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Article: [The life and works of Li Shouxian, a medical doctor in the Qing Dynasty].

Deng, C / Zhou, Y

Zhonghua yi shi za zhi (Beijing, China : 1980)

2024 Volume 54, Issue 1, Page(s) 17–22

Abstract: Li Shouxian, styled as Shanshu, was a medical doctor in the Qing Dynasty. His work ...

Abstract	Li Shouxian, styled as Shanshu, was a medical doctor in the Qing Dynasty. His work
MeSH term(s)	Acupuncture Therapy ; Moxibustion ; Acupuncture ; Books ; Libraries ; China ; Medicine, Chinese Traditional
Language	Chinese
Publishing date	2024-03-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.cn112155-20230106-00003
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Article ; Online: Chang Wei Qing Decoction enhances the anti-tumor effect of PD-1 inhibitor therapy by regulating the immune microenvironment and gut microbiota in colorectal cancer.

Wang, Ting / Wu, Linguangjin / Wang, Shuyun / Shi, Xiaolan / Liu, Hui / Deng, Wanli

Chinese journal of natural medicines

2023 Volume 21, Issue 5, Page(s) 333–345

Abstract: ... immune microenvironment (TIME). This study aimed to mechanistically assess whether Chang Wei Qing (CWQ ...

Abstract	The anti-tumor effect of anti-PD-1 antibody has long been shown to be strongly related to the tumor immune microenvironment (TIME). This study aimed to mechanistically assess whether Chang Wei Qing (CWQ) Decoction can enhance the anti-tumor effect of PD-1 inhibitor therapy. PD-1 inhibitor therapy showed the significant anti-tumor effect in patients with mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC), rather than those with mismatch repair-proficient/microsatellite stable (pMMR/MSS) CRC. Hence, immunofluorescence double-label staining was utilized to explore the difference in the TIME between dMMR/MSI-H and pMMR/MSS CRC patients. Flow cytometry was used to analyze T-lymphocytes in tumors from mice. Western blot was used to measure the expression of PD-L1 protein in mouse tumors. The intestinal mucosal barrier of mice was evaluated by hematoxylin-eosin staining and immunohistochemistry. 16S rRNA-gene sequencing was used to examine the structure of the gut microbiota in mice. Subsequently, Spearmanapos;s correlation analysis was used to analyze the relationship between the gut microbiota and tumor-infiltrating T-lymphocytes. The results showed that dMMR/MSI-H CRC patients had more CD8
MeSH term(s)	Animals ; Mice ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Gastrointestinal Microbiome ; CD8-Positive T-Lymphocytes ; B7-H1 Antigen ; RNA, Ribosomal, 16S ; Colorectal Neoplasms/metabolism ; Colonic Neoplasms ; Tumor Microenvironment
Chemical Substances	Immune Checkpoint Inhibitors ; B7-H1 Antigen ; RNA, Ribosomal, 16S
Language	English
Publishing date	2023-03-03
Publishing country	China
Document type	Journal Article
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(23)60451-0
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Article ; Online: Chang Wei Qing Decoction enhances the anti-tumor effect of PD-1 inhibitor therapy by regulating the immune microenvironment and gut microbiota in colorectal cancer

Wang, Ting / WU, Linguangjin / Wang, Shuyun / SHI, Xiaolan / Liu, Hui / DENG, Wanli

Chinese Journal of Natural Medicines. 2023 May, v. 21, no. 5 p.333-345

2023

Abstract: ... immune microenvironment (TIME). This study aimed to mechanistically assess whether Chang Wei Qing (CWQ ...

Abstract	The anti-tumor effect of anti-PD-1 antibody has long been shown to be strongly related to the tumor immune microenvironment (TIME). This study aimed to mechanistically assess whether Chang Wei Qing (CWQ) Decoction can enhance the anti-tumor effect of PD-1 inhibitor therapy. PD-1 inhibitor therapy showed the significant anti-tumor effect in patients with mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC), rather than those with mismatch repair-proficient/microsatellite stable (pMMR/MSS) CRC. Hence, immunofluorescence double-label staining was utilized to explore the difference in the TIME between dMMR/MSI-H and pMMR/MSS CRC patients. Flow cytometry was used to analyze T-lymphocytes in tumors from mice. Western blot was used to measure the expression of PD-L1 protein in mouse tumors. The intestinal mucosal barrier of mice was evaluated by hematoxylin-eosin staining and immunohistochemistry. 16S rRNA-gene sequencing was used to examine the structure of the gut microbiota in mice. Subsequently, Spearmanapos;s correlation analysis was used to analyze the relationship between the gut microbiota and tumor-infiltrating T-lymphocytes. The results showed that dMMR/MSI-H CRC patients had more CD8⁺T cells and higher expression of PD-1 and PD-L1 proteins. In vivo, CWQ enhanced the anti-tumor effect of anti-PD-1 antibody and increased the infiltration of CD8⁺ and PD-1⁺CD8⁺ T cells in tumors. Additionally, the combination of CWQ with anti-PD-1 antibody resulted in lower inflammation in the intestinal mucosa than that induced by anti-PD-1 antibody alone. CWQ and anti-PD-1 antibody co-treatment upregulated PD-L1 protein and reduced the abundance of Bacteroides in the gut microbiota but increased the abundance of Akkermansia,Firmicutes, andActinobacteria. Additionally, the proportion of infiltrated CD8⁺PD-1⁺, CD8⁺, and CD3⁺ T cells were found to be positively correlated with the abundance of Akkermansia. Accordingly, CWQ may modulate the TIME by modifying the gut microbiota and consequently enhance the anti-tumor effect of PD-1 inhibitor therapy.
Keywords	Bacteroides ; T-lymphocytes ; Western blotting ; antibodies ; antineoplastic activity ; colorectal neoplasms ; flow cytometry ; fluorescent antibody technique ; immunohistochemistry ; inflammation ; intestinal microorganisms ; intestinal mucosa ; mice ; therapeutics ; Tumor immune microenvironment ; PD-1 inhibitor therapy ; Gut microbiota ; CD8+ T cells ; Chang Wei Qing
Language	English
Dates of publication	2023-05
Size	p. 333-345.
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(23)60451-0
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Article: Gan-Qing-Ning Formula Inhibits the Growth of Hepatocellular Carcinoma by Promoting Apoptosis and Inhibiting Angiogenesis in H

Zeng, Fan-Yan / Zhao, Kai-Li / Lin, Le-Zhen / Deng, Ying / Qin, Si / Ye, Jin-Rong / Huang, Zeng-Qiong

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 6376912

Abstract: Objective: Gang-Qing-Ning (GQN) is a traditional Chinese medicine formula that has been used ...

Abstract	Objective: Gang-Qing-Ning (GQN) is a traditional Chinese medicine formula that has been used in the treatment of hepatocellular carcinoma (HCC) in the folk population for decades. However, scientific validation is still necessary to lend credibility to the traditional use of GQN against HCC. This study investigates the antitumor effect of GQN on H Methods: Fifty H Results: The tumor inhibitory rates of high, medium, and low dosages of GQN groups were 47.39%, 38.26%, and 22.17%, respectively. The high dosage of the GQN group significantly increased the protein and mRNA expression levels of Bax, Cyt-C, and cleaved Caspase 3 (or Caspase 3) ( Conclusions: The high dosage of GQN can significantly inhibit the tumor growth in H
Language	English
Publishing date	2020-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/6376912
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Article ; Online: Network pharmacology analysis on mechanism of Jian Pi Qing Gan Yin decoction ameliorating high fat diet-induced non-alcoholic fatty liver disease and validated in vivo.

Liu, Weiwei / Shang, Jingyu / Deng, Yinxiang / Han, Xiuzhen / Chen, Yugen / Wang, Shuangshuang / Yang, Ruwen / Dong, Fan / Shang, Hongtao

Journal of ethnopharmacology

2022 Volume 295, Page(s) 115382

Abstract: Ethnopharmacological relevance: Jian Pi Qing Gan Yin (JPQGY) has been used clinically to relieve ...

Abstract	Ethnopharmacological relevance: Jian Pi Qing Gan Yin (JPQGY) has been used clinically to relieve non-alcoholic fatty liver disease (NAFLD) in China for decades; however, the underlying mechanisms of JPQGY remain unclear. Aim of the study: We evaluated the effects and mechanisms of JPQGY and hepatic steatosis caused by the middle stage of 13-week-high-fat-diet-induced NAFLD in mice. Materials and methods: Different dosages of JPQGY (5.5, 11, and 22 g/kg/day) were administered to NAFLD mice simultaneously. Body weight, body mass index (BMI), and liver lipid- and inflammation-related serum indicators were measured enzymatically. Liver samples were stained with Oil Red O and hematoxylin and eosin (H&E). Next, we performed a network pharmacology analysis and verified eight target genes mapping to NAFLD-related lipid metabolism pathways. The mRNA/protein expression was analyzed by real-time polymerase chain reaction (PCR) and western blotting. Results: JPQGY significantly relieved histological damage (steatosis-inflammation-fibrosis), prevented the downregulation of AMPK and Pparα, and upregulated LXRα, Srebp-1c, F4/80, Nf-κb, and Cyp2e1 in the HFD-induced NAFLD mouse model. Conclusions: The present results suggest that chronic treatment with JPQGY ameliorated HFD-induced NAFLD in mice by targeting the first and second phases of hepatic steatosis by stimulating the AMPK/PPARα pathway and inhibiting the LXRα/Srebp1/Nf-κb pathway. Our findings provide evidence that supports the clinical use of this formula for high-fat diet-induced fatty liver disease.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Animals ; Diet, High-Fat ; Inflammation/pathology ; Lipid Metabolism ; Liver ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Network Pharmacology ; Non-alcoholic Fatty Liver Disease/metabolism ; PPAR alpha/genetics ; PPAR alpha/metabolism
Chemical Substances	NF-kappa B ; PPAR alpha ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2022-05-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115382
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Zs.A 1494: Show issues

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Article: Network pharmacology analysis on mechanism of Jian Pi Qing Gan Yin decoction ameliorating high fat diet-induced non-alcoholic fatty liver disease and validated in vivo

Liu, Weiwei / Shang, Jingyu / Deng, Yinxiang / Han, Xiuzhen / Chen, Yugen / Wang, Shuangshuang / Yang, Ruwen / Dong, Fan / Shang, Hongtao

Journal of ethnopharmacology. 2022 Sept. 15, v. 295

2022

Abstract: Jian Pi Qing Gan Yin (JPQGY) has been used clinically to relieve non-alcoholic fatty liver disease ...

Abstract	Jian Pi Qing Gan Yin (JPQGY) has been used clinically to relieve non-alcoholic fatty liver disease (NAFLD) in China for decades; however, the underlying mechanisms of JPQGY remain unclear. We evaluated the effects and mechanisms of JPQGY and hepatic steatosis caused by the middle stage of 13-week-high-fat-diet-induced NAFLD in mice. Different dosages of JPQGY (5.5, 11, and 22 g/kg/day) were administered to NAFLD mice simultaneously. Body weight, body mass index (BMI), and liver lipid- and inflammation-related serum indicators were measured enzymatically. Liver samples were stained with Oil Red O and hematoxylin and eosin (H&E). Next, we performed a network pharmacology analysis and verified eight target genes mapping to NAFLD-related lipid metabolism pathways. The mRNA/protein expression was analyzed by real-time polymerase chain reaction (PCR) and western blotting. JPQGY significantly relieved histological damage (steatosis-inflammation-fibrosis), prevented the downregulation of AMPK and Pparα, and upregulated LXRα, Srebp-1c, F4/80, Nf-κb, and Cyp2e1 in the HFD-induced NAFLD mouse model. The present results suggest that chronic treatment with JPQGY ameliorated HFD-induced NAFLD in mice by targeting the first and second phases of hepatic steatosis by stimulating the AMPK/PPARα pathway and inhibiting the LXRα/Srebp1/Nf-κb pathway. Our findings provide evidence that supports the clinical use of this formula for high-fat diet-induced fatty liver disease.
Keywords	blood serum ; body weight ; eosin ; fatty liver ; high fat diet ; histology ; lipid metabolism ; liver ; mice ; pharmacology ; protein synthesis ; quantitative polymerase chain reaction ; traditional medicine
Language	English
Dates of publication	2022-0915
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115382
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Gan-Qing-Ning Formula Inhibits the Growth of Hepatocellular Carcinoma by Promoting Apoptosis and Inhibiting Angiogenesis in H22 Tumor-Bearing Mice

Fan-Yan Zeng / Kai-Li Zhao / Le-Zhen Lin / Ying Deng / Si Qin / Jin-Rong Ye / Zeng-Qiong Huang

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: Objective. Gang-Qing-Ning (GQN) is a traditional Chinese medicine formula that has been used ...

Abstract	Objective. Gang-Qing-Ning (GQN) is a traditional Chinese medicine formula that has been used in the treatment of hepatocellular carcinoma (HCC) in the folk population for decades. However, scientific validation is still necessary to lend credibility to the traditional use of GQN against HCC. This study investigates the antitumor effect of GQN on H22 tumor-bearing mice and its possible mechanism. Methods. Fifty H22 tumor-bearing mice were randomly assigned to five groups. Three groups were treated with high, medium, and low dosages of GQN (27.68, 13.84, and 6.92 g/kg, respectively); the positive control group was treated with cytoxan (CTX) (20 mg/kg) and the model group was treated with normal saline. After 10 days’ treatment, the tumor inhibitory rates were calculated. Pathological changes in tumor tissue were observed, and the key proteins and genes of the mitochondrial apoptosis pathway were measured, as well as the mRNA expression levels of VEGF in tumor tissue. Results. The tumor inhibitory rates of high, medium, and low dosages of GQN groups were 47.39%, 38.26%, and 22.17%, respectively. The high dosage of the GQN group significantly increased the protein and mRNA expression levels of Bax, Cyt-C, and cleaved Caspase 3 (or Caspase 3) (P<0.01) but decreased the expression levels of Bcl-2, VEGF, and microvessel density (MVD) (P<0.01). Conclusions. The high dosage of GQN can significantly inhibit the tumor growth in H22 tumor-bearing mice. It exerts the antitumor effect by enhancing proapoptotic factors and inhibiting the antiapoptotic factor of the mitochondrial apoptosis pathway and inhibiting tumor angiogenesis.
Keywords	Other systems of medicine ; RZ201-999
Subject code	630
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fumigation treatment of Four Yellow Qing Ling Water with artificial tears for dry eyes

Yan-Yan Chen / Chong Huang / Yun-Hong Feng / Yuan-Fang Luo / Qiu-Hua Huang / Xin-Hui Yao / Shou-Mei Jin / Jing Xie / Yuan-Hong Lin / Ren-Feng Deng

Guoji Yanke Zazhi, Vol 18, Iss 4, Pp 762-

2018 Volume 764

Abstract: ... Yellow Qing Ling Water)for dry eye, and to provide the reference for clinical treatment of dry eye ... of traditional Chinese(Four Yellow Qing Ling Water)once a day. After treatment for 14d, the Schirmer Ⅰ test(SⅠt ... CONCLUSION: The fumigation treatment of traditional Chinese medicine(Four Yellow Qing Ling Water)combined ...

Abstract	AIM: To observe the clinical efficacy of fumigation treatment of traditional Chinese medicine(Four Yellow Qing Ling Water)for dry eye, and to provide the reference for clinical treatment of dry eye. METHODS: Totally 82 patients(164 eyes)were randomly divided into two groups from June 2016 to December 2016 in Ophthalmology Department of our hospital. The patients in control group were given artificial tears; the patients in the observation group were given artificial tears and fumigation treatment of traditional Chinese(Four Yellow Qing Ling Water)once a day. After treatment for 14d, the Schirmer Ⅰ test(SⅠt), break-up time(BUT), cornea fluorescein staining(FL)and clinical efficacy of two groups were compared. RESULTS: The efficiency rate of observation group was significantly better than the control group(87.8% vs 70.7%, P <0.5). The SⅠt and BUT in the observation group were significantly higher than those in the control group(8.43±2.51mm/5min vs 6.38±2.52mm/5min, P <0.05; 8.60±2.47s vs 6.35±2.29s, P <0.05); the FL in the observation group(0.84±0.75 vs 1.26±0.84, P <0.05)significantly lower than those in the control group. CONCLUSION: The fumigation treatment of traditional Chinese medicine(Four Yellow Qing Ling Water)combined with artificial tears for dry eyes can improve the clinical symptoms of dry eye syndrome.
Keywords	traditional Chinese medicine ; herbal fumigation ; artificial tears ; dry eye ; Ophthalmology ; RE1-994
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	Press of International Journal of Ophthalmology (IJO PRESS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: China’s population expansion and its causes during the Qing Period, 1644 – 1911

Deng, Kent

(Economic history working papers / LSE, Economic History Department ; 219)

2015

Author's details	Kent Deng
Series title	Economic history working papers / LSE, Economic History Department ; 219
Language	English
Size	Online-Ressource (55 S.), graph. Darst.
Publisher	London School of Economics, Dept. of Economic History
Publishing place	London
Document type	Book ; Online
Database	ECONomics Information System

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Article ; Online: Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.

Gao, Wenqi / Xiao, Changyi / Hu, Jun / Chen, Biaoxin / Wang, Chunyan / Cui, Bangping / Deng, Pengyi / Yang, Jian / Deng, Zhifang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2018 Volume 103, Page(s) 637–644

Abstract: Background: Qing brick tea (QBT), traditional and popular beverage for Chinese people, is ...

Abstract	Background: Qing brick tea (QBT), traditional and popular beverage for Chinese people, is an important post-fermentation dark tea. Our present study was performed to investigate the ameliorative effects of QBT aqueous extract on metabolic syndrome (Mets) in monosodium glutamate-induced obese mice and the potential mechanisms. Method: Monosodium glutamate-induced obese mice were used to evaluate the anti-Mets effects of QBT. Content levels of malonaldehyde (MDA), reactive oxygen species (ROS) and protein carbonylation, antioxidant enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR) in the skeletal muscle were assessed by commercial kits, respectively. Western blot and Q-PCR were used to detect the expressions of Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) signaling pathway and downstream antioxidant factors. In addition, activity of AKT signaling and expression of glucose transporter type 4 (GLUT4) in the skeletal muscle were investigated by western blot. Result: QBT treatment limited gain of body weight, waistline and LEE index, improved insulin resistance and glucose intolerance, reduced lipid level in MSG mice. Content levels of MDA, ROS and protein carbonylation in skeletal muscle of QBT group were significantly improved compared to those of MSG mice. The antioxidant enzyme activities of SOD, GPx, CAT, and GR were increased in skeletal muscle of MSG mice intervened with QBT. After 20-week QBT treatment, Nrf2 signaling pathway and downstream antioxidant factors were both increased in the skeletal muscle. In addition, QBT treatment improved insulin signaling by preferentially augmenting AKT signaling, as well as increased the protein expression of GLUT4 in the skeletal muscle. Conclusion: Our results showed that QBT intake was effective in protecting monosodium glutamate-induced obese mice against metabolic syndrome and involved in the Nrf2 signaling pathway in the skeletal muscle.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Dose-Response Relationship, Drug ; Male ; Metabolic Syndrome/chemically induced ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/prevention & control ; Mice ; NF-E2-Related Factor 2/metabolism ; Obesity/chemically induced ; Obesity/metabolism ; Obesity/prevention & control ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Sodium Glutamate/toxicity ; Tea ; Up-Regulation/drug effects ; Up-Regulation/physiology
Chemical Substances	Antioxidants ; NF-E2-Related Factor 2 ; Nfe2l2 protein, mouse ; Plant Extracts ; Tea ; Sodium Glutamate (W81N5U6R6U)
Language	English
Publishing date	2018-04-24
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2018.04.043
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