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  1. Article ; Online: Reply to "The use of basophil activation tests (BATs) in the diagnosis of penicillin allergy".

    Bennett, Miriam R / Mathioudakis, Alexander G / Tontini, Chiara / Simpson, Angela

    The journal of allergy and clinical immunology. In practice

    2024  Volume 12, Issue 3, Page(s) 802–803

    MeSH term(s) Humans ; Basophil Degranulation Test ; Drug Hypersensitivity/diagnosis ; Basophils ; Hypersensitivity/diagnosis ; Penicillins/adverse effects
    Chemical Substances Penicillins
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Letter
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.12.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Capsule Commentary on Bremmer et. al., Impact of Procalcitonin Guidance on Management of Adults Hospitalized with Chronic Obstructive Pulmonary Disease Exacerbations.

    Mathioudakis, Alexander G

    Journal of general internal medicine

    2018  Volume 33, Issue 5, Page(s) 749

    MeSH term(s) Adult ; Calcitonin ; Humans ; Procalcitonin ; Pulmonary Disease, Chronic Obstructive
    Chemical Substances Procalcitonin ; Calcitonin (9007-12-9)
    Language English
    Publishing date 2018-02-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-018-4341-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: How to peer review: practical advice for early career researchers.

    Mathioudakis, Alexander G / Wagner, Darcy / Dumas, Orianne

    Breathe (Sheffield, England)

    2022  Volume 18, Issue 4, Page(s) 220160

    Abstract: Practical tips and guidance on peer review are provided by three scientists in the respiratory field, to help early career researchers who may be invited to review papers for respiratory ... ...

    Abstract Practical tips and guidance on peer review are provided by three scientists in the respiratory field, to help early career researchers who may be invited to review papers for respiratory journals
    Language English
    Publishing date 2022-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0160-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Combined Pulmonary Fibrosis and Emphysema: Comparative Evidence on a Complex Condition.

    Calaras, Diana / Mathioudakis, Alexander G / Lazar, Zsofia / Corlateanu, Alexandru

    Biomedicines

    2023  Volume 11, Issue 6

    Abstract: Combined pulmonary fibrosis and emphysema (CPFE) is a clinical syndrome characterized by upper lobe emphysema and lower lobe fibrosis manifested by exercise hypoxemia, normal lung volumes, and severe reduction of diffusion capacity of carbon monoxide. It ...

    Abstract Combined pulmonary fibrosis and emphysema (CPFE) is a clinical syndrome characterized by upper lobe emphysema and lower lobe fibrosis manifested by exercise hypoxemia, normal lung volumes, and severe reduction of diffusion capacity of carbon monoxide. It has varying prevalence worldwide with a male predominance, and with smoking history of more than 40 pack-years being a common risk factor. The unique imaging features of CPFE emphasize its distinct entity, aiding in the timely detection of pulmonary hypertension and lung cancer, both of which are common complications. High-resolution computed tomography (HRCT) is an important diagnostic and prognostic tool, while lung cancer is an independent factor that alters the prognosis in CPFE patients. Treatment options for CPFE are limited, but smoking cessation, usual treatments of pulmonary fibrosis and emphysema, and avoidance of environmental exposures are encouraged.
    Language English
    Publishing date 2023-06-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11061636
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  5. Article: Impact of triple therapy on mortality in COPD.

    Soumagne, Thibaud / Zysman, Maeva / Karadogan, Dilek / Lahousse, Lies / Mathioudakis, Alexander G

    Breathe (Sheffield, England)

    2023  Volume 19, Issue 1, Page(s) 220260

    Abstract: Only a few therapies have been shown to prolong survival in specific patients with COPD. In recent years, the IMPACT and the ETHOS trials suggested that triple therapy (a combination of inhaled corticosteroid (ICS), long-acting muscarinic antagonist ( ... ...

    Abstract Only a few therapies have been shown to prolong survival in specific patients with COPD. In recent years, the IMPACT and the ETHOS trials suggested that triple therapy (a combination of inhaled corticosteroid (ICS), long-acting muscarinic antagonist (LAMA) and long-acting β
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0260-2022
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  6. Article ; Online: Stigma: an unmet public health priority in COPD.

    Mathioudakis, Alexander G / Ananth, Sachin / Vestbo, Jørgen

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 9, Page(s) 955–956

    MeSH term(s) Health Priorities ; Humans ; Public Health ; Pulmonary Disease, Chronic Obstructive/psychology ; Social Stigma ; United Kingdom
    Language English
    Publishing date 2021-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00316-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: The clinical spectrum of aspergillosis in chronic obstructive pulmonary disease.

    Otu, Akaninyene / Kosmidis, Chris / Mathioudakis, Alexander G / Ibe, Chibuike / Denning, David W

    Infection

    2023  Volume 51, Issue 4, Page(s) 813–829

    Abstract: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. In this review, we present the clinical spectrum and pathogenesis of syndromes caused by Aspergillus in COPD namely invasive aspergillosis (IA), community- ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. In this review, we present the clinical spectrum and pathogenesis of syndromes caused by Aspergillus in COPD namely invasive aspergillosis (IA), community-acquired Aspergillus pneumonia, chronic pulmonary Aspergillosis and Aspergillus sensitisation. Some of these entities are clearly linked to COPD, while others may coexist, but are less clearly liked directly to COPD. We discuss current uncertainties as these pertain to IA in COPD cohorts and explore areas for future research in this field.
    MeSH term(s) Humans ; Aspergillosis/complications ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Aspergillosis/complications ; Pulmonary Aspergillosis/diagnosis ; Aspergillus
    Language English
    Publishing date 2023-01-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01960-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 528: Show issues

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  8. Article ; Online: Combined Pulmonary Fibrosis and Emphysema

    Diana Calaras / Alexander G. Mathioudakis / Zsofia Lazar / Alexandru Corlateanu

    Biomedicines, Vol 11, Iss 1636, p

    Comparative Evidence on a Complex Condition

    2023  Volume 1636

    Abstract: Combined pulmonary fibrosis and emphysema (CPFE) is a clinical syndrome characterized by upper lobe emphysema and lower lobe fibrosis manifested by exercise hypoxemia, normal lung volumes, and severe reduction of diffusion capacity of carbon monoxide. It ...

    Abstract Combined pulmonary fibrosis and emphysema (CPFE) is a clinical syndrome characterized by upper lobe emphysema and lower lobe fibrosis manifested by exercise hypoxemia, normal lung volumes, and severe reduction of diffusion capacity of carbon monoxide. It has varying prevalence worldwide with a male predominance, and with smoking history of more than 40 pack-years being a common risk factor. The unique imaging features of CPFE emphasize its distinct entity, aiding in the timely detection of pulmonary hypertension and lung cancer, both of which are common complications. High-resolution computed tomography (HRCT) is an important diagnostic and prognostic tool, while lung cancer is an independent factor that alters the prognosis in CPFE patients. Treatment options for CPFE are limited, but smoking cessation, usual treatments of pulmonary fibrosis and emphysema, and avoidance of environmental exposures are encouraged.
    Keywords emphysema ; lung fibrosis ; interstitial lung disease ; lung function ; pulmonary hypertension ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Was the implementation strategy of the ProACT trial adequately proactive?

    Mathioudakis, Alexander G / Vestbo, Jørgen

    Breathe (Sheffield, England)

    2019  Volume 15, Issue 1, Page(s) 77–80

    Abstract: The ProACT trial does not inform the evidence base regarding safety and clinical effectiveness of procalcitonin (PCT) as a biomarker to guide antibiotic administration for LRTIs, but reveals potential challenges in the introduction of PCT in real life. ...

    Abstract The ProACT trial does not inform the evidence base regarding safety and clinical effectiveness of procalcitonin (PCT) as a biomarker to guide antibiotic administration for LRTIs, but reveals potential challenges in the introduction of PCT in real life.
    Language English
    Publishing date 2019-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0338-2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Covariates in population pharmacokinetic studies of critically ill adults receiving β-lactam antimicrobials: a systematic review and narrative synthesis.

    Hansel, Jan / Mannan, Fahmida / Robey, Rebecca / Kumarendran, Mary / Bladon, Siân / Mathioudakis, Alexander G / Ogungbenro, Kayode / Dark, Paul / Felton, Timothy W

    JAC-antimicrobial resistance

    2024  Volume 6, Issue 1, Page(s) dlae030

    Abstract: Introduction: Population pharmacokinetic studies of β-lactam antimicrobials in critically ill patients derive models that inform their dosing. In non-linear mixed-effects modelling, covariates are often used to improve model fit and explain variability. ...

    Abstract Introduction: Population pharmacokinetic studies of β-lactam antimicrobials in critically ill patients derive models that inform their dosing. In non-linear mixed-effects modelling, covariates are often used to improve model fit and explain variability. We aimed to investigate which covariates are most commonly assessed and which are found to be significant, along with global patterns of publication.
    Methods: We conducted a systematic review, searching MEDLINE, Embase, CENTRAL and Web of Science on 01 March 2023, including studies of critically ill adults receiving β-lactam antimicrobials who underwent blood sampling for population pharmacokinetic studies. We extracted and categorized all reported covariates and assessed reporting quality using the ClinPK checklist.
    Results: Our search identified 151 studies with 6018 participants. Most studies reported observational cohorts (120 studies, 80%), with the majority conducted in high-income settings (136 studies, 90%). Of the 1083 identified covariate instances, 237 were unique; the most common categories were patient characteristics (
    Conclusions: Covariates are most commonly chosen based on biological plausibility, with patient characteristics and biomarkers the most frequently investigated. We developed an openly accessible database of reported covariates to aid investigators with covariate selection when designing population pharmacokinetic studies. Novel covariates, such as sepsis subphenotypes, have not been explored yet, leaving a research gap for future work.
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlae030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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