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  1. Article ; Online: N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection.

    Shan, Dandan / Johnson, Joseph M / Fernandes, Syrena C / Suib, Hannah / Hwang, Soyoon / Wuelfing, Danica / Mendes, Muriel / Holdridge, Marcella / Burke, Elaine M / Beauregard, Katie / Zhang, Ying / Cleary, Megan / Xu, Samantha / Yao, Xiao / Patel, Purvish P / Plavina, Tatiana / Wilson, David H / Chang, Lei / Kaiser, Kim M /
    Nattermann, Jacob / Schmidt, Susanne V / Latz, Eicke / Hrusovsky, Kevin / Mattoon, Dawn / Ball, Andrew J

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 1931

    Abstract: ... in development for detection of SARS-CoV-2 nucleocapsid protein (N-protein) in venous and capillary blood and ... pre-symptomatic PCR+ individuals. N-protein load decreases as anti-SARS-CoV-2 spike-IgG increases, and ... capillary blood samples. This Simoa SARS-CoV-2 N-protein assay effectively detects SARS-CoV-2 infection via ...

    Abstract The COVID-19 pandemic continues to have an unprecedented impact on societies and economies worldwide. There remains an ongoing need for high-performance SARS-CoV-2 tests which may be broadly deployed for infection monitoring. Here we report a highly sensitive single molecule array (Simoa) immunoassay in development for detection of SARS-CoV-2 nucleocapsid protein (N-protein) in venous and capillary blood and saliva. In all matrices in the studies conducted to date we observe >98% negative percent agreement and >90% positive percent agreement with molecular testing for days 1-7 in symptomatic, asymptomatic, and pre-symptomatic PCR+ individuals. N-protein load decreases as anti-SARS-CoV-2 spike-IgG increases, and N-protein levels correlate with RT-PCR Ct-values in saliva, and between matched saliva and capillary blood samples. This Simoa SARS-CoV-2 N-protein assay effectively detects SARS-CoV-2 infection via measurement of antigen levels in blood or saliva, using non-invasive, swab-independent collection methods, offering potential for at home and point of care sample collection.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/virology ; COVID-19 Testing/methods ; Coronavirus Nucleocapsid Proteins/blood ; Coronavirus Nucleocapsid Proteins/genetics ; Epidemics ; Home Care Services ; Humans ; Point-of-Care Systems ; ROC Curve ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; SARS-CoV-2/physiology ; Saliva/virology ; Specimen Handling/methods
    Chemical Substances Coronavirus Nucleocapsid Proteins
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-22072-9
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  2. Article ; Online: N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection

    Dandan Shan / Joseph M. Johnson / Syrena C. Fernandes / Hannah Suib / Soyoon Hwang / Danica Wuelfing / Muriel Mendes / Marcella Holdridge / Elaine M. Burke / Katie Beauregard / Ying Zhang / Megan Cleary / Samantha Xu / Xiao Yao / Purvish P. Patel / Tatiana Plavina / David H. Wilson / Lei Chang / Kim M. Kaiser /
    Jacob Nattermann / Susanne V. Schmidt / Eicke Latz / Kevin Hrusovsky / Dawn Mattoon / Andrew J. Ball

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 8

    Abstract: Here the authors develop a single molecule array (Simoa) immunoassay for detection of SARS-CoV-2 ...

    Abstract Here the authors develop a single molecule array (Simoa) immunoassay for detection of SARS-CoV-2 nucleocapsid protein in venous and dried capillary blood as well as saliva. The assay shows good performance in symptomatic, asymptomatic, and pre-symptomatic PCR+ individuals.
    Keywords Science ; Q
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Floating ideas on theta waves.

    Burke, Sara N / Maurer, Drew P

    Behavioral neuroscience

    2021  Volume 134, Issue 6, Page(s) 471–474

    Abstract: This special issue on the theta rhythm highlights recent experiments aimed at understanding the relationship between this slow, large amplitude oscillation and plasticity, fast oscillations, cellular activity and disease in both animals and humans. The ... ...

    Abstract This special issue on the theta rhythm highlights recent experiments aimed at understanding the relationship between this slow, large amplitude oscillation and plasticity, fast oscillations, cellular activity and disease in both animals and humans. The articles in this issue of Behavioral Neuroscience use a number of approaches across different model systems and behavioral paradigms to provide an up-to-date account of recent progress in understanding how the theta rhythm coordinates neural activity in the service of cognition. Prominent themes that emerge are how theta is tightly related to movement in humans and rodents and how this rhythm could be leveraged as a biomarker for understanding and testing therapeutic approaches to treat psychiatric and neurological diseases. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
    MeSH term(s) Animals ; Cognition ; Humans ; Mental Disorders ; Nervous System Diseases ; Theta Rhythm
    Language English
    Publishing date 2021-02-07
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 230159-3
    ISSN 1939-0084 ; 0735-7044
    ISSN (online) 1939-0084
    ISSN 0735-7044
    DOI 10.1037/bne0000438
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  4. Article: A long-term ketogenic diet in young and aged rats has dissociable effects on prelimbic cortex and CA3 ensemble activity.

    Hernandez, Abbi R / Barrett, Maya E / Lubke, Katelyn N / Maurer, Andrew P / Burke, Sara N

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Age-related cognitive decline has been linked to distinct patterns of cellular dysfunction in the prelimbic cortex (PL) and the CA3 subregion of the hippocampus. Because higher cognitive functions require both structures, selectively targeting a ... ...

    Abstract Age-related cognitive decline has been linked to distinct patterns of cellular dysfunction in the prelimbic cortex (PL) and the CA3 subregion of the hippocampus. Because higher cognitive functions require both structures, selectively targeting a neurobiological change in one region, at the expense of the other, is not likely to restore normal behavior in older animals. One change with age that both the PL and CA3 share, however, is a reduced ability to utilize glucose, which can produce aberrant neural activity patterns. The current study used a ketogenic diet (KD) intervention, which reduces the brain’s reliance on glucose, and has been shown to improve cognition, as a metabolic treatment for restoring neural ensemble dynamics in aged rats. Expression of the immediate-early genes
    Significance statement: This study extends understanding of how a ketogenic diet (KD) intervention may improve cognitive function in older adults. Young and aged rats were given 3 months of a KD or a calorie-match control diet and then expression of the immediate-early genes
    Language English
    Publishing date 2023-02-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.18.529095
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  5. Article: A long-term ketogenic diet in young and aged rats has dissociable effects on prelimbic cortex and CA3 ensemble activity.

    Hernandez, Abbi R / Barrett, Maya E / Lubke, Katelyn N / Maurer, Andrew P / Burke, Sara N

    Frontiers in aging neuroscience

    2023  Volume 15, Page(s) 1274624

    Abstract: Introduction: Age-related cognitive decline has been linked to distinct patterns of cellular dysfunction in the prelimbic cortex (PL) and the CA3 subregion of the hippocampus. Because higher cognitive functions require both structures, selectively ... ...

    Abstract Introduction: Age-related cognitive decline has been linked to distinct patterns of cellular dysfunction in the prelimbic cortex (PL) and the CA3 subregion of the hippocampus. Because higher cognitive functions require both structures, selectively targeting a neurobiological change in one region, at the expense of the other, is not likely to restore normal behavior in older animals. One change with age that both the PL and CA3 share, however, is a reduced ability to utilize glucose, which can produce aberrant neural activity patterns.
    Methods: The current study used a ketogenic diet (KD) intervention, which reduces the brain's reliance on glucose, and has been shown to improve cognition, as a metabolic treatment for restoring neural ensemble dynamics in aged rats. Expression of the immediate-early genes
    Results: Aged rats on the control diet had increased activity in CA3 and less ensemble overlap in PL between different task conditions than did the young animals. In the PL, the KD was associated with increased activation of neurons in the superficial cortical layers, establishing a clear link between dietary macronutrient content and frontal cortical activity. The KD did not lead to any significant changes in CA3 activity.
    Discussion: These observations suggest that the availability of ketone bodies may permit the engagement of compensatory mechanisms in the frontal cortices that produce better cognitive outcomes.
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1274624
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  6. Article ; Online: Phototoxicity of Tridentate Ru(II) Polypyridyl Complex with Expanded Bite Angles toward Mammalian Cells and Multicellular Tumor Spheroids.

    Curley, Rhianne C / Burke, Christopher S / Gkika, Karmel S / Noorani, Sara / Walsh, Naomi / Keyes, Tia E

    Inorganic chemistry

    2023  Volume 62, Issue 32, Page(s) 13089–13102

    Abstract: Tridentate ligand-coordinated ruthenium (II) polypyridyl complexes with large N-Ru-N bite angles ...

    Abstract Tridentate ligand-coordinated ruthenium (II) polypyridyl complexes with large N-Ru-N bite angles have been shown to promote ligand field splitting and reduce singlet-triplet state mixing leading to dramatically extended emission quantum yields and lifetimes under ambient conditions. These effects are anticipated to enhance their photoinduced singlet oxygen production, promoting prospects for such complexes as type II phototherapeutics. In this contribution, we examined this putative effect for [Ru(bqp)(bqpCOOEt)]
    MeSH term(s) Animals ; Cricetinae ; Humans ; CHO Cells ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Cricetulus ; Ligands ; Neoplasms ; Photochemotherapy ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Ruthenium/chemistry ; Ruthenium/pharmacology
    Chemical Substances Coordination Complexes ; Ligands ; Photosensitizing Agents ; Ruthenium (7UI0TKC3U5)
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c01982
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  7. Article ; Online: Age-related changes in 'hub' neurons.

    Hernandez, Abbi R / Burke, Sara N

    Aging

    2018  Volume 10, Issue 10, Page(s) 2551–2552

    MeSH term(s) Neurons ; Prefrontal Cortex ; Temporal Lobe
    Language English
    Publishing date 2018-10-17
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.101606
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  8. Article ; Online: Nonlinear Theta-Gamma Coupling between the Anterior Thalamus and Hippocampus Increases as a Function of Running Speed.

    Qin, Yu / Sheremet, Alex / Cooper, Tara L / Burke, Sara N / Maurer, Andrew P

    eNeuro

    2023  Volume 10, Issue 3

    Abstract: The hippocampal theta rhythm strongly correlates to awake behavior leading to theories that it represents a cognitive state of the brain. As theta has been observed in other regions of the Papez circuit, it has been theorized that activity propagates in ... ...

    Abstract The hippocampal theta rhythm strongly correlates to awake behavior leading to theories that it represents a cognitive state of the brain. As theta has been observed in other regions of the Papez circuit, it has been theorized that activity propagates in a reentrant manner. These observations complement the energy cascade hypothesis in which large-amplitude, slow-frequency oscillations reflect activity propagating across a large population of neurons. Higher frequency oscillations, such as gamma, are related to the speed with which inhibitory and excitatory neurons interact and distribute activity on the local level. The energy cascade hypothesis suggests that the larger anatomic loops, maintaining theta, drive the smaller loops. As hippocampal theta increases in power with running speed, so does the power and frequency of the gamma rhythm. If theta is propagated through the circuit, it stands to reason that the local field potential (LFP) recorded in other regions would be coupled to the hippocampal theta, with the coupling increasing with running speed. We explored this hypothesis using open-source simultaneous recorded data from the CA1 region of the hippocampus and the anterior dorsal and anterior ventral thalamus. Cross-regional theta coupling increased with running speed. Although the power of the gamma rhythm was lower in the anterior thalamus, there was an increase in the coupling of hippocampal theta to anterior thalamic gamma. Broadly, the data support models of how activity moves across the nervous system, suggesting that the brain uses large-scale volleys of activity to support higher cognitive processes.
    MeSH term(s) Anterior Thalamic Nuclei ; Hippocampus/physiology ; Theta Rhythm/physiology ; Running/physiology ; Neurons/physiology
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0470-21.2023
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  9. Article: Animal models of cognitive aging and circuit-specific vulnerability.

    Burke, Sara N / Foster, Thomas C

    Handbook of clinical neurology

    2019  Volume 167, Page(s) 19–36

    Abstract: Medial temporal lobe and prefrontal cortical structures are particularly vulnerable to dysfunction in advanced age and neurodegenerative diseases. This review focuses on cognitive aging studies in animals to illustrate the important aspects of the animal ...

    Abstract Medial temporal lobe and prefrontal cortical structures are particularly vulnerable to dysfunction in advanced age and neurodegenerative diseases. This review focuses on cognitive aging studies in animals to illustrate the important aspects of the animal model paradigm for investigation of age-related memory and executive function loss. Particular attention is paid to the discussion of the face, construct, and predictive validity of animal models for determining the possible mechanisms of regional vulnerability in aging and for identifying novel therapeutic strategies. Aging is associated with a host of regionally specific neurobiologic alterations. Thus, targeted interventions that restore normal activity in one brain region may exacerbate aberrant activity in another, hindering the restoration of function at the behavioral level. As such, interventions that target the optimization of "cognitive networks" rather than discrete brain regions may be more effective for improving functional outcomes in the elderly.
    MeSH term(s) Animals ; Brain/physiology ; Cognitive Aging/physiology ; Disease Models, Animal ; Nerve Net/physiology
    Language English
    Publishing date 2019-11-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-12-804766-8.00002-9
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  10. Article ; Online: Urban Soil Safety Policies: The Next Frontier for Mitigating Lead Exposures and Promoting Sustainable Food Production.

    Lupolt, Sara N / Santo, Raychel E / Kim, Brent F / Burke, Thomas A / Nachman, Keeve E

    GeoHealth

    2022  Volume 6, Issue 9, Page(s) e2022GH000615

    Abstract: Urban soils bear the persistent legacy of leaded gasoline and past industrial practices. Soil safety policies (SSPs) are an important public health tool with the potential to inform, identify, and mitigate potential health risks faced by urban growers, ... ...

    Abstract Urban soils bear the persistent legacy of leaded gasoline and past industrial practices. Soil safety policies (SSPs) are an important public health tool with the potential to inform, identify, and mitigate potential health risks faced by urban growers, but little is known about how these policies may protect growers from exposures to lead and other soil contaminants. We reviewed and evaluated 43 urban agriculture (UA) policies in 40 US cities pertaining to soil safety. About half of these cities had a least one SSP that offered recommendations or provided services for soil testing. Eight cities had at least one SSP containing a requirement pertaining to any topic (e.g., soil testing, a specific best practice for growing). We found notable inconsistencies across SSPs for "acceptable" levels of lead in soils and the activities and behaviors recommended at each level. We specify research needed to inform revisions to US Environmental Protection Agency guidance for lead in soils specific to UA. We conclude with a series of recommendations to guide the development or revision of SSPs.
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 2471-1403
    ISSN (online) 2471-1403
    DOI 10.1029/2022GH000615
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