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Article ; Online: Real-World Lung Cancer CT Screening Performance, Smoking Behavior, and Adherence to Recommendations: Lung-RADS Category and Smoking Status Predict Adherence.

Barbosa, Eduardo J Mortani / Yang, Rochelle / Hershman, Michelle

2021 Volume 216, Issue 4, Page(s) 919–926

Abstract: BACKGROUND. ...

Abstract	BACKGROUND.
MeSH term(s)	Aged ; Early Detection of Cancer/methods ; Early Detection of Cancer/psychology ; Early Detection of Cancer/statistics & numerical data ; False Positive Reactions ; Female ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/diagnostic imaging ; Male ; Middle Aged ; Patient Compliance/psychology ; Patient Compliance/statistics & numerical data ; Retrospective Studies ; Smoking/adverse effects ; Smoking/epidemiology ; Smoking/psychology ; Tomography, X-Ray Computed/methods ; Tomography, X-Ray Computed/psychology
Language	English
Publishing date	2021-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.20.23637
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Article ; Online: How anthropogenic factors influence the dissolved oxygen in surface water over three decades in eastern China?

Xu, Yang / Zhou, Tingting / Su, Yingying / Fang, Luyue / Naidoo, Anastacia Rochelle / Lv, Peiyao / Lv, Sheng / Meng, Xiang-Zhou

Journal of Environmental Management. 2023 Jan., v. 326 p.116828-

2023

Abstract: The aquatic environment, linked to the sustainable development of human existence and ecological environment, is influenced comprehensively by anthropogenic and natural activities. In light of the continuously low concentration of dissolved oxygen (DO) ... ...

Abstract	The aquatic environment, linked to the sustainable development of human existence and ecological environment, is influenced comprehensively by anthropogenic and natural activities. In light of the continuously low concentration of dissolved oxygen (DO) in surface water in plain river networks and the phenomenon of delay in the improvement of surface water quality, this research aims to introduce a method that may be utilized in identifying the critical driving forces of DO in surface water and their lagging characteristics, which will contribute to the assessment and adjustment of water quality drivers and/or policies. The research analyzes a typical small watershed in a river network region of the Yangtze River Delta plain as the study area, collecting 35-year (1986–2020) data on several water quality parameters, decades of anthropogenic activities, and two natural factors. The time series methods of vector autoregressive model, Granger causality tests, forecast error variance decompositions, and impulse response functions (hereinafter referred to as VAR+), which are rarely applied in related research, were employed in this study and proved helpful for screening out pivotal drivers and capturing the lagging responses of DO level to driving forces at each lagged time. Results show that there exists a fluctuating drop in DO level in surface water from 1986 to 2008 and a steady climb from 2008 to 2020, with the lowest DO level being present in 2008. The impulsive perturbations of phosphate fertilizer consumption (PFC), motor vessel number, and precipitation minimally increase DO concentration, while the impulsive perturbation of gross domestic product (GDP) causes the sharpest drop in DO level. With these perturbations, the driving force of PFC persists for approximately seven years, and the driving forces of water temperature, permanent population, and GDP persist for only five years. Future research could be conducted with spatial hysteresis, selection of lag order and variable quantity within the model, as well as intermediate variables between drivers and DO level for exploring driving pathways and mechanisms.
Keywords	aquatic environment ; dissolved oxygen ; environmental management ; gross domestic product ; humans ; hysteresis ; models ; phosphorus fertilizers ; river deltas ; rivers ; surface water ; sustainable development ; time series analysis ; variance ; water quality ; water temperature ; watersheds ; China ; Yangtze River ; Anthropogenic drivers ; Vector autoregressive model ; Lagging characteristics ; Plain river network
Language	English
Dates of publication	2023-01
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2022.116828
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Ovarian/Adnexal Reporting and Data System for Ultrasound: From Standardized Terminology to Optimal Risk Assessment and Management.

Phillips, Catherine H / Guo, Yang / Strachowski, Loretta M / Jha, Priyanka / Reinhold, Caroline / Andreotti, Rochelle F

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes

2022 , Page(s) 8465371221108057

Abstract: The American College of Radiology (ACR) Ovarian-Adnexal Reporting and Data System (O-RADS) lexicon and risk assessment tool for ultrasound (US) provides a framework for characterization of ovarian and adnexal pathology with the ultimate goal of ... ...

Abstract	The American College of Radiology (ACR) Ovarian-Adnexal Reporting and Data System (O-RADS) lexicon and risk assessment tool for ultrasound (US) provides a framework for characterization of ovarian and adnexal pathology with the ultimate goal of harmonizing reporting and patient management strategies. Since the first O-RADS US publication in 2018, multiple validation studies have shown O-RADS US to have excellent diagnostic accuracy, with the majority of these studies using O-RADS 4 as the optimal cut-off for detecting ovarian cancer. Most of the existing validation studies include a dedicated training phase and confirm that ORADS US categories and lexicon descriptors are associated with high level inter-read agreement, regardless of radiologist training level or practice experience. O-RADS US has a similar inter-reader agreement when compared to Gynecologic Imaging Reporting and Data System (GIRADS), Assessment of Different Neoplasias in the adnexa (ADNEX), and International Tumor Analysis Group (IOTA) simple rules. System descriptors have been shown to correlate with expected malignancy rates and the O-RADS US risk stratification system has been shown to perform in the expected range of malignancy risk per category. Further directions will focus on clarifying governing concepts and lexicon terminology as well as further refining risk stratification categories based on data from published validation studies.
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	418190-6
ISSN	1488-2361 ; 0846-5371 ; 0008-2902
ISSN (online)	1488-2361
ISSN	0846-5371 ; 0008-2902
DOI	10.1177/08465371221108057
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Article ; Online: Ion-selective membrane modified microfluidic paper-based solution sampling substrates for potentiometric heavy metal detection.

Silva, Rochelle / Zhao, Ke / Ding, Ruiyu / Chan, Wei Ping / Yang, Mingpeng / Yip, Jane Si Qi / Lisak, Grzegorz

The Analyst

2022 Volume 147, Issue 20, Page(s) 4500–4509

Abstract: Paper-based microfluidic solution sampling is a viable option for potentiometric sensors to be used for the determination of analytes in samples with high solid-to-liquid ratios. Unfortunately, heavy metal sensitive electrodes cannot be easily integrated ...

Abstract	Paper-based microfluidic solution sampling is a viable option for potentiometric sensors to be used for the determination of analytes in samples with high solid-to-liquid ratios. Unfortunately, heavy metal sensitive electrodes cannot be easily integrated with paper-based solution sampling as heavy metals have strong physicochemical adsorption affinity towards paper substrates. In this work, paper substrates were modified with an ion-selective membrane (ISM) cocktail (used for the preparation of Pb
MeSH term(s)	Ion-Selective Electrodes ; Lead ; Metals, Heavy ; Microfluidics ; Potentiometry
Chemical Substances	Metals, Heavy ; Lead (2P299V784P)
Language	English
Publishing date	2022-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d2an01108e
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Book ; Online: DeepROCK

Chen, Winston / Noble, William Stafford / Lu, Yang Young

Error-controlled interaction detection in deep neural networks

2023

Abstract: ... In this paper, we introduce a method, called DeepROCK, to address this limitation by using knockoffs, which are ... a pairwise-coupling layer, DeepROCK jointly controls the false discovery rate (FDR) and maximizes statistical ... interaction importance measures. DeepROCK overcomes this challenge by proposing a calibration procedure ...

Abstract	The complexity of deep neural networks (DNNs) makes them powerful but also makes them challenging to interpret, hindering their applicability in error-intolerant domains. Existing methods attempt to reason about the internal mechanism of DNNs by identifying feature interactions that influence prediction outcomes. However, such methods typically lack a systematic strategy to prioritize interactions while controlling confidence levels, making them difficult to apply in practice for scientific discovery and hypothesis validation. In this paper, we introduce a method, called DeepROCK, to address this limitation by using knockoffs, which are dummy variables that are designed to mimic the dependence structure of a given set of features while being conditionally independent of the response. Together with a novel DNN architecture involving a pairwise-coupling layer, DeepROCK jointly controls the false discovery rate (FDR) and maximizes statistical power. In addition, we identify a challenge in correctly controlling FDR using off-the-shelf feature interaction importance measures. DeepROCK overcomes this challenge by proposing a calibration procedure applied to existing interaction importance measures to make the FDR under control at a target level. Finally, we validate the effectiveness of DeepROCK through extensive experiments on simulated and real datasets.
Keywords	Computer Science - Machine Learning ; Quantitative Biology - Quantitative Methods
Subject code	501
Publishing date	2023-09-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Value of quantitative airspace disease measured on chest CT and chest radiography at initial diagnosis compared to clinical variables for prediction of severe COVID-19.

Jung, Hae-Min / Yang, Rochelle / Gefter, Warren B / Ghesu, Florin C / Mailhe, Boris / Mansoor, Awais / Grbic, Sasa / Comaniciu, Dorin / Vogt, Sebastian / Mortani Barbosa, Eduardo J

Journal of medical imaging (Bellingham, Wash.)

2022 Volume 9, Issue 3, Page(s) 34003

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Journal Article
ISSN	2329-4302
ISSN	2329-4302
DOI	10.1117/1.JMI.9.3.034003
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Article: Leveling up Organic Semiconductors with Crystal Twisting.

Whittaker, St John / Zhou, Hengyu / Spencer, Rochelle B / Yang, Yongfan / Tiwari, Akash / Bendesky, Justin / McDowell, Merritt / Sundaram, Pallavi / Lozano, Idalys / Kim, Shin / An, Zhihua / Shtukenberg, Alexander G / Kahr, Bart / Lee, Stephanie S

Crystal growth & design

2023 Volume 24, Issue 2, Page(s) 613–626

Abstract: The performance of crystalline organic semiconductors depends on the solid-state structure, especially the orientation of the conjugated components with respect to device platforms. Often, crystals can be engineered by modifying chromophore substituents ... ...

Abstract	The performance of crystalline organic semiconductors depends on the solid-state structure, especially the orientation of the conjugated components with respect to device platforms. Often, crystals can be engineered by modifying chromophore substituents through synthesis. Meanwhile, dissymetry is necessary for high-tech applications like chiral sensing, optical telecommunications, and data storage. The synthesis of dissymmetric molecules is a labor-intensive exercise that might be undermined because common processing methods offer little control over orientation. Crystal twisting has emerged as a generalizable method for processing organic semiconductors and offers unique advantages, such as patterning of physical and chemical properties and chirality that arises from mesoscale twisting. The precession of crystal orientations can enrich performance because achiral molecules in achiral space groups suddenly become candidates for the aforementioned technologies that require dissymetry.
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1528-7483
ISSN	1528-7483
DOI	10.1021/acs.cgd.3c01072
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach).

Vafaei, Somayeh / Ciebiera, Michał / Omran, Mervat M / Ghasroldasht, Mohammad Mousaei / Yang, Qiwei / Leake, Tanya / Wolfe, Rochelle / Ali, Mohamed / Al-Hendy, Ayman

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs' associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is ... ...

Abstract	Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs' associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is not only highly expensive, but it also deprives patients of good quality of life (QOL). Unfortunately, even if the disease is discovered early, no medical intervention is traditionally initiated until the disease burden becomes high, and only then is surgical intervention performed. Furthermore, after myomectomy, the recurrence rate of UFs is extremely high with the need for additional surgeries and other interventions. This confused approach is invasive and extremely costly with an overall negative impact on women's health. Secondary prevention is the management of early disease to slow down its progression or even halt it completely. The current approach of watchful observation for early disease is considered a major missed opportunity in the literature. The aim of this article is to present an approach named the ESCAPE (Evidence-Based Approach for Secondary Prevention) of UF management. It comprises simple, inexpensive, and safe steps that can arrest the development of UFs, promote overall reproductive health, decrease the number of unnecessary surgeries, and save billions of health care systems' dollars worldwide.
MeSH term(s)	Humans ; Female ; Quality of Life ; Uterine Neoplasms/prevention & control ; Uterine Neoplasms/pathology ; Secondary Prevention ; Leiomyoma/prevention & control ; Leiomyoma/diagnosis ; Uterine Myomectomy/adverse effects
Language	English
Publishing date	2023-11-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115972
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Article ; Online: Perspectives of users for a future interactive wearable system for upper extremity rehabilitation following stroke: a qualitative study.

Yang, Chieh-Ling / Chui, Rochelle / Mortenson, W Ben / Servati, Peyman / Servati, Amir / Tashakori, Arvin / Eng, Janice J

Journal of neuroengineering and rehabilitation

2023 Volume 20, Issue 1, Page(s) 77

Abstract: Background: Wearable sensor technology can facilitate diagnostics and monitoring of people with upper extremity (UE) paresis after stroke. The purpose of this study is to investigate the perspectives of clinicians, people living with stroke, and their ... ...

Abstract	Background: Wearable sensor technology can facilitate diagnostics and monitoring of people with upper extremity (UE) paresis after stroke. The purpose of this study is to investigate the perspectives of clinicians, people living with stroke, and their caregivers on an interactive wearable system that detects UE movements and provides feedback. Methods: This qualitative study used semi-structured interviews relating to the perspectives of a future interactive wearable system including a wearable sensor to capture UE movement and a user interface to provide feedback as the means of data collection. Ten rehabilitation therapists, 9 people with stroke, and 2 caregivers participated in this study. Results: Four themes were identified (1) "Everyone is different" highlighted the need for addressing individual user's rehabilitation goal and personal preference; (2) "The wearable system should identify UE and trunk movements" emphasized that in addition to arm, hand, and finger movements, detecting compensatory trunk movements during UE movements is also of interest; (3) "Both quality and amount of movements are necessary to measure" described the parameters related to how well and how much the user is using their affected UE that participants envisioned the system to monitor; (4) "Functional activities should be practiced by the users" outlined UE movements and activities that are of priority in designing the system. Conclusions: Narratives from clinicians, people with stroke, and their caregivers offer insight into the design of interactive wearable systems. Future studies examining the experience and acceptability of existing wearable systems from end-users are warranted to guide the adoption of this technology.
MeSH term(s)	Humans ; Upper Extremity ; Hand ; Fingers ; Stroke/complications ; Wearable Electronic Devices
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2164377-5
ISSN	1743-0003 ; 1743-0003
ISSN (online)	1743-0003
ISSN	1743-0003
DOI	10.1186/s12984-023-01197-6
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Article ; Online: Changes in Concurrent Opioid and Benzodiazepine Use Following a Low-Touch Prescriber Fax Intervention.

Yang, Rochelle / Carruth, Sara E / Qiu, Wenyi Amanda / Leslie, R Scott

Journal of managed care & specialty pharmacy

2020 Volume 26, Issue 2, Page(s) 160–167

Abstract: Background: Concurrent use of opioids and benzodiazepines (COB) can lead to additive respiratory and central nervous system effects, putting patients at increased risk of fatal overdose. In 2016, the Centers for Disease Control and Prevention released ... ...

Abstract	Background: Concurrent use of opioids and benzodiazepines (COB) can lead to additive respiratory and central nervous system effects, putting patients at increased risk of fatal overdose. In 2016, the Centers for Disease Control and Prevention released an opioid-prescribing guideline recommending against COB, and the Pharmacy Quality Alliance (PQA) endorsed a COB measure in its core opioid set. From May 1, 2017, to December 4, 2017, a California Medicaid plan launched a COB-focused prescriber outreach intervention for members receiving recent opioid and benzodiazepine claims with the intent of decreasing concurrent use. Objective: To assess the effect of a prescriber fax intervention by a Medicaid plan on COB. Methods: Two retrospective analyses were conducted using administrative pharmacy claims data: a comparison of the PQA COB rate among selected California Medicaid plans for 2016 and 2017 and a cohort utilization analysis of members identified for the fax intervention compared with controls. Intervention and control members were matched based on 12 pre-index utilization characteristics. Outcomes assessed included proportion of members with resolution of COB in the post-index period, change in mean number of COB days before and after the index date, and proportion of members with decreased benzodiazepine daily dose after the index date. Analyses were also performed for the subgroups of members with < 30 days of COB and ≥ 30 days of COB in the pre-index period. Results: All California Medicaid plans in the study saw an improvement in the PQA COB rate between 2016 and 2017. In the utilization analysis, 4,182 intervention members were eligible according to study criteria and matched to similar control members. Many differences in medication use existed between the subgroups with < 30 days and ≥ 30 days of COB in the pre-index period, with the latter group consisting of much more chronic, complex users. The intervention cohort had a statistically significant higher proportion of members with complete resolution of COB compared with the control cohort (43.8% vs. 40.0%; Conclusions: Our analyses demonstrated that this low-touch prescriber fax intervention produced statistically significant improvements in COB outcomes, despite the overall trend of declining COB among the other California Medicaid plans. Low-touch, targeted prescriber outreach can be an inexpensive yet effective tool to affect prescriber behavior, particularly before COB becomes chronic. Disclosures: No outside funding was used to support this study. The authors do not have any financial relationships or potential conflicts of interest relevant to this article to disclose. At the time of conducting this research, all authors were employees of MedImpact Healthcare Systems. The results of this study were presented at the AMCP Managed Care & Specialty Pharmacy Annual Meeting 2019; March 25-28, 2019; San Diego, CA.
MeSH term(s)	Adult ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Benzodiazepines/administration & dosage ; Benzodiazepines/adverse effects ; California ; Cohort Studies ; Female ; Humans ; Male ; Medicaid ; Middle Aged ; Physicians/statistics & numerical data ; Practice Patterns, Physicians'/statistics & numerical data ; Retrospective Studies ; Telefacsimile ; United States
Chemical Substances	Analgesics, Opioid ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2020-02-06
Publishing country	United States
Document type	Journal Article
ISSN	2376-1032
ISSN (online)	2376-1032
DOI	10.18553/jmcp.2020.26.2.160
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