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Article ; Online: Balancing the sustainability in the 2030 agenda

Carmen García- Peña / Bárbara Díaz / María M. Muñoz

Journal of Integrative Environmental Sciences, Vol 19, Iss 1, Pp 243-

the OECD countries

2022 Volume 271

Abstract: ABSTRACTWhen assessing the achievement of the 2030 Agenda, the equilibrium among the dimensions of the sustainable development should be taken into account, recognizing the balanced and integrated nature of the Sustainable Development Goals (SDGs). To ... ...

Abstract	ABSTRACTWhen assessing the achievement of the 2030 Agenda, the equilibrium among the dimensions of the sustainable development should be taken into account, recognizing the balanced and integrated nature of the Sustainable Development Goals (SDGs). To this end, we propose the use of a Balance Index to complement the performance indexes of the SDGs and the integration of sustainable development dimensions and experts’ opinions in the normalization process. The data source is the 2020 SDG Index Report proposed by the Bertelsmann Stiftung and the Sustainable Development Solutions Network. Provide and analyse the performance and the balance indexes for OECD countries. Finally, we propose a visual matrix of the two indexes with four progress scenarios to orientate the decision-making. This proposal allows a more accurate quantification of the situation of each country and is, therefore, a useful tool for evaluating the integrated nature of the sustainability (SDG 17).
Keywords	2030 agenda ; balance ; sustainable development ; policy integration ; Sustainable Development Goals ; concentration index ; Environmental sciences ; GE1-350
Subject code	710
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Balancing the sustainability in the 2030 agenda: the OECD countries

García-Peña, María del Carmen / Díaz, Bárbara / Muñoz, María M.

Journal of Integrative Environmental Sciences. 2022 Dec. 31, v. 19, no. 1 p.243-271

2022

Abstract: When assessing the achievement of the 2030 Agenda, the equilibrium among the dimensions of the sustainable development should be taken into account, recognizing the balanced and integrated nature of the Sustainable Development Goals (SDGs). To this end, ... ...

Abstract	When assessing the achievement of the 2030 Agenda, the equilibrium among the dimensions of the sustainable development should be taken into account, recognizing the balanced and integrated nature of the Sustainable Development Goals (SDGs). To this end, we propose the use of a Balance Index to complement the performance indexes of the SDGs and the integration of sustainable development dimensions and experts’ opinions in the normalization process. The data source is the 2020 SDG Index Report proposed by the Bertelsmann Stiftung and the Sustainable Development Solutions Network. Provide and analyse the performance and the balance indexes for OECD countries. Finally, we propose a visual matrix of the two indexes with four progress scenarios to orientate the decision-making. This proposal allows a more accurate quantification of the situation of each country and is, therefore, a useful tool for evaluating the integrated nature of the sustainability (SDG 17).
Keywords	decision making ; developed countries ; environmental science ; expert opinion ; journals ; sustainable development ; 2030 agenda ; balance ; policy integration ; Sustainable Development Goals ; concentration index ; composite indicators
Language	English
Dates of publication	2022-1231
Size	p. 243-271.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2477830-8
ISSN	1943-8168
ISSN	1943-8168
DOI	10.1080/1943815X.2022.2143530
Database	NAL-Catalogue (AGRICOLA)

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Article: Prevalence of Bovine Genital Campylobacteriosis, Associated Risk Factors and Spatial Distribution in Spanish Beef Cattle Based on Veterinary Laboratory Database Records.

Pena-Fernández, Nerea / Cano-Terriza, David / García-Bocanegra, Ignacio / Horcajo, Pilar / Vázquez-Arbaizar, Patricia / Cleofé-Resta, Darío / Pérez-Arroyo, Bárbara / Ortega-Mora, Luis M / Collantes-Fernández, Esther

Frontiers in veterinary science

2021 Volume 8, Page(s) 750183

Abstract: Bovine genital campylobacteriosis (BGC) is a sexually transmitted disease that causes early reproductive failure in natural breeding cattle that are managed extensively. The aim of this study was to assess the BGC prevalence in Spain from 2011 to 2019 ... ...

Abstract	Bovine genital campylobacteriosis (BGC) is a sexually transmitted disease that causes early reproductive failure in natural breeding cattle that are managed extensively. The aim of this study was to assess the BGC prevalence in Spain from 2011 to 2019 using data collected cross-sectionally from the diagnostic reports issued by the SALUVET veterinary diagnostic laboratory from a total of 5,182 breeding bulls from 1,950 herds managed under "dehesa" systems (large herds within fenced pastures and all-year breeding season) or mountain systems (smaller herds with seasonal breeding management and grazing in communal mountain pastures). Infection was detected by PCR in 7.7 and 12.2% of the bulls and herds tested, respectively. The "dehesa" herd management system (OR = 2.078,
Language	English
Publishing date	2021-12-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2021.750183
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Article ; Online: Topical insulin for refractory persistent corneal epithelial defects.

Diaz-Valle, David / Burgos-Blasco, Barbara / Gegundez-Fernandez, Jose A / Garcia-Caride, Sara / Puebla-Garcia, Virginia / Peña-Urbina, Pilar / Benitez-Del-Castillo, Jose M

European journal of ophthalmology

2020 Volume 31, Issue 5, Page(s) 2280–2286

Abstract: Purpose: To evaluate insulin eye drops for persistent epithelial defects (PEDs) that are refractory to usual treatment in clinical practice and to analyze how it may improve epithelization.: Methods: A prospective non-randomized hospital-based study ... ...

Abstract	Purpose: To evaluate insulin eye drops for persistent epithelial defects (PEDs) that are refractory to usual treatment in clinical practice and to analyze how it may improve epithelization. Methods: A prospective non-randomized hospital-based study was performed. Patients with PEDs that were refractory to conventional treatment were treated with insulin eye drops four times a day. Patients' demographics, PED etiology, concomitant treatments, and comorbidities were reviewed. The rate of PED closure and epithelial healing time were considered the primary outcome measures. Results: 21 patients were treated with insulin drops (12 females and 9 males; mean age 72.2 years). Mean PED area before treatment was 17.6 ± 16.5 mm Conclusion: Topical insulin can promote and accelerate corneal reepithelization of refractory PEDs. It also offers many other advantages, including excellent tolerance, availability, and cost-effectiveness.
MeSH term(s)	Aged ; Corneal Diseases/drug therapy ; Epithelium, Corneal ; Female ; Humans ; Insulin ; Male ; Ophthalmic Solutions ; Prospective Studies ; Treatment Outcome
Chemical Substances	Insulin ; Ophthalmic Solutions
Language	English
Publishing date	2020-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/1120672120958307
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Article ; Online: Tumor Intrinsic PD-L1 Promotes DNA Repair in Distinct Cancers and Suppresses PARP Inhibitor-Induced Synthetic Lethality.

Cancer research

2022 Volume 82, Issue 11, Page(s) 2156–2170

Abstract: BRCA1-mediated homologous recombination is an important DNA repair mechanism that is the target of FDA-approved PARP inhibitors, yet details of BRCA1-mediated functions remain to be fully elucidated. Similarly, immune checkpoint molecules are targets of ... ...

Abstract	BRCA1-mediated homologous recombination is an important DNA repair mechanism that is the target of FDA-approved PARP inhibitors, yet details of BRCA1-mediated functions remain to be fully elucidated. Similarly, immune checkpoint molecules are targets of FDA-approved cancer immunotherapies, but the biological and mechanistic consequences of their application are incompletely understood. We show here that the immune checkpoint molecule PD-L1 regulates homologous recombination in cancer cells by promoting BRCA1 nuclear foci formation and DNA end resection. Genetic depletion of tumor PD-L1 reduced homologous recombination, increased nonhomologous end joining, and elicited synthetic lethality to PARP inhibitors olaparib and talazoparib in vitro in some, but not all, BRCA1 wild-type tumor cells. In vivo, genetic depletion of tumor PD-L1 rendered olaparib-resistant tumors sensitive to olaparib. In contrast, anti-PD-L1 immune checkpoint blockade neither enhanced olaparib synthetic lethality nor improved its efficacy in vitro or in wild-type mice. Tumor PD-L1 did not alter expression of BRCA1 or its cofactor BARD1 but instead coimmunoprecipitated with BARD1 and increased BRCA1 nuclear accumulation. Tumor PD-L1 depletion enhanced tumor CCL5 expression and TANK-binding kinase 1 activation in vitro, similar to known immune-potentiating effects of PARP inhibitors. Collectively, these data define immune-dependent and immune-independent effects of PARP inhibitor treatment and genetic tumor PD-L1 depletion. Moreover, they implicate a tumor cell-intrinsic, immune checkpoint-independent function of PD-L1 in cancer cell BRCA1-mediated DNA damage repair with translational potential, including as a treatment response biomarker. Significance: PD-L1 upregulates BRCA1-mediated homologous recombination, and PD-L1-deficient tumors exhibit BRCAness by manifesting synthetic lethality in response to PARP inhibitors, revealing an exploitable therapeutic vulnerability and a candidate treatment response biomarker. See related commentary by Hanks, p. 2069.
MeSH term(s)	Animals ; Antineoplastic Agents/therapeutic use ; B7-H1 Antigen/genetics ; BRCA1 Protein/genetics ; Cell Line, Tumor ; DNA Repair ; Humans ; Mice ; Neoplasms/drug therapy ; Neoplasms/genetics ; Phthalazines/pharmacology ; Phthalazines/therapeutic use ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Synthetic Lethal Mutations
Chemical Substances	Antineoplastic Agents ; B7-H1 Antigen ; BRCA1 Protein ; CD274 protein, human ; Phthalazines ; Poly(ADP-ribose) Polymerase Inhibitors
Language	English
Publishing date	2022-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-21-2076
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Article ; Online: Prevalence of Bovine Genital Campylobacteriosis, Associated Risk Factors and Spatial Distribution in Spanish Beef Cattle Based on Veterinary Laboratory Database Records

Nerea Pena-Fernández / David Cano-Terriza / Ignacio García-Bocanegra / Pilar Horcajo / Patricia Vázquez-Arbaizar / Darío Cleofé-Resta / Bárbara Pérez-Arroyo / Luis M. Ortega-Mora / Esther Collantes-Fernández

Frontiers in Veterinary Science, Vol

2021 Volume 8

Abstract	Bovine genital campylobacteriosis (BGC) is a sexually transmitted disease that causes early reproductive failure in natural breeding cattle that are managed extensively. The aim of this study was to assess the BGC prevalence in Spain from 2011 to 2019 using data collected cross-sectionally from the diagnostic reports issued by the SALUVET veterinary diagnostic laboratory from a total of 5,182 breeding bulls from 1,950 herds managed under “dehesa” systems (large herds within fenced pastures and all-year breeding season) or mountain systems (smaller herds with seasonal breeding management and grazing in communal mountain pastures). Infection was detected by PCR in 7.7 and 12.2% of the bulls and herds tested, respectively. The “dehesa” herd management system (OR = 2.078, P = < 0.001, 95% CI = 1.55–1.77), bovine trichomonosis status of the herd (OR = 1.606, P = 0.004, 95% CI = 1.15–2.22), and bulls ≥3 years old (OR = 1.392, P = 0.04, 95% CI = 1.01–1.92) were identified as risk factors associated with Campylobacter fetus venerealis infection. We also studied the high-risk areas for circulation of the infection in extensive beef cattle herds in Spain, showing four significant clusters in “dehesa” areas in the south-western provinces of the country and a fifth cluster located in a mountain area in northern Spain. The results obtained in the present study indicate that BGC is endemic and widely distributed in Spanish beef herds. Specifically, “dehesa” herds are at greater risk for introduction of Cfv based on relatively high local prevalence of the infection and the use of specific management practices.
Keywords	bovine genital campylobacteriosis ; Campylobacter fetus subsp. venerealis ; risk factors ; prevalence ; spatial distribution ; bulls ; Veterinary medicine ; SF600-1100
Subject code	910
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cervical Spine Motion During Airway Management Using Two Manual In-line Immobilization Techniques: A Human Simulator Model Study.

De Jesus, Clarines Rosa / García Peña, Barbara M / Lozano, Juan Manuel / Maniaci, Vincenzo

Pediatric emergency care

2015 Volume 31, Issue 9, Page(s) 627–632

Abstract: Objective: The aim of this study is to evaluate cervical spine motion using 2 manual inline immobilization techniques with the use of a human simulator model.: Methods: Medical students, pediatric and family practice residents, and pediatric ... ...

Abstract	Objective: The aim of this study is to evaluate cervical spine motion using 2 manual inline immobilization techniques with the use of a human simulator model. Methods: Medical students, pediatric and family practice residents, and pediatric emergency medicine fellows were recruited to maintain cervical manual in line immobilization above the head of the bed and across the chest of a human simulator while orotracheal intubation was performed. Participants were then instructed on appropriate holding techniques after the initial session took place. Orotracheal intubation followed. A tilt sensor measured time to intubation and cervical extension and rotation angle. Results: Seventy-one subjects participated in a total of 284 successful orotracheal intubations. No change in cervical spine movement or time to intubation was observed when using 2 different inline manual immobilization techniques with no training. However, a statistically significant difference with assistants above the head versus across the chest was observed after training in: extension 2.1° (95% confidence interval [95% CI], 1.15 to 3.00; P < 0.0001); rotation 0.7° (95% CI, 0.26 to 1.19; P = 0.003) and intubation time of -1.9 seconds (95% CI, -3.45 to -0.13; P = 0.035) after training. Conclusions: Cervical spine movement did not change when maintaining cervical spine immobilization from above the head versus across the chest before training. There was a statistically significant change in extension and rotation when assistants were above the head and in time to intubation when assistants were across the chest after training. The clinical significance of these results is unclear.
MeSH term(s)	Advanced Trauma Life Support Care ; Airway Management ; Cervical Vertebrae/injuries ; Cervical Vertebrae/pathology ; Computer Simulation ; Humans ; Immobilization/methods ; Intubation, Intratracheal/methods ; Motion ; Patient Simulation ; Spinal Injuries/etiology ; Spine/anatomy & histology ; Spine/physiology ; Students, Medical
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000000245
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Article ; Online: Self-adhesive hydrogel meshes reduce tissue incorporation and mechanical behavior versus microgrips self-fixation: a preclinical study.

Benito-Martínez, Selma / Rodríguez, Marta / García-Moreno, Francisca / Pérez-Köhler, Bárbara / Peña, Estefanía / Calvo, Begoña / Pascual, Gemma / Bellón, Juan Manuel

Hernia : the journal of hernias and abdominal wall surgery

2022 Volume 26, Issue 2, Page(s) 543–555

Abstract: Purpose: Atraumatic mesh fixation for abdominal hernia repair has been developed to avoid the disadvantages of classical fixation with sutures, which is considered a cause of chronic pain and discomfort. This study was designed to analyze, in the short ... ...

Abstract	Purpose: Atraumatic mesh fixation for abdominal hernia repair has been developed to avoid the disadvantages of classical fixation with sutures, which is considered a cause of chronic pain and discomfort. This study was designed to analyze, in the short and medium term, the biological and mechanical behavior of two self-fixing meshes compared to that of a polypropylene (PP) mesh fixed with a cyanoacrylate (CA) tissue adhesive. Methods: Partial abdominal wall defects (6 × 4 cm) were created in New Zealand rabbits (n = 36) and repaired using a self-adhesive hydrogel mesh (Adhesix™), a self-gripping mesh (ProGrip™) or a PP mesh fixed with CA (Surgipro™ CA). After 14 and 90 days, the host tissue incorporation, macrophage response and biomechanical strength were examined. Results: At 14 and 90 days, the ProGrip and Surgipro CA meshes showed good host tissue incorporation; however, the Adhesix implants presented poor integration, seroma formation and a higher degree of shrinkage. The Adhesix hydrogel was completely reabsorbed at 14 days, whereas ProGrip microhooks were observed at all study times. The macrophage response was higher in the ProGrip and Surgipro CA groups at 14 and 90 days, respectively, and decreased over time. At 90 days, the ProGrip implants showed the highest tensile strength values and the Adhesix implants showed the highest failure stretch. Conclusion: Meshes with mechanical microgrip self-fixation (ProGrip) show better biological and mechanical behavior than those with adhesive hydrogel (Adhesix) in a preclinical model of abdominal hernia repair in rabbits.
MeSH term(s)	Adhesives ; Animals ; Cyanoacrylates ; Hernia, Abdominal/surgery ; Herniorrhaphy ; Humans ; Hydrogels ; Polypropylenes ; Rabbits ; Resin Cements ; Surgical Mesh
Chemical Substances	Adhesives ; Cyanoacrylates ; Hydrogels ; Polypropylenes ; Resin Cements
Language	English
Publishing date	2022-01-07
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-021-02552-z
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Article ; Online: Systematic Review and Meta-Analyses of Aminopeptidases as Prognostic Biomarkers in Amyotrophic Lateral Sclerosis.

Teruel-Peña, Bárbara / Gómez-Urquiza, José Luís / Suleiman-Martos, Nora / Prieto, Isabel / García-Cózar, Francisco José / Ramírez-Sánchez, Manuel / Fernández-Martos, Carmen / Domínguez-Vías, Germán

International journal of molecular sciences

2023 Volume 24, Issue 8

Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the spinal cord, brain stem, and cerebral cortex. Biomarkers for ALS are essential for disease detection and to provide ... ...

Abstract	Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the spinal cord, brain stem, and cerebral cortex. Biomarkers for ALS are essential for disease detection and to provide information on potential therapeutic targets. Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein or substrates such as neuropeptides. Since certain aminopeptidases are known to increase the risk of neurodegeneration, such mechanisms may reveal new targets to determine their association with ALS risk and their interest as a diagnostic biomarker. The authors performed a systematic review and meta-analyses of genome-wide association studies (GWASs) to identify reported aminopeptidases genetic loci associated with the risk of ALS. PubMed, Scopus, CINAHL, ISI Web of Science, ProQuest, LILACS, and Cochrane databases were searched to retrieve eligible studies in English or Spanish, published up to 27 January 2023. A total of 16 studies were included in this systematic review, where a series of aminopeptidases could be related to ALS and could be promising biomarkers (DPP1, DPP2, DPP4, LeuAP, pGluAP, and PSA/NPEPPS). The literature reported the association of single-nucleotide polymorphisms (SNPs: rs10260404 and rs17174381) with the risk of ALS. The genetic variation rs10260404 in the DPP6 gene was identified to be highly associated with ALS susceptibility, but meta-analyses of genotypes in five studies in a matched cohort of different ancestry (1873 cases and 1861 control subjects) showed no ALS risk association. Meta-analyses of eight studies for minor allele frequency (MAF) also found no ALS association for the "C" allele. The systematic review identified aminopeptidases as possible biomarkers. However, the meta-analyses for rs1060404 of DPP6 do not show a risk associated with ALS.
MeSH term(s)	Humans ; Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/genetics ; Aminopeptidases ; Genome-Wide Association Study ; Neurodegenerative Diseases ; Prognosis ; Biomarkers
Chemical Substances	Aminopeptidases (EC 3.4.11.-) ; Biomarkers
Language	English
Publishing date	2023-04-12
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24087169
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Article ; Online: Heelys injuries: a review of the National Electronic Injury Surveillance System data.

Beach, Heather / Garcia Peña, Barbara M / Linares, Marc Yves-Rene

Pediatric emergency care

2011 Volume 25, Issue 10, Page(s) 642–644

Abstract: Objective: The purpose of this study was to describe the types and severity of Heelys-related injuries reported to the National Electronic Injury Surveillance System (NEISS). Strategies for prevention of these injuries may be developed using this ... ...

Abstract	Objective: The purpose of this study was to describe the types and severity of Heelys-related injuries reported to the National Electronic Injury Surveillance System (NEISS). Strategies for prevention of these injuries may be developed using this information. Methods: We performed a retrospective analysis of the NEISS data of the US Consumer Safety Product Commission between 2002 and 2006. Results: The NEISS had 131 reported Heelys injuries in children. The mean age was 10.02 years. The upper extremity was most commonly injured, accounting for 75 (57.3%) of the 131 injuries. Fractures were the most common injuries, accounting for 66 (50.4%) of the 131 injuries. Children younger than 12 years were more likely to sustain fractures than their older counterparts (P = 0.001). Children 12 years or older were more likely to sustain sprains than the younger children (P ≤ 0.001). There was no difference in injury patterns between the sexes (P = not significant). Six children required hospital admission. There was 1 reported death. Conclusions: Most injuries sustained from Heelys use are orthopedic injuries. However, a wide variety of other injuries occur with Heelys use. Children can sustain injuries serious enough to require hospital admission. Parents and children should be educated about the importance of protective gear use while "heeling."
MeSH term(s)	Accidental Falls/statistics & numerical data ; Adolescent ; Chi-Square Distribution ; Child ; Child, Preschool ; Consumer Product Safety ; Female ; Humans ; Male ; Population Surveillance ; Protective Clothing ; Retrospective Studies ; Shoes ; United States/epidemiology ; Wounds and Injuries/epidemiology ; Young Adult
Language	English
Publishing date	2011-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/pec.0b013e3181b920f5
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