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  1. Article ; Online: High-performance p-type V

    Ainabayev, Ardak / Walls, Brian / Mullarkey, Daragh / Caffrey, David / Fleischer, Karsten / Smith, Christopher M / McGlinchey, Amy / Casey, Daniel / McCormack, Sarah J / Shvets, Igor

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1928

    Abstract: High-quality epitaxial p-type ... ...

    Abstract High-quality epitaxial p-type V
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52024-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predicting and prioritizing genetic diversity outcomes of animal translocations

    Matthew M. Smith / Clare G. Knife / Daniel Eklund / Brian Heeringa / Jonathan N. Pauli

    Conservation Science and Practice, Vol 5, Iss 6, Pp n/a-n/a (2023)

    2023  

    Keywords augmentation ; connectivity ; genetic diversity ; reintroductions ; sharp‐tailed grouse ; simulations ; Ecology ; QH540-549.5 ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article ; Online: Density-dependent habitat selection alters drivers of population distribution in northern Yellowstone elk.

    Smith, Brian J / MacNulty, Daniel R / Stahler, Daniel R / Smith, Douglas W / Avgar, Tal

    Ecology letters

    2022  Volume 26, Issue 2, Page(s) 245–256

    Abstract: Although it is well established that density dependence drives changes in organismal abundance over time, relatively little is known about how density dependence affects variation in abundance over space. We tested the hypothesis that spatial trade-offs ... ...

    Abstract Although it is well established that density dependence drives changes in organismal abundance over time, relatively little is known about how density dependence affects variation in abundance over space. We tested the hypothesis that spatial trade-offs between food and safety can change the drivers of population distribution, caused by opposing patterns of density-dependent habitat selection (DDHS) that are predicted by the multidimensional ideal free distribution. We addressed this using winter aerial survey data of northern Yellowstone elk (Cervus canadensis) spanning four decades. Supporting our hypothesis, we found positive DDHS for food (herbaceous biomass) and negative DDHS for safety (openness and roughness), such that the primary driver of habitat selection switched from food to safety as elk density decreased from 9.3 to 2.0 elk/km
    MeSH term(s) Animals ; Deer ; Ecosystem ; Population Density ; Predatory Behavior ; Seasons ; Wolves ; Parks, Recreational ; Northwestern United States
    Language English
    Publishing date 2022-12-26
    Publishing country England
    Document type Letter
    ZDB-ID 1441608-6
    ISSN 1461-0248 ; 1461-023X
    ISSN (online) 1461-0248
    ISSN 1461-023X
    DOI 10.1111/ele.14155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2005/709: Show issues

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  4. Article ; Online: Density‐dependent habitat selection alters drivers of population distribution in northern Yellowstone elk

    Smith, Brian J. / MacNulty, Daniel R. / Stahler, Daniel R. / Smith, Douglas W. / Avgar, Tal

    Ecology Letters. 2023 Feb., v. 26, no. 2 p.245-256

    2023  

    Abstract: Although it is well established that density dependence drives changes in organismal abundance over time, relatively little is known about how density dependence affects variation in abundance over space. We tested the hypothesis that spatial trade‐offs ... ...

    Abstract Although it is well established that density dependence drives changes in organismal abundance over time, relatively little is known about how density dependence affects variation in abundance over space. We tested the hypothesis that spatial trade‐offs between food and safety can change the drivers of population distribution, caused by opposing patterns of density‐dependent habitat selection (DDHS) that are predicted by the multidimensional ideal free distribution. We addressed this using winter aerial survey data of northern Yellowstone elk (Cervus canadensis) spanning four decades. Supporting our hypothesis, we found positive DDHS for food (herbaceous biomass) and negative DDHS for safety (openness and roughness), such that the primary driver of habitat selection switched from food to safety as elk density decreased from 9.3 to 2.0 elk/km². Our results demonstrate how population density can drive landscape‐level shifts in population distribution, confounding habitat selection inference and prediction and potentially affecting community‐level interactions.
    Keywords Cervus canadensis ; aerial surveys ; biomass ; elks ; habitat preferences ; population density ; population distribution ; population dynamics ; prediction ; roughness
    Language English
    Dates of publication 2023-02
    Size p. 245-256.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note LETTER
    ZDB-ID 1441608-6
    ISSN 1461-0248 ; 1461-023X
    ISSN (online) 1461-0248
    ISSN 1461-023X
    DOI 10.1111/ele.14155
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Publisher Correction: A United States multi-site randomized control trial of Schroth-based therapy in adolescents with mild idiopathic scoliosis.

    Zapata, Karina Amani / Dieckmann, Rebecca J / Hresko, M Timothy / Sponseller, Paul D / Vitale, Michael G / Glassman, Steven D / Smith, Brian G / Jo, Chan-Hee / Sucato, Daniel J

    Spine deformity

    2024  Volume 12, Issue 2, Page(s) 519–520

    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2717704-X
    ISSN 2212-1358 ; 2212-134X ; 2212-1358
    ISSN (online) 2212-1358 ; 2212-134X
    ISSN 2212-1358
    DOI 10.1007/s43390-023-00817-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types.

    Jones Lipinski, Rachel A / Stancill, Jennifer S / Nuñez, Raymundo / Wynia-Smith, Sarah L / Sprague, Daniel J / Nord, Joshua A / Bird, Amir / Corbett, John A / Smith, Brian C

    American journal of physiology. Regulatory, integrative and comparative physiology

    2024  

    Abstract: Inhibition of the bromodomain and extraterminal domain (BET) protein family is a potential strategy to prevent and treat diabetes; however, the clinical use of BET bromodomain inhibitors (BETi) is associated with adverse effects. Here, we explore a ... ...

    Abstract Inhibition of the bromodomain and extraterminal domain (BET) protein family is a potential strategy to prevent and treat diabetes; however, the clinical use of BET bromodomain inhibitors (BETi) is associated with adverse effects. Here, we explore a strategy for targeting BETi to β-cells by exploiting the high zinc (Zn
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00259.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Comparing symptom networks of daytime and nocturnal panic attacks in a community-based sample.

    Smith, Nicole S / Bauer, Brian W / Capron, Daniel W

    Journal of anxiety disorders

    2021  Volume 85, Page(s) 102514

    Abstract: Nocturnal panic refers to waking in a state of panic without obvious triggers, experiencing the same symptoms as panic attacks that occur while awake. Interrelationships between daytime and nocturnal panic symptoms have not been examined despite theories ...

    Abstract Nocturnal panic refers to waking in a state of panic without obvious triggers, experiencing the same symptoms as panic attacks that occur while awake. Interrelationships between daytime and nocturnal panic symptoms have not been examined despite theories suggesting panic symptoms perpetuate one another in a forward feedback loop. The current study compared associations between symptoms in daytime and nocturnal panic using network analysis. Network theory conceptualizes symptoms as causing one another, rather than originating from a latent variable (i.e., a disorder). Given that nocturnal panic originates from sleep stages without cognitive activity, cognitive symptoms were expected to be more central in daytime panic networks than nocturnal panic networks. Prior literature indicates similar nocturnal and daytime panic severity; thus, we expected that panic groups would report equivalent panic symptom severity. An online community sample (N = 215) provided panic symptom history. Panic network structures did not differ, although the daytime panic network produced stronger and more numerous connections between physical and cognitive symptoms. The nocturnal panic group, however, reported more severe cognitive symptoms than the daytime panic group. These results challenge biologically-focused nocturnal panic theories and suggest a more significant role of cognitive symptoms in perpetuating nocturnal panic attacks once the individual awakens.
    MeSH term(s) Humans ; Panic ; Panic Disorder/diagnosis ; Panic Disorder/psychology ; Sleep Wake Disorders/psychology
    Language English
    Publishing date 2021-12-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 619417-5
    ISSN 1873-7897 ; 0887-6185
    ISSN (online) 1873-7897
    ISSN 0887-6185
    DOI 10.1016/j.janxdis.2021.102514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3269: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Development of activity-based probes for the protein deacylase Sirt1.

    Goetz, Christopher J / Sprague, Daniel J / Smith, Brian C

    Bioorganic chemistry

    2020  Volume 104, Page(s) 104232

    Abstract: Sirtuins are ... ...

    Abstract Sirtuins are NAD
    MeSH term(s) Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Development ; HEK293 Cells ; Humans ; Molecular Probes/chemical synthesis ; Molecular Probes/chemistry ; Molecular Probes/pharmacology ; Molecular Structure ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/pharmacology ; Sirtuin 1/analysis ; Sirtuin 1/antagonists & inhibitors ; Sirtuin 1/metabolism ; Structure-Activity Relationship
    Chemical Substances Molecular Probes ; Peptides ; SIRT1 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-)
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2020.104232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12.

    Sprague, Daniel J / Getschman, Anthony E / Fenske, Tyler G / Volkman, Brian F / Smith, Brian C

    ACS medicinal chemistry letters

    2021  Volume 12, Issue 11, Page(s) 1773–1782

    Abstract: CXCL12, a CXC-type chemokine, binds its receptor CXCR4, and the resulting signaling cascade is essential during development and subsequently in immune function. Pathologically, the CXCL12-CXCR4 signaling axis is involved in many cancers and inflammatory ... ...

    Abstract CXCL12, a CXC-type chemokine, binds its receptor CXCR4, and the resulting signaling cascade is essential during development and subsequently in immune function. Pathologically, the CXCL12-CXCR4 signaling axis is involved in many cancers and inflammatory diseases and thus has sparked continued interest in the development of therapeutics. Small molecules targeting CXCR4 have had mixed results in clinical trials. Alternatively, small molecules targeting the chemokine instead of the receptor provide a largely unexplored space for therapeutic development. Here we report that trisubstituted 1,3,5-triazines are competent ligands for the sY12-binding pocket of CXCL12. The initial hit was optimized to be more synthetically tractable. Fifty unique triazines were synthesized, and the structure-activity relationship was probed. Using computational modeling, we suggest key structural interactions that are responsible for ligand-chemokine binding. The lipophilic ligand efficiency was improved, resulting in more soluble, drug-like molecules with chemical handles for future development and structural studies.
    Language English
    Publishing date 2021-10-18
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.1c00388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Author Correction: A United States multi-site randomized control trial of Schroth-based therapy in adolescents with mild idiopathic scoliosis.

    Zapata, Karina Amani / Dieckmann, Rebecca J / Hresko, M Timothy / Sponseller, Paul D / Vitale, Michael G / Glassman, Steven D / Smith, Brian G / Jo, Chan-Hee / Sucato, Daniel J

    Spine deformity

    2023  Volume 11, Issue 5, Page(s) 1293

    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2717704-X
    ISSN 2212-1358 ; 2212-134X ; 2212-1358
    ISSN (online) 2212-1358 ; 2212-134X
    ISSN 2212-1358
    DOI 10.1007/s43390-023-00695-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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