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  1. Article ; Online: Cardiovascular disease in women: Do we need new diagnostic and therapeutic strategies?

    Jiménez-Quevedo, Pilar / Alonso-Martin, Concepción / Campuzano Ruiz, Raquel / Guzmán-Martinez, Gabriela / Pedreira Perez, Milagros / Sambola, Antonia

    Kardiologia polska

    2023  Volume 81, Issue 4, Page(s) 338–349

    Abstract: Cardiovascular disease (CVD) is the leading cause of death worldwide affecting both sexes equally. However, in comparison to men, in women, it often is underrecognized and undertreated in both primary and secondary prevention settings. It is clear, that ... ...

    Abstract Cardiovascular disease (CVD) is the leading cause of death worldwide affecting both sexes equally. However, in comparison to men, in women, it often is underrecognized and undertreated in both primary and secondary prevention settings. It is clear, that in the healthy population, there are profound differences both anatomically and biochemically between women and men, and this may impact how both groups present when they become ill. Moreover, some diseases affect more frequently women than men such as myocardial ischemia or infarction without obstructive coronary disease, Takotsubo syndrome, some atrial arrhythmias, or heart failure with preserved ejection fraction. Therefore, diagnostic and therapeutic strategies that have been established largely on the basis of clinical studies with a predominantly male population must be adapted before being applied to women. There is a paucity of data regarding cardiovascular disease in women. It is inadequate to only perform a subgroup analysis evaluating a specific treatment or invasive technique when women constitute fifty percent of the population. In this regard, this may affect the time of clinical diagnosis and severity assessments of some valvulopathies. In this review, we will focus on the differences in the diagnosis, management, and outcomes for women with the most frequent cardiovascular pathologies including coronary artery disease, arrhythmia, heart failure, and valvopathies. In addition, we will describe diseases that exclusively affect women that are related to pregnancy, and some of them are life-threatening. Although the lack of research on women plays a role in the poorer outcomes in women, especially in ischemic heart disease, some techniques such as transcatheter aortic valve implantation and transcatheter edge-to-edge therapy seem to have better outcomes in women.
    MeSH term(s) Humans ; Male ; Female ; Cardiovascular Diseases ; Risk Factors ; Coronary Artery Disease ; Myocardial Ischemia ; Heart Failure
    Language English
    Publishing date 2023-03-05
    Publishing country Poland
    Document type Review ; Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2023.0051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multidisciplinary Panel Consensus for the Management of Patients with Type 2 Diabetes: A Delphi Study.

    Cebrián-Cuenca, Ana M / Moreno-Pérez, Oscar / Campuzano-Ruiz, Raquel / Soler, Maria Jose / García de Lucas, M Dolores / Orozco-Beltrán, Domingo

    Archives of medical research

    2023  Volume 55, Issue 1, Page(s) 102923

    Abstract: Aim: To reach a multidisciplinary consensus on managing patients with type 2 diabetes among specialists in family medicine, cardiology, endocrinology, internal medicine, and nephrology.: Methods: A two-round Delphi study was conducted using a ... ...

    Abstract Aim: To reach a multidisciplinary consensus on managing patients with type 2 diabetes among specialists in family medicine, cardiology, endocrinology, internal medicine, and nephrology.
    Methods: A two-round Delphi study was conducted using a questionnaire with 68 positive/negative statements distributed in four thematic blocks on diabetes management: early diagnosis and prediabetes, referral criteria, treatment and comorbidities, and clinical management. The expert panel was composed of 105 physicians from different specialties (family medicine, cardiology, endocrinology, internal medicine, and nephrology) with experience in managing patients with diabetes and who were members of a diabetes-related society.
    Results: Response rates for the first and second rounds were 86.7 and 75.2%, respectively. After both rounds, a consensus was reached on 52 (76.5%) items. The recommendations with the highest degree of consensus (median = 10, IQR = 0.00) were related to anti-smoking education, cardiovascular risk factor target control, and diabetic kidney disease. There were significant differences between family physicians and other specialties for some items.
    Conclusions: This study provides a set of recommendations for diabetes management agreed upon by specialists from different healthcare settings.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/therapy ; Consensus ; Delphi Technique ; Comorbidity ; Surveys and Questionnaires
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2023.102923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Post-event follow-up costs in patients with atherosclerotic cardiovascular disease in Spain.

    Martínez López, Icíar / Gómez Cerezo, Jorge Francisco / Gámez, José M / Egocheaga Cabello, Isabel / Castellanos, Mar / Campuzano Ruiz, Raquel / Barrios, Vivencio / Pallarés-Carratalá, Vicente / Rodríguez, José Manuel / Morant Talamante, Nuria / Parrondo, Javier / Mostaza, José María

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1324537

    Abstract: Introduction: Atherosclerotic cardiovascular disease (ASCVD) is one of the main causes of morbidity and mortality in developed countries and entails high resources use and costs for health systems. The risk of suffering future cardiovascular (CV) events ...

    Abstract Introduction: Atherosclerotic cardiovascular disease (ASCVD) is one of the main causes of morbidity and mortality in developed countries and entails high resources use and costs for health systems. The risk of suffering future cardiovascular (CV) events and the consequent resources use is higher in those patients who have already had a previous cardiovascular event. The objective of the study was to determine the average annual cost of patients with a new or recurrent atherosclerotic CV event during the 2 years after the event.
    Methodology: Retrospective observational study of electronic medical records of patients from the BIG-PAC® database (7 integrated health areas of 7 Autonomous Communities;
    Results: A total of 26,976 patients with an ASCVD episode were identified during the recruitment period; Out of them, 6,798 had a recurrent event during the follow-up period and 2,414 died. The average costs per patient were €11,171 during the first year and €9,944 during the second year.
    Discussion: Patients with ASCVD represent a significant economic burden for the health system and for society. Despite the perception that drug costs in the follow-up of chronic patients imply a high percentage of the costs, these accounted for only one tenth of the total amount. Implementing preventive programs and increasing the control of cardiovascular risk factors may have a significant social and health impact by helping to reduce mortality and costs for the Spanish National Health System. The costs derived from pharmacological treatments were obtained from the NHS pricing nomenclator database (https://www.sanidad.gob.es/profesionales/nomenclator.do).
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1324537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of Coronavirus-19 Pandemic and Lockdown on Admissions for Ischemic Heart Disease.

    García, Juan Enrique Puche / Guevara, Marta Iturregui / García, Etelvino Silva / Ruiz, Raquel Campuzano / García, Rafael Vázquez

    Cardiology and cardiovascular medicine

    2022  Volume 6, Issue 4, Page(s) 353–363

    Abstract: Background: In early 2020, the SARS-CoV-2 pandemic caused an unprecedented overload for the health service. A decrease in admissions for Acute Coronary Syndrome (ACS) was reported during lockdown, although many aspects remain to be clarified. The main ... ...

    Abstract Background: In early 2020, the SARS-CoV-2 pandemic caused an unprecedented overload for the health service. A decrease in admissions for Acute Coronary Syndrome (ACS) was reported during lockdown, although many aspects remain to be clarified. The main objective of this study was to evaluate the impact of the pandemic and of lockdown itself in this area.
    Methods: We performed a retrospective observational study based on data from patients who visited the emergency department of a tertiary hospital with chest pain during 2018-2020, as well as those who were admitted for ACS. Personal details, date of admission, additional test results (laboratory and echocardiography), and therapy were recorded. Patients were divided into 3 groups: preCOVID (n=1,301), lockdown (n=45), and postlockdown (n=343).
    Results: Fewer visits to the emergency department for chest pain and admissions for ACS were recorded during lockdown (48.6% and 51.1% respectively, p<0.05). Patients who were admitted during lockdown were characterized by poorer control of cardiovascular risk factors, visited later (more evolving infarctions: 2.7% vs. 14.3%, p<0.05), experienced more echocardiographic complications during admission, and had more than 3-fold mortality rates (both in-hospital and postdischarge).
    Conclusion: The COVID-19 pandemic and lockdown itself had a negative effect on ischemic heart disease beyond SARS-CoV-2 infection.
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article
    ISSN 2572-9292
    ISSN (online) 2572-9292
    DOI 10.26502/fccm.92920270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Resolución completa de quiste pericárdico atípico tras pleuropericarditis aguda.

    Jiménez Martínez, Carla / España Barrio, Elena / Sanz Merino, Ana Isabel / Robles Velasco, Pablo / Olmedilla Arregui, Pilar / Campuzano Ruiz, Raquel

    Revista espanola de cardiologia

    2021  Volume 74, Issue 12, Page(s) 1111–1113

    Title translation Complete resolution of atypical pericardial cyst after acute pleuropericarditis.
    Language Spanish
    Publishing date 2021-06-03
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 128925-1
    ISSN 1579-2242 ; 0300-8932
    ISSN (online) 1579-2242
    ISSN 0300-8932
    DOI 10.1016/j.recesp.2021.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Complete resolution of atypical pericardial cyst after acute pleuropericarditis.

    Jiménez Martínez, Carla / España Barrio, Elena / Sanz Merino, Ana Isabel / Robles Velasco, Pablo / Olmedilla Arregui, Pilar / Campuzano Ruiz, Raquel

    Revista espanola de cardiologia (English ed.)

    2021  Volume 74, Issue 12, Page(s) 1110–1112

    MeSH term(s) Echocardiography ; Humans ; Mediastinal Cyst/complications ; Mediastinal Cyst/diagnosis ; Mediastinal Cyst/surgery ; Pericarditis/diagnosis ; Pericarditis/etiology
    Language Spanish
    Publishing date 2021-07-08
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2021.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Disposable electrochemical immunoplatform to shed light on the role of the multifunctional glycoprotein TIM-1 in cancer cells invasion.

    Quinchia, Jennifer / Blázquez-García, Marina / Torrente-Rodríguez, Rebeca M / Ruiz-Valdepeñas Montiel, Víctor / Serafín, Verónica / Rejas-González, Raquel / Montero-Calle, Ana / Orozco, Jahir / Pingarrón, José M / Barderas, Rodrigo / Campuzano, Susana

    Talanta

    2023  Volume 267, Page(s) 125155

    Abstract: Detecting overexpression of cancer biomarkers is an excellent tool for diagnostic/prognostic and follow-up of patients with cancer or their response to treatment. This work illustrates the relevance of interrogating the levels of T-cell immunoglobulin ... ...

    Abstract Detecting overexpression of cancer biomarkers is an excellent tool for diagnostic/prognostic and follow-up of patients with cancer or their response to treatment. This work illustrates the relevance of interrogating the levels of T-cell immunoglobulin and mucin domain 1 (TIM-1) protein as a diagnostic/prognostic biomarker of high-prevalence breast and lung cancers by using an amperometric disposable magnetic microparticles-assisted immunoplatform. The developed method integrates the inherent advantages of carboxylic acid-functionalized magnetic beads (HOOC-MBs) as pre-concentrator support and the amperometric transduction at screen-printed carbon electrodes (SPCEs). The immunoplatform involves a sandwich-type immunoassay assembled on HOOC-MBs through the specific capture/labeling of TIM-1 using capture antibodies and horseradish peroxidase (HRP)-conjugated biotinylated detection antibodies as biorecognition elements. The magnetic immunoconjugates were confined onto the working electrode (WE) surface of the SPCEs for amperometric detection using the hydroquinone/hydrogen peroxide/HRP (HQ/H
    MeSH term(s) Humans ; Hydrogen Peroxide/chemistry ; Antibodies/chemistry ; Immunoconjugates/chemistry ; Magnetics ; Horseradish Peroxidase ; Glycoproteins ; Biosensing Techniques/methods ; Electrochemical Techniques/methods ; Electrodes ; Immunoassay/methods ; Limit of Detection ; Neoplasms
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Antibodies ; Immunoconjugates ; Horseradish Peroxidase (EC 1.11.1.-) ; Glycoproteins
    Language English
    Publishing date 2023-09-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.125155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hypercholesterolaemia control in Spain: The same situation with different regional realities.

    Pedro-Botet, Juan / Plana, Núria / Mostaza, José María / Gómez-Doblas, Juan José / Fernández Olmo, María Rosa / Escobar Cervantes, Carlos / Díaz-Díaz, José Luis / Campuzano Ruiz, Raquel / Valdivielso, Pedro / Cosín-Sales, Juan

    Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis

    2023  Volume 35, Issue 5, Page(s) 219–225

    Abstract: Introduction and objective: The cardiovascular prevention strategy by autonomous communities can be variable since the competences in health are transferred. The objective of the study was to determine the degree of dyslipidaemia control and the lipid- ... ...

    Title translation Control de la hipercolesterolemia en España: una misma situación con diferentes realidades autonómicas.
    Abstract Introduction and objective: The cardiovascular prevention strategy by autonomous communities can be variable since the competences in health are transferred. The objective of the study was to determine the degree of dyslipidaemia control and the lipid-lowering pharmacological therapy used in patients at high/very high cardiovascular risk (CVR) by autonomous communities.
    Methods: Observational, cross-sectional, descriptive study based on a consensus methodology. Information on the clinical practice of 145 health areas belonging to 17 Spanish autonomous communities was collected through face-to-face meetings and questionnaires administered to the 435 participating physicians. Furthermore, aggregate non-identifiable data were compiled from 10 consecutive dyslipidaemic patients that each participant had recently visited.
    Results: Of the 4010 patients collected, 649 (16%) had high and 2458 (61%) very high CVR. The distribution of the 3107 high/very high CVR patients was balanced across regions, but there were inter-regional differences (P<.0001) in the achievement of target LDL-C <70 and <55mg/dL, respectively. High-intensity statins in monotherapy or in combination with ezetimibe and/or PCSK9 inhibitors were used in 44, 21 and 4% of high CVR patients, while in those at very high CVR it rose to 38, 45 and 6%, respectively. The use of these lipid-lowering therapies at national level was significantly different between regions (P=.0079).
    Conclusions: Even though the distribution of patients at high/very high CVR was similar between autonomous communities, inter-territorial differences were identified in the degree of achievement of LDL cholesterol therapeutic goal and use of lipid-lowering therapy.
    MeSH term(s) Humans ; Hypercholesterolemia/drug therapy ; Hypercholesterolemia/epidemiology ; Proprotein Convertase 9 ; Spain ; Cross-Sectional Studies ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Ezetimibe/therapeutic use ; Hyperlipidemias/drug therapy ; Cholesterol, LDL ; Dyslipidemias/complications ; Dyslipidemias/drug therapy ; Dyslipidemias/epidemiology ; Anticholesteremic Agents/therapeutic use
    Chemical Substances PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Ezetimibe (EOR26LQQ24) ; Cholesterol, LDL ; Anticholesteremic Agents
    Language Spanish
    Publishing date 2023-04-27
    Publishing country Spain
    Document type Observational Study ; Journal Article
    ISSN 1578-1879
    ISSN (online) 1578-1879
    DOI 10.1016/j.arteri.2023.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of physician's perception about LDL cholesterol control in clinical practice when treating patients in Spain.

    Cosín-Sales, Juan / Campuzano Ruiz, Raquel / Díaz Díaz, José Luis / Escobar Cervantes, Carlos / Fernández Olmo, María Rosa / Gómez-Doblas, Juan José / Mostaza, José María / Pedro-Botet, Juan / Plana Gil, Núria / Valdivielso, Pedro

    Atherosclerosis

    2023  Volume 375, Page(s) 38–44

    Abstract: Background and aims: We aimed to understand the impact of physicians' perception about LDL-cholesterol (LDLc) control on the management of patients with dyslipidemia in Spain.: Methods: We performed a cross-sectional and multicenter study, in which ... ...

    Abstract Background and aims: We aimed to understand the impact of physicians' perception about LDL-cholesterol (LDLc) control on the management of patients with dyslipidemia in Spain.
    Methods: We performed a cross-sectional and multicenter study, in which 435 healthcare professionals participated in face-to-face meetings, collecting qualitative and quantitative information related to hypercholesterolemia management. Additionally, aggregated anonymized data of the last 10 patients with hypercholesterolemia attended by each physician were collected.
    Results: A total of 4,010 patients (8%, 13%, 16% and 61% with low, moderate, high, and very high cardiovascular [CV] risk) were included. Physicians' perception was that 62% of their patients attained LDLc goals (66%, 63%, 61% and 56%, for low, moderate, high and very high CV risk, respectively). However, when looking into the data only 31% (vs 62% p<0.01) of patients attained the LDLc goals (47%, 36%, 22% and 25%, respectively). Overall, 33% of patients were taking high intensity statins, 32% statin/ezetimibe, 21% low/moderate intensity statins and 4% PCSK9 inhibitors. These numbers were 38%, 45%, 8% and 6% for very high risk patients and 44%, 21%, 21% and 4% for high CV risk patients. In 32% of patients, a change in lipid lowering therapy was performed after the visit, mainly combining statins/ezetimibe (55%).
    Conclusions: In Spain, most patients with dyslipidemia do not achieve the recommended LDLc goals because of an insufficient intensification of lipid lowering therapy. On the one hand, this is in part due to physicians misperception on preventive LDLc control and the need for repeated advice to patient, and, on the other, to the lack of patient adherence.
    MeSH term(s) Humans ; Cholesterol, LDL ; Proprotein Convertase 9 ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hypercholesterolemia/diagnosis ; Hypercholesterolemia/drug therapy ; Spain/epidemiology ; Cross-Sectional Studies ; Treatment Outcome ; Ezetimibe/therapeutic use ; Dyslipidemias/diagnosis ; Dyslipidemias/drug therapy ; Dyslipidemias/epidemiology ; Perception ; Anticholesteremic Agents/therapeutic use
    Chemical Substances Cholesterol, LDL ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Ezetimibe (EOR26LQQ24) ; Anticholesteremic Agents
    Language English
    Publishing date 2023-05-11
    Publishing country Ireland
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2023.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Caracterización clínica y terapéutica de la cardiopatía isquémica en España. Importancia de los programas de rehabilitación cardiaca

    Alberto Cordero / Raquel Campuzano Ruiz / Ángel Cequier Fillat / Esteban López De Sá Areses / José Ramón González-Juanatey

    Medicina Clínica Práctica, Vol 5, Iss 3, Pp 100322- (2022)

    2022  

    Abstract: Resumen: Antecedentes y objetivo: El objetivo del estudio fue caracterizar el perfil clínico y terapéutico de los pacientes con cardiopatía isquémica en España en los pacientes (grupo 1) al alta tras un síndrome coronario agudo, (grupo 2) en primera ... ...

    Abstract Resumen: Antecedentes y objetivo: El objetivo del estudio fue caracterizar el perfil clínico y terapéutico de los pacientes con cardiopatía isquémica en España en los pacientes (grupo 1) al alta tras un síndrome coronario agudo, (grupo 2) en primera visita post-alta y (grupo 3) entre uno o 2 años tras el síndrome coronario agudo. Materiales y métodos: Estudio observacional, multicéntrico, transversal, de ámbito nacional, realizado en condiciones de práctica clínica habitual. Resultados: Se incluyeron 1.018 pacientes: 354 (34,8%) del grupo 1, 326 (32,0%) del 2 y 338 (33,2%) del 3. En comparación con el grupo 3, en el grupo 1 había un porcentaje significativamente mayor de pacientes fumadores (32,2 contra 10,9%), que consumían alcohol (28,2 contra 19,5%), que no realizaba ejercicio físico (61,0 contra 38,2%) o que no seguían una dieta (57,1 contra 32,5%). El 65,4% de los pacientes del grupo 1 no fue derivado a un programa de rehabilitación cardiaca (PRC). Del grupo 2, el 53,1% no tenía cita prevista para comenzar un PRC. Respecto al grupo 3, al 58,3% no se le recomendó nunca hacer rehabilitación cardiaca. Las variables asociadas al control de los factores de riesgo cardiovascular fueron la ausencia de obesidad y la asistencia a un PRC. Conclusiones: En el momento actual, menos de la mitad de los pacientes con cardiopatía isquémica en España son remitidos a un PRC, aunque estos programas se asocian a un mejor control de los factores de riesgo cardiovascular. Abstract: Introduction and objectives: The objective of the study was to characterize the clinical and therapeutic profile of patients with ischemic cardiopathy (IC) in Spain in patients (group 1) at the time of hospital discharge after an acute coronary syndrome (ACS), (group 2) at the first post-discharge follow-up visit, and (group 3) after one year of the ACS. Patients and methods: Observational, multicenter, cross-sectional, nationwide, performed in conditions of routine clinical practice. Results: A total of 1018 patients were included: 354 (34.8%) in the ...
    Keywords Ischemic cardiopathy ; Spain ; Registry ; Profile ; Treatments ; Cardiac rehabilitation ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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