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  1. Article ; Online: Absence of maribavir penetration into the central nervous system: confirmation by multiple cerebrospinal fluid dosages in a solid organ transplant recipient.

    Luque-Paz, David / Lalanne, Sébastien / Besombes, Juliette / Dorel, Marie / Maamar, Adel / Revest, Matthieu

    The Journal of antimicrobial chemotherapy

    2024  

    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkae094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 2030: the need for microbiologists and antimicrobial stewardship teams will still remain paramount.

    Luque-Paz, David / Turban, Adrien / Tattevin, Pierre / Cattoir, Vincent

    Intensive care medicine

    2023  Volume 49, Issue 11, Page(s) 1433–1434

    MeSH term(s) Humans ; Antimicrobial Stewardship ; Anti-Infective Agents/therapeutic use ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07221-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Which trial do we need? Aminopenicillin-gentamicin versus aminopenicillin-ceftriaxone for Enterococcus faecalis endocarditis.

    Luque-Paz, David / Cuervo, Guillermo / Miró, José M / Tattevin, Pierre

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 6, Page(s) 676–678

    MeSH term(s) Humans ; Ceftriaxone/therapeutic use ; Gentamicins/therapeutic use ; Enterococcus faecalis ; Anti-Bacterial Agents/therapeutic use ; Penicillins/therapeutic use ; Endocarditis/drug therapy ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/microbiology ; Drug Therapy, Combination ; Ampicillin/therapeutic use ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/microbiology
    Chemical Substances Ceftriaxone (75J73V1629) ; Gentamicins ; Anti-Bacterial Agents ; Penicillins ; Ampicillin (7C782967RD)
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.02.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treatment of infections caused by multidrug-resistant Gram-negative bacilli: a practical approach by the Italian (SIMIT) and French (SPILF) Societies of Infectious Diseases.

    Meschiari, Marianna / Asquier-Khati, Antoine / Tiseo, Giusy / Luque-Paz, David / Murri, Rita / Boutoille, David / Falcone, Marco / Mussini, Cristina / Tattevin, Pierre

    International journal of antimicrobial agents

    2024  , Page(s) 107186

    Abstract: Introduction: The emergence of multidrug-resistant Gram-negative bacilli, and the development of new antibiotics have complexified selection of optimal regimens. International guidelines are valuable tools, though limited by scarcity of high-quality ... ...

    Abstract Introduction: The emergence of multidrug-resistant Gram-negative bacilli, and the development of new antibiotics have complexified selection of optimal regimens. International guidelines are valuable tools, though limited by scarcity of high-quality randomized trials in many situations.
    Methods: A panel of experts from the French and Italian Societies of Infectious Diseases aimed to address unresolved issues in clinical practice based on their experience, updated literature review, and open discussions.
    Results: The panel reached a consensus for the following 'first-choices': i) cefepime for ventilator-acquired pneumonia due to AmpC β-lactamase-producing Enterobacterales; ii) The β-lactam/β-lactamase inhibitors combination most active in vitro, or cefiderocol combined with fosfomycin, and aerosolized colistin or aminoglycosides, for severe pneumonia due to Pseudomonas aeruginosa resistant to ceftolozane-tazobactam; iii) high-dose piperacillin-tazobactam (including loading dose and continuous infusion), for complicated urinary tract infections (cUTIs) caused by ESBL-producing Enterobacterales with piperacillin-tazobactam MIC ≤8 mg/L; iv) high-dose cefepime for cUTIs due to AmpC β-lactamase-producing Enterobacterales other than Enterobacter species if cefepime MIC ≤2 mg/L; v) ceftolozane-tazobactam or ceftazidime-avibactam plus metronidazole for intra-abdominal infections (IAIs) due to 3
    Conclusions: These expert choices were based on the necessary balance between antimicrobial stewardship principles, and the need to provide optimal treatment for individual patients in each situation.
    Language English
    Publishing date 2024-04-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2024.107186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cerebrospinal fluid concentrations of cefiderocol during the treatment of extensively drug-resistant Pseudomonas aeruginosa ventriculitis.

    Luque-Paz, David / Bennis, Youssef / Jaubert, Paul / Dubée, Vincent / Wolff, Michel / Mortaza, Satar

    The Journal of antimicrobial chemotherapy

    2022  Volume 77, Issue 6, Page(s) 1787–1789

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cephalosporins/therapeutic use ; Cerebral Ventriculitis/drug therapy ; Drug Resistance, Multiple, Bacterial ; Humans ; Microbial Sensitivity Tests ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa ; Cefiderocol
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins
    Language English
    Publishing date 2022-02-22
    Publishing country England
    Document type Letter
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Validation of a short turnaround time automated method for the 24/7 determination of plasma d-lactate on Roche Cobas c502.

    Turban, Adrien / Gaubert, Sophie / Luque-Paz, David / René, Céline / Collet, Nicolas / Pawlowski, Maxime / Bendavid, Claude / Lefèvre, Charles R

    Practical laboratory medicine

    2023  Volume 36, Page(s) e00317

    Language English
    Publishing date 2023-06-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834973-8
    ISSN 2352-5517
    ISSN 2352-5517
    DOI 10.1016/j.plabm.2023.e00317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The burden of SARS-CoV-2 in patients receiving chimeric antigen receptor T cell immunotherapy: everything to lose.

    Luque-Paz, David / Sesques, Pierre / Wallet, Florent / Bachy, Emmanuel / Ader, Florence

    Expert review of anti-infective therapy

    2022  Volume 20, Issue 9, Page(s) 1155–1162

    Abstract: Introduction: Chimeric antigen receptor T (CAR-T) cell immunotherapy has revolutionized the prognosis of refractory or relapsed B-cell malignancies. CAR-T cell recipients have immunosuppression generated by B-cell aplasia, leading to a higher ... ...

    Abstract Introduction: Chimeric antigen receptor T (CAR-T) cell immunotherapy has revolutionized the prognosis of refractory or relapsed B-cell malignancies. CAR-T cell recipients have immunosuppression generated by B-cell aplasia, leading to a higher susceptibility to respiratory virus infections and poor response to vaccination.
    Areas covered: This review focuses on the challenge posed by B-cell targeted immunotherapies: managing long-lasting B-cell impairment during the successive surges of a deadly viral pandemic. We restricted this report to data regarding vaccine efficacy in CAR-T cell recipients, outcomes after developing COVID-19 and specificities of treatment management. We searched in MEDLINE database to identify relevant studies until 31 March 2022.
    Expert opinion: Among available observational studies, the pooled mortality rate reached 40% in CAR-T cell recipients infected by SARS-CoV-2. Additionally, vaccine responses seem to be widely impaired in recipients (seroconversion 20%, T-cell response 50%). In this setting of B-cell depletion, passive immunotherapy is the backbone of treatment. Convalescent plasma therapy has proven to be a highly effective curative treatment with rare adverse events. Neutralizing monoclonal antibodies could be used as pre-exposure prophylaxis or early treatment but their neutralizing activity is constantly challenged by new variants. In order to reduce viral replication, direct-acting antiviral drugs should be considered.
    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19/therapy ; Hepatitis C, Chronic/drug therapy ; Humans ; Immunization, Passive ; Immunotherapy ; Receptors, Chimeric Antigen ; SARS-CoV-2 ; T-Lymphocytes
    Chemical Substances Antiviral Agents ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2022.2101448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: B-cell malignancies and COVID-19: a narrative review.

    Luque-Paz, David / Sesques, Pierre / Wallet, Florent / Bachy, Emmanuel / Ader, Florence

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 29, Issue 3, Page(s) 332–337

    Abstract: Background: COVID-19 has been extensively characterized in immunocompetent hosts and to a lesser extent in immunocompromised populations. Among the latter, patients treated for B-cell malignancies have immunosuppression generated by B-cell ... ...

    Abstract Background: COVID-19 has been extensively characterized in immunocompetent hosts and to a lesser extent in immunocompromised populations. Among the latter, patients treated for B-cell malignancies have immunosuppression generated by B-cell lymphodepletion/aplasia resulting in an increased susceptibility to respiratory virus infections and poor response to vaccination. The consequence is that these patients are likely to develop severe or critical COVID-19.
    Objectives: To examine the overall impact of COVID-19 in patients treated for a B-cell malignancy or receiving chimeric antigen receptor T (CAR-T) immunotherapy administered in case of relapsed or refractory disease.
    Sources: We searched in the MEDLINE database to identify relevant studies, trials, reviews, or meta-analyses focusing on SARS-CoV-2 vaccination or COVID-19 management in patients treated for a B-cell malignancy or recipients of CAR-T cell therapy up to 8 July 2022.
    Content: The epidemiology and outcomes of COVID-19 in patients with B-cell malignancy and CAR-T cell recipients are summarized. Vaccine efficacy in these subgroups is compiled. Considering the successive surges of variants of concern, we propose a critical appraisal of treatment strategies by discussing the use of neutralizing monoclonal antibodies, convalescent plasma therapy, direct-acting antiviral drugs, corticosteroids, and immunomodulators.
    Implications: For patients with B-cell malignancy, preventive vaccination against SARS-CoV-2 remains essential and the management of COVID-19 includes control of viral replication because of protracted SARS-CoV-2 shedding. Passive immunotherapy (monoclonal neutralizing antibody therapy and convalescent plasma therapy) and direct-active antivirals, such as remdesivir and nirmatrelvir/ritonavir are the best currently available treatments. Real-world data and subgroup analyses in larger trials are warranted to assess COVID-19 therapeutics in B-cell depleted populations.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Antiviral Agents ; COVID-19 Vaccines ; Receptors, Chimeric Antigen ; COVID-19 Serotherapy ; Hepatitis C, Chronic ; Antibodies, Monoclonal ; Antibodies, Neutralizing
    Chemical Substances Antiviral Agents ; COVID-19 Vaccines ; Receptors, Chimeric Antigen ; Antibodies, Monoclonal ; Antibodies, Neutralizing
    Language English
    Publishing date 2022-11-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.10.030
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  9. Article ; Online: Amphotericin B deoxycholate instillations through nephrostomy catheter as salvage treatment of massive Nakaseomyces glabrata renal fungus balls.

    Le Moulec, Joseph / Picard, Léa / Belaz, Sorya / Couturier, Audrey / Revest, Matthieu / Tattevin, Pierre / Luque-Paz, David

    Journal de mycologie medicale

    2023  Volume 34, Issue 1, Page(s) 101454

    MeSH term(s) Salvage Therapy ; Antifungal Agents/therapeutic use ; Catheters ; Nephrotomy ; Fungi ; Candida glabrata ; Amphotericin B ; Deoxycholic Acid ; Drug Combinations
    Chemical Substances amphotericin B, deoxycholate drug combination (87687-70-5) ; Antifungal Agents ; Amphotericin B (7XU7A7DROE) ; Deoxycholic Acid (005990WHZZ) ; Drug Combinations
    Language English
    Publishing date 2023-11-17
    Publishing country France
    Document type Letter
    ZDB-ID 1067006-3
    ISSN 1773-0449 ; 1156-5233
    ISSN (online) 1773-0449
    ISSN 1156-5233
    DOI 10.1016/j.mycmed.2023.101454
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  10. Article ; Online: Selective digestive decontamination to reduce the high rate of ventilator-associated pneumonia in critical COVID-19.

    Luque-Paz, David / Tattevin, Pierre / Jaubert, Paul / Reizine, Florian / Kouatchet, Achille / Camus, Christophe

    Anaesthesia, critical care & pain medicine

    2021  Volume 41, Issue 1, Page(s) 100987

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; COVID-19 ; Critical Care ; Decontamination ; Humans ; Pneumonia, Ventilator-Associated/drug therapy ; Pneumonia, Ventilator-Associated/epidemiology ; Pneumonia, Ventilator-Associated/prevention & control ; SARS-CoV-2
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-11-26
    Publishing country France
    Document type Letter
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2021.100987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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