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  1. Article ; Online: Use of anaesthesia machines for mechanical ventilation and sedation in patients with COVID-19 ARDS.

    Hanidziar, Dusan

    British journal of anaesthesia

    2021  Volume 127, Issue 2, Page(s) e72–e73

    MeSH term(s) Anesthesia ; COVID-19 ; Humans ; Respiration, Artificial ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-05-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2021.05.002
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  2. Article ; Online: Monitoring of sedation in mechanically ventilated patients using remote technology.

    Hanidziar, Dusan / Westover, Michael Brandon

    Current opinion in critical care

    2022  Volume 28, Issue 3, Page(s) 360–366

    Abstract: Purpose of review: Two years of coronavirus disease 2019 (COVID-19) pandemic highlighted that excessive sedation in the ICU leading to coma and other adverse outcomes remains pervasive. There is a need to improve monitoring and management of sedation in ...

    Abstract Purpose of review: Two years of coronavirus disease 2019 (COVID-19) pandemic highlighted that excessive sedation in the ICU leading to coma and other adverse outcomes remains pervasive. There is a need to improve monitoring and management of sedation in mechanically ventilated patients. Remote technologies that are based on automated analysis of electroencephalogram (EEG) could enhance standard care and alert clinicians real-time when severe EEG suppression or other abnormal brain states are detected.
    Recent findings: High rates of drug-induced coma as well as delirium were found in several large cohorts of mechanically ventilated patients with COVID-19 pneumonia. In patients with acute respiratory distress syndrome, high doses of sedatives comparable to general anesthesia have been commonly administered without defined EEG endpoints. Continuous limited-channel EEG can reveal pathologic brain states such as burst suppression, that cannot be diagnosed by neurological examination alone. Recent studies documented that machine learning-based analysis of continuous EEG signal is feasible and that this approach can identify burst suppression as well as delirium with high specificity.
    Summary: Preventing oversedation in the ICU remains a challenge. Continuous monitoring of EEG activity, automated EEG analysis, and generation of alerts to clinicians may reduce drug-induced coma and potentially improve patient outcomes.
    MeSH term(s) COVID-19 ; Coma ; Delirium/diagnosis ; Humans ; Intensive Care Units ; Respiration, Artificial ; Technology
    Language English
    Publishing date 2022-06-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000940
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  3. Article ; Online: In Response.

    Hanidziar, Dusan / Bittner, Edward A

    Anesthesia and analgesia

    2020  Volume 131, Issue 4, Page(s) e200–e202

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Respiration, Artificial ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005132
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  4. Article ; Online: In Response.

    Hanidziar, Dusan / Bittner, Edward A

    Anesthesia and analgesia

    2020  Volume 131, Issue 2, Page(s) e124–e125

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Respiration, Artificial ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000004961
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  5. Article ; Online: Synapomorphic features of hepatic and pulmonary vasculatures include comparable purinergic signaling responses in host defense and modulation of inflammation.

    Hanidziar, Dusan / Robson, Simon C

    American journal of physiology. Gastrointestinal and liver physiology

    2021  Volume 321, Issue 2, Page(s) G200–G212

    Abstract: Hepatosplanchnic and pulmonary vasculatures constitute synapomorphic, highly comparable networks integrated with the external environment. Given functionality related to obligatory requirements of "feeding and breathing," these organs are subject to ... ...

    Abstract Hepatosplanchnic and pulmonary vasculatures constitute synapomorphic, highly comparable networks integrated with the external environment. Given functionality related to obligatory requirements of "feeding and breathing," these organs are subject to constant environmental challenges entailing infectious risk, antigenic and xenobiotic exposures. Host responses to these stimuli need to be both protective and tightly regulated. These functions are facilitated by dualistic, high-low pressure blood supply of the liver and lungs, as well as tolerogenic characteristics of resident immune cells and signaling pathways. Dysregulation in hepatosplanchnic and pulmonary blood flow, immune responses, and microbiome implicate common pathogenic mechanisms across these vascular networks. Hepatosplanchnic diseases, such as cirrhosis and portal hypertension, often impact lungs and perturb pulmonary circulation and oxygenation. The reverse situation is also noted with lung disease resulting in hepatic dysfunction. Others, and we, have described common features of dysregulated cell signaling during liver and lung inflammation involving extracellular purines (e.g., ATP, ADP), either generated exogenously or endogenously. These metabokines serve as danger signals, when released by bacteria or during cellular stress and cause proinflammatory and prothrombotic signals in the gut/liver-lung vasculature. Dampening of these danger signals and organ protection largely depends upon activities of vascular and immune cell-expressed ectonucleotidases (CD39 and CD73), which convert ATP and ADP into anti-inflammatory adenosine. However, in many inflammatory disorders involving gut, liver, and lung, these protective mechanisms are compromised, causing perpetuation of tissue injury. We propose that interventions that specifically target aberrant purinergic signaling might prevent and/or ameliorate inflammatory disorders of the gut/liver and lung axis.
    MeSH term(s) Animals ; Blood Vessels/immunology ; Blood Vessels/metabolism ; Humans ; Liver/blood supply ; Liver/metabolism ; Lung/blood supply ; Lung/metabolism ; Purine Nucleotides/metabolism ; Receptors, Purinergic/metabolism ; Sepsis/metabolism ; Signal Transduction
    Chemical Substances Purine Nucleotides ; Receptors, Purinergic
    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00406.2020
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  6. Article ; Online: Acute Infection and Myocardial Infarction.

    Frank, Rachel C / Hanidziar, Dusan

    The New England journal of medicine

    2019  Volume 380, Issue 15, Page(s) e21

    MeSH term(s) Humans ; Infections ; Myocardial Infarction
    Language English
    Publishing date 2019-04-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1901647
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  7. Article ; Online: Sedation of Mechanically Ventilated COVID-19 Patients: Challenges and Special Considerations.

    Hanidziar, Dusan / Bittner, Edward A

    Anesthesia and analgesia

    2020  Volume 131, Issue 1, Page(s) e40–e41

    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Drug Monitoring ; Host-Pathogen Interactions ; Humans ; Hypnotics and Sedatives/administration & dosage ; Hypnotics and Sedatives/adverse effects ; Hypnotics and Sedatives/pharmacokinetics ; Intubation, Intratracheal/adverse effects ; Pandemics ; Patient Safety ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Respiration, Artificial/adverse effects ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Time Factors ; Treatment Outcome
    Chemical Substances Hypnotics and Sedatives
    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Letter
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000004887
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  8. Article ; Online: Hypotension, Systemic Inflammatory Response Syndrome, and COVID-19: A Clinical Conundrum.

    Hanidziar, Dusan / Bittner, Edward A

    Anesthesia and analgesia

    2020  Volume 131, Issue 3, Page(s) e175–e176

    MeSH term(s) Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; Blood Pressure ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Host-Pathogen Interactions ; Humans ; Hypotension/immunology ; Hypotension/physiopathology ; Hypotension/therapy ; Hypotension/virology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Prognosis ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/immunology ; Systemic Inflammatory Response Syndrome/physiopathology ; Systemic Inflammatory Response Syndrome/therapy ; Systemic Inflammatory Response Syndrome/virology
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Letter
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005062
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  9. Article ; Online: Dicrotic Pulse Due to Abdominal Aortic Aneurysm.

    Hanidziar, Dusan / Bittner, Edward A / Pino, Richard M

    Journal of cardiothoracic and vascular anesthesia

    2021  Volume 36, Issue 3, Page(s) 919–920

    MeSH term(s) Aortic Aneurysm, Abdominal/complications ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/surgery ; Blood Pressure ; Humans
    Language English
    Publishing date 2021-10-08
    Publishing country United States
    Document type Letter
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2021.10.004
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  10. Article ; Online: Hyperoxia and modulation of pulmonary vascular and immune responses in COVID-19.

    Hanidziar, Dusan / Robson, Simon C

    American journal of physiology. Lung cellular and molecular physiology

    2020  Volume 320, Issue 1, Page(s) L12–L16

    Abstract: Oxygen is the most commonly used therapy in hospitalized patients with COVID-19. In those patients who develop worsening pneumonia and acute respiratory distress syndrome (ARDS), high concentrations of oxygen may need to be administered for prolonged ... ...

    Abstract Oxygen is the most commonly used therapy in hospitalized patients with COVID-19. In those patients who develop worsening pneumonia and acute respiratory distress syndrome (ARDS), high concentrations of oxygen may need to be administered for prolonged time periods, often together with mechanical ventilation. Hyperoxia, although lifesaving and essential for maintaining adequate oxygenation in the short term, may have adverse long-term consequences upon lung parenchymal structure and function. How hyperoxia per se impacts lung disease in COVID-19 has remained largely unexplored. Numbers of experimental studies have previously established that hyperoxia is associated with deleterious outcomes inclusive of perturbations in immunologic responses, abnormal metabolic function, and alterations in hemodynamics and alveolar barrier function. Such changes may ultimately progress into clinically evident lung injury and adverse remodeling and result in parenchymal fibrosis when exposure is prolonged. Given that significant exposure to hyperoxia in patients with severe COVID-19 may be unavoidable to preserve life, these sequelae of hyperoxia, superimposed on the cytopathic effects of SARS-CoV-2 virus, may well impact pathogenesis of COVID-19-induced ARDS.
    MeSH term(s) COVID-19/complications ; Hemodynamics ; Humans ; Immunity/immunology ; Lung/blood supply ; Lung/immunology ; Lung/pathology ; Lung/virology ; Oxygen/adverse effects ; Respiration, Artificial ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/pathology ; SARS-CoV-2/isolation & purification
    Chemical Substances Oxygen (S88TT14065)
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00304.2020
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