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Article: A Rare Case of Pulmonary Cavitary Disease Caused by Mycobacterium xenopi.

Dogra, Megha / Thakur, Manish / Thakur, Garima / Kumar, Amrat

2023 Volume 15, Issue 2, Page(s) e34561

Abstract: Mycobacterium xenopi is a slow-growing, acid-fast, non-tuberculous mycobacterium (NTM). It is often considered to be a saprophyte or an environmental contaminant. Mycobacterium xenopi has low pathogenicity and is usually seen in patients with pre- ... ...

Abstract	Mycobacterium xenopi is a slow-growing, acid-fast, non-tuberculous mycobacterium (NTM). It is often considered to be a saprophyte or an environmental contaminant. Mycobacterium xenopi has low pathogenicity and is usually seen in patients with pre-existing chronic lung diseases and immunocompromised patients. We present a case of Mycobacterium xenopi causing a cavitary lesion in a patient with chronic obstructive pulmonary disease (COPD) that was discovered incidentally during the low-dose CT scan done for lung cancer screening in a patient with COPD. The initial workup was negative for NTM. An Interventional-guided (IR) core needle biopsy was done given the high suspicion for NTM and revealed a positive culture for Mycobacterium xenopi. Our case highlights the importance of considering NTM in the differential diagnosis of at-risk patients and pursuing invasive testing if there is a high clinical suspicion.
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.34561
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Tick-Borne Rhabdomyolysis: A Rare Case of Rhabdomyolysis and Acute Kidney Injury Due to Anaplasmosis.

Dogra, Megha / Thakur, Manish / Kumar, Amrat / Thakur, Garima

Cureus

2023 Volume 15, Issue 2, Page(s) e34835

Abstract: Anaplasmosis is a tick-borne illness commonly seen in the northeastern states of the United States. The most common presenting signs are fever, malaise, and body aches accompanied by leukopenia, thrombocytopenia, and transaminitis. Rhabdomyolysis and ... ...

Abstract	Anaplasmosis is a tick-borne illness commonly seen in the northeastern states of the United States. The most common presenting signs are fever, malaise, and body aches accompanied by leukopenia, thrombocytopenia, and transaminitis. Rhabdomyolysis and acute kidney injury are rare presentations that can lead to significant morbidity. We present the case of a patient who presented with non-specific symptoms of malaise, fatigue, and body aches and was found to have rhabdomyolysis and acute kidney injury on laboratory workup. A presumptive diagnosis of anaplasmosis was made, and the patient was started on treatment for the same. The patient recovered successfully. Our case highlights the rare presentation of anaplasmosis with rhabdomyolysis and acute kidney injury. Physician awareness is needed for early diagnosis and preventing morbidity.
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.34835
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Article ; Online: Convolutional Neural Networks Guided Raman Spectroscopy as a Process Analytical Technology (PAT) Tool for Monitoring and Simultaneous Prediction of Monoclonal Antibody Charge Variants.

Nitika, Nitika / Keerthiveena, B / Thakur, Garima / Rathore, Anurag S

Pharmaceutical research

2024 Volume 41, Issue 3, Page(s) 463–479

Abstract: Background: Charge related heterogeneities of monoclonal antibody (mAb) based therapeutic products are increasingly being considered as a critical quality attribute (CQA). They are typically estimated using analytical cation exchange chromatography (CEX) ...

Abstract	Background: Charge related heterogeneities of monoclonal antibody (mAb) based therapeutic products are increasingly being considered as a critical quality attribute (CQA). They are typically estimated using analytical cation exchange chromatography (CEX), which is time consuming and not suitable for real time control. Raman spectroscopy coupled with artificial intelligence (AI) tools offers an opportunity for real time monitoring and control of charge variants. Objective: We present a process analytical technology (PAT) tool for on-line and real-time charge variant determination during process scale CEX based on Raman spectroscopy employing machine learning techniques. Method: Raman spectra are collected from a reference library of samples with distribution of acidic, main, and basic species from 0-100% in a mAb concentration range of 0-20 g/L generated from process-scale CEX. The performance of different machine learning techniques for spectral processing is compared for predicting different charge variant species. Result: A convolutional neural network (CNN) based model was successfully calibrated for quantification of acidic species, main species, basic species, and total protein concentration with R Conclusion: We demonstrate that Raman spectroscopy combined with AI-ML frameworks can deliver rapid and accurate determination of product related impurities. This approach can be used for real time CEX pooling decisions in mAb production processes, thus enabling consistent charge variant profiles to be achieved.
MeSH term(s)	Antibodies, Monoclonal/chemistry ; Spectrum Analysis, Raman/methods ; Artificial Intelligence ; Technology ; Neural Networks, Computer
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	843063-9
ISSN	1573-904X ; 0724-8741 ; 0739-0742
ISSN (online)	1573-904X
ISSN	0724-8741 ; 0739-0742
DOI	10.1007/s11095-024-03663-9
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Article ; Online: FRET-GP - A Local Measure of the Impact of Transmembrane Peptide on Lipids.

Thakur, Garima C N / Uday, Arunima / Jurkiewicz, Piotr

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 50, Page(s) 18390–18402

Abstract: Reconstitution of a transmembrane protein in model lipid systems allows studying its structure and dynamics in isolation from the complexity of the natural environment. This approach also provides a well-defined environment for studying the interactions ... ...

Abstract	Reconstitution of a transmembrane protein in model lipid systems allows studying its structure and dynamics in isolation from the complexity of the natural environment. This approach also provides a well-defined environment for studying the interactions of proteins with lipids. In this work, we describe the FRET-GP method, which utilizes Förster resonance energy transfer (FRET) to specifically probe the nanoenvironment of a transmembrane domain. The tryptophan residues flanking this domain act as efficient FRET donors, while Laurdan acts as acceptor. The fluorescence of this solvatochromic probe is quantified using generalized polarization (GP) to report on lipid mobility in the vicinity of the transmembrane domain. We applied FRET-GP to study the transmembrane peptide WALP incorporated in liposomes. We found that the direct excitation of Laurdan to its second singlet state strongly contributes to GP values measured in FRET conditions. Removal of this parasitic contribution was essential for proper determination of GP
MeSH term(s)	Fluorescence Resonance Energy Transfer ; Laurates ; Liposomes/chemistry ; Peptides ; Fluorescent Dyes
Chemical Substances	laurdan (Y97FBL93VW) ; Laurates ; Liposomes ; Peptides ; Fluorescent Dyes
Language	English
Publishing date	2023-12-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c02505
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Article ; Online: Continuous manufacturing of monoclonal antibodies: Dynamic control of multiple integrated polishing chromatography steps using BioSMB.

Nitika, Nitika / Thakur, Garima / Rathore, Anurag S

Journal of chromatography. A

2023 Volume 1690, Page(s) 463784

Abstract: We propose a strategy for automation and control of multi-step polishing chromatography in integrated continuous manufacturing of monoclonal antibodies. The strategy is demonstrated for a multi-step polishing process consisting of cation exchange ... ...

Abstract	We propose a strategy for automation and control of multi-step polishing chromatography in integrated continuous manufacturing of monoclonal antibodies. The strategy is demonstrated for a multi-step polishing process consisting of cation exchange chromatography in bind-and-elute mode followed by mixed-mode chromatography in flowthrough mode. A BioSMB system with a customized Python control layer is used for automation and scheduling of both the chromatography steps. Further, the BioSMB valve manifold is leveraged for in-line conditioning between the two steps, as tight control of pH and conductivity is essential when operating with multimodal resins because even slight fluctuations in load conditions adversely affect the chromatography performance. The pH and conductivity of the load to the multimodal chromatography columns is consistent, despite the elution gradient of the preceding cation exchange chromatography step. Inputs from the BioSMB pH and conductivity sensors are used for real-time control of the 7 pumps and 240 valves to achieve in-line conditioning inside the BioSMB manifold in a fully automated manner. This is confirmed by showcasing different elution strategies in cation exchange chromatography, including linear gradient, step gradient and process deviations like tubing leakage. In all the above cases, the model was able to maintain the pH and conductivity of multimodal chromatography load within the range of 6 ± 0.1 pH and 7 ± 0.3 mS/cm conductivity. The strategy eliminates the need for using multiple BioSMB units or integrating external pumps, valves, mixers, surge tanks, or sensors between the two steps as is currently the standard approach, thus offering a simple and robust structure for integrating multiple polishing chromatography steps in continuous downstream monoclonal antibody purification trains.
MeSH term(s)	Cricetinae ; Animals ; Antibodies, Monoclonal/chemistry ; Chromatography, Ion Exchange/methods ; CHO Cells ; Cations/chemistry
Chemical Substances	Antibodies, Monoclonal ; Cations
Language	English
Publishing date	2023-01-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2023.463784
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Article: Association studies in linseed (Linum usitatissimum L.) under different production systems over locations

Thakur, Garima / Paul, Satish

Electronic journal of plant breeding. 2022 June, v. 13, no. 2

2022

Abstract: The present experiment was conducted to determine the important yield components and their association with one another and with yield. The experiment was laid out under two production systems over four different locations in the mid-hills of the North- ... ...

Abstract	The present experiment was conducted to determine the important yield components and their association with one another and with yield. The experiment was laid out under two production systems over four different locations in the mid-hills of the North-western Himalayas. Correlation studies indicated a strong positive correlation for seed yield with harvest index (EI 0.668; EII 0.472) and biological yield (EI 0.362; EII 0.532) in both the production systems. Whereas, a non-significant positive correlation was observed for the number of primary branches (EI 0.103; EII 0.122) and the number of secondary branches (EI 0.033; EII 0.160) in both production systems. Whereas, among other traits highly significant correlation was observed for days to 50% flowering with days to 75% maturity in both production systems (EI 0.837; EII 0.781) followed by plant height (EI- 0.626; EII- 0.562) and technical plant height (EI 0.617; EII 0.598). Path coefficient analysis indicated that only biological yield (EI 0.70348; EII 0.60597) and harvest index (EI 0.90210; EII 0.53283) showed a highly significant direct effect with seed yield in both production systems. This showed that selection for biological yield and harvest index would have a direct positive effect in the improvement of grain yield and are the most important determinants of yield in linseed. However, traits such as number of primary branches, number of secondary branches and 1000 seed weight should also be given significant importance since these traits also showed a positive correlation with seed yield but with indirect effects via biological yield and harvest index in EI and EII, respectively.
Keywords	Linum usitatissimum ; grain yield ; harvest index ; linseed ; plant height ; seed weight ; seed yield ; Himalayan region
Language	English
Dates of publication	2022-06
Size	p. 731-738.
Publishing place	Indian Society of Plant Breeders
Document type	Article
ZDB-ID	2534084-0
ISSN	0975-928X
ISSN	0975-928X
DOI	10.37992/2022.1302.100
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Candida auris biofilm: a review on model to mechanism conservation.

Khari, Arsha / Biswas, Biswambhar / Gangwar, Garima / Thakur, Anil / Puria, Rekha

Expert review of anti-infective therapy

2023 Volume 21, Issue 3, Page(s) 295–308

Abstract: Introduction: Candida auris: Areas covered: This review provides brief insights into the understanding of : Expert opinion: The selection of an appropriate model system is a must for the accuracy and reproducibility of results. The conservation of ...

Abstract	Introduction: Candida auris Areas covered: This review provides brief insights into the understanding of Expert opinion: The selection of an appropriate model system is a must for the accuracy and reproducibility of results. The conservation of major signaling pathways in
MeSH term(s)	Humans ; Candida/physiology ; Candida auris ; Reproducibility of Results ; Saccharomyces cerevisiae ; Biofilms ; Candida albicans ; Antifungal Agents/pharmacology
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2023-02-16
Publishing country	England
Document type	Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2181279-2
ISSN	1744-8336 ; 1478-7210
ISSN (online)	1744-8336
ISSN	1478-7210
DOI	10.1080/14787210.2023.2179036
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Article ; Online: An Updated Review on Functionalized Graphene as Sensitive Materials in Sensing of Pesticides.

Raman, Anirudh Pratap Singh / Thakur, Gauri / Pandey, Garima / Kumari, Kamlesh / Singh, Prashant

Chemistry & biodiversity

2024 , Page(s) e202302080

Abstract: Numerous chemical pesticides were employed for a long time to manage pests, but their uncontrolled application harmed the health and the environment. Accurately quantifying pesticide residues is essential for risk evaluation and regulatory purposes. ... ...

Abstract	Numerous chemical pesticides were employed for a long time to manage pests, but their uncontrolled application harmed the health and the environment. Accurately quantifying pesticide residues is essential for risk evaluation and regulatory purposes. Numerous analytical methods have been developed and utilized to achieve sensitive and specific detection of pesticides in intricate samples like water, soil, food, and air. Electrochemical sensors based on amperometry, potentiometry, or impedance spectroscopy offer portable, rapid, and sensitive detection suitable for on-site analysis. This study examines the potential of electrochemical sensors for the accurate evaluation of various effects of pesticides. Emphasizing the use of Graphene (GR), Graphene Oxide (GO), Reduced Graphene Oxide (rGO), and Graphdiyne composites, the study highlights their enhanced performance in pesticide sensing by stating the account of many actual sensors that have been made for specific pesticides. Computational studies provide valuable insights into the adsorption kinetics, binding energies, and electronic properties of pesticide-graphene complexes, guiding the design and optimization of graphene-based sensors with improved performance. Furthermore, the discussion extends to the emerging field of biopesticides. While the GR/GO/rGO based sensors hold immense future prospects, their existing limitations have also been discussed, which need to be solved with future research.
Language	English
Publishing date	2024-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202302080
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Article: An alternative yogic approach for cyclical mastalgia-A narrative review.

Jaiswal, Garima / Thakur, Ghanshyam S

Journal of family medicine and primary care

2021 Volume 10, Issue 2, Page(s) 601–608

Abstract: Background: Mastalgia or breast pain common benign breast disorder in women in her reproductive life. Mastalgia estimate prevalence 41-71%. It affects to overall quality of life and associated with anxiety, stress, and other psychological factors.: ... ...

Abstract	Background: Mastalgia or breast pain common benign breast disorder in women in her reproductive life. Mastalgia estimate prevalence 41-71%. It affects to overall quality of life and associated with anxiety, stress, and other psychological factors. Objective: The purpose of the study was to conduct a review of alternative therapy in the management of mastalgia. Method: A review was conducted using search terms cyclical mastalgia (CM), yoga therapy, breast treatment, primrose oil, oestrogen, progesterone and all the probable term in national and international data repositories such as PubMed, Scopus, science direct, google scholar, web of science in English language. Result: The review of alternative therapies in the management of CM suggests that most of the studies used primrose oil, vitamins, and physical activity. There are very few studies conducted in relation to yoga and cyclical mastalgia. Further, most of the studies explored effect of alternative therapies on psychological outcomes. None of the studies investigated efficacy of these therapies on hormonal changes. Conclusion: Evidence suggests that biochemical clinical trial is effective with side effect, primrose oil and seeds treatment is less effective. One evidence-based study with integrated yoga therapy should be considered in the management of cyclical mastalgia. More high-quality trial with yogic approach needed to first line management of patients presenting with CM.
Language	English
Publishing date	2021-02-27
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_1688_20
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Article ; Online: An alternative yogic approach for cyclical mastalgia—A narrative review

Garima Jaiswal / Ghanshyam S Thakur

Journal of Family Medicine and Primary Care, Vol 10, Iss 2, Pp 601-

2021 Volume 608

Abstract: Background: Mastalgia or breast pain common benign breast disorder in women in her reproductive life. Mastalgia estimate prevalence 41–71%. It affects to overall quality of life and associated with anxiety, stress, and other psychological factors. ... ...

Abstract	Background: Mastalgia or breast pain common benign breast disorder in women in her reproductive life. Mastalgia estimate prevalence 41–71%. It affects to overall quality of life and associated with anxiety, stress, and other psychological factors. Objective: The purpose of the study was to conduct a review of alternative therapy in the management of mastalgia. Method: A review was conducted using search terms cyclical mastalgia (CM), yoga therapy, breast treatment, primrose oil, oestrogen, progesterone and all the probable term in national and international data repositories such as PubMed, Scopus, science direct, google scholar, web of science in English language. Result: The review of alternative therapies in the management of CM suggests that most of the studies used primrose oil, vitamins, and physical activity. There are very few studies conducted in relation to yoga and cyclical mastalgia. Further, most of the studies explored effect of alternative therapies on psychological outcomes. None of the studies investigated efficacy of these therapies on hormonal changes. Conclusion: Evidence suggests that biochemical clinical trial is effective with side effect, primrose oil and seeds treatment is less effective. One evidence-based study with integrated yoga therapy should be considered in the management of cyclical mastalgia. More high-quality trial with yogic approach needed to first line management of patients presenting with CM.
Keywords	anxiety ; cyclical mastalgia ; oestrogen ; progesterone ; stress ; yoga therapy ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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