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Article ; Online: Hormonothérapies de transition chez les personnes transgenres.

Johnson, Nicolaï / Chabbert-Buffet, Nathalie

2022 Volume 38, Issue 11, Page(s) 905–912

Abstract: Medical care for transgender patients is still characterized by an insufficient availability of healthcare services, as well as by poor provider education and training. Transgender patients often require gender-affirming hormone therapy (GAHT), and ... ...

Title translation	Gender-affirming hormone therapy in transgender persons.
Abstract	Medical care for transgender patients is still characterized by an insufficient availability of healthcare services, as well as by poor provider education and training. Transgender patients often require gender-affirming hormone therapy (GAHT), and physicians, including endocrinologists, general practitioners, and others, should be trained to initiate and monitor these treatments throughout the transition process, and beyond. This article will address the specific issues surrounding GAHT in adult transgender women and men.
MeSH term(s)	Adult ; Male ; Humans ; Female ; Transgender Persons ; Physicians ; Hormones/therapeutic use
Chemical Substances	Hormones
Language	French
Publishing date	2022-11-30
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2022151
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Article ; Online: Impact of hormonal contraception on endometrial histology in patients with Lynch syndrome, a retrospective pilot study.

Mawet, Marie / Evrevin, Clémence / Dardenne, Antoine / Kridelka, Frédéric / Pintiaux, Axelle / Chabbert-Buffet, Nathalie

Familial cancer

2024

Abstract: Hormonal contraception (HC) is a well-recognized protection against endometrial cancer (EC) in the general population. It has not been established if this is also applicable to women with Lynch syndrome (LS), a condition associated with a up to 50% ... ...

Abstract	Hormonal contraception (HC) is a well-recognized protection against endometrial cancer (EC) in the general population. It has not been established if this is also applicable to women with Lynch syndrome (LS), a condition associated with a up to 50% lifetime risk of developing EC. The objective of this study was to evaluate if the use of HC influences the incidence of endometrial hyperplasia and EC in women with LS by comparing the histology of annual endometrial biopsies obtained in patients with LS who are using HC versus non-users. This is a retrospective cohort study conducted with endometrial biopsies obtained in women 30 to 50 years of age with LS. The Pearson Chi-square test was performed to compare the prevalence of cancer and hyperplasia in the HC users and in the non-HC users groups. A total of 164 endometrial biopsies obtained among 75 women were suitable for analysis. Among the 86 biopsies obtained in the non-HC group, 81.4% (70/86) were normal. Two cases of endometrial carcinoma (2.3%) and 6 endometrial hyperplasia without atypia were found (7.0%). Among the 78 biopsies performed in patients using HC, 78.2% (61/78) were normal. Three endometrial hyperplasia without atypia (3.8%) and three cases of EC were diagnosed (3.8%). This study suggests that, in women of 30 to 50 years of age with LS, the use of hormonal contraception does not seem to decrease the occurrence of endometrial hyperplasia/carcinoma on annual endometrial histology.
Language	English
Publishing date	2024-04-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1502496-9
ISSN	1573-7292 ; 1389-9600
ISSN (online)	1573-7292
ISSN	1389-9600
DOI	10.1007/s10689-024-00387-y
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Article ; Online: Ovarian reserve in patients with FMR1 gene premutation and the role of fertility preservation.

Poulennec, Tiphaine Le / Dubreuil, Sophie / Grynberg, Michael / Chabbert-Buffet, Nathalie / Sermondade, Nathalie / Fourati, Salma / Siffroi, Jean-Pierre / Héron, Delphine / Bachelot, Anne

Annales d'endocrinologie

2024

Abstract: Introduction: Women with premutation (PM) of the FMR1 gene may suffer from reduced ovarian reserve or even premature ovarian insufficiency (POI). We studied hormonal and ultrasound ovarian reserve, fertility and fertility preservation outcomes in these ... ...

Abstract	Introduction: Women with premutation (PM) of the FMR1 gene may suffer from reduced ovarian reserve or even premature ovarian insufficiency (POI). We studied hormonal and ultrasound ovarian reserve, fertility and fertility preservation outcomes in these patients. Patients and method: Retrospective cohort study of 63 female FMR1 premutation carriers. Results: Sixty-three female patients bearing an FMR1 premutation were included. Median age was 30 years [26.5-35]. Median number of CGG triplets was 83 [77.2-92]. Before diagnosis of PM, 19 women (30%) had had in all 35 pregnancies, resulting in 20 births, including 7 affected children. After diagnosis of PM, 17 women (26.1%) had in all 23 pregnancies, at a median age of 34.5 years [32.2-36.0]: 2 after preimplantation genetic diagnosis, 3 after oocyte donation, 18 spontaneously, and 5 ending in medical termination for Fragile X syndrome. Thirty-three patients (52.4%) had POI diagnosis (median age, 30 years [27-34]) with median FSH level 84 IU/L [50.5-110] and median AMH level 0.08 ng/ml [0.01-0.19]. After POI diagnosis, 8 women had in all 9 pregnancies: 3 following oocyte donation, and 6 spontaneous in 5 women (15.1%). Eight of the 9 pregnancies resulted in a live birth (including 2 affected children) and 1 in medical termination for trisomy 13. The median age of the 30 patients without POI was 31 years [25.2-35.0]. Thirteen women (20.6%) underwent fertility preservation, at a median age of 29 years [24-33]: FSH 7.7 IU/L [6.8-9.9], AMH 1.1 ng/mL [0.95-2.1], antral follicle count 9.5 [7.7-14.7]. A median 15 oocytes [10-26] were cryopreserved in a median 2 cycles [1-3]. At the time of writing, no oocytes had yet been thawed for in vitro fertilization. Conclusions: This study shows the importance of early fertility preservation after diagnosis of FMR1 premutation in women, due to early deterioration of ovarian reserve. Genetic counseling is essential in these patients, as spontaneous pregnancies are not uncommon, even in cases of impaired ovarian reserve, and can lead to birth of affected children.
Language	English
Publishing date	2024-05-01
Publishing country	France
Document type	Journal Article
ZDB-ID	299-9
ISSN	2213-3941 ; 0003-4266
ISSN (online)	2213-3941
ISSN	0003-4266
DOI	10.1016/j.ando.2024.04.004
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Article: Fertility-Sparing Surgery for Ovarian Cancer.

Canlorbe, Geoffroy / Chabbert-Buffet, Nathalie / Uzan, Catherine

Journal of clinical medicine

2021 Volume 10, Issue 18

Abstract: 1) Background: although most patients with epithelial ovarian cancer (EOC) undergo radical surgery, patients with early-stage disease, borderline ovarian tumor (BOT) or a non-epithelial tumor could be offered fertility-sparing surgery (FSS) depending on ...

Abstract	(1) Background: although most patients with epithelial ovarian cancer (EOC) undergo radical surgery, patients with early-stage disease, borderline ovarian tumor (BOT) or a non-epithelial tumor could be offered fertility-sparing surgery (FSS) depending on histologic subtypes and prognostic factors. (2) Methods: we conducted a systematic review to assess the safety and fertility outcomes of FSS in the treatment of ovarian cancer. We queried the MEDLINE, PubMed, Cochrane Library, and Cochrane ("Cochrane Reviews") databases for articles published in English or French between 1985 and 15 January 2021. (3) Results: for patients with BOT, FSS should be offered to young women with a desire to conceive, even if peritoneal implants are discovered at the time of initial surgery. Women with mucinous BOT should undergo initial unilateral salpingo-oophorectomy, whereas cystectomy is an acceptable option for women with serous BOT. Assisted reproductive technology (ART) can be initiated in patients with stage I BOT if infertility persists after surgery. For patients with EOC, FSS should only be considered after staging for women with stage IA grade 1 (and probably 2, or low-grade in the current classification) serous, mucinous or endometrioid tumors. FSS could also be offered to patients with stage IC grade 1 (or low-grade) disease. For women with serous, mucinous or endometrioid high-grade stage IA or low-grade stage IC1 or IC2 EOC, bilateral salpingo-oophorectomy and uterine conservation could be offered to allow pregnancy by egg donation. Finally, FSS has a large role to play in patients with non- epithelial ovarian cancer, and particularly women with malignant ovarian germ cell tumors.
Language	English
Publishing date	2021-09-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10184235
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Article ; Online: Fertility-Sparing Surgery for Ovarian Cancer

Geoffroy Canlorbe / Nathalie Chabbert-Buffet / Catherine Uzan

Journal of Clinical Medicine, Vol 10, Iss 4235, p

2021 Volume 4235

Abstract	(1) Background: although most patients with epithelial ovarian cancer (EOC) undergo radical surgery, patients with early-stage disease, borderline ovarian tumor (BOT) or a non-epithelial tumor could be offered fertility-sparing surgery (FSS) depending on histologic subtypes and prognostic factors. (2) Methods: we conducted a systematic review to assess the safety and fertility outcomes of FSS in the treatment of ovarian cancer. We queried the MEDLINE, PubMed, Cochrane Library, and Cochrane (“Cochrane Reviews”) databases for articles published in English or French between 1985 and 15 January 2021. (3) Results: for patients with BOT, FSS should be offered to young women with a desire to conceive, even if peritoneal implants are discovered at the time of initial surgery. Women with mucinous BOT should undergo initial unilateral salpingo-oophorectomy, whereas cystectomy is an acceptable option for women with serous BOT. Assisted reproductive technology (ART) can be initiated in patients with stage I BOT if infertility persists after surgery. For patients with EOC, FSS should only be considered after staging for women with stage IA grade 1 (and probably 2, or low-grade in the current classification) serous, mucinous or endometrioid tumors. FSS could also be offered to patients with stage IC grade 1 (or low-grade) disease. For women with serous, mucinous or endometrioid high-grade stage IA or low-grade stage IC1 or IC2 EOC, bilateral salpingo-oophorectomy and uterine conservation could be offered to allow pregnancy by egg donation. Finally, FSS has a large role to play in patients with non- epithelial ovarian cancer, and particularly women with malignant ovarian germ cell tumors.
Keywords	ovarian cancer ; fertility sparing surgery ; conservative surgery ; borderline ovarian ; epithelial ovarian cancer ; Medicine ; R
Subject code	616 ; 610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Second-trimester medical abortion after exposure to lorlatinib during early pregnancy, a case report.

Mawet, Marie / Basse, Clémence / Barrois, Mathilde / Gligorov, Joseph / Cadranel, Jacques / Chabbert-Buffet, Nathalie / Selleret, Lise

Journal of gynecology obstetrics and human reproduction

2023 Volume 52, Issue 10, Page(s) 102673

Abstract: Use of Lorlatinib, a third-generation tyrosine kinase inhibitor currently indicated in the treatment of non-small-cell lung cancer (NSCLC) with ALK or ROS1 gene fusion, is formally contra-indicated during pregnancy due to teratogenic effects observed ... ...

Abstract	Use of Lorlatinib, a third-generation tyrosine kinase inhibitor currently indicated in the treatment of non-small-cell lung cancer (NSCLC) with ALK or ROS1 gene fusion, is formally contra-indicated during pregnancy due to teratogenic effects observed during pre-clinical studies. We report the case of a 38-year-old woman with a ROS1-positive NSCLC, successfully treated with lorlatinib as second line therapy, who became pregnant while on treatment. Due to significant disease progression 12 weeks after lorlatinib stop and the great uncertainty on the pregnancy outcome, she finally decided to interrupt the pregnancy at 22 weeks of gestation. Echography and gross infant examination did not reveal any malformation. Pregnancies occurring under this kind of new oncologic treatment is expected to happen more frequently in the future. It seems therefore important to us to report any information on the topic to increase our level of knowledge and improve decision-making.
MeSH term(s)	Female ; Humans ; Pregnancy ; Adult ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/therapeutic use ; Pregnancy Trimester, Second ; Anaplastic Lymphoma Kinase/genetics ; Anaplastic Lymphoma Kinase/therapeutic use ; Proto-Oncogene Proteins/genetics ; Lactams, Macrocyclic/pharmacology ; Lactams, Macrocyclic/therapeutic use
Chemical Substances	lorlatinib (OSP71S83EU) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Proto-Oncogene Proteins ; Lactams, Macrocyclic
Language	English
Publishing date	2023-09-28
Publishing country	France
Document type	Case Reports
ISSN	2468-7847
ISSN (online)	2468-7847
DOI	10.1016/j.jogoh.2023.102673
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Article ; Online: Endométriose : pour une meilleure prise en charge.

Daraï, Emile / Chabbert-Buffet, Nathalie

Presse medicale (Paris, France : 1983)

2017 Volume 46, Issue 12 Pt 1, Page(s) 1154–1155

Title translation	How to improve endometriosis management.
MeSH term(s)	Delayed Diagnosis ; Diagnosis, Differential ; Endometriosis/complications ; Endometriosis/diagnosis ; Endometriosis/therapy ; Female ; Humans ; Infertility, Female/diagnosis ; Infertility, Female/etiology ; Infertility, Female/therapy ; Quality Improvement ; Reproductive Techniques, Assisted/standards
Language	French
Publishing date	2017-12
Publishing country	France
Document type	Editorial ; Introductory Journal Article
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2017.10.018
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Article ; Online: How to optimize breast MRI protocol? The value of combined analysis of ultrafast and diffusion-weighted MRI sequences.

Milon, Audrey / Flament, Vincent / Gueniche, Yoram / Kermarrec, Edith / Chabbert-Buffet, Nathalie / Darai, Émile / Touboul, Cyril / Razakamanantsoa, Leo / Thomassin-Naggara, Isabelle

Diagnostic and interventional imaging

2023 Volume 104, Issue 6, Page(s) 284–291

Abstract: Purpose: The purpose of this retrospective study was to demonstrate the validity of early enhancement criteria on ultrafast magnetic resonance imaging (MRI) sequence to predict malignancy in a large population, and the benefit of diffusion-weighted ... ...

Abstract	Purpose: The purpose of this retrospective study was to demonstrate the validity of early enhancement criteria on ultrafast magnetic resonance imaging (MRI) sequence to predict malignancy in a large population, and the benefit of diffusion-weighted imaging (DWI) to improve the performance of breast MRI. Material and methods: Women who underwent breast MRI examination between April 2018 and September 2020 and further breast biopsy were retrospectively included. Two readers quoted the different conventional features and classified the lesion according to the BI-RADS classification based on the conventional protocol. Then, the readers checked for the presence of early enhancement (≤ 30 s) on ultrafast sequence and the presence of an apparent diffusion coefficient (ADC) ≥ 1.5 × 10 Results: Two hundred fifty-seven women (median age: 51 years; range: 16-92 years) with 436 lesions (157 benign, 11 borderline and 268 malignant) were included. A MRI protocol plus two simple functional features, early enhancement (≤ 30 s) and an ADC value ≥ 1.5 × 10 Conclusion: BI-RADS analysis based on a simple short MRI protocol plus early enhancement on ultrafast sequence and ADC value has a greaterr diagnostic accuracy than a conventional protocol and may avoid unnecessary biopsy.
MeSH term(s)	Female ; Humans ; Middle Aged ; Retrospective Studies ; Contrast Media ; Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Breast Neoplasms/diagnostic imaging ; Sensitivity and Specificity ; Diagnosis, Differential
Chemical Substances	Contrast Media
Language	English
Publishing date	2023-02-15
Publishing country	France
Document type	Journal Article
ZDB-ID	2648283-6
ISSN	2211-5684 ; 2211-5684
ISSN (online)	2211-5684
ISSN	2211-5684
DOI	10.1016/j.diii.2023.01.010
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Article ; Online: The history and use of the progesterone receptor modulator ulipristal acetate for heavy menstrual bleeding with uterine fibroids.

Bouchard, Philippe / Chabbert-Buffet, Nathalie

Best practice & research. Clinical obstetrics & gynaecology

2017 Volume 40, Page(s) 105–110

Abstract: Progesterone receptor modulators (PRM) or selective progesterone receptor modulators have two remarkable effects in treated women. They considerably suppress endometrial bleeding by incompletely understood mechanisms, and when administered in women with ... ...

Abstract	Progesterone receptor modulators (PRM) or selective progesterone receptor modulators have two remarkable effects in treated women. They considerably suppress endometrial bleeding by incompletely understood mechanisms, and when administered in women with symptomatic fibroids, they produce a significant and potentially long-term decrease in fibroid volume. The crucial advantage of this therapy lies with the absence of suppression of ovarian oestrogen secretion, which is in contrast to GnRH agonists. Long-term treatments have proven to be useful, especially in women approaching the menopausal transition. However, their use is associated with endometrial modifications called PRM-associated endometrial changes (PAECs). Although these abnormalities are now described as benign, the treatment is best administered in an intermittent manner where the PAECs rapidly disappear, while the beneficial effects on fibroid size and uterine bleeding are maintained or even improved in the long term.
MeSH term(s)	Administration, Oral ; Drug Administration Schedule ; Endometrium/drug effects ; Female ; Humans ; Leiomyoma/complications ; Leiomyoma/drug therapy ; Menorrhagia/complications ; Menorrhagia/drug therapy ; Norpregnadienes/administration & dosage ; Randomized Controlled Trials as Topic ; Receptors, Progesterone/antagonists & inhibitors
Chemical Substances	Norpregnadienes ; Receptors, Progesterone ; ulipristal acetate (YF7V70N02B)
Language	English
Publishing date	2017-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2050090-7
ISSN	1532-1932 ; 1521-6934
ISSN (online)	1532-1932
ISSN	1521-6934
DOI	10.1016/j.bpobgyn.2016.12.002
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Article ; Online: Artificial intelligence in medicine: A matter of joy or concern?

Kolanska, Kamila / Chabbert-Buffet, Nathalie / Daraï, Emile / Antoine, Jean-Marie

Journal of gynecology obstetrics and human reproduction

2020 Volume 50, Issue 1, Page(s) 101962

Abstract: Artificial Intelligence (AI), a concept which dates back to the 1950s, is increasingly being developed by many medical specialties, especially those based on imaging or surgery. While the cognitive component of AI is far superior to that of human ... ...

Abstract	Artificial Intelligence (AI), a concept which dates back to the 1950s, is increasingly being developed by many medical specialties, especially those based on imaging or surgery. While the cognitive component of AI is far superior to that of human intelligence, it lacks consciousness, feelings, intuition and adaptation to unexpected situations. Furthermore, fundamental questions arise with regard to data security, the impact on healthcare professions, and the distribution of roles between physicians and AI especially concerning consent to medical care and liability in the event of a therapeutic accident.
MeSH term(s)	Artificial Intelligence/ethics ; Artificial Intelligence/trends ; Humans ; Medicine/trends
Language	English
Publishing date	2020-10-23
Publishing country	France
Document type	Journal Article ; Review
ISSN	2468-7847
ISSN (online)	2468-7847
DOI	10.1016/j.jogoh.2020.101962
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