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Article ; Online: Sleep disorders during the COVID-19 pandemic: Results from the second phase of web-based EPICOVID19 study.

Trevisan, Caterina / De Vincentis, Antonio / Noale, Marianna / Maggi, Stefania / Antonelli Incalzi, Raffaele / Pedone, Claudio / Prinelli, Federica / Giacomelli, Andrea / Fortunato, Loredana / Molinaro, Sabrina / Cori, Liliana / Adorni, Fulvio

Stress and health : journal of the International Society for the Investigation of Stress

2024

Abstract: The COVID-19 pandemic has induced significant impairments, including sleep disturbances. The present study aimed to explore the impact of fear in relation to stress on sleep disorders among Italian adults and older participants in the second phase of the ...

Abstract	The COVID-19 pandemic has induced significant impairments, including sleep disturbances. The present study aimed to explore the impact of fear in relation to stress on sleep disorders among Italian adults and older participants in the second phase of the EPICOVID19 web-based survey (January-February 2021). Sleep disturbances during the pandemic were evaluated using the Jenkins Sleep Scale, perceived stress through the 10-item Perceived Stress Scale and fear of contagion and about economic and job situation with four ad hoc items. The strength of the pathways between stress, sleep disturbances and fear was explored using structural equation modelling, hypothesising that stress was related to sleep disturbances and that fear was associated with both stress and sleep problems. Out of 41,473 participants (74.7% women; mean age 49.7 ± 13.1 years), 8.1% reported sleep disturbances and were more frequently women, employed in a work category at risk of infection or unemployed, and showed higher deprivation scores. Considering an a priori hypotheses model defining sleep and stress scores as endogenous variables and fear as an exogenous variable, we found that fear was associated with sleep problems and stress, and stress was associated with sleep problems; almost half of the total impact of fear on sleep quality was mediated by stress. The impact of stress on sleep quality was more evident in the younger age group, among individuals with a lower socioeconomic status and healthcare workers. Fear related to COVID-19 seem to be associated with sleep disturbances directly and indirectly through stress.
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2042041-9
ISSN	1532-2998 ; 1532-3005
ISSN (online)	1532-2998
ISSN	1532-3005
DOI	10.1002/smi.3369
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Article ; Online: Combining biological and hydrogeological approaches: The grass Molinia arundinacea as a possible bioindicator of temporary perched aquifers in ophiolitic systems

Segadelli, Stefano / Adorni, Michele / Carbognani, Michele / Celico, Fulvio / Tomaselli, Marcello

Catena. 2022 Oct., v. 217 p.106448-

2022

Abstract: Springs represent relevant habitats which support high levels of biodiversity and productivity, providing refugia to both plants and animals together with essential ecosystem services. However, springs are often overlooked or even destroyed by human ... ...

Abstract	Springs represent relevant habitats which support high levels of biodiversity and productivity, providing refugia to both plants and animals together with essential ecosystem services. However, springs are often overlooked or even destroyed by human activity. Locating, inventorying, and monitoring springs is, therefore, becoming of increasing importance. This study aims at developing a multidisciplinary approach to detect ephemeral springs, which can only be discovered by hydrogeological surveys when discharge occurs. We suggest potential cooperation between hydrogeologists and botanists based on the use of a plant species as an indicator of the occurrence of ephemeral springs fed by ophiolitic perched groundwater aquifers. In this study, the grass Molinia arundinacea was used as a bioindicator, observed in periods when there was no discharge and whose occurrence on ophiolite bodies was revealed by previous studies in the northern Apennines (Italy). A total of twenty ophiolitic bodies were explored and grassland stands including Molinia populations were discovered in 86 springs (15 reported for the first time). Detailed geomorphological and hydrogeological sampling was also performed in ten springs, recording the occupancy area, cover and functional traits of Molinia at two permanent and eight ephemeral springs and along their streambeds. Molinia not only colonised the spring outlets, but also occurred along the streambeds fed by ephemeral springs, with a higher occupancy area where the rocky outcrops were covered by detrital deposits and at the base of the morphological incision. Additionally, the cover of Molina populations was correlated with the average water discharge, with the highest functional trait values found in locations with high soil moisture. Results confirmed that while Molinia performs best on permanently moist soils, it is also able to grow on soils with a fluctuating water-table or even in dry conditions, thus representing an excellent indicator of springs fed by temporary perched aquifers.
Keywords	Molinia arundinacea ; biodiversity ; catenas ; ecosystems ; geomorphology ; grasses ; grasslands ; groundwater ; humans ; refuge habitats ; soil water ; spring ; stream channels ; water table ; Italy ; Perched aquifers ; Ephemeral springs ; Ophiolitic aquifers ; Plant species indicators ; Functional traits ; Emilian Apennines
Language	English
Dates of publication	2022-10
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	519608-5
ISSN	1872-6887 ; 0008-7769 ; 0341-8162
ISSN (online)	1872-6887 ; 0008-7769
ISSN	0341-8162
DOI	10.1016/j.catena.2022.106448
Database	NAL-Catalogue (AGRICOLA)

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Article: COVID-19 Vaccine Hesitancy among Unvaccinated Adults: A Cross-Sectional Exploratory Analysis of Vaccination Intentions in Italy Related to Fear of Infection.

Curzio, Olivia / Cori, Liliana / Bianchi, Fabrizio / Prinelli, Federica / Galli, Massimo / Giacomelli, Andrea / Imiotti, Maria Cristina / Jesuthasan, Nithiya / Recchia, Virginia / Adorni, Fulvio

Vaccines

2023 Volume 11, Issue 12

Abstract: From the initial COVID-19 outbreak, Italy was the first Western country to be seriously affected by the pandemic. Understanding vaccine hesitancy can help efforts to achieve broad vaccination coverage. The objectives of this research were to determine ... ...

Abstract	From the initial COVID-19 outbreak, Italy was the first Western country to be seriously affected by the pandemic. Understanding vaccine hesitancy can help efforts to achieve broad vaccination coverage. The objectives of this research were to determine the extent of vaccine hesitancy in Italy and to understand the characteristics of those segments of the population with some hesitancy. Between January and February 2021, 41,473 subjects answered the second questionnaire delivered in phase II of the web-based EPICOVID19 survey. Among the included adult volunteers living in Italy, 4653 (11.2%) reported having previously received at least one dose of the COVID-19 vaccine. In the sample of 36,820 respondents, all not vaccinated (age 51.1 ± 13.5; 59.7% female; 63.6% high level of education), the comparison between hesitant and inclined participants was accompanied by percentages and odds ratios. A total of 2449 individuals were hesitant (6.7% of the unvaccinated ones). Hesitancy was higher among women (OR = 1.48; 95%CI: 1.36-1.62); it was highest in the 50-59 and 40-49 age groups and among those with a lower educational level. A higher level of education was associated with a lower proportion of hesitancy (5.54%) compared with 9.44% among respondents with a low level of education (OR = 0.56; 95%CI: 0.46-0.68). Hesitancy was most common in subjects who did not report fear of infection (12.4%, OR = 4.0; 95%CI: 3.46-4.61). The results can guide the design of tailored information and communication campaigns through considering objective and subjective characteristics.
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11121790
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Article ; Online: Fear of COVID-19 for Individuals and Family Members: Indications from the National Cross-Sectional Study of the EPICOVID19 Web-Based Survey.

Cori, Liliana / Curzio, Olivia / Adorni, Fulvio / Prinelli, Federica / Noale, Marianna / Trevisan, Caterina / Fortunato, Loredana / Giacomelli, Andrea / Bianchi, Fabrizio

International journal of environmental research and public health

2021 Volume 18, Issue 6

Abstract: The study analyzed the association of the fear of contagion for oneself and for family members (FMs) during the first wave of the COVID-19 pandemic, with demographic and socioeconomic status (SES) and health factors. The study was performed within the ... ...

Abstract	The study analyzed the association of the fear of contagion for oneself and for family members (FMs) during the first wave of the COVID-19 pandemic, with demographic and socioeconomic status (SES) and health factors. The study was performed within the EPICOVID19 web-based Italian survey, involving adults from April-June 2020. Out of 207,341 respondents, 95.9% completed the questionnaire (60% women with an average age of 47.3 vs. 48.9 years among men). The association between fear and demographic and SES characteristics, contacts with COVID-19 cases, nasopharyngeal swab, self-perceived health, flu vaccination, chronic diseases and specific symptoms was analyzed by logistic regression model; odds ratios adjusted for sex, age, education and occupation were calculated (aORs). Fear for FMs prevailed over fear for oneself and was higher among women than men. Fear for oneself decreased with higher levels of education and in those who perceived good health. Among those vaccinated for the flu, 40.8% responded they had feelings of fear for themselves vs. 34.2% of the not vaccinated. Fear increased when diseases were declared and it was higher when associated with symptoms such as chest pain, olfactory/taste disorders, heart palpitations (aORs > 1.5), lung or kidney diseases, hypertension, depression and/or anxiety. Trends in fear by region showed the highest percentage of positive responses in the southern regions. The knowledge gained from these results should be used to produce tailored messages and shared public health decisions.
MeSH term(s)	Adult ; Anxiety ; COVID-19 ; Cross-Sectional Studies ; Family ; Fear ; Female ; Humans ; Internet ; Italy/epidemiology ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2 ; Surveys and Questionnaires
Language	English
Publishing date	2021-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18063248
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Article ; Online: COVID-19 Vaccine Hesitancy among Unvaccinated Adults

Olivia Curzio / Liliana Cori / Fabrizio Bianchi / Federica Prinelli / Massimo Galli / Andrea Giacomelli / Maria Cristina Imiotti / Nithiya Jesuthasan / Virginia Recchia / Fulvio Adorni

Vaccines, Vol 11, Iss 12, p

A Cross-Sectional Exploratory Analysis of Vaccination Intentions in Italy Related to Fear of Infection

2023 Volume 1790

Abstract	From the initial COVID-19 outbreak, Italy was the first Western country to be seriously affected by the pandemic. Understanding vaccine hesitancy can help efforts to achieve broad vaccination coverage. The objectives of this research were to determine the extent of vaccine hesitancy in Italy and to understand the characteristics of those segments of the population with some hesitancy. Between January and February 2021, 41,473 subjects answered the second questionnaire delivered in phase II of the web-based EPICOVID19 survey. Among the included adult volunteers living in Italy, 4653 (11.2%) reported having previously received at least one dose of the COVID-19 vaccine. In the sample of 36,820 respondents, all not vaccinated (age 51.1 ± 13.5; 59.7% female; 63.6% high level of education), the comparison between hesitant and inclined participants was accompanied by percentages and odds ratios. A total of 2449 individuals were hesitant (6.7% of the unvaccinated ones). Hesitancy was higher among women (OR = 1.48; 95%CI: 1.36–1.62); it was highest in the 50–59 and 40–49 age groups and among those with a lower educational level. A higher level of education was associated with a lower proportion of hesitancy (5.54%) compared with 9.44% among respondents with a low level of education (OR = 0.56; 95%CI: 0.46–0.68). Hesitancy was most common in subjects who did not report fear of infection (12.4%, OR = 4.0; 95%CI: 3.46–4.61). The results can guide the design of tailored information and communication campaigns through considering objective and subjective characteristics.
Keywords	COVID-19 ; SARS-CoV-2 ; observational study ; public health ; self-reported data ; web-based survey ; Medicine ; R
Subject code	300
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Influenza Vaccination Uptake in the General Italian Population during the 2020-2021 Flu Season: Data from the EPICOVID-19 Online Web-Based Survey.

Giacomelli, Andrea / Galli, Massimo / Maggi, Stefania / Noale, Marianna / Trevisan, Caterina / Pagani, Gabriele / Antonelli-Incalzi, Raffaele / Molinaro, Sabrina / Bastiani, Luca / Cori, Liliana / Bianchi, Fabrizio / Jesuthasan, Nithiya / Prinelli, Federica / Adorni, Fulvio

Vaccines

2022 Volume 10, Issue 2

Abstract: To assess influenza vaccine uptake during the 2020/2021 flu season and compare it with that of the 2019/2020 flu season among respondents to the second phase of the web-based EPICOVID-19 survey, we performed an observational web-based nationwide online ... ...

Abstract	To assess influenza vaccine uptake during the 2020/2021 flu season and compare it with that of the 2019/2020 flu season among respondents to the second phase of the web-based EPICOVID-19 survey, we performed an observational web-based nationwide online survey (January-February 2021) in which respondents to the first survey (April-June 2020) were contacted and asked to complete a second questionnaire. Factors associated with vaccine uptake in the 2020/2021 flu season were assessed by applying a multivariable multinomial logistic regression model. Out of the 198,822 respondents to the first survey, 41,473 (20.9%) agreed to fill out the follow-up questionnaire; of these, 8339 (20.1%) were vaccinated only during the 2020/2021 season, 8828 (21.3%) were vaccinated during both seasons and 22,710 (54.8%) were vaccinated in neither season. Educational level (medium (aOR 1.33 95%CI 1.13-1.56) and high (aOR 1.69 95%CI 1.44-1.97) vs. low) and socio-economic deprivation according to SES scoring (1 point aOR 0.83 (95%CI 0.78-0.89), 2 aOR 0.68 (95%CI 0.60-0.77) points or ≥3 points aOR 0.42 (95%CI 0.28-0.45) vs. 0 points) were found to be associated with flu vaccine uptake. Our study shows that social determinants seemed to affect flu vaccination uptake and identifies specific categories of the population to target during future influenza vaccination campaigns.
Language	English
Publishing date	2022-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10020293
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of a 2-year exercise training on neuromuscular system health in older individuals with low muscle function.

Monti, Elena / Tagliaferri, Sara / Zampieri, Sandra / Sarto, Fabio / Sirago, Giuseppe / Franchi, Martino Vladimiro / Ticinesi, Andrea / Longobucco, Yari / Adorni, Elisa / Lauretani, Fulvio / Von Haehling, Stephan / Marzetti, Emanuele / Calvani, Riccardo / Bernabei, Roberto / Cesari, Matteo / Maggio, Marcello / Narici, Marco Vincenzo

Journal of cachexia, sarcopenia and muscle

2023 Volume 14, Issue 2, Page(s) 794–804

Abstract: Background: Ageing is accompanied by a progressive loss of skeletal muscle mass and strength, potentially determining the insurgence of sarcopenia. Evidence suggests that motoneuron and neuromuscular junction (NMJ) degeneration contribute to sarcopenia ... ...

Abstract	Background: Ageing is accompanied by a progressive loss of skeletal muscle mass and strength, potentially determining the insurgence of sarcopenia. Evidence suggests that motoneuron and neuromuscular junction (NMJ) degeneration contribute to sarcopenia pathogenesis. Seeking for strategies able to slow down sarcopenia insurgence and progression, we investigated whether a 2-year mixed-model training involving aerobic, strength and balance exercises would be effective for improving or preserving motoneuronal health and NMJ stability, together with muscle mass, strength and functionality in an old, sarcopenic population. Methods: Forty-five sarcopenic elderly (34 females; 11 males) with low dual-energy X-ray absorptiometry (DXA) lean mass and Short Physical Performance Battery (SPPB) score <9 were randomly assigned to either a control group [Healthy Aging Lifestyle Education (HALE), n = 21] or an intervention group [MultiComponent Intervention (MCI), n = 24]. MCI trained three times per week for 2 years with a mix of aerobic, strength and balance exercises matched with nutritional advice. Before and after the intervention, ultrasound scans of the vastus lateralis (VL), SPPB and a blood sample were obtained. VL architecture [pennation angle (PA) and fascicle length (Lf)] and cross-sectional area (CSA) were measured. As biomarkers of neuronal health and NMJ stability status, neurofilament light chain (NfL) and C-terminal agrin fragment (CAF) concentrations were measured in serum. Differences in ultrasound parameters, NfL and CAF concentration and physical performance between baseline and follow-up were tested with mixed ANOVA or Wilcoxon test. The relationship between changes in physical performance and NfL or CAF concentration was assessed through correlation analyses. Results: At follow-up, MCI showed preserved VL architecture (PA, Lf) despite a reduced CSA (-8.4%, P < 0.001), accompanied by maintained CAF concentration and ameliorated overall SPPB performance (P = 0.007). Conversely, HALE showed 12.7% decrease in muscle CSA (P < 0.001), together with 5.1% and 5.5% reduction in PA and Lf (P < 0.001 and P = 0.001, respectively), and a 6.2% increase in CAF (P = 0.009) but improved SPPB balance score (P = 0.007). NfL concentration did not change in either group. In the population, negative correlations between changes in CAF concentration and SPPB total score were found (P = 0.047), whereas no correlation between NfL and SPPB variations was observed. Conclusions: The present findings suggest that our 2-year mixed aerobic, strength and balance training seemed effective for preventing the age and sarcopenia-related increases in CAF concentration, preserving NMJ stability as well as muscle structure (PA and Lf) and improving physical performance in sarcopenic older individuals.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Sarcopenia/epidemiology ; Aging/physiology ; Exercise/physiology ; Muscle, Skeletal/pathology ; Absorptiometry, Photon
Language	English
Publishing date	2023-01-28
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1002/jcsm.13173
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Article: PEGASO e-Diary: User Engagement and Dietary Behavior Change of a Mobile Food Record for Adolescents.

Caon, Maurizio / Prinelli, Federica / Angelini, Leonardo / Carrino, Stefano / Mugellini, Elena / Orte, Silvia / Serrano, José C E / Atkinson, Sarah / Martin, Anne / Adorni, Fulvio

Frontiers in nutrition

2022 Volume 9, Page(s) 727480

Abstract: Background: Obesity amongst children and adolescents is becoming a major health problem globally and mobile food records can play a crucial role in promoting healthy dietary habits.: Objective: To describe the methodology for the implementation of ... ...

Abstract	Background: Obesity amongst children and adolescents is becoming a major health problem globally and mobile food records can play a crucial role in promoting healthy dietary habits. Objective: To describe the methodology for the implementation of the e-Diary mobile food record, to assess its capability in promoting healthy eating habits, to evaluate the factors associated with its usage and engagement. Methods: This is a descriptive study that compared the characteristics of participants engaged in the e-Diary, which was part of the PEGASO project in which an app to provide proactive health promotion was given to 365 students at 4 European sites enrolled during October to December 2016: England (UK), Scotland (UK), Lombardy (Italy), and Catalonia (Spain). The e-Diary tracked the users' dietary habits in terms of food groups, dietary indexes, and 6 dietary target behaviors relating to consumption of: fruit; vegetable; breakfast; sugar-sweetened beverages; fast-food; and snacks. The e-Diary provided also personalized suggestions for the next meal and gamification. Results: The e-Diary was used for 6 months by 357 adolescents (53.8% females). The study showed that females used the e-Diary much more than males (aOR 3.8, 95% CI 1.6-8.8). Participants aged 14 years were more engaged in the e-Diary than older age groups (aOR 5.1, 95% CI 1.4-18.8) as were those with a very good/excellent self-perceived health status compared to their peers with fair/poor health perception (aOR 4.2, 95% CI 1.3-13.3). Compared to the intervention sites, those living in Catalonia (aOR 13.2 95% CI 2.5-68.8) were more engaged. In terms of behavior change, a significant positive correlation between fruit ( Conclusions: The users highly engaged with the e-Diary were associated with improved dietary behaviors: increased consumption of fruit and vegetables and reduced skipping of breakfast. Although the overall usage of the e-Diary was high during the first weeks, it declined thereafter. Future applications should foster user engagement, particularly targeting adolescents at high risk. Clinical trial registration: https://www.clinicaltrials.gov/, identifier: NCT02930148.
Language	English
Publishing date	2022-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.727480
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Article ; Online: Fear of COVID-19 for Individuals and Family Members

Liliana Cori / Olivia Curzio / Fulvio Adorni / Federica Prinelli / Marianna Noale / Caterina Trevisan / Loredana Fortunato / Andrea Giacomelli / Fabrizio Bianchi

International Journal of Environmental Research and Public Health, Vol 18, Iss 3248, p

Indications from the National Cross-Sectional Study of the EPICOVID19 Web-Based Survey

2021 Volume 3248

Abstract	The study analyzed the association of the fear of contagion for oneself and for family members (FMs) during the first wave of the COVID-19 pandemic, with demographic and socioeconomic status (SES) and health factors. The study was performed within the EPICOVID19 web-based Italian survey, involving adults from April–June 2020. Out of 207,341 respondents, 95.9% completed the questionnaire (60% women with an average age of 47.3 vs. 48.9 years among men). The association between fear and demographic and SES characteristics, contacts with COVID-19 cases, nasopharyngeal swab, self-perceived health, flu vaccination, chronic diseases and specific symptoms was analyzed by logistic regression model; odds ratios adjusted for sex, age, education and occupation were calculated (aORs). Fear for FMs prevailed over fear for oneself and was higher among women than men. Fear for oneself decreased with higher levels of education and in those who perceived good health. Among those vaccinated for the flu, 40.8% responded they had feelings of fear for themselves vs. 34.2% of the not vaccinated. Fear increased when diseases were declared and it was higher when associated with symptoms such as chest pain, olfactory/taste disorders, heart palpitations (aORs > 1.5), lung or kidney diseases, hypertension, depression and/or anxiety. Trends in fear by region showed the highest percentage of positive responses in the southern regions. The knowledge gained from these results should be used to produce tailored messages and shared public health decisions.
Keywords	Coronavirus disease (COVID-19) ; voluntary respondents ; web-based survey ; self-reported symptoms ; fear ; health status ; Medicine ; R
Subject code	150
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Exploring the relationship between Nutrition, gUT microbiota, and BRain AgINg in community-dwelling seniors: the Italian NutBrain population-based cohort study protocol.

Prinelli, Federica / Jesuthasan, Nithiya / Severgnini, Marco / Musicco, Massimo / Adorni, Fulvio / Correa Leite, Maria Lea / Crespi, Chiara / Bernini, Sara

BMC geriatrics

2020 Volume 20, Issue 1, Page(s) 253

Abstract: Background: Epidemiological evidence suggests that healthy diet is associated with a slowdown of cognitive decline leading to dementia, but the underlying mechanisms are still partially unexplored. Diet is the main determinant of gut microbiota ... ...

Abstract	Background: Epidemiological evidence suggests that healthy diet is associated with a slowdown of cognitive decline leading to dementia, but the underlying mechanisms are still partially unexplored. Diet is the main determinant of gut microbiota composition, which in turn impacts on brain structures and functions, however to date no studies on this topic are available. The goal of the present paper is to describe the design and methodology of the NutBrain Study aimed at investigating the association of dietary habits with cognitive function and their role in modulating the gut microbiota composition, and brain measures as well. Methods/design: This is a population-based cohort study of community-dwelling adults aged 65 years or more living in Northern Milan, Italy. At the point of presentation people are screened for cognitive functions. Socio-demographic characteristics along with lifestyles and dietary habits, medical history, drugs, functional status, and anthropometric measurements are also recorded. Individuals suspected to have cognitive impairment at the screening phase undergo a clinical evaluation including a neurological examination and a Magnetic Resonance Imaging (MRI) scanning (both structural and functional). Stool and blood samples for the gut microbiota analysis and for the evaluation of putative biological markers are also collected. For each subject with a confirmed diagnosis of Mild Cognitive Impairment (MCI), two cognitively intact controls of the same sex and age are visited. We intend to enrol at least 683 individuals for the screening phase and 240 persons for the clinical assessment. Discussion: The NutBrain is an innovative study that incorporates modern and advanced technologies (i.e. microbiome and neuroimaging) into traditional epidemiologic design. The study represents a unique opportunity to address key questions about the role of modifiable risk factors on cognitive impairment, with a particular focus on dietary habits and their association with gut microbiota and markers of the brain-aging process. These findings will help to encourage and plan lifestyle interventions, for both prevention and treatment, aiming at promoting healthy cognitive ageing. Trial registration: Trial registration number NCT04461951 , date of registration July 7, 2020 (retrospectively registered, ClinicalTrials.gov ).
MeSH term(s)	Aged ; Aging ; Brain ; Cohort Studies ; Gastrointestinal Microbiome ; Humans ; Independent Living ; Italy/epidemiology
Language	English
Publishing date	2020-07-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-020-01652-2
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