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  1. Article: Occurrence of Fatal Tubulopathy in an Old, Fit Patient Receiving Nivolumab and Ipilimumab for Metastatic Melanoma: A Case Report.

    Georgery, Marine / Ram, Aurélie / Van Meerhaeghe, Tess / Drowart, Annie / Clause, Anne-Lorraine / Dal Lago, Lissandra / Rouvière, Héloïse

    Case reports in oncology

    2024  Volume 17, Issue 1, Page(s) 239–246

    Abstract: Introduction: The use of immune checkpoint inhibitors has revolutionized cancer treatment, and their application to older people is considered safe by the scientific community. However, immune-related adverse events (irAEs) remain common, and their ... ...

    Abstract Introduction: The use of immune checkpoint inhibitors has revolutionized cancer treatment, and their application to older people is considered safe by the scientific community. However, immune-related adverse events (irAEs) remain common, and their management poses significant challenges, especially in this population.
    Case presentation: We report the case of a fit 82-year-old woman who developed immune-mediated colitis and Fanconi syndrome during treatment with ipilimumab and nivolumab for metastatic melanoma. Treatment consisted of discontinuation of immunotherapy, use of systemic corticosteroids, and second-line immunosuppressants. Despite well-managed treatment, the patient did not recover and died from a gastrointestinal infection.
    Conclusion: Although studies have shown identical efficacy and safety in younger patients compared to older patients, the consequences of irAEs can potentially be more serious in the older population. The fatal outcome despite well-managed treatment highlights the need to identify predictive factors of immunotherapy-related adverse events in the older population.
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000535553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Old age: An extra risk for febrile neutropenia?

    Klastersky, Jean / Lago, Lissandra Dal

    Journal of geriatric oncology

    2017  Volume 8, Issue 2, Page(s) 84–85

    MeSH term(s) Aged ; Febrile Neutropenia/complications ; Humans ; Neoplasms/complications ; Neoplasms/drug therapy ; Risk Factors
    Language English
    Publishing date 2017-01-24
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2017.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Use of granulocyte-colony stimulating factors in older patients: a review of recently published data.

    Klastersky, Jean A / Dal Lago, Lissandra / Lalami, Yassine

    Current opinion in oncology

    2020  Volume 32, Issue 4, Page(s) 258–261

    Abstract: Purpose of review: This review presents the analysis of recently published studies about the benefit from granulocyte-colony stimulating factors (G-CSF) in older cancer patients receiving chemotherapy.: Recent findings: During the last years, no ... ...

    Abstract Purpose of review: This review presents the analysis of recently published studies about the benefit from granulocyte-colony stimulating factors (G-CSF) in older cancer patients receiving chemotherapy.
    Recent findings: During the last years, no major study aiming to confirm the clinical benefit of G-CSF prophylaxis in older patients treated with chemotherapy has been published. Nonetheless, all the data made recently available confirm that age, especially if other comorbid conditions are present as well, is a major risk factor for febrile neutropenia occurrence and that G-CSF prophylaxis can reduce significantly that risk.
    Summary: New modalities of administering G-CSF prophylaxis might be considered in older people in the future. Among these approaches, the 'same day' administration of prophylaxis and chemotherapy and the development of less-expensive approaches for G-CSF prophylaxis, such as the use of biosimilars are studied.
    MeSH term(s) Age Factors ; Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Chemotherapy-Induced Febrile Neutropenia/etiology ; Chemotherapy-Induced Febrile Neutropenia/prevention & control ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Humans ; Neoplasms/drug therapy
    Chemical Substances Antineoplastic Agents ; Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3046: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Rare Features of Dermatomyositis in a Patient with Ovarian Cancer.

    Dal Lago, Lissandra / Vandergheynst, Frédéric / Awada, Ahmad / Pepersack, Thierry

    European journal of case reports in internal medicine

    2020  Volume 7, Issue 12, Page(s) 1946

    Abstract: Despite having a classic presentation of dermatomyositis, a patient with ovarian cancer demonstrated several uncommon features: (i) unexpected onset of dermatomyositis in spite of cancer remission, (ii) development of Evans' syndrome and subcutaneous ... ...

    Abstract Despite having a classic presentation of dermatomyositis, a patient with ovarian cancer demonstrated several uncommon features: (i) unexpected onset of dermatomyositis in spite of cancer remission, (ii) development of Evans' syndrome and subcutaneous oedema, and (iii) dysphagia. We discuss the occurrence of these conditions as well as their treatment.
    Learning points: This case illustrates a mode of onset of dermatomyositis that could challenge its classification as a 'paraneoplastic' syndrome, as the dermatomyositis appeared when the patient was in complete metabolic remission.This case also raises questions about the observed relationship between IVIG administration and the onset of subcutaneous oedema and Evans' syndrome.
    Language English
    Publishing date 2020-12-15
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sarcoidosis Versus Lymphoma?

    Dal Lago, Lissandra / Sarrand, Julie / Woff, Erwin / Awada, Ahmad / Vouche, Michaël / Pepersack, Thierry

    European journal of case reports in internal medicine

    2021  Volume 8, Issue 3, Page(s) 2250

    Abstract: An association between lymphoma and sarcoidosis was first suggested in 1960. We report a case of sarcoidosis-lymphoma syndrome, which is a diagnostically challenging condition. We conclude that an associated lymphoma should be considered in all patients ... ...

    Abstract An association between lymphoma and sarcoidosis was first suggested in 1960. We report a case of sarcoidosis-lymphoma syndrome, which is a diagnostically challenging condition. We conclude that an associated lymphoma should be considered in all patients with suspected sarcoidosis, especially those who do not respond to treatment or who present with persistent haematological abnormalities. Splenomegaly should prompt splenectomy to rule out lymphoma if a less invasive approach has failed to confirm the diagnosis.
    Learning points: Clinical consideration should be given to an associated lymphoma in all patients with sarcoidosis, especially those who do not respond to treatment or who present with persistent haematological abnormalities.Splenomegaly should raise the possibility of splenectomy to rule out associated lymphoma.
    Language English
    Publishing date 2021-02-15
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2021_002250
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  6. Article ; Online: Prostate Cancer and Reactive Haemophagocytic Lymphohistiocytosis.

    Dumont, Laura / Salaroli, Adriano / Dal Lago, Lissandra / Gil, Thierry / Pepersack, Thierry

    European journal of case reports in internal medicine

    2021  Volume 8, Issue 4, Page(s) 2425

    Abstract: We report the case of a 76-year-old man presenting with reactive haemophagocytic lymphohistiocytosis (rHLH) in the setting of disseminated prostate cancer. This often fatal syndrome must be diagnosed early in order to maximize survival. Treatment should ... ...

    Abstract We report the case of a 76-year-old man presenting with reactive haemophagocytic lymphohistiocytosis (rHLH) in the setting of disseminated prostate cancer. This often fatal syndrome must be diagnosed early in order to maximize survival. Treatment should be initiated whenever the clinical diagnosis is suspected, even if the HLH-2004 criteria are not met. The HScore is a useful diagnostic tool for rHLH. In case of neurological symptoms, an extensive assessment must be performed. The goal of this case report is to raise awareness of this rare syndrome among oncologists.
    Learning points: The association of prostate cancer and reactive haemophagocytic lymphohistiocytosis (rHLH) has rarely been described.This often fatal syndrome must be recognized early in order to start specific treatment and maximize survival.Specific treatment for rHLH must be accompanied by treatment of the triggering factors.
    Language English
    Publishing date 2021-04-01
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2021_002425
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  7. Article ; Online: Rare Features of Dermatomyositis in a Patient with Ovarian Cancer

    Lissandra Dal Lago / Frédéric Vandergheynst / Ahmad Awada / Thierry Pepersack

    European Journal of Case Reports in Internal Medicine (2020)

    2020  

    Abstract: Despite a classical presentation of dermatomyositis, a patient with ovarian cancer had several uncommon features: (i) unexpected onset of dermatomyositis in spite of cancer remission, (ii) development of Evans’ syndrome and subcutaneous edema, and (iii) ... ...

    Abstract Despite a classical presentation of dermatomyositis, a patient with ovarian cancer had several uncommon features: (i) unexpected onset of dermatomyositis in spite of cancer remission, (ii) development of Evans’ syndrome and subcutaneous edema, and (iii) dysphagia. We discuss the occurrence of these clinical situations as well as the treatments.
    Keywords paraneoplastic syndrome ; dermatomyositis ; evans’ syndrome ; ovarian neoplasm ; Medicine ; R
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  8. Article ; Online: Sarcoidosis Versus Lymphoma?

    Lissandra Dal Lago / Julie Sarrand / Erwin Woff / Ahmad Awada / Michaël Vouche / Thierry Pepersack

    European Journal of Case Reports in Internal Medicine (2021)

    2021  

    Abstract: An association between lymphoma and sarcoidosis was first suggested in 1960. We report a case of sarcoidosis-lymphoma syndrome, which is a diagnostically challenging condition. We conclude that an associated lymphoma should be considered in all patients ... ...

    Abstract An association between lymphoma and sarcoidosis was first suggested in 1960. We report a case of sarcoidosis-lymphoma syndrome, which is a diagnostically challenging condition. We conclude that an associated lymphoma should be considered in all patients with suspected sarcoidosis, especially those who do not respond to treatment or who present with persistent haematological abnormalities. Splenomegaly should prompt splenectomy to rule out lymphoma if a less invasive approach has failed to confirm the diagnosis.
    Keywords granulomatous diseases ; sarcoidosis ; lymphoma ; Medicine ; R
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  9. Article ; Online: Prostate Cancer and Reactive Haemophagocytic Lymphohistiocytosis

    Laura Dumont / Adriano Salaroli / Lissandra Dal Lago / Thierry Gil / Thierry Pepersack

    European Journal of Case Reports in Internal Medicine (2021)

    2021  

    Abstract: We report the case of a 76-year-old man presenting with reactive haemophagocytic lymphohistiocytosis (rHLH) in the setting of disseminated prostate cancer. This often fatal syndrome must be diagnosed early in order to maximize survival. Treatment should ... ...

    Abstract We report the case of a 76-year-old man presenting with reactive haemophagocytic lymphohistiocytosis (rHLH) in the setting of disseminated prostate cancer. This often fatal syndrome must be diagnosed early in order to maximize survival. Treatment should be initiated whenever the clinical diagnosis is suspected, even if the HLH-2004 criteria are not met. The HScore is a useful diagnostic tool for rHLH. In case of neurological symptoms, an extensive assessment must be performed. The goal of this case report is to raise awareness of this rare syndrome among oncologists.
    Keywords prostate cancer ; reactive hemophagocytic lymphohistiocytosis ; hyperferritinemia ; drug-induced-pancytopenia ; hypertriglyceridemia ; hscore ; Medicine ; R
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Evaluation of the Comprehensive Geriatric Assessment (CGA) tool as a predictor of postoperative complications following major oncological abdominal surgery in geriatric patients.

    Penning, Yoon / El Asmar, Antoine / Moreau, Michel / Raspé, Julie / Dal Lago, Lissandra / Pepersack, Thierry / Donckier, Vincent / Liberale, Gabriel

    PloS one

    2022  Volume 17, Issue 3, Page(s) e0264790

    Abstract: Introduction: The concept of frailty extends beyond chronological age. Identifying frailty using a two-step approach, starting with the use of a screening tool (G8) followed by comprehensive geriatric assessment (CGA), may be useful in guiding treatment ...

    Abstract Introduction: The concept of frailty extends beyond chronological age. Identifying frailty using a two-step approach, starting with the use of a screening tool (G8) followed by comprehensive geriatric assessment (CGA), may be useful in guiding treatment decisions and follow-up. This study evaluated the association between G8 and CGA, and the risk of 90-day postoperative complications risk, in oncogeriatric patients.
    Methods: Data on geriatric patients with major oncological abdominal surgery was retrospectively collected from our hospital records between 2016 and 2019. Patients with an impaired G8 screening score, who subsequently underwent CGA geriatric screening, were included. Postoperative complications were classified using the Clavien-Dindo classification (CD), and the Comprehensive Complication Index (CCI). The association between the individual components of the geriatric assessment tools and the 90-day postoperative complications risk was analyzed.
    Results: One hundred and twelve patients, aged ≥ 70 years, operated for an intra-abdominal tumor with curative intent, were included. Seventy-six patients (67.9%) presented with an impaired G8, out of whom sixty-six (58.9%) had a CGA performed. On univariate analysis, altered nutritional status assessed by the Mini-Nutritional Assessment-Short Form was the only variable associated with higher postoperative total complication rate (p = 0.01). Patients with an impaired G8 had significantly more postoperative complications and higher 1-year mortality rates than patients with normal G8. Fifteen patients (13.4%) had grade III-IVb complications. A CCI > 50 was recorded in 16 patients (14.3%). All-cause 90-day postoperative mortality was 10.7%.
    Conclusion: Identifying an altered preoperative nutritional status, as part of the CGA, in patients screening positive for frailty, is a potentially modifiable risk factor that can enhance preoperative management and optimize treatment decision making. G8 may be a predictive factor for postoperative complications in oncogeriatric patients.
    MeSH term(s) Aged ; Frailty/complications ; Frailty/diagnosis ; Geriatric Assessment ; Humans ; Medical Oncology ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Retrospective Studies
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0264790
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