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  1. Book ; Online ; E-Book: The basics of cancer immunotherapy

    Dong, Haidong / Markovic, Svetomir N.

    2018  

    Author's details Haidong Dong, Svetomir N. Markovic editors
    Keywords Popular works ; Cancer research ; Immunology ; Medicine ; Health
    Subject code 610
    Language English
    Size 1 Online-Ressource (X, 160 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021489558
    ISBN 978-3-319-70622-1 ; 9783319706214 ; 3-319-70622-5 ; 3319706217
    DOI 10.1007/978-3-319-70622-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Seeking and destroying the evils from the inside-translating cancer immunity to fight COVID-19.

    Dong, Haidong

    Cancer immunology, immunotherapy : CII

    2020  Volume 69, Issue 6, Page(s) 911–912

    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Cancer Vaccines/standards ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Humans ; Immunity, Cellular/immunology ; Immunity, Humoral/immunology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; T-Lymphocytes/immunology ; Viral Vaccines/immunology
    Chemical Substances COVID-19 Vaccines ; Cancer Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country Germany
    Document type Editorial
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-020-02580-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1237: Show issues Location:
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  3. Article ; Online: Solid pavestones are needed to pave a solid way to success.

    Dong, Haidong

    Cancer immunology, immunotherapy : CII

    2019  Volume 69, Issue 1, Page(s) 1

    MeSH term(s) Humans ; Immunotherapy/methods ; Immunotherapy/trends ; Neoplasms/immunology ; Neoplasms/therapy ; Publishing ; Treatment Outcome
    Language English
    Publishing date 2019-11-26
    Publishing country Germany
    Document type Editorial ; Portrait
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-019-02436-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Seeking and destroying the evils from the inside-translating cancer immunity to fight COVID-19

    Dong, Haidong

    Cancer Immunology, Immunotherapy

    2020  Volume 69, Issue 6, Page(s) 911–912

    Keywords Immunology ; Immunology and Allergy ; Cancer Research ; Oncology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-020-02580-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Exploring the Association Between Physical Activity and Cognitive Function Among People Living with Dementia.

    Jehu, Deborah A / Pottayil, Faheem / Dong, Yanbin / Zhu, Haidong / Sams, Richard / Young, Lufei

    Journal of Alzheimer's disease : JAD

    2024  

    Abstract: Background: Physical activity preserves cognitive function in people without dementia, but the relationship between physical activity and cognitive domains among people living with dementia is unclear.: Objective: The objective of this study was to ... ...

    Abstract Background: Physical activity preserves cognitive function in people without dementia, but the relationship between physical activity and cognitive domains among people living with dementia is unclear.
    Objective: The objective of this study was to explore the association between physical activity and cognition domains among people living with dementia.
    Methods: Participants living with dementia in residential care facilities (complete case analysis: n = 24/42) completed a battery of cognitive tests (global cognition: Montreal Cognitive Assessment; executive function: Trail-Making Test, Digit Span Forward Test; perception and orientation: Benton Judgement of Line Orientation Test; language: Boston Naming Test; learning and memory: Rey Auditory Verbal Learning Test; complex attention: Digit Symbol Substitution Test). Participants wore an actigraphy monitor on their non-dominant wrist over seven days. We conducted a linear regression for total physical activity (independent variable) with race (white/black), fall risk (Morse Fall Scale), and the number of comorbidities (Functional Comorbidities Index) as covariates, and cognitive tests as variables of interest.
    Results: Participants were primarily male (75%), white (87.5%), and 50%had unspecified dementia (Alzheimer's disease: 33%). Greater physical activity was associated with poorer global cognition, better executive function, and better learning and memory (ps <  0.05). Physical activity was not related to visuospatial perception, language, or complex attention.
    Conclusions: Physical activity may preserve executive function and learning and memory among people living with dementia. Wandering is more common in later stages of dementia, which may explain greater physical activity observed with lower global cognition. Regularly assessing physical activity may be useful in screening and monitoring cognitive changes.
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Platinum Nanoparticles-Enhanced Ferritin-Mn

    Liu, Shuangqing / Tian, Liya / Mu, Mengyao / Liu, Ziyan / Dong, Mengzhen / Gong, Yufang / Liu, Hui / Wang, Ximing / Meng, Qingwei / Zhang, Haidong / Sun, Xiao

    Advanced healthcare materials

    2024  , Page(s) e2303939

    Abstract: Nanoplatforms with high ... ...

    Abstract Nanoplatforms with high Mn
    Language English
    Publishing date 2024-03-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202303939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6966: Show issues Location:
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  8. Article ; Online: Impact of PD-1 Blockade in Nonresponders: Pitfalls and Promise.

    Yoon, Harry H / Dong, Haidong / Shi, Qian

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 28, Issue 15, Page(s) 3173–3175

    Abstract: Exploratory analysis of a phase III trial in esophageal cancer found that the patients who most contributed to an overall survival benefit from PD-1 blockade were not responders, but non-responders. The analysis has limitations but may have implications ... ...

    Abstract Exploratory analysis of a phase III trial in esophageal cancer found that the patients who most contributed to an overall survival benefit from PD-1 blockade were not responders, but non-responders. The analysis has limitations but may have implications for investigating the optimal timing of immunotherapy relative to other treatments. See related article by Okada et al., p. 3277.
    MeSH term(s) Esophageal Neoplasms/drug therapy ; Esophageal Squamous Cell Carcinoma ; Follow-Up Studies ; Humans ; Immunotherapy ; Nivolumab/therapeutic use ; Programmed Cell Death 1 Receptor
    Chemical Substances Programmed Cell Death 1 Receptor ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-22-0932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
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  9. Article ; Online: Electrically induced cancellation and inversion of piezoelectricity in ferroelectric Hf

    Lu, Haidong / Kim, Dong-Jik / Aramberri, Hugo / Holzer, Marco / Buragohain, Pratyush / Dutta, Sangita / Schroeder, Uwe / Deshpande, Veeresh / Íñiguez, Jorge / Gruverman, Alexei / Dubourdieu, Catherine

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 860

    Abstract: ... ...

    Abstract HfO
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44690-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus.

    Geng, Wenwen / Cao, Meiling / Dong, Ke / An, Junhua / Gao, Haidong

    Cancer biology & therapy

    2023  Volume 24, Issue 1, Page(s) 2206362

    Abstract: Aberrant activation of the mTOR pathway is a characteristic alteration in triple-negative breast cancer, but the mTOR pathway inhibitor everolimus is not effective for the triple-negative breast cancer (TNBC) patients. Presently, we showed that the ... ...

    Abstract Aberrant activation of the mTOR pathway is a characteristic alteration in triple-negative breast cancer, but the mTOR pathway inhibitor everolimus is not effective for the triple-negative breast cancer (TNBC) patients. Presently, we showed that the activation of ERK pathway was an important mechanism of resistance to everolimus in TNBC cells in this study. SHOC2, a key protein mediating the Ras-Raf-ERK pathway, could act as a scaffolding protein to facilitate the activation of the pathway by mediating the interaction of key components of the pathway. Our results showed that everolimus activated the Raf-ERK pathway by promoting the interaction between SHOC2 and c-Raf and that knockdown of SHOC2 significantly inhibited the Raf-ERK pathway induced by everolimus. We further demonstrated that SHOC2 expression levels were closely related to the sensitivity of TNBC cells to everolimus and that interference with SHOC2 expression in combination with everolimus had significant effects on the cell cycle progression and apoptosis in vitro experiments. Western blotting analysis showed that cell cycle regulators and apoptosis-related proteins were significantly altered by the combination treatment. Xenograft model also demonstrated that knockdown of SHOC2 significantly increased the sensitivity of tumor to everolimus in nude mice. In conclusion, our study showed that SHOC2 is a key factor in regulating the sensitivity of TNBC cells to everolimus and that combined therapy may be a more effective therapeutic approach for TNBC patients.
    MeSH term(s) Animals ; Female ; Humans ; Mice ; Cell Line, Tumor ; Cell Proliferation ; Drug Resistance, Neoplasm/genetics ; Everolimus/pharmacology ; Everolimus/therapeutic use ; Intracellular Signaling Peptides and Proteins ; Mice, Nude ; TOR Serine-Threonine Kinases/metabolism ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/metabolism ; Xenograft Model Antitumor Assays
    Chemical Substances Everolimus (9HW64Q8G6G) ; Intracellular Signaling Peptides and Proteins ; SHOC2 protein, human ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146305-0
    ISSN 1555-8576 ; 1538-4047
    ISSN (online) 1555-8576
    ISSN 1538-4047
    DOI 10.1080/15384047.2023.2206362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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