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  1. Article: Unexpected chiral vicinal tetrasubstituted diamines via borylcopper-mediated homocoupling of isatin imines.

    Manenti, Marco / Lo Presti, Leonardo / Molteni, Giorgio / Silvani, Alessandra

    Beilstein journal of organic chemistry

    2022  Volume 18, Page(s) 303–308

    Abstract: Addressing the asymmetric synthesis of oxindole-based α-aminoboronic acids, instead of the expected products we disclosed the efficient homocoupling of oxindole- ... ...

    Abstract Addressing the asymmetric synthesis of oxindole-based α-aminoboronic acids, instead of the expected products we disclosed the efficient homocoupling of oxindole-based
    Language English
    Publishing date 2022-03-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.18.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Scapular Kinematics and Patterns of Scapular Dyskinesis in Rotator Cuff Tears: A Prospective Cohort Study.

    Longo, Umile Giuseppe / Risi Ambrogioni, Laura / Candela, Vincenzo / Berton, Alessandra / Lo Presti, Daniela / Denaro, Vincenzo

    Journal of clinical medicine

    2023  Volume 12, Issue 11

    Abstract: Scapular dyskinesis (SD) is a condition of loss of normal mobility or function of the scapula. SD is frequently observed in patients with other shoulder disorders, such as rotator cuff (RC) tears. This study evaluates the different presentations in ... ...

    Abstract Scapular dyskinesis (SD) is a condition of loss of normal mobility or function of the scapula. SD is frequently observed in patients with other shoulder disorders, such as rotator cuff (RC) tears. This study evaluates the different presentations in clinical outcomes and range of motions (ROMs) in patients suffering from RC tears with and without SD. A total of 52 patients were enrolled, of which 32 patients with RC tears and SD (group A) and 20 patients with RC tears without SD (group B). Statistically significant differences between the groups in terms of clinical outcomes were identified. There were statistically significant differences in terms of flexion (
    Language English
    Publishing date 2023-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12113841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Enantiopure β-isocyano-boronic esters: synthesis and exploitation in isocyanide-based multicomponent reactions.

    Manenti, Marco / Gusmini, Simone / Lo Presti, Leonardo / Molteni, Giorgio / Silvani, Alessandra

    Molecular diversity

    2022  Volume 27, Issue 5, Page(s) 2161–2168

    Abstract: Various boron-containing isocyanides have been efficiently synthesized from the corresponding enantiopure β-substituted β-amino boronic acid pinacol esters, without need for protecting group interconversion, through a two-step, purification-free ... ...

    Abstract Various boron-containing isocyanides have been efficiently synthesized from the corresponding enantiopure β-substituted β-amino boronic acid pinacol esters, without need for protecting group interconversion, through a two-step, purification-free procedure. They were employed in a variety of isocyanide-based multicomponent reactions, proving to be reliable components for all of them and allowing the efficient synthesis of unprecedented, boron-containing peptidomimetics and heteroatom-rich small molecules, including biologically relevant cyclic boronates. Jointing together the β-amido boronic acid moiety, deriving from the isocyanide component, with prominent pharmacophoric rings emerging from the multicomponent process, a successful application of the molecular hybridization concept could be realized.
    MeSH term(s) Cyanides ; Boron ; Esters ; Boronic Acids ; Peptidomimetics
    Chemical Substances Cyanides ; Boron (N9E3X5056Q) ; Esters ; Boronic Acids ; Peptidomimetics
    Language English
    Publishing date 2022-10-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-022-10549-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4946: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Selective pressure on SARS-CoV-2 protein coding genes and glycosylation site prediction.

    Lo Presti, Alessandra / Rezza, Giovanni / Stefanelli, Paola

    Heliyon

    2020  Volume 6, Issue 9, Page(s) e05001

    Abstract: Background: An outbreak of a febrile respiratory illness due to the newly discovered Coronavirus, SARS-CoV-2, was initially detected in mid-December 2019 in the city of Wuhan, Hubei province (China). The virus then spread to most countries in the world. ...

    Abstract Background: An outbreak of a febrile respiratory illness due to the newly discovered Coronavirus, SARS-CoV-2, was initially detected in mid-December 2019 in the city of Wuhan, Hubei province (China). The virus then spread to most countries in the world. As an RNA virus, SARS-CoV-2 may acquire mutations that may be fixed. The aim of this study was to evaluate the selective pressure acting on SARS-CoV-2 protein coding genes.
    Methods: Mutations and glycosylation site prediction were analyzed in SARS-CoV-2 genomes (from 464 to 477 sequences).
    Results: Selective pressure on
    Conclusion: Overall, the data showed positive pressure and mutations acting on specific protein coding genes. These findings may provide useful information on: i) markers for vaccine design, ii) new therapeutic approach, iii) information to implement mutagenesis experiments to inhibit SARS-CoV-2 cell entry. The negative selection identified in SARS-CoV-2 protein coding genes may help the identification of highly conserved regions useful to implement new future diagnostic protocols.
    Keywords covid19
    Language English
    Publishing date 2020-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2020.e05001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Unexpected chiral vicinal tetrasubstituted diamines via borylcopper-mediated homocoupling of isatin imines

    Marco Manenti / Leonardo Lo Presti / Giorgio Molteni / Alessandra Silvani

    Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 303-

    2022  Volume 308

    Abstract: Addressing the asymmetric synthesis of oxindole-based α-aminoboronic acids, instead of the expected products we disclosed the efficient homocoupling of oxindole-based N-tert-butanesulfinyl imines, with the generation of chiral, quaternary 1,2-diamines in ...

    Abstract Addressing the asymmetric synthesis of oxindole-based α-aminoboronic acids, instead of the expected products we disclosed the efficient homocoupling of oxindole-based N-tert-butanesulfinyl imines, with the generation of chiral, quaternary 1,2-diamines in a mild and completely stereoselective way. The obtained 3,3′-bisoxindole derivatives were fully characterized by NMR and single-crystal X-ray diffraction analysis and proved to be single diastereoisomers and atropisomers. A plausible mechanism for the one-pot Cu(II)-catalyzed Bpin addition to the isatin-derived ketimine substrate and subsequent homocoupling is described.
    Keywords atropoisomer ; bis(pinacolato)diboron ; 3,3′-bisoxindole ; n-tert-butanesulfinyl ketimine ; homocoupling ; Science ; Q ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Beilstein-Institut
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: FHbp variants among meningococci of serogroup B in Italy: Evolution and selective pressure, 2014-2017.

    Lo Presti, Alessandra / Carannante, Anna / Fazio, Cecilia / Neri, Arianna / Vacca, Paola / Ambrosio, Luigina / Lista, Florigio / Fillo, Silvia / Stefanelli, Paola

    PloS one

    2023  Volume 18, Issue 2, Page(s) e0277976

    Abstract: Background: Neisseria meningitidis (meningococcus) is the causative agent of invasive meningococcal disease (IMD). Meningococcus of serogroup B (MenB) is one of the main serogroup causing IMD. MenB strains may be prevented by meningococcal B vaccines. ... ...

    Abstract Background: Neisseria meningitidis (meningococcus) is the causative agent of invasive meningococcal disease (IMD). Meningococcus of serogroup B (MenB) is one of the main serogroup causing IMD. MenB strains may be prevented by meningococcal B vaccines. In particular, vaccines with Factor H-binding protein (FHbp), classified into two subfamilies (A or B) or in three variants (v1, v2 or v3), are those available. The objective of the study was to investigate the phylogenetic relationships of FHbp subfamilies A and B (variants v1, v2 or v3) genes and proteins, together with their evolution patterns and selective pressure.
    Materials and methods: Overall, alignments of FHbp nucleotide and protein sequence from 155 MenB samples collected in different parts of Italy, from 2014 to 2017, were analyzed by ClustalW. JModeltest and the Smart Model Selection software were used for the statistical selection of the best-fit substitution models for nucleotide and protein alignments. Site-specific positive and negative selection were estimated through the HYPHY package. The phylogenetic signal was investigated with the likelihood mapping method. The Maximum Likelihood (ML) phylogenetic reconstructions were performed with Phyml.
    Results: The phylogenic analysis identified different clusters within the FHbp subfamily A and B variants, confirming sequence diversity. The pattern of selective pressure in our study indicated that subfamily B FHbp sequences are subjected to greater variations and positive selective pressure respect to subfamily A, with 16 positively supported selected sites identified.
    Conclusion: The study pointed out the need for continued genomic surveillance for meningococci to monitor selective pressure and amino acidic changes. Monitoring the genetic diversity and molecular evolution of FHbp variants may be useful to investigate genetic diversity which may emerge over time.
    MeSH term(s) Humans ; Neisseria meningitidis/genetics ; Bacterial Proteins/genetics ; Antigens, Bacterial/genetics ; Carrier Proteins/genetics ; Complement Factor H/genetics ; Serogroup ; Phylogeny ; Neisseria meningitidis, Serogroup B/genetics ; Meningococcal Infections/epidemiology ; Meningococcal Infections/genetics ; Meningococcal Vaccines ; Italy
    Chemical Substances Bacterial Proteins ; Antigens, Bacterial ; Carrier Proteins ; Complement Factor H (80295-65-4) ; Meningococcal Vaccines
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277976
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  7. Article ; Online: Evidence of immune response to BNT162b2 COVID-19 vaccine in systemic lupus erythematosus patients treated with Belimumab.

    Schiavoni, Ilaria / Olivetta, Eleonora / Natalucci, Francesco / Olivieri, Giulio / Lo Presti, Alessandra / Fedele, Giorgio / Stefanelli, Paola / Ceccarelli, Fulvia / Conti, Fabrizio

    Lupus

    2023  Volume 32, Issue 3, Page(s) 394–400

    Abstract: Objectives: To evaluate humoral and cell-mediated response after three doses of BNT162b2 SARS-CoV-2 vaccine in patients with systemic lupus erythematosus (SLE) treated with Belimumab (BLM).: Methods: SLE patients were vaccinated with three doses of ... ...

    Abstract Objectives: To evaluate humoral and cell-mediated response after three doses of BNT162b2 SARS-CoV-2 vaccine in patients with systemic lupus erythematosus (SLE) treated with Belimumab (BLM).
    Methods: SLE patients were vaccinated with three doses of BNT162b2-mRNA vaccine (two-dose primary vaccination, third booster dose after 6 months). The humoral immune response was assessed one and 6 months after the second dose (T1, T2), and 6 months after the booster dose (T3). Serological assay was performed (The Liaison® SARS-CoV-2 TrimericS IgG chemiluminescent). Spike-specific T-cell response was monitored 6 months after the second vaccine dose and the percentage of cytokines producing T cells was assessed by flow cytometry.
    Results: Twelve patients [12F; median age 46 years (IQR 8.25); median disease duration 156 months (IQR 188)] were enrolled. At T1, all patients showed seroconversion (median anti-Spike IgG levels 1610 BAU/mL, IQR 1390). At T2--day of the third dose--a significant reduction of median anti-Spike IgG antibodies levels was observed [214 BAU/mL (IQR 94);
    Conclusions: BLM does not impair humoral response to primary BNT162b2 SARS-CoV-2 vaccination. During the follow-up, a decline in antibody levels is evident and the third dose is crucial to increase the specific immune response. Finally, we observed a recall T-cell response to the Spike antigen 6 months after the first vaccination cycle.
    MeSH term(s) Humans ; Middle Aged ; BNT162 Vaccine ; COVID-19 Vaccines ; COVID-19 ; Lupus Erythematosus, Systemic ; SARS-CoV-2 ; Immunoglobulin G ; Antibodies, Viral ; Immunity
    Chemical Substances BNT162 Vaccine ; belimumab (73B0K5S26A) ; COVID-19 Vaccines ; Immunoglobulin G ; Antibodies, Viral
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/09612033221151012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3717: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Selective pressure on SARS-CoV-2 protein coding genes and glycosylation site prediction

    Lo Presti, Alessandra / Rezza, Giovanni / Stefanelli, Paola

    Heliyon. 2020 Sept., v. 6, no. 9

    2020  

    Abstract: An outbreak of a febrile respiratory illness due to the newly discovered Coronavirus, SARS-CoV-2, was initially detected in mid-December 2019 in the city of Wuhan, Hubei province (China). The virus then spread to most countries in the world. As an RNA ... ...

    Abstract An outbreak of a febrile respiratory illness due to the newly discovered Coronavirus, SARS-CoV-2, was initially detected in mid-December 2019 in the city of Wuhan, Hubei province (China). The virus then spread to most countries in the world. As an RNA virus, SARS-CoV-2 may acquire mutations that may be fixed. The aim of this study was to evaluate the selective pressure acting on SARS-CoV-2 protein coding genes.Mutations and glycosylation site prediction were analyzed in SARS-CoV-2 genomes (from 464 to 477 sequences).Selective pressure on surface glycoprotein (S) revealed one positively selected site (AA 943), located outside the receptor binding domain (RBD). Mutation analysis identified five residues on the surface glycoprotein, with variations (AA positions 367, 458, 477, 483, 491) located inside the RDB. Positive selective pressure was identified in nsp2, nsp3, nsp4, nsp6, nsp12, helicase, ORF3a, ORF8, and N sub-sets. A total of 22 predicted N-glycosylation positions were found in the SARS-CoV-2 surface glycoprotein; one of them, 343N, was located within the RBD. One predicted N-glycosylation site was found in the M protein and 4 potential O-glycosylation sites in specific protein 3a sequences.Overall, the data showed positive pressure and mutations acting on specific protein coding genes. These findings may provide useful information on: i) markers for vaccine design, ii) new therapeutic approach, iii) information to implement mutagenesis experiments to inhibit SARS-CoV-2 cell entry. The negative selection identified in SARS-CoV-2 protein coding genes may help the identification of highly conserved regions useful to implement new future diagnostic protocols.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; glycoproteins ; glycosylation ; mutagenesis ; mutational analysis ; prediction ; respiratory tract diseases ; therapeutics ; vaccine development ; viruses ; China
    Language English
    Dates of publication 2020-09
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2020.e05001
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Selective pressure on SARS-CoV-2 protein coding genes and glycosylation site prediction

    Lo Presti, Alessandra / Rezza, Giovanni / Stefanelli, Paola

    Heliyon

    2020  Volume 6, Issue 9, Page(s) e05001

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2020.e05001
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Highly diastereoselective entry to chiral oxindole-based β-amino boronic acids and spiro derivatives.

    Manenti, Marco / Gazzotti, Stefano / Lo Presti, Leonardo / Molteni, Giorgio / Silvani, Alessandra

    Organic & biomolecular chemistry

    2021  Volume 19, Issue 33, Page(s) 7211–7216

    Abstract: We here describe the first Cu-catalysed, diastereoselective 1,2-addition of 1,1-diborylmethane to chiral ketimines for the synthesis of quaternary stereocenters and spiro compounds. The method provides easy access to a range of chiral, highly ... ...

    Abstract We here describe the first Cu-catalysed, diastereoselective 1,2-addition of 1,1-diborylmethane to chiral ketimines for the synthesis of quaternary stereocenters and spiro compounds. The method provides easy access to a range of chiral, highly functionalized compounds, namely oxindole-based β,β'-disubstituted β-amino boronates, boron-containing peptidomimetics and six-, seven-membered spirocyclic hemiboronic esters. Such unprecedented compounds are mostly obtained in high yields and easily isolated as single diastereoisomers, paving the way to a more intense exploitation of boron-containing compounds in diversity-oriented chemistry and drug-discovery programs. Concerning stereochemistry, the application of Ellman's auxiliary strategy allows in principle to access both steric series of target compounds.
    Language English
    Publishing date 2021-08-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d1ob01303c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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