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  1. Book: Development and engineering of dopamine neurons

    Pasterkamp, Ronald Jeroen

    (Advances in experimental medicine and biology ; 651)

    2009  

    Author's details ed. by R. Jeroen Pasterkamp
    Series title Advances in experimental medicine and biology ; 651
    Collection
    Keywords Neurons / physiology ; Dopamine / physiology ; Neurotransmitter Agents / physiology
    Language English
    Size XVIII, 127 S. : Ill., graph. Darst., 21 schw.-w. Ill., 5 farb. Ill., 12 schw.-w. Tab., 235 mm x 155 mm
    Publisher Springer Science + Business Media LLC ; Landes Bioscience
    Publishing place New York, NY ; Austin, Tex
    Publishing country United States
    Document type Book
    HBZ-ID HT016025493
    ISBN 978-1-441-90321-1 ; 1-441-90321-6
    Database Catalogue ZB MED Medicine, Health

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    Zs A 3192 -651- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Publisher Correction: Microglial transcriptomics meets genetics: new disease leads.

    Hol, Elly M / Pasterkamp, R Jeroen

    Nature reviews. Neurology

    2022  Volume 18, Issue 4, Page(s) 249

    Language English
    Publishing date 2022-03-08
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-022-00643-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microglial transcriptomics meets genetics: new disease leads.

    Hol, Elly M / Pasterkamp, R Jeroen

    Nature reviews. Neurology

    2022  Volume 18, Issue 4, Page(s) 191–192

    MeSH term(s) Humans ; Microglia ; Transcriptome/genetics
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-022-00633-w
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  4. Book: Semaphorins: receptor and intracellular signaling mechanisms

    Pasterkamp, R. Jeroen

    (Advances in experimental medicine and biology ; 600)

    2007  

    Title variant Semaphorins
    Author's details ed. by R. Jeroen Pasterkamp
    Series title Advances in experimental medicine and biology ; 600
    Collection
    Keywords Intercellular Signaling Peptides and Proteins / physiology ; Semaphorins / physiology ; Receptors, Cell Surface / physiology
    Language English
    Size XIV, 147 S. : Ill.
    Publisher Springer u.a.
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT015232972
    ISBN 978-0-387-70955-0 ; 0-387-70955-X
    Database Catalogue ZB MED Medicine, Health

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  5. Article: Editorial: Mental health: cell models to mechanisms.

    Harwood, Adrian J / Petrakis, Spyros / Oktay, Yavuz / Pasterkamp, R Jeroen

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1244425

    Language English
    Publishing date 2023-07-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1244425
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  6. Article ; Online: Development, wiring and function of dopamine neuron subtypes.

    Garritsen, Oxana / van Battum, Eljo Y / Grossouw, Laurens M / Pasterkamp, R Jeroen

    Nature reviews. Neuroscience

    2023  Volume 24, Issue 3, Page(s) 134–152

    Abstract: The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and ...

    Abstract The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and recent work has begun to unveil how these neuronal subtypes develop and organize into functional brain structures. This progress is important for further understanding the disparate physiological functions of mDA neurons and their selective vulnerability in disease, and will ultimately accelerate therapy development. This Review discusses recent advances in our understanding of molecularly defined mDA neuron subtypes and their circuits, ranging from early developmental events, such as neuron migration and axon guidance, to their wiring and function, and future implications for therapeutic strategies.
    MeSH term(s) Humans ; Dopaminergic Neurons/physiology ; Mesencephalon ; Brain ; Dopamine ; Brain Diseases
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-022-00669-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Axons Navigate Noise with 190RhoGAP.

    Zelina, Pavol / Pasterkamp, R Jeroen

    Neuron

    2019  Volume 102, Issue 3, Page(s) 512–514

    Abstract: In this issue of Neuron, Bonanomi et al. (2019) investigate how navigating axons ignore irrelevant guidance signals. They show that the binding of p190RhoGAP to DCC suppresses inappropriate responses to Netrin-1, allowing motor axons to exit the ... ...

    Abstract In this issue of Neuron, Bonanomi et al. (2019) investigate how navigating axons ignore irrelevant guidance signals. They show that the binding of p190RhoGAP to DCC suppresses inappropriate responses to Netrin-1, allowing motor axons to exit the embryonic spinal cord.
    MeSH term(s) Axon Guidance ; Axons ; DCC Receptor ; Nerve Growth Factors ; Netrin-1 ; Tumor Suppressor Proteins
    Chemical Substances DCC Receptor ; Nerve Growth Factors ; Tumor Suppressor Proteins ; Netrin-1 (158651-98-0)
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2019.04.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Disrupted neuronal trafficking in amyotrophic lateral sclerosis.

    Burk, Katja / Pasterkamp, R Jeroen

    Acta neuropathologica

    2019  Volume 137, Issue 6, Page(s) 859–877

    Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disease caused by degeneration of motor neurons in the brain and spinal cord leading to muscle weakness. Median survival after symptom onset in patients is 3-5 years and ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disease caused by degeneration of motor neurons in the brain and spinal cord leading to muscle weakness. Median survival after symptom onset in patients is 3-5 years and no effective therapies are available to treat or cure ALS. Therefore, further insight is needed into the molecular and cellular mechanisms that cause motor neuron degeneration and ALS. Different ALS disease mechanisms have been identified and recent evidence supports a prominent role for defects in intracellular transport. Several different ALS-causing gene mutations (e.g., in FUS, TDP-43, or C9ORF72) have been linked to defects in neuronal trafficking and a picture is emerging on how these defects may trigger disease. This review summarizes and discusses these recent findings. An overview of how endosomal and receptor trafficking are affected in ALS is followed by a description on dysregulated autophagy and ER/Golgi trafficking. Finally, changes in axonal transport and nucleocytoplasmic transport are discussed. Further insight into intracellular trafficking defects in ALS will deepen our understanding of ALS pathogenesis and will provide novel avenues for therapeutic intervention.
    MeSH term(s) Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Autophagy ; Axonal Transport ; Biological Transport/physiology ; C9orf72 Protein/deficiency ; C9orf72 Protein/genetics ; C9orf72 Protein/physiology ; DNA Repeat Expansion ; Endoplasmic Reticulum/metabolism ; Endosomes/metabolism ; Flavoproteins/genetics ; Golgi Apparatus/metabolism ; Humans ; Lysosomes/metabolism ; Motor Neurons/metabolism ; Mutation ; Nerve Degeneration/physiopathology ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/physiology ; Phosphoric Monoester Hydrolases/genetics ; Protein Transport ; Receptors, Glutamate/physiology ; Receptors, N-Methyl-D-Aspartate/physiology ; TDP-43 Proteinopathies/genetics ; Valosin Containing Protein/genetics ; rab GTP-Binding Proteins/metabolism
    Chemical Substances C9orf72 Protein ; C9orf72 protein, human ; Flavoproteins ; Nerve Tissue Proteins ; Receptors, Glutamate ; Receptors, N-Methyl-D-Aspartate ; FIG4 protein, human (EC 3.1.3.-) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; VCP protein, human (EC 3.6.4.6) ; Valosin Containing Protein (EC 3.6.4.6) ; rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2019-02-05
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-019-01964-7
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  9. Book ; Online: Chapter Genetics of Amyotrophic Lateral Sclerosis

    Koppers, Max / Es, Michael van / Berg, Leonard H. van den / Veldink, Jan H. / Pasterkamp, R. Jeroen

    2012  

    Keywords Astronautics ; Technology, engineering, agriculture
    Size 1 Online-Ressource
    Publisher InTechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047423
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Advances in Central Nervous System Organoids: A Focus on Organoid-Based Models for Motor Neuron Disease.

    Vieira de Sá, Renata / Cañizares Luna, Marta / Pasterkamp, R Jeroen

    Tissue engineering. Part C, Methods

    2021  Volume 27, Issue 3, Page(s) 213–224

    Abstract: Despite their large societal burden, the development of therapeutic treatments for neurodegenerative diseases (NDDs) has been relatively unsuccessful. This is, in part, due to a lack of representative experimental models that reveal fundamental aspects ... ...

    Abstract Despite their large societal burden, the development of therapeutic treatments for neurodegenerative diseases (NDDs) has been relatively unsuccessful. This is, in part, due to a lack of representative experimental models that reveal fundamental aspects of human brain pathology. Recently, assays for
    MeSH term(s) Animals ; Brain ; Central Nervous System ; Humans ; Induced Pluripotent Stem Cells ; Motor Neuron Disease/therapy ; Organoids
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2420585-0
    ISSN 1937-3392 ; 1937-3384
    ISSN (online) 1937-3392
    ISSN 1937-3384
    DOI 10.1089/ten.TEC.2020.0337
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