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  1. Article: Early middle Holocene climate oscillations recorded in the Beihuqiao Core, Yuhang, Zhejiang Province, China

    Ye, Wei / Qu Chen / Lidong Zhu / Fengquan Li / Tianyang Wang / Longjuan Cheng / Yunxia Zhang

    Journal of paleolimnology. 2018 Feb., v. 59, no. 2

    2018  

    Abstract: A long-standing controversy exists concerning the spatial and temporal characteristics of Holocene climate change in China. Zhejiang is located in the southeast of China, where the East Asian monsoon dominates the climate and a Neolithic culture ... ...

    Abstract A long-standing controversy exists concerning the spatial and temporal characteristics of Holocene climate change in China. Zhejiang is located in the southeast of China, where the East Asian monsoon dominates the climate and a Neolithic culture flourished. In recent years, geographers have debated the climatic conditions existing at the time of the Neolithic cultures. This study reconstructed the sedimentary environment between 11.30 and 4.17 cal ka BP based on a multi-proxy analysis of a 14.3 meter sediment core, drilled in Beihuqiao, Zhejiang Province, China. The results show: (1) The climate was getting warm between 11.50 and 8.77 cal ka BP. Grain size became finer from the bottom to the top layer, accompanied by an increase in the chemical index of alteration (CIA), Mg/Sr ratio, the percentage of clay, pollen concentrations, and a decrease in SiO₂/Al₂O₃ ratio, and the value of bases–alumina (ba), as well as other trace elements. (2) Between 8.77 and 7.99 cal ka BP, the sediment is composed of gray-yellow and gray silt. The percentage of CaO and the ratio of CaO + Na₂O + K₂O to Al₂O₃ is much higher. The pollen concentration sharply decreases. The climate was cold and dry in the early stages of this period, but became relatively warmer and wetter in the later stages. (3) The Holocene Climatic Optimum occurred at 7.99–5.68 cal ka BP. Higher contents of clay, total Fe₂O₃, Al₂O₃, CIA, the chemical proxy of alteration, pollen concentration, evergreen pollens, and high values of Mg/Sr are observed at this stage, coinciding with a lower SiO₂/Al₂O₃ value, (CaO + Na₂O + K₂O)/Al₂O₃ ratio, and an obvious reduction in silt/clay, and SiO₂ and CaO concentrations. (4) During the period 5.68–4.17 cal ka BP, the temperature in the study area declined in a stepwise fashion. The grain size became finer, and the Mg/Sr ratio decreased gradually.
    Keywords aluminum oxide ; calcium oxide ; clay ; climate change ; climatic factors ; ferric oxide ; limnology ; magnesium ; monsoon season ; paleontology ; pollen ; silica ; silt ; strontium ; temperature ; China
    Language English
    Dates of publication 2018-02
    Size p. 263-278.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 1478181-5
    ISSN 1573-0417 ; 0921-2728
    ISSN (online) 1573-0417
    ISSN 0921-2728
    DOI 10.1007/s10933-017-9959-x
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: [Investigation on life quality of patients with chronic lymphatic filariasis in Yuhang district of Hangzhou].

    Wang, Lai-gen / Hu, Yong-qin / Tang, Ai-qi / Fang, Hang-yan / Gan, Wei-qun

    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases

    2011  Volume 29, Issue 2, Page(s) 159–161

    Abstract: Data were collected from chronic lymphatic filariasis patients and the public in Yuhang District ...

    Abstract Data were collected from chronic lymphatic filariasis patients and the public in Yuhang District of Hangzhou. Health status was assessed by using EuroQol (EQ)-5D. A total of 600 questionnaires were sent and 550 (91.7%) returned (276 chronic lymphatic filariasis patients and 274 members of the public). The EQ-SD index score for patients with chronic lymphatic filariasis (0.770 +/- 0.128) were lower than the general public (0.872 +/- 0.073). In contrast to the public (6.6%, 5.8%, 12.0%, 20.4%, and 10.6%), patients reported more problems with their mobility (43.8%), self-care (22.5%), daily activities (44.9%), anxiety/depression (47.8%), and pain/discomfort (29.0%) (P < 0.01). Strength of association were 6.67, 3.86, 3.74, 2.73, and 2.34, respectively. These results indicated that chronic lymphatic filariasis shows an impact on patients' health-related quality of life. It particularly causes great problems in the dimensions of mobility, self-care, and daily activities.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Chronic Disease ; Elephantiasis, Filarial/epidemiology ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Quality of Life ; Sickness Impact Profile ; Surveys and Questionnaires
    Language Chinese
    Publishing date 2011-04-30
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 639272-6
    ISSN 1000-7423
    ISSN 1000-7423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Erdr1 Drives Macrophage Programming via Dynamic Interplay with YAP1 and Mid1.

    Wang, Yuhang

    ImmunoHorizons

    2024  Volume 8, Issue 2, Page(s) 198–213

    Abstract: Erythroid differentiation regulator 1 (Erdr1) is a stress-induced, widely expressed, highly conserved secreted factor found in both humans and mice. Erdr1 is linked with the Hippo-YAP1 signaling. Initially identified as an inducer of hemoglobin synthesis, ...

    Abstract Erythroid differentiation regulator 1 (Erdr1) is a stress-induced, widely expressed, highly conserved secreted factor found in both humans and mice. Erdr1 is linked with the Hippo-YAP1 signaling. Initially identified as an inducer of hemoglobin synthesis, Erdr1 emerged as a multifunctional protein, especially in immune cells. Although Erdr1 has been implicated in regulating T cells and NK cell function, its role in macrophage remains unclear. This study explored the function and mechanism of Erdr1 in macrophage inflammatory response. The data demonstrated that Erdr1 could promote anti-inflammatory cytokine production, a function that also has been reported by previous research. However, I found Erdr1 also could play a proinflammatory role. The function of Erdr1 in macrophages depends on its dose and cell density. I observed that Erdr1 expression was inhibited in M1 macrophages but was upregulated in M2 macrophages compared with unpolarized macrophages. I hypothesized that Erdr1 balances the inflammatory response by binding with distinct adaptors dependent on varying concentrations. Mechanistically, I demonstrated YAP1 and Mid1 as the two adaptor proteins of Erdr1. The Erdr1-YAP1 interaction promotes anti-inflammatory cytokine production when Erdr1 levels are elevated, whereas the Erdr1-Mid1 interaction induces proinflammatory cytokine production when Erdr1 levels are decreased. This study highlights the effects of Erdr1 on regulating cytokine production from polarized macrophages potentially by regulating YAP1 in the nonclassical Hippo pathway.
    MeSH term(s) Animals ; Humans ; Mice ; Cytokines ; Gene Expression ; T-Lymphocytes ; Ubiquitin-Protein Ligases/metabolism ; YAP-Signaling Proteins/metabolism ; Tumor Suppressor Proteins/metabolism ; Membrane Proteins/metabolism
    Chemical Substances Cytokines ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; MID1 protein, human (EC 2.3.2.27) ; YAP1 protein, human ; erythroid differentiation regulator 1, human ; YAP-Signaling Proteins ; Tumor Suppressor Proteins ; Membrane Proteins
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2400004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Erdr1 orchestrates macrophage polarization and determines cell fate via dynamic interplay with YAP1 and Mid1.

    Wang, Yuhang

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Erythroid differentiation regulator 1 (Erdr1) is a stress-induced, widely distributed, extremely conserved secreted factor found in both humans and mice. Erdr1 is highly linked with the Hippo-YAP1 signaling. Initially identified as an inducer of ... ...

    Abstract Erythroid differentiation regulator 1 (Erdr1) is a stress-induced, widely distributed, extremely conserved secreted factor found in both humans and mice. Erdr1 is highly linked with the Hippo-YAP1 signaling. Initially identified as an inducer of hemoglobin synthesis, it has emerged as a multifunctional protein, especially in immune cells. Although Erdr1 has been implicated in T cells and NK cell function, its role in macrophage remains unclear. This study aims to explore the function and mechanism of Erdr1 in IL-1β production in macrophages. Data manifest Erdr1 could play an inhibition role in IL-1β production, which also has been reported by previous research. What significance is we discovered Erdr1 can promote IL-1β production which is associated with Erdr1 dose and cell density. We observed that Erdr1 was inhibited in pro-inflammatory (M1) macrophages but was upregulated in anti-inflammatory (M2) macrophages compared to naive macrophages. We hypothesized that Erdr1 dual drives and modulates IL-1β production by binding with distinct adaptors via concentration change. Mechanistically, we demonstrated that Erdr1 dual regulates IL-1β production by dynamic interaction with YAP1 and Mid1 by distinct domains. Erdr1-YAP1 interplay mediates macrophage M2 polarization by promoting an anti-inflammatory response, enhancing catabolic metabolism, and leading to sterile cell death. Whereas, Erdr1-Mid1 interplay mediates macrophage M1 polarization by initiating a pro-inflammatory response, facilitating anabolic metabolism, and causing inflammatory cell death. This study highlights Erdr1 orchestrates macrophage polarization and determines cell date by regulating YAP1 through non-classical Hippo pathway.
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.17.557960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ru- and Co-Catalyzed Intermolecular Carbonyl-Alkyne Metathesis Reactions of 1

    Wang, Yuhang / Ma, Peng / Wang, Jianhui

    Organic letters

    2024  Volume 26, Issue 15, Page(s) 3164–3168

    Abstract: The catalyst-dependent intermolecular carbonyl-alkyne metathesis (CAM) reaction of ... ...

    Abstract The catalyst-dependent intermolecular carbonyl-alkyne metathesis (CAM) reaction of 1
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Alkaline-Metal-Promoted Divergent Synthesis of 1-Aminoisoquinolines and Isoquinolines.

    Ma, Peng / Wang, Yuhang / Ma, Ning / Wang, Jianhui

    The Journal of organic chemistry

    2024  Volume 89, Issue 2, Page(s) 1235–1240

    Abstract: Alkaline-metal-promoted divergent syntheses of 1-aminoisoquinolines and isoquinolines have been reported involving 2-methylaryl aldehydes, nitriles, and LiN( ... ...

    Abstract Alkaline-metal-promoted divergent syntheses of 1-aminoisoquinolines and isoquinolines have been reported involving 2-methylaryl aldehydes, nitriles, and LiN(SiMe
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: DYT-

    Fan, Yuhang / Si, Zhibo / Wang, Linlin / Zhang, Lei

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1216929

    Abstract: DYT- ...

    Abstract DYT-
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1216929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Highly selective separation of tetravalent plutonium from complex system with novel phenylpyridine diamide ligands.

    Yao, Liu / Junli, Wang / Yuhang, Le / Hui, Wang / Wentao, Wang / Baole, Li / Taihong, Yan

    RSC advances

    2024  Volume 14, Issue 1, Page(s) 560–567

    Abstract: In this study, three phenylpyridine diamide ligands, namely, 2,2'-((pyridine-2,6-diylbis(3,1-phenylene))bis(oxy))bis( ...

    Abstract In this study, three phenylpyridine diamide ligands, namely, 2,2'-((pyridine-2,6-diylbis(3,1-phenylene))bis(oxy))bis(
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra07418h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Efficient preparation of icariin from epimedin C by recyclable biphasic enzymatic hydrolysis.

    Chen, Wang / Zhang, Yue / Zhang, Yuhang / Feng, Zili / He, Xu

    Natural product research

    2024  , Page(s) 1–7

    Abstract: Icariin is the most bioactive ingredient ... ...

    Abstract Icariin is the most bioactive ingredient of
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2340057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: China's Medical Alliance and Patients' Rights to Medical Self-determination.

    Wang, Dongni / Zhou, Xinfa / Zhan, Dongtong / Xiao, Yuhang / Cheng, Zhe

    Asia-Pacific journal of public health

    2024  Volume 36, Issue 2-3, Page(s) 297–298

    MeSH term(s) Humans ; International Cooperation ; Patient Rights ; China
    Language English
    Publishing date 2024-01-23
    Publishing country China
    Document type Letter
    ZDB-ID 1025444-4
    ISSN 1941-2479 ; 1010-5395
    ISSN (online) 1941-2479
    ISSN 1010-5395
    DOI 10.1177/10105395241226510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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