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Article ; Online: Low Birth Weight is Associated with More Severe Course of Steroid-Sensitive Nephrotic Syndrome in Children, Multicentric Study.

Konopásek, Patrik / Skálová, Sylva / Sládková, Eva / Pecková, Monika / Flachsová, Eva / Urbanová, Ivana / Laubová, Jana / Samešová, Martina / Dvořák, Pavel / Zieg, Jakub

Klinische Padiatrie

2024

Abstract: Background: Several previous studies have reported a more severe course of nephrotic syndrome in children with low birth weight.: Patients: Cohort of 223 children with idiopathic nephrotic syndrome.: Methods: We aimed to investigate the ... ...

Title translation	Niedriges Geburtsgewicht ist mit einem schwereren Verlauf des steroidsensitiven nephrotischen Syndroms bei Kindern verbunden, multizentrische Studie.
Abstract	Background: Several previous studies have reported a more severe course of nephrotic syndrome in children with low birth weight. Patients: Cohort of 223 children with idiopathic nephrotic syndrome. Methods: We aimed to investigate the association between course of nephrotic syndrome and low birth weight. Data from seven paediatric nephrology centres were used. Results: Children with low birth weight had 3.84 times higher odds for a more severe course of steroid-sensitive nephrotic syndrome (95% CI 1.20-17.22, P=0.041), and those with low birth weight and remission after 7 days had much higher odds for a more severe course of disease (OR 8.7). Low birth weight children had a longer time to remission (median 12 vs. 10 days, P=0.03). They had a higher need for steroid-sparing agents (OR for the same sex=3.26 [95% CI 1.17-11.62, P=0.039]), and the odds were even higher in females with low birth weight (OR 6.81). There was no evidence of an association either between low birth weight and focal segmental glomerulosclerosis or between low birth weight and steroid-resistant nephrotic syndrome. Discussion: We conducted the first multicentric study confirming the worse outcomes of children with NS and LBW and we found additional risk factors. Conclusions: Low birth weight is associated with a more severe course of steroid-sensitive nephrotic syndrome, while being female and achieving remission after 7 days are additional risk factors.
Language	English
Publishing date	2024-02-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	120650-3
ISSN	1439-3824 ; 0300-8630
ISSN (online)	1439-3824
ISSN	0300-8630
DOI	10.1055/a-2227-4892
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [No title information]

Konopásek, Patrik / Skálová, Sylva / Sládková, Eva / Pecková, Monika / Flachsová, Eva / Urbanová, Ivana / Laubová, Jana / Samešová, Martina / Dvořák, Pavel / Zieg, Jakub

Klinische Pädiatrie

2024

Abstract	Background: Several previous studies have reported a more severe course of nephrotic syndrome in children with low birth weight. Patients: Cohort of 223 children with idiopathic nephrotic syndrome. Methods: We aimed to investigate the association between course of nephrotic syndrome and low birth weight. Data from seven paediatric nephrology centres were used. Results: Children with low birth weight had 3.84 times higher odds for a more severe course of steroid-sensitive nephrotic syndrome (95% CI 1.20–17.22, P=0.041), and those with low birth weight and remission after 7 days had much higher odds for a more severe course of disease (OR 8.7). Low birth weight children had a longer time to remission (median 12 vs. 10 days, P=0.03). They had a higher need for steroid-sparing agents (OR for the same sex=3.26 [95% CI 1.17–11.62, P=0.039]), and the odds were even higher in females with low birth weight (OR 6.81). There was no evidence of an association either between low birth weight and focal segmental glomerulosclerosis or between low birth weight and steroid-resistant nephrotic syndrome. Discussion: We conducted the first multicentric study confirming the worse outcomes of children with NS and LBW and we found additional risk factors. Conclusions: Low birth weight is associated with a more severe course of steroid-sensitive nephrotic syndrome, while being female and achieving remission after 7 days are additional risk factors.
Keywords	Remission ; Low birth weight ; nephrotic syndrome ; children ; steroidsparing agent ; Remission ; niedriges Geburtsgewicht ; nephrotisches Syndrom ; Kinder ; steroidsparende Mittel
Language	English
Publishing date	2024-02-06
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	120650-3
ISSN	1439-3824 ; 0300-8630
ISSN (online)	1439-3824
ISSN	0300-8630
DOI	10.1055/a-2227-4892
Database	Thieme publisher's database

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Book ; Online ; Conference proceedings: Functional Plurality of Language in Contextualised Discourse

Gumbaridze, Zhuzhuna / Gvarishvili, Zeinab / Hastrdlová, Šárka / Huschová, Petra / Hüttner, Julia / Lahodová Vališová, Marie / Lapina, Evgeniia / Malá, Markéta / Peldová, Petra / Sládková, Věra / Twardzisz, Piotr / Headlandová Kalischová, Irena / Němec, Martin

Eighth Brno Conference on Linguistics Studies in English. Conference Proceedings. Brno, 12-13 September 2019

2020

Keywords	linguistics ; corpus ; CLIL ; pragmatics ; metaphor ; phraseology ; gender ; spoken language ; written discourse
Language	English
Size	1 electronic resource (173 pages)
Publisher	Masaryk University Press
Document type	Book ; Online ; Conference proceedings
Note	English
HBZ-ID	HT030375401
ISBN	9788021097667 ; 8021097663
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Human induced mesenchymal stem cells display increased sensitivity to matrix stiffness.

Gultian, Kirstene A / Gandhi, Roshni / Sarin, Khushi / Sladkova-Faure, Martina / Zimmer, Matthew / de Peppo, Giuseppe Maria / Vega, Sebastián L

Scientific reports

2022 Volume 12, Issue 1, Page(s) 8483

Abstract: The clinical translation of mesenchymal stem cells (MSCs) is limited by population heterogeneity and inconsistent responses to engineered signals. Specifically, the extent in which MSCs respond to mechanical cues varies significantly across MSC lines. ... ...

Abstract	The clinical translation of mesenchymal stem cells (MSCs) is limited by population heterogeneity and inconsistent responses to engineered signals. Specifically, the extent in which MSCs respond to mechanical cues varies significantly across MSC lines. Although induced pluripotent stem cells (iPSCs) have recently emerged as a novel cell source for creating highly homogeneous MSC (iMSC) lines, cellular mechanosensing of iMSCs on engineered materials with defined mechanics is not well understood. Here, we tested the mechanosensing properties of three human iMSC lines derived from iPSCs generated using a fully automated platform. Stiffness-driven changes in morphology were comparable between MSCs and iMSCs cultured atop hydrogels of different stiffness. However, contrary to tissue derived MSCs, no significant changes in iMSC morphology were observed between iMSC lines atop different stiffness hydrogels, demonstrating a consistent response to mechanical signals. Further, stiffness-driven changes in mechanosensitive biomarkers were more pronounced in iMSCs than MSCs, which shows that iMSCs are more adaptive and responsive to mechanical cues than MSCs. This study reports that iMSCs are a promising stem cell source for basic and applied research due to their homogeneity and high sensitivity to engineered mechanical signals.
MeSH term(s)	Biomarkers/metabolism ; Cell Differentiation ; Humans ; Hydrogels/metabolism ; Induced Pluripotent Stem Cells ; Mesenchymal Stem Cells
Chemical Substances	Biomarkers ; Hydrogels
Language	English
Publishing date	2022-05-19
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-12143-2
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Article ; Online: Human induced mesenchymal stem cells display increased sensitivity to matrix stiffness

Kirstene A. Gultian / Roshni Gandhi / Khushi Sarin / Martina Sladkova-Faure / Matthew Zimmer / Giuseppe Maria de Peppo / Sebastián L. Vega

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 9

Abstract: Abstract The clinical translation of mesenchymal stem cells (MSCs) is limited by population heterogeneity and inconsistent responses to engineered signals. Specifically, the extent in which MSCs respond to mechanical cues varies significantly across MSC ... ...

Abstract	Abstract The clinical translation of mesenchymal stem cells (MSCs) is limited by population heterogeneity and inconsistent responses to engineered signals. Specifically, the extent in which MSCs respond to mechanical cues varies significantly across MSC lines. Although induced pluripotent stem cells (iPSCs) have recently emerged as a novel cell source for creating highly homogeneous MSC (iMSC) lines, cellular mechanosensing of iMSCs on engineered materials with defined mechanics is not well understood. Here, we tested the mechanosensing properties of three human iMSC lines derived from iPSCs generated using a fully automated platform. Stiffness-driven changes in morphology were comparable between MSCs and iMSCs cultured atop hydrogels of different stiffness. However, contrary to tissue derived MSCs, no significant changes in iMSC morphology were observed between iMSC lines atop different stiffness hydrogels, demonstrating a consistent response to mechanical signals. Further, stiffness-driven changes in mechanosensitive biomarkers were more pronounced in iMSCs than MSCs, which shows that iMSCs are more adaptive and responsive to mechanical cues than MSCs. This study reports that iMSCs are a promising stem cell source for basic and applied research due to their homogeneity and high sensitivity to engineered mechanical signals.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transient Hyperphosphatasemia in a Child with Autism Spectrum Disorder.

Kutílek, Štěpán / Rondziková-Mlynarčíková, Eva / Pečenková, Kamila / Pikner, Richard / Šmída, Tomáš / Sládková, Eva / Honzík, Tomáš / Kolářová, Hana / Magner, Martin

Acta medica (Hradec Kralove)

2022 Volume 65, Issue 1, Page(s) 41–43

Abstract: Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and the presence of restricted interests and repetitive behaviors. Transient hyperphosphatasemia of infancy and early ... ...

Abstract	Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and the presence of restricted interests and repetitive behaviors. Transient hyperphosphatasemia of infancy and early childhood (THI) is a benign laboratory disorder characterized by transiently extremely elevated activity of serum alkaline phosphatase (S-ALP). Case report: We present a 21-month-old girl with a right leg limp, most probably due to reactive arthritis after febrile viral infection, and deterioration of psychomotor development with concomitant transient elevation of S-ALP (61.74 μkat/L; normal 2.36-7.68 μkat/L). Normal values of serum creatinine, aspartate-aminotransferase, alanin-aminotransferase, calcium, phosphate, together with normal wrist X-ray ruled out rickets or other bone or hepatic cause of high S-ALP. The S-ALP gradually decreased within 3 months, thus fulfilling the THI criteria. Screening for inborn errors of metabolism was negative and meticulous neurologic, psychologic and psychiatric assessment pointed to the diagnosis of autism spectrum disorder (ASD). There was no causal relationship between THI and ASD, as high S-ALP was an accidental and transient finding within the routine laboratory assessment. However, when THI occurs in a child with an onset of a new disorder, or with a pre-existing bone or liver disease, it might seriously concern the physician. Conclusion: Children with THI should be spared from extensive evaluations and unnecessary blood draws.
MeSH term(s)	Autism Spectrum Disorder/complications ; Autism Spectrum Disorder/diagnosis ; Female ; Humans ; Hyperphosphatemia/diagnosis ; Hyperphosphatemia/etiology ; Infant ; Reference Values
Language	English
Publishing date	2022-07-07
Publishing country	Czech Republic
Document type	Case Reports ; Journal Article
ZDB-ID	1360995-6
ISSN	1805-9694 ; 1211-4286
ISSN (online)	1805-9694
ISSN	1211-4286
DOI	10.14712/18059694.2022.16
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Article ; Online: Nephrotic syndrome sera induce different transcriptomes in podocytes based on the steroid response.

Bezdicka, Martin / Cinek, Ondrej / Semjonov, Valerij / Polackova, Katerina / Sladkova, Eva / Zieg, Jakub / Saleem, Moin A / Soucek, Ondrej

Physiological reports

2024 Volume 12, Issue 3, Page(s) e15932

Abstract: As the molecular mechanism of nephrotic syndrome remains largely undiscovered, patients continue to be exposed to the pros and cons of uniform glucocorticoid treatment. We explored whether the exposure of in vitro-cultivated podocytes to sera from ... ...

Abstract	As the molecular mechanism of nephrotic syndrome remains largely undiscovered, patients continue to be exposed to the pros and cons of uniform glucocorticoid treatment. We explored whether the exposure of in vitro-cultivated podocytes to sera from children with steroid-sensitive or steroid-resistant nephrotic syndrome induces differences in gene expression profiles, which could help to elucidate the pathogenesis of the steroid response. Human immortalized podocytes were cultivated with patient sera for 3 days. After cell lysis, RNA extraction, 3'-mRNA libraries were prepared and sequenced. There were 34 significantly upregulated and 14 downregulated genes (fold difference <0.5 and >2.0, respectively, and false discovery rate-corrected p < 0.05) and 22 significantly upregulated and 6 downregulated pathways (false discovery rate-corrected p < 0.01) in the steroid-sensitive (n = 9) versus steroid-resistant group (n = 4). The observed pathways included upregulated redox reactions, DNA repair, mitosis, protein translation and downregulated cholesterol biosynthesis. Sera from children with nephrotic syndrome induce disease subtype-specific transcriptome changes in human podocytes in vitro. However, further exploration of a larger cohort is needed to verify whether clinically distinct types of nephrotic syndrome or disease activity may be differentiated by specific transcriptomic profiles and whether this information may help to elucidate the pathogenesis of the steroid response.
MeSH term(s)	Child ; Humans ; Nephrotic Syndrome/genetics ; Podocytes/metabolism ; Transcriptome ; Glucocorticoids/pharmacology ; Steroids/metabolism
Chemical Substances	Glucocorticoids ; Steroids
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15932
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Contents of Selected Risk Elements and Organic Pollutants in Soil and Vegetation within a Former Military Area

Sládková, Aneta / Száková, Jiřina / Havelcová, Martina / Najmanová, Jana / Tlustoš, Pavel

Soil & sediment contamination. 2015 Apr. 3, v. 24, no. 3

2015

Abstract: The contents of selected risk elements (As, Ba, Be, Cd, Co, Cr, Cu, Fe, Ni, Pb, Sb, Ti, V, Zn), polycyclic aromatic hydrocarbons, and n-alkanes were determined in soils collected at the former military training base Milovice-Mladá (Czech Republic), where ...

Abstract	The contents of selected risk elements (As, Ba, Be, Cd, Co, Cr, Cu, Fe, Ni, Pb, Sb, Ti, V, Zn), polycyclic aromatic hydrocarbons, and n-alkanes were determined in soils collected at the former military training base Milovice-Mladá (Czech Republic), where military activities were terminated in 1991. Seventeen soil samples were collected from the former tank shooting range called “Benátecký vrch” (area 16.2 ha) covered with herbaceous vegetation cover. No sample exceeding the threshold limits for maximum permissible limits of risk elements in soil was identified. The contents of organic pollutants in soil also did not pose a potential environmental risk. The risk element contents (especially Cu, Ni, Pb, and Zn) in aboveground biomass of Dactylis glomerata (Poaceae), Hypericum perforatum (Hypericaceae), Galium verum (Rubiaceae), and Plantago lanceolata (Plantaginaceae) sampled close to the soil sampling points indicated, however, potential environmental damage originating from the municipal landfill covering a substantial part of the area since 1995.
Keywords	Dactylis glomerata ; Galium ; Hypericum perforatum ; Plantago lanceolata ; aboveground biomass ; alkanes ; arsenic ; barium ; cadmium ; chromium ; cobalt ; copper ; iron ; landfills ; lead ; nickel ; polycyclic aromatic hydrocarbons ; risk ; soil ; soil pollution ; soil sampling ; vegetation cover ; zinc ; Czech Republic
Language	English
Dates of publication	2015-0403
Size	p. 325-342.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2017739-2
ISSN	1549-7887 ; 1532-0383
ISSN (online)	1549-7887
ISSN	1532-0383
DOI	10.1080/15320383.2015.955605
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A biomimetic engineered bone platform for advanced testing of prosthetic implants.

Sladkova-Faure, Martina / Pujari-Palmer, Michael / Öhman-Mägi, Caroline / López, Alejandro / Wang, Hanbin / Engqvist, Håkan / de Peppo, Giuseppe Maria

Scientific reports

2020 Volume 10, Issue 1, Page(s) 22154

Abstract: Existing methods for testing prosthetic implants suffer from critical limitations, creating an urgent need for new strategies that facilitate research and development of implants with enhanced osseointegration potential. Herein, we describe a novel, ... ...

Abstract	Existing methods for testing prosthetic implants suffer from critical limitations, creating an urgent need for new strategies that facilitate research and development of implants with enhanced osseointegration potential. Herein, we describe a novel, biomimetic, human bone platform for advanced testing of implants in vitro, and demonstrate the scientific validity and predictive value of this approach using an assortment of complementary evaluation methods. We anchored titanium (Ti) and stainless steel (SS) implants into biomimetic scaffolds, seeded with human induced mesenchymal stem cells, to recapitulate the osseointegration process in vitro. We show distinct patterns of gene expression, matrix deposition, and mineralization in response to the two materials, with Ti implants ultimately resulting in stronger integration strength, as seen in other preclinical and clinical studies. Interestingly, RNAseq analysis reveals that the TGF-beta and the FGF2 pathways are overexpressed in response to Ti implants, while the Wnt, BMP, and IGF pathways are overexpressed in response to SS implants. High-resolution imaging shows significantly increased tissue mineralization and calcium deposition at the tissue-implant interface in response to Ti implants, contributing to a twofold increase in pullout strength compared to SS implants. Our technology creates unprecedented research opportunities towards the design of implants and biomaterials that can be personalized, and exhibit enhanced osseointegration potential, with reduced need for animal testing.
MeSH term(s)	Biomimetic Materials ; Biomimetics/methods ; Bone and Bones ; Humans ; Materials Testing ; Osseointegration ; Prostheses and Implants ; Stainless Steel ; Tissue Engineering/methods ; Titanium
Chemical Substances	Stainless Steel (12597-68-1) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2020-12-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-78416-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Contents of Selected Risk Elements and Organic Pollutants in Soil and Vegetation within a Former Military Area

Sládková, Aneta / Száková, Jirina / Havelcová, Martina / Najmanová, Jana / Tlustos, Pavel

Soil & sediment contamination

2015 Volume 24, Issue 1/4, Page(s) 325

Language	English
Document type	Article
ZDB-ID	2017739-2
ISSN	1532-0383
Database	Current Contents Nutrition, Environment, Agriculture

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