrointestinal endoscopy

2023 Volume 99, Issue 1, Page(s) 41–49

Abstract: Background and aims: Endoscopic suturing is a complex skill with broad applications. The aim of this study was to develop and validate a novel endoscopic suturing simulator and scoring system for the purse-string suture pattern.: Methods: This was a ... ...

Abstract	Background and aims: Endoscopic suturing is a complex skill with broad applications. The aim of this study was to develop and validate a novel endoscopic suturing simulator and scoring system for the purse-string suture pattern. Methods: This was a prospective study of an endoscopic suturing simulator that consists of a circular opening representing a dilated gastrojejunal anastomosis of Roux-en-Y gastric bypass with 12 small target holes around its circumference. Purse-string suturing is performed in a counterclockwise fashion. Time allotted is 5 minutes, and each successful bite is awarded 10 points. Participants were divided into the novice, intermediate, and experienced groups. Validity evidence based on content, validity evidence based on other variables, and validity evidence based on consequences of testing were assessed. Results: Seventeen subjects (3 novice, 7 intermediate, and 7 experienced) participated in the study. Validity evidence based on content: The content validity index for realism, relevance, and representativeness was 0.89, 1.00, and 1.00, respectively. Validity evidence based on other variables: The novice, intermediate, and experienced groups scored 30.0 ± 8.2, 57.1 ± 28.1, and 131.2 ± 51.7 (P = .001). Validity evidence based on consequences of testing: The simulator group required 5 ± 5 transoral outlet reduction cases before being able to independently complete an entire purse-string, whereas the non-simulator group required 38 ± 11 clinical cases (P < .0001). Conclusions: This novel endoscopic suturing simulator seems realistic, relevant, and representative of the clinical suturing experience. In addition, it seems effective at objectively assessing suturing skills and shortening the clinical learning curve.
MeSH term(s)	Humans ; Learning Curve ; Prospective Studies ; Endoscopy ; Gastric Bypass ; Reoperation ; Suture Techniques ; Clinical Competence ; Laparoscopy
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Video-Audio Media ; Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2023.07.045
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Article ; Online: Combining transoral outlet reduction with pharmacotherapy yields similar 1-year efficacy with improved safety compared with surgical revision for weight regain after Roux-en-Y gastric bypass (with videos).

Jirapinyo, Pichamol / Thompson, Christopher C

Gastrointestinal endoscopy

2023 Volume 98, Issue 4, Page(s) 552–558

Abstract: Background and aims: Transoral outlet reduction (TORe) and antiobesity medication (AOM) are effective treatments for weight regain after Roux-en-Y gastric bypass (RYGB). This study aims to assess the efficacy of combination therapy (TORe + AOM) for ... ...

Abstract	Background and aims: Transoral outlet reduction (TORe) and antiobesity medication (AOM) are effective treatments for weight regain after Roux-en-Y gastric bypass (RYGB). This study aims to assess the efficacy of combination therapy (TORe + AOM) for treating weight regain and to compare the safety and efficacy of combination therapy with AOM alone, TORe alone, and surgical revision of RYGB. Methods: This was a retrospective study of RYGB patients with weight regain who underwent combination therapy, defined as initiation of at least 1 AOM within 6 months before or after TORe. Outcomes were weight loss after combination therapy and comparison of combination therapy with AOM alone, TORe alone, and surgical revision. Results: One hundred forty-five RYGB patients underwent combination therapy. Most commonly prescribed AOMs were topiramate, phentermine/topiramate, phentermine, and liraglutide. At 12 months, patients experienced 15.2% ± 7.4% total weight loss (TWL). Ninety percent of patients achieved ≥5% TWL at 12 months. Combination therapy was associated with greater weight loss than AOM alone (15.2% ± 7.4% vs 6.8% ± 8.2% TWL, P < .0001) or TORe alone (15.2% ± 7.4% vs 8.7% ± 8.3% TWL, P < .0001), with similar serious adverse event rates (2.1% vs 4.7% vs .6% for combination therapy vs AOM alone vs TORe alone, P > .05). Combination therapy yielded similar weight loss to surgical revision (15.2% ± 7.4% vs 16.4% ± 13.1% TWL, P = .34), with a lower serious adverse event rate (2.1% vs 14.3%, P = .0004). Conclusions: Combination of TORe with AOM is superior to either therapy alone, providing similar efficacy to surgical revision with a better safety profile for the treatment of weight regain after RYGB.
MeSH term(s)	Humans ; Reoperation ; Gastric Bypass ; Retrospective Studies ; Topiramate ; Phentermine ; Weight Loss ; Weight Gain
Chemical Substances	Topiramate (0H73WJJ391) ; Phentermine (C045TQL4WP)
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2023.04.2092
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Article ; Online: Reply.

Jirapinyo, Pichamol / Thompson, Christopher C

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2021 Volume 20, Issue 5, Page(s) 1187–1188

Language	English
Publishing date	2021-06-26
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2021.06.022
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Article ; Online: Primary Bariatric Procedures.

Jirapinyo, Pichamol / Thompson, Christopher C

Digestive diseases and sciences

2022 Volume 67, Issue 5, Page(s) 1674–1687

Abstract: Obesity is pandemic. It is estimated that by 2030, half of the U.S. population will have obesity. Current treatment options for obesity includes lifestyle modification, pharmacotherapy, endoscopic bariatric and metabolic therapy (EBMT) and bariatric ... ...

Abstract	Obesity is pandemic. It is estimated that by 2030, half of the U.S. population will have obesity. Current treatment options for obesity includes lifestyle modification, pharmacotherapy, endoscopic bariatric and metabolic therapy (EBMT) and bariatric surgery. Over the past decades, an increasing number of EBMTs have been developed and become available. As a gastroenterologist, it is therefore important to become familiar with the available EBMTs as well as their safety and efficacy profiles in order to educate and expeditiously refer patients for the appropriate therapy when eligible. This chapter will review currently available and upcoming EBMTs. Details on how the procedures are performed, their mechanisms of action as well as data from pivotal studies will be summarized.
MeSH term(s)	Bariatric Surgery/adverse effects ; Bariatrics ; Endoscopy/methods ; Humans ; Obesity/etiology ; Treatment Outcome
Language	English
Publishing date	2022-03-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-022-07393-z
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Article ; Online: Combination Therapy of Endoscopic Gastric Remodeling with GLP-1RA for the Treatment of MASLD.

Jirapinyo, Pichamol / Jaroenlapnopparat, Aunchalee / Zucker, Stephen D / Thompson, Christopher C

Obesity surgery

2024 Volume 34, Issue 5, Page(s) 1471–1478

Abstract: Purpose: The mainstay of treatment for metabolic dysfunction-associated steatotic liver disease (MASLD) is weight loss. Endoscopic gastric remodeling (EGR) and glucagon-like peptide-1 receptor agonist (GLP-1RA) are effective weight loss therapies. This ... ...

Abstract	Purpose: The mainstay of treatment for metabolic dysfunction-associated steatotic liver disease (MASLD) is weight loss. Endoscopic gastric remodeling (EGR) and glucagon-like peptide-1 receptor agonist (GLP-1RA) are effective weight loss therapies. This study aims to assess the effect of combining EGR with GLP-1RA on liver-related outcomes and weight profile. Materials and methods: This is a retrospective study of a prospectively collected registry of patients with MASLD and compensated advanced chronic liver disease (cACLD) who underwent EGR. Patients were categorized as (1) monotherapy: EGR alone and (2) combination therapy: GLP-1RA prescribed within 6 months prior to or after EGR. Outcomes included changes in noninvasive tests of hepatic fibrosis, weight profile, and insulin resistance status at 12 months. Results: Thirty patients (body mass index 40.7 ± 9.3 kg/m Conclusions: In patients with MASLD and cACLD, combination of EGR with GLP-1RA is associated with greater improvements in hepatic fibrosis, weight profile, and insulin resistance compared to EGR alone.
MeSH term(s)	Humans ; Hypoglycemic Agents ; Diabetes Mellitus, Type 2/metabolism ; Insulin ; Retrospective Studies ; Insulin Resistance ; Obesity, Morbid/surgery ; Weight Loss ; Metabolic Diseases ; Liver Diseases ; Liver Cirrhosis/drug therapy ; Fibrosis
Chemical Substances	Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-024-07178-5
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Article ; Online: Endoscopic gastric plication for the treatment of weight regain after Roux-en-Y gastric bypass (with video).

Jirapinyo, Pichamol / Thompson, Christopher C

Gastrointestinal endoscopy

2022 Volume 96, Issue 1, Page(s) 51–56

Abstract: Background and aims: Gastric plication involves inverting the stomach with tissue anchor placement to achieve serosa-to-serosa apposition. One potential application of gastric plication is the treatment of weight regain after Roux-en-Y gastric bypass ( ... ...

Abstract	Background and aims: Gastric plication involves inverting the stomach with tissue anchor placement to achieve serosa-to-serosa apposition. One potential application of gastric plication is the treatment of weight regain after Roux-en-Y gastric bypass (RYGB), a procedure also known as plication transoral outlet reduction (P-TORe). This study aims to assess technical feasibility, safety, and efficacy of P-TORe. Methods: This was a registry study of RYGB patients who underwent P-TORe for weight regain. The primary outcome was the amount of weight loss and clinical success rate, defined as percentage of total weight loss (TWL) of at least 5% at 12 months. Secondary outcomes were technical success, adverse events (AEs), and predictors of weight loss. Results: One hundred eleven RYGB patients underwent P-TORe. Average body mass index (BMI) was 38.5 ± 7.5 kg/m Conclusions: This novel P-TORe technique combining APC with gastric plication appears to be technically feasible, safe, and effective at treating weight regain after RYGB.
MeSH term(s)	Anastomosis, Roux-en-Y ; Gastric Bypass/adverse effects ; Humans ; Obesity, Morbid/surgery ; Reoperation/methods ; Retrospective Studies ; Stomach/surgery ; Treatment Outcome ; Weight Gain ; Weight Loss
Language	English
Publishing date	2022-03-05
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2022.02.051
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Article ; Online: Comparison of distal primary obesity surgery endolumenal techniques for the treatment of obesity (with videos).

Jirapinyo, Pichamol / Thompson, Christopher C

Gastrointestinal endoscopy

2022 Volume 96, Issue 3, Page(s) 479–486

Abstract: Background and aims: Distal primary obesity surgery endolumenal (POSE) procedures involve plication of the gastric body, sparing the fundus. We aim to assess the efficacy of distal POSE procedures and to compare plication techniques (single-helix vs ... ...

Abstract	Background and aims: Distal primary obesity surgery endolumenal (POSE) procedures involve plication of the gastric body, sparing the fundus. We aim to assess the efficacy of distal POSE procedures and to compare plication techniques (single-helix vs double-helix approaches). Methods: This is a prospective registry study of patients who underwent distal POSE procedures using 2 techniques: the single-helix plication technique, in which a single plication with serosa-to-serosa approximation is obtained with each device activation, and the double-helix plication technique, where 2 serosa-to-serosa plications with an internal mucosa-to-mucosa approximation are obtained with each device activation. Results: One hundred ten patients (90 women; mean age, 43 ± 13 years) underwent distal POSE procedures. Baseline body mass index was 38.2 ± 6.1 kg/m Conclusions: Distal POSE techniques appear to be effective at treating obesity and its related comorbidities. The double-helix technique is associated with greater gastric volume reduction, weight loss, and response rate.
MeSH term(s)	Adult ; Bariatric Surgery/methods ; Female ; Humans ; Male ; Middle Aged ; Obesity/surgery ; Prospective Studies ; Treatment Outcome ; Weight Loss
Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2022.04.1346
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Article ; Online: Gastroplasty with endoscopic myotomy for the treatment of obesity.

Thompson, Christopher C / Jirapinyo, Pichamol / Shah, Raj / Simsek, Cem

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

2023 Volume 8, Issue 5, Page(s) 193–195

Abstract: Video 1Demonstration of the steps of gastroplasty with endoscopic myotomy for the treatment of obesity. ...

Abstract	Video 1Demonstration of the steps of gastroplasty with endoscopic myotomy for the treatment of obesity.
Language	English
Publishing date	2023-04-02
Publishing country	United States
Document type	Journal Article
ISSN	2468-4481
ISSN (online)	2468-4481
DOI	10.1016/j.vgie.2022.12.004
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Article: Endoscopic closure versus surgical revision in the management of gastro-gastric fistula following Roux-en-Y gastric bypass.

Dolan, Russell D / Jirapinyo, Pichamol / Maahs, Ethan D / Thompson, Christopher C

Endoscopy international open

2023 Volume 11, Issue 6, Page(s) E629–E634

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2023-06-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-2037-4764
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