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Article ; Online: Visual loss following cosmetic facial filler injection.

Shoughy, Samir S

2019 Volume 82, Issue 6, Page(s) 511–513

Abstract: Facial filler injection for soft-tissue augmentation, wrinkle reduction, and rejuvenation has recently become increasingly popular. This procedure is well accepted and widely performed because of its safety and excellent outcomes. However, complications ... ...

Abstract	Facial filler injection for soft-tissue augmentation, wrinkle reduction, and rejuvenation has recently become increasingly popular. This procedure is well accepted and widely performed because of its safety and excellent outcomes. However, complications may occur even in the most skilled hands. A 36-year-old female presented with immediate loss of vision in her right eye following the periocular injection of cosmetic hyaluronic acid facial filler into the glabellar region. The visual loss was accompanied by weakness of her left arm. Blindness may complicate cosmetic facial filler injection. The treating physician should have a firm knowledge of the facial vascular anatomy, and the patient should be aware of the potential blinding complications associated with facial filler injection.
MeSH term(s)	Adult ; Blindness/chemically induced ; Cosmetic Techniques/adverse effects ; Dermal Fillers/adverse effects ; Face ; Female ; Humans ; Hyaluronic Acid/adverse effects ; Injections, Intradermal/adverse effects ; Retinal Detachment/chemically induced
Chemical Substances	Dermal Fillers ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2019-09-12
Publishing country	Brazil
Document type	Case Reports ; Letter
ZDB-ID	603915-7
ISSN	1678-2925 ; 0004-2749
ISSN (online)	1678-2925
ISSN	0004-2749
DOI	10.5935/0004-2749.20190092
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unusual ocular presentation in a patient with lichen planus.

Shoughy, Samir S

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2017 Volume 53, Issue 3, Page(s) e122–e124

MeSH term(s)	Administration, Oral ; Anti-Inflammatory Agents/administration & dosage ; Biopsy ; Cyclooxygenase Inhibitors/administration & dosage ; Diagnosis, Differential ; Female ; Humans ; Lichen Planus/complications ; Lichen Planus/diagnosis ; Lichen Planus/drug therapy ; Middle Aged ; Ophthalmic Solutions ; Piroxicam/administration & dosage ; Prednisolone/administration & dosage ; Prednisolone/analogs & derivatives ; Sclera/pathology ; Scleritis/diagnosis ; Scleritis/drug therapy ; Scleritis/etiology
Chemical Substances	Anti-Inflammatory Agents ; Cyclooxygenase Inhibitors ; Ophthalmic Solutions ; Piroxicam (13T4O6VMAM) ; prednisolone acetate (8B2807733D) ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2017-11-23
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2017.09.016
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Article: Topical tacrolimus in anterior segment inflammatory disorders.

Shoughy, Samir S

Eye and vision (London, England)

2017 Volume 4, Page(s) 7

Abstract: Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding ... ...

Abstract	Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulatory drugs are being used more frequently. Tacrolimus is a calcineurin inhibitor that induces suppression of T lymphocytes activity and reduction of ocular inflammation. Tacrolimus was recently investigated for application in various anterior segment inflammatory disorders. In this review, we will discuss the therapeutic application of topical tacrolimus as a steroid-sparing agent in treating T cell mediated anterior segment inflammation.
Language	English
Publishing date	2017-03-09
Publishing country	England
Document type	Journal Article ; Review
ISSN	2326-0254
ISSN	2326-0254
DOI	10.1186/s40662-017-0072-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Incidence of posterior capsule opacification following phacoemulsification in patients with uveitis.

Shoughy, Samir S / Jaroudi, Mahmoud O / Tabbara, Khalid F

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society

2021 Volume 34, Issue 3, Page(s) 182–185

Abstract: Purpose: The purpose of this study was to evaluate the incidence of posterior capsule opacification (PCO) in patients with inactive uveitis who underwent phacoemulsification with acrylic hydrophobic intraocular lens.: Methods: Thus was a ... ...

Abstract	Purpose: The purpose of this study was to evaluate the incidence of posterior capsule opacification (PCO) in patients with inactive uveitis who underwent phacoemulsification with acrylic hydrophobic intraocular lens. Methods: Thus was a retrospective review of 25 consecutive patients (31 eyes) with uveitis who underwent phacoemulsification. A group of 100 patients (140 eyes) without uveitis served as historical controls. Results: In patients with uveitis, PCO occurred in 11 eyes (35.5%), 6 (19%) of which were visually significant and required treatment with neodymium-doped yttrium aluminum garnet (Nd: YAG) laser. In the control group, PCO developed in 17 (12%) eyes which required treatment with Nd: YAG laser. The incidence of PCO was significantly higher in uveitis patients compared to the control group ( Conclusion: The incidence of PCO in patients with uveitis was significantly higher than those without uveitis, but the need for Nd: YAG laser capsulotomy for visually significant PCO was not statistically significant.
Language	English
Publishing date	2021-02-27
Publishing country	India
Document type	Journal Article
ISSN	1319-4534
ISSN	1319-4534
DOI	10.4103/1319-4534.310414
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Article: Hydroxychloroquine dosing and toxicity: A real-world experience in Saudi Arabia of 63 patients.

Al Adel, Fadwa / Shoughy, Samir S / Tabbara, Khalid F

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society

2021 Volume 34, Issue 3, Page(s) 151–155

Abstract: ... at a tertiary hospital and a private clinic in Saudi Arabia. A data collection sheet was used to collect patient's ...

Abstract	Purpose: To assess the ocular toxicity in patients on high doses of hydroxychloroquine (HCQ) per weight, as per the latest American Academy of Ophthalmology (AAO) screening guidelines for HCQ toxicity. Methods: This is a multi-center study looking at consecutive patients attending the ophthalmology clinics at a tertiary hospital and a private clinic in Saudi Arabia. A data collection sheet was used to collect patient's information regarding the dose per body weight, duration of HCQ use and any risk factors associated with the use of the medication as per the latest AAO guidelines for HCQ screening. Ancillary testing including fundus photography, automated visual field (10-2) and spectral domain ocular coherence tomography were done. Further testing with fundus auto-fluorescence and multifocal ERG were done when needed. The presence or absence of toxicity was recorded. Results: A total of 63 patients were included in the study, 58 females and 5 males. The average patient age was 45 years (range 18-72). The mean dosage of HCQ was 3.9 mg/kg. Fourteen (22%) patients were on doses higher than 5 mg/kg. The duration of treatment ranged from 1-30 years (average 8.3). Thirty six (57%) patients were on the drug for more than 5 years. We found only one (1.58%) patient with HCQ toxic retinopathy over a mean of 8 years treatment period. Conclusion: A significant number of our patients were found to be on doses of >5 mg/kg of HCQ, which may put them at a higher risk for retinal toxicity. Low dose HCQ such as 100 mg tablets should be made available to help physicians in adjusting the dose as per the latest reported guidelines by the AAO.
Language	English
Publishing date	2021-02-27
Publishing country	India
Document type	Journal Article
ISSN	1319-4534
ISSN	1319-4534
DOI	10.4103/1319-4534.310400
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Topical Tacrolimus in Thygeson Superficial Punctate Keratitis.

Shoughy, Samir S / Tabbara, Khalid F

Cornea

2019 Volume 39, Issue 6, Page(s) 742–744

Abstract: Purpose: To evaluate the efficacy of topical tacrolimus 0.02% eye drops in the treatment of patients with Thygeson superficial punctate keratitis.: Methods: Ten consecutive patients with Thygeson superficial punctate keratitis were included ... ...

Abstract	Purpose: To evaluate the efficacy of topical tacrolimus 0.02% eye drops in the treatment of patients with Thygeson superficial punctate keratitis. Methods: Ten consecutive patients with Thygeson superficial punctate keratitis were included retrospectively. Seven patients were unresponsive to topical steroids and/or lubricants. Diagnosis was made based on the history and clinical findings. All patients were treated with topical tacrolimus 0.02% solution twice daily. Outcome measures included improvement in symptoms of tearing and photophobia, whereas improvement in signs included decrease in the number of the lesions, resolution of the lesions, flattening of the lesions, and decrease in stain of the lesions. Results: There were 3 male and 7 female patients with an age range of 3 to 51 years (mean 17 years). All patients had bilateral ocular involvement. Duration of treatment ranged from 1 to 42 weeks (mean 10 weeks). All patients had subjective improvement in symptoms of tearing and photophobia and resolution of the superficial punctate keratitis. The response to treatment was noted 72 hours after initiation of therapy in all patients. Topical tacrolimus was well tolerated in all patients. Conclusions: Topical tacrolimus 0.02% is safe and effective in reducing ocular surface inflammation in patients with Thygeson superficial punctate keratitis who are not responsive to conventional therapy. Tacrolimus is helpful as a steroid-sparing agent to avoid vision-threatening complications.
MeSH term(s)	Administration, Topical ; Adolescent ; Adult ; Child ; Child, Preschool ; Cornea/drug effects ; Cornea/pathology ; Female ; Follow-Up Studies ; Humans ; Immunosuppressive Agents/administration & dosage ; Keratitis/diagnosis ; Keratitis/drug therapy ; Male ; Middle Aged ; Ophthalmic Solutions/administration & dosage ; Retrospective Studies ; Tacrolimus/administration & dosage ; Treatment Outcome ; Young Adult
Chemical Substances	Immunosuppressive Agents ; Ophthalmic Solutions ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2019-12-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000002224
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Aqueous penetration of topical tacrolimus.

Shoughy, Samir S / Aljassar, Faisal M / Tabbara, Khalid F

American journal of ophthalmology case reports

2020 Volume 17, Page(s) 100582

Abstract: Purpose: To evaluate the penetration of topical tacrolimus 0.05% into the aqueous humor.: Observations: A total of four patients scheduled for routine cataract surgery were included prospectively. We excluded patients with corneal pathology or ocular ...

Abstract	Purpose: To evaluate the penetration of topical tacrolimus 0.05% into the aqueous humor. Observations: A total of four patients scheduled for routine cataract surgery were included prospectively. We excluded patients with corneal pathology or ocular surface diseases. Topical tacrolimus 0.05% was compounded at our facility. It was dosed every 1 min for 5 min an hour before the aqueous was sampled. Aqueous samples were collected at the time of cataract surgery and were subjected to detection of presence and level of tacrolimus. There were 2 male and 2 female patients. The age range was 58-73 years with a mean age of 66 years. Tacrolimus was detected in the aqueous humor in all patients. The concentration of tacrolimus in the aqueous ranged from 2.6 to 5.6 ng/ml (mean 4.15 ± 1.18 ng/ml). In all patients, the aqueous tacrolimus concentration was greater than the minimal therapeutic level. The study was registered at clinicaltrials.gov (registration number is NCT02794610). Conclusions and importance: Tacrolimus was detected in the aqueous humor following topical application. Topical tacrolimus may be a promising steroid-sparing modality for the treatment of anterior uveitis.
Language	English
Publishing date	2020-01-17
Publishing country	United States
Document type	Case Reports
ISSN	2451-9936
ISSN (online)	2451-9936
DOI	10.1016/j.ajoc.2019.100582
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Initial misdiagnosis of Vogt-Koyanagi-Harada disease.

Shoughy, Samir S / Tabbara, Khalid F

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society

2018 Volume 33, Issue 1, Page(s) 52–55

Abstract: Purpose: To report the initial misdiagnosis of patients with Vogt-Koyanagi-Harada (VKH) disease.: Methods: The medical records of 76 consecutive patients diagnosed with VKH disease were reviewed retrospectively at The Eye Center, Riyadh, Saudi Arabia. ...

Abstract	Purpose: To report the initial misdiagnosis of patients with Vogt-Koyanagi-Harada (VKH) disease. Methods: The medical records of 76 consecutive patients diagnosed with VKH disease were reviewed retrospectively at The Eye Center, Riyadh, Saudi Arabia. Patients were referred to The Eye Center from Saudi Arabia and other Middle Eastern countries. The initial diagnosis was made by an ophthalmologist or neurologist. The main outcome measure was to evaluate cases with VKH disease who were initially misdiagnosed. Results: In 7 (9.2%) out of the 76 patients the initial diagnosis was incorrect. Patients were initially misdiagnosed as optic neuritis (1.3%), intracranial hypertension (1.3%), brain tumor (1.3%), Susac disease (1.3%), migraine (1.3%), rhegmatogenous retinal detachment (1.3%) or anterior granulomatous uveitis of unknown etiology (1.3%). Patients underwent unnecessary tests including MRI and invasive procedures including CSF analysis and anterior chamber paracentesis. Conclusion: The initial diagnosis of patients with VKH disease was incorrect in 9 % of the cases. Delay in the diagnosis of VKH disease may lead to delay in management and may cause irreversible damage to the photoreceptors with poor visual outcome.
Language	English
Publishing date	2018-12-07
Publishing country	India
Document type	Journal Article
ZDB-ID	2515644-5
ISSN	1319-4534
ISSN	1319-4534
DOI	10.1016/j.sjopt.2018.11.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The role of microbiome in uveitis

Hind Amin / Samir Shoughy

Exploration of Medicine, Vol 4, Iss 6, Pp 1001-

2023 Volume 1013

Abstract: ... microbiome’s relationship with ocular inflammation. Additionally, it explores the potential of modulating ...

Abstract	The gut microbiota comprises a complex bacterial community that resides in the intestine. Imbalances in the gut microbiota can disrupt immune homeostasis, triggering autoimmune diseases including non-infectious uveitis. Despite recent advances, the underlying mechanisms linking the microbiome and uveitis are not fully understood. This review offers a comprehensive analysis of the literature addressing microbiome’s relationship with ocular inflammation. Additionally, it explores the potential of modulating the gut microbiota as a novel therapeutic target. A literature search of published articles related to the role of ocular microbiome in non-infectious uveitis in PubMed and Scopus databases was conducted. The following keywords were used: microbiome, uveitis, and immune-mediate diseases.
Keywords	microbiome ; uveitis ; autoimmune ; Other systems of medicine ; RZ201-999
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Open Exploration Publishing Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Topical tacrolimus solution in autoimmune polyglandular syndrome-1-associated keratitis.

Shoughy, Samir S / Tabbara, Khalid F

The British journal of ophthalmology

2017 Volume 101, Issue 9, Page(s) 1230–1233

Abstract: Purpose: To evaluate the efficacy of topical tacrloimus eye drops in the treatment of keratitis associated with autoimmune polyglandular syndrome (APS)-1.: Methods: This is a retrospective review of 10 patients with APS-1. The patients were treated ... ...

Abstract	Purpose: To evaluate the efficacy of topical tacrloimus eye drops in the treatment of keratitis associated with autoimmune polyglandular syndrome (APS)-1. Methods: This is a retrospective review of 10 patients with APS-1. The patients were treated with topical tacrolimus 0.01% solution at The Eye Center, between 1 March 2012 and 30 April 2016. The outcome measures included improvement in visual acuity, photophobia and keratitis following treatment. Clinical assessment was carried out before, during and on the last visit following initiation of therapy. Results: A total of 10 patients were included. There were five male and five female patients. The mean age was 11 years with age range of 3-42 years. The mean duration of treatment with topical tacrolimus was 26 months (range 8-46 months). There was improvement of photophobia in 7 out of 10 patients following therapy with topical tacrolimus. In three patients, the photophobia was persistent. There was no clinically detectable improvement in the severity of keratitis in all patients. The mean best corrected visual acuity was 0.1 before and following therapy. Conclusion: Topical tacrolimus is effective in reducing the photophobia in patients with APS-1-associated keratitis, but showed no effects on the severity of keratitis.
MeSH term(s)	Administration, Topical ; Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Immunosuppressive Agents/administration & dosage ; Keratitis/diagnosis ; Keratitis/drug therapy ; Keratitis/physiopathology ; Male ; Ophthalmic Solutions ; Photophobia/drug therapy ; Polyendocrinopathies, Autoimmune/diagnosis ; Polyendocrinopathies, Autoimmune/drug therapy ; Polyendocrinopathies, Autoimmune/physiopathology ; Retrospective Studies ; Tacrolimus/administration & dosage ; Treatment Outcome ; Visual Acuity/physiology
Chemical Substances	Immunosuppressive Agents ; Ophthalmic Solutions ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2017-09
Publishing country	England
Document type	Journal Article
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjophthalmol-2016-309808
Database	MEDical Literature Analysis and Retrieval System OnLINE

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