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  1. Article ; Online: Development of an insulin-like growth factor-1 certified reference material by SI-traceable isotope-dilution mass spectrometry.

    Liu, Zihan / Zhao, Xu / Liu, Yahui / Shi, Lianhua / Wu, Liqing / Yuan, Hui / Jin, Youxun

    Talanta

    2024  Volume 273, Page(s) 125812

    Abstract: In this study, an insulin-like growth factor-1 (IGF-1) certified reference material (CRM) was developed by the National Institute of Metrology (NIM), and two different principles for evaluating the IGF-1 CRM were established. After optimisation of the ... ...

    Abstract In this study, an insulin-like growth factor-1 (IGF-1) certified reference material (CRM) was developed by the National Institute of Metrology (NIM), and two different principles for evaluating the IGF-1 CRM were established. After optimisation of the acid hydrolysis conditions (110 °C, 36 h), quantitative determination of peptide purity, and chromatographic separation and mass spectrometric detection, amino acid analysis-based high-performance liquid chromatography combined with isotope-dilution tandem mass spectrometry (AAA-HPLC-IDMS/MS) and peptide analysis-based HPLC-IDMS/MS (Peptide-HPLC-IDMS/MS) were used for certified value assignment; the results obtained were 136.28 and 135.01 μg/g, respectively, which were in good agreement. These results were subjected to the normal distribution test, outlier test, and method consistency test. The homogeneity and stability of the reference materials were also examined, and the uncertainty introduced in the experimental process was calculated. The final certified value was (136 ± 15) μg g
    MeSH term(s) Insulin-Like Peptides ; Insulin-Like Growth Factor I ; Tandem Mass Spectrometry/methods ; Peptides ; Isotopes ; Reference Standards
    Chemical Substances Insulin-Like Peptides ; Insulin-Like Growth Factor I (67763-96-6) ; Peptides ; Isotopes
    Language English
    Publishing date 2024-02-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.125812
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  2. Article ; Online: Synergy of Pd atoms and oxygen vacancies on In

    Luo, Lei / Fu, Lei / Liu, Huifen / Xu, Youxun / Xing, Jialiang / Chang, Chun-Ran / Yang, Dong-Yuan / Tang, Junwang

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2930

    Abstract: ... Methane ( ... ...

    Abstract Methane (CH
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30434-0
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  3. Article: Olaparib Induces RPL5/RPL11-Dependent p53 Activation

    Han, Tao / Tong, Jing / Wang, Mengxin / Gan, Yu / Gao, Bo / Chen, Jiaxiang / Liu, Youxun / Hao, Qian / Zhou, Xiang

    Frontiers in oncology

    2022  Volume 12, Page(s) 821366

    Abstract: The poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) Olaparib is a widely used targeted therapy for a variety of solid tumors with homologous recombination deficiency (HRD) caused by mutation ... ...

    Abstract The poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) Olaparib is a widely used targeted therapy for a variety of solid tumors with homologous recombination deficiency (HRD) caused by mutation of
    Language English
    Publishing date 2022-06-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.821366
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  4. Article ; Online: Synergy of Pd atoms and oxygen vacancies on In2O3 for methane conversion under visible light

    Lei Luo / Lei Fu / Huifen Liu / Youxun Xu / Jialiang Xing / Chun-Ran Chang / Dong-Yuan Yang / Junwang Tang

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 12

    Abstract: CH4 oxidation to high value chemicals under mild conditions through photocatalysis confronts critical issues regarding both conversion and selectivity. Here, atomic Pd and oxygen vacancies were integrated on In2O3 nanorods, leading to visible-driven CH4 ... ...

    Abstract CH4 oxidation to high value chemicals under mild conditions through photocatalysis confronts critical issues regarding both conversion and selectivity. Here, atomic Pd and oxygen vacancies were integrated on In2O3 nanorods, leading to visible-driven CH4 conversion with a remarkable yield of oxygenates and high selectivity of primary products.
    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Environmentally Friendly and Recyclable Natural-Mediator-Modified Magnetic Nanoparticles for Laccase-Catalyzed Decolorization

    Kun Zhang / Yeying Wu / Juan Huang / Youxun Liu

    Journal of Chemistry, Vol

    2019  Volume 2019

    Abstract: The high cost, potential toxicity, and possible enzyme inhibition ability of artificial mediators have limited the large-scale application of laccase (Lac)/mediator systems. Here, sinapic acid (SA), a natural mediator, was covalently attached to amino- ... ...

    Abstract The high cost, potential toxicity, and possible enzyme inhibition ability of artificial mediators have limited the large-scale application of laccase (Lac)/mediator systems. Here, sinapic acid (SA), a natural mediator, was covalently attached to amino-functionalized magnetic nanoparticles (MNPs) via amide bond formation. The as-prepared SA@MNPs were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, cyclic voltammetry, and thermogravimetric analysis. The SA@MNPs were then applied to evaluate the activity of the immobilized mediator for Lac-catalyzed dye decolorization using indigo carmine (IC) as a model dye. When SA and SA@MNPs were used as Lac mediators, IC decolorization yields of ∼93% and 96%, respectively, were obtained after 60 min. Moreover, SA@MNPs exhibited an IC decolorization yield of ∼90% after being reused for 8 cycles. The Lac/SA@MNP system was shown to degrade IC by breaking down the chromophoric group. The easy recyclability, good reusability, nontoxicity, and relatively low cost of SA@MNPs make this immobilized natural mediator a promising tool for dye treatment.
    Keywords Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Binary Au-Cu Reaction Sites Decorated ZnO for Selective Methane Oxidation to C1 Oxygenates with Nearly 100% Selectivity at Room Temperature.

    Luo, Lei / Gong, Zhuyu / Xu, Youxun / Ma, Jiani / Liu, Huifen / Xing, Jialiang / Tang, Junwang

    Journal of the American Chemical Society

    2021  Volume 144, Issue 2, Page(s) 740–750

    Abstract: Direct and efficient oxidation of methane to methanol and the related liquid oxygenates provides a promising pathway for sustainable chemical industry, while still remaining an ongoing challenge owing to the dilemma between methane activation and ... ...

    Abstract Direct and efficient oxidation of methane to methanol and the related liquid oxygenates provides a promising pathway for sustainable chemical industry, while still remaining an ongoing challenge owing to the dilemma between methane activation and overoxidation. Here, ZnO with highly dispersed dual Au and Cu species as cocatalysts enables efficient and selective photocatalytic conversion of methane to methanol and one-carbon (C1) oxygenates using O
    Language English
    Publishing date 2021-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c09141
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  7. Article ; Online: Surface defect passivation of Ta

    Li, Fan / Jian, Jie / Xu, Youxun / Liu, Wei / Ye, Qian / Feng, Fan / Li, Can / Jia, Lichao / Wang, Hongqiang

    The Journal of chemical physics

    2020  Volume 153, Issue 2, Page(s) 24705

    Abstract: Tantalum nitride ( ... ...

    Abstract Tantalum nitride (Ta
    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0012873
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  8. Article: Binary Au–Cu Reaction Sites Decorated ZnO for Selective Methane Oxidation to C1 Oxygenates with Nearly 100% Selectivity at Room Temperature

    Luo, Lei / Gong, Zhuyu / Xu, Youxun / Ma, Jiani / Liu, Huifen / Xing, Jialiang / Tang, Junwang

    Journal of the American Chemical Society. 2021 Dec. 20, v. 144, no. 2

    2021  

    Abstract: Direct and efficient oxidation of methane to methanol and the related liquid oxygenates provides a promising pathway for sustainable chemical industry, while still remaining an ongoing challenge owing to the dilemma between methane activation and ... ...

    Abstract Direct and efficient oxidation of methane to methanol and the related liquid oxygenates provides a promising pathway for sustainable chemical industry, while still remaining an ongoing challenge owing to the dilemma between methane activation and overoxidation. Here, ZnO with highly dispersed dual Au and Cu species as cocatalysts enables efficient and selective photocatalytic conversion of methane to methanol and one-carbon (C1) oxygenates using O₂ as the oxidant operated at ambient temperature. The optimized AuCu–ZnO photocatalyst achieves up to 11225 μmol·g–¹·h–¹ of primary products (CH₃OH and CH₃OOH) and HCHO with a nearly 100% selectivity, resulting in a 14.1% apparent quantum yield at 365 nm, much higher than the previous best photocatalysts reported for methane conversion to oxygenates. In situ EPR and XPS disclose that Cu species serve as photoinduced electron mediators to promote O₂ activation to •OOH, and simultaneously that Au is an efficient hole acceptor to enhance H₂O oxidation to •OH, thus synergistically promoting charge separation and methane transformation. This work highlights the significances of co-modification with suitable dual cocatalysts on simultaneous regulation of activity and selectivity.
    Keywords ambient temperature ; chemical industry ; liquids ; methane ; methanol ; oxidants ; oxidation ; photocatalysis ; photocatalysts
    Language English
    Dates of publication 2021-1220
    Size p. 740-750.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c09141
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  9. Article: A novel NIR fluorescence probe with cysteine-activated structure for specific detection of cysteine and its application in vitro and in vivo

    Ge, Chunpo / Shen, Fengge / Yin, Yanyan / Chang, Kaiwen / Zhang, Xuan / Zhou, Pingxin / Li, Junmei / Liu, Youxun / Lu, Chengbiao

    Talanta. 2021 Feb. 01, v. 223

    2021  

    Abstract: Cysteine (Cys) as a vital antioxidant molecule and an effective biomarker for illness, plays an essential role in physiological functions and pathological processes. Extensive work has been done to explore the physiological functions of Cys and develop ... ...

    Abstract Cysteine (Cys) as a vital antioxidant molecule and an effective biomarker for illness, plays an essential role in physiological functions and pathological processes. Extensive work has been done to explore the physiological functions of Cys and develop probes for detection of biothiols. However, the challenge to differentiate Cys from glutathione and homocystine remains. In this work, we constructed a novel near-infrared (NIR) probe, termed TMN-Cys, using TMN-NH₂ and thionoesters. The probe could selectively detect Cys over homocysteine and glutathione in solution. It displayed a large Stokes shift (210 nm) upon treatment with Cys, and its detection limit was as low as 79 nM. Moreover, this probe showed low toxicity and was successfully employed in monitoring endogenous Cys in living cells and mice.
    Keywords antioxidants ; biomarkers ; cells ; cysteine ; detection limit ; fluorescent dyes ; glutathione ; homocysteine ; mice ; monitoring ; toxicity
    Language English
    Dates of publication 2021-0201
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2020.121758
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  10. Article: Split-type assay for wide-range sensitive sensing of ochratoxin A with praseodymia nanorods

    Jiang, Lei / Han, Yaning / Li, Youxun / Li, Zhuang / Zhang, Shuyuan / Zhu, Xiudong / Liu, Zhibin / Chen, Yuxue / Fernandez-Garcia, Susana / Tang, Yongjiao / Chen, Xiaowei

    Colloids and surfaces. 2022 Nov. 05, v. 652

    2022  

    Abstract: The ubiquitous presence of ochratoxin A (OTA), a toxic food contaminant, requires development of fast and sensitive detection tools. However, it is difficult to find a method that can address high sensitivity and wide detection range simultaneously. In ... ...

    Abstract The ubiquitous presence of ochratoxin A (OTA), a toxic food contaminant, requires development of fast and sensitive detection tools. However, it is difficult to find a method that can address high sensitivity and wide detection range simultaneously. In this work, a sensing platform composed of praseodymia nanorods (Pr₆O₁₁-NRs) and aptamers for OTA is established. Under the dual-readout modes, this platform provides a highly sensitive detection of OTA with extra-wide range, over three orders of magnitude with limit of detection (LOD) of 0.8 ng/mL. Both fluorometric and colorimetric signals were obtained because of the excellent fluorescent quenching and oxidase-like activity of Pr₆O₁₁-NRs. This probe enables a detection range of OTA which covers the maximum acceptable levels of most foods. Real samples were tested with this method, demonstrating high sensitivity and good recoveries. This sensing strategy has great potential for an expanded application in point-of-care detection of other toxins via portable devices.
    Keywords colorimetry ; detection limit ; fluorescence ; fluorometry ; food contamination ; nanorods ; ochratoxin A ; oligonucleotides ; point-of-care systems ; toxicity
    Language English
    Dates of publication 2022-1105
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500517-3
    ISSN 0927-7757
    ISSN 0927-7757
    DOI 10.1016/j.colsurfa.2022.129804
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