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  1. Article ; Online: What Evolutionary Evidence Implies About the Identity of the Mechanoelectrical Couplers in Vascular Smooth Muscle Cells.

    Drummond, Heather A

    Physiology (Bethesda, Md.)

    2021  Volume 36, Issue 5, Page(s) 292–306

    Abstract: Loss of pressure-induced vasoconstriction increases susceptibility to renal and cerebral vascular injury. Favored paradigms underlying initiation of the response include transient receptor potential channels coupled to G protein-coupled receptors or ... ...

    Abstract Loss of pressure-induced vasoconstriction increases susceptibility to renal and cerebral vascular injury. Favored paradigms underlying initiation of the response include transient receptor potential channels coupled to G protein-coupled receptors or integrins as transducers. Degenerin channels may also mediate the response. This review addresses the
    MeSH term(s) Kidney ; Muscle, Smooth, Vascular ; Myocytes, Smooth Muscle ; Vasoconstriction
    Language English
    Publishing date 2021-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00008.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Small regulatory RNAs are mediators of the

    Drummond, India Y / DePaolo, Alessandra / Krieger, Madeline / Driscoll, Heather / Eckstrom, Korin / Spatafora, Grace A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Dental caries is among the most prevalent chronic infectious diseases worldwide. : Importance: Small regulatory RNAs (sRNAs) are critical mediators of environmental signaling, particularly in bacterial cells under stress, but their role ... ...

    Abstract Dental caries is among the most prevalent chronic infectious diseases worldwide.
    Importance: Small regulatory RNAs (sRNAs) are critical mediators of environmental signaling, particularly in bacterial cells under stress, but their role in
    Language English
    Publishing date 2023-06-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.02.543485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Small regulatory RNAs are mediators of the

    Drummond, India Y / DePaolo, Alessandra / Krieger, Madeline / Driscoll, Heather / Eckstrom, Korin / Spatafora, Grace A

    Journal of bacteriology

    2023  Volume 205, Issue 9, Page(s) e0017223

    Abstract: Dental caries is among the most prevalent chronic diseases worldwide. ...

    Abstract Dental caries is among the most prevalent chronic diseases worldwide.
    MeSH term(s) Humans ; Cariostatic Agents ; Dental Caries ; Manganese ; Regulon ; Streptococcus mutans/genetics
    Chemical Substances Cariostatic Agents ; Manganese (42Z2K6ZL8P)
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00172-23
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  4. Article ; Online: Integrating Board-Certified Psychiatric Pharmacists in a Certified Community Behavioral Health Clinic.

    Li, Luming / Cooper, Heather Rozea / Parmentier, Brittany L / Williamson, Mark / Crouch, Mitchell / Muzquiz-Drummond, Sylvia / Babin, Angela

    Psychiatric services (Washington, D.C.)

    2024  , Page(s) appips20230521

    Abstract: Demand for mental health services has dramatically increased in recent years, raising concerns about the availability of service providers to meet these increased needs. One approach to expanding access to care is the use of highly qualified board- ... ...

    Abstract Demand for mental health services has dramatically increased in recent years, raising concerns about the availability of service providers to meet these increased needs. One approach to expanding access to care is the use of highly qualified board-certified psychiatric pharmacists (BCPPs). However, the implementation of programs for integrating BCPPs has not been well characterized in community mental health settings. This column describes the development and implementation of a comprehensive practice model to incorporate BCPPs in a certified community behavioral health clinic. The authors report the results from the first 14 months of BCPP integration (based on 3,221 direct patient care interventions), offer recommendations, and highlight lessons learned.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.20230521
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  5. Article: Nontubular epithelial Na+ channel proteins in cardiovascular regulation.

    Drummond, Heather A

    Physiological reports

    2015  Volume 3, Issue 5

    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2724325-4
    ISSN 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.12404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Is there a role of proinflammatory cytokines on degenerin-mediated cerebrovascular function in preeclampsia?

    Nemeth, Zoltan / Granger, Joey P / Ryan, Michael J / Drummond, Heather A

    Physiological reports

    2022  Volume 10, Issue 13, Page(s) e15376

    Abstract: Preeclampsia (PE) is associated with adverse cerebrovascular effects during and following parturition including stroke, small vessel disease, and vascular dementia. A potential contributing factor to the cerebrovascular dysfunction is the loss of ... ...

    Abstract Preeclampsia (PE) is associated with adverse cerebrovascular effects during and following parturition including stroke, small vessel disease, and vascular dementia. A potential contributing factor to the cerebrovascular dysfunction is the loss of cerebral blood flow (CBF) autoregulation. Autoregulation is the maintenance of CBF to meet local demands with changes in perfusion pressure. When perfusion pressure rises, vasoconstriction of cerebral arteries and arterioles maintains flow and prevents the transfer of higher systemic pressure to downstream microvasculature. In the face of concurrent hypertension, loss of autoregulatory control exposes small delicate microvessels to injury from elevated systemic blood pressure. While placental ischemia is considered the initiating event in the preeclamptic cascade, the factor(s) mediating cerebrovascular dysfunction are poorly understood. Elevated plasma proinflammatory cytokines, such as tumor necrosis factor α (TNF-α) and interleukin-17 (IL-17), are potential mediators of autoregulatory loss. Impaired CBF responses to increases in systemic pressure are attributed to the impaired pressure-induced (myogenic) constriction of small cerebral arteries and arterioles in PE. Myogenic vasoconstriction is initiated by pressure-induced vascular smooth muscle cell (VSMC) stretch. Recent studies from our laboratory group indicate that proinflammatory cytokines impair the myogenic mechanism of CBF autoregulation via inhibition of vascular degenerin proteins, putative mediators of myogenic constriction in VSMCs. This brief review links studies showing the effect of proinflammatory cytokines on degenerin expression and CBF autoregulation to the pathological cerebral consequences of preeclampsia.
    MeSH term(s) Cerebrovascular Circulation/physiology ; Cytokines/pharmacology ; Degenerin Sodium Channels ; Female ; Humans ; Placenta ; Pre-Eclampsia ; Pregnancy
    Chemical Substances Cytokines ; Degenerin Sodium Channels
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole.

    Lu, Yan / Stec, David E / Liu, Ruisheng / Ryan, Michael / Drummond, Heather A

    American journal of physiology. Renal physiology

    2022  Volume 322, Issue 5, Page(s) F498–F511

    Abstract: In independent studies, our laboratory has shown the importance of the degenerin proteins β-epithelial ... ...

    Abstract In independent studies, our laboratory has shown the importance of the degenerin proteins β-epithelial Na
    MeSH term(s) Animals ; Arterioles ; Constriction ; Kidney ; Mice ; Muscle, Smooth, Vascular/metabolism ; Vasoconstriction
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00003.2022
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  8. Article ; Online: HIV-associated lung disease.

    Konstantinidis, Ioannis / Crothers, Kristina / Kunisaki, Ken M / Drummond, M Bradley / Benfield, Thomas / Zar, Heather J / Huang, Laurence / Morris, Alison

    Nature reviews. Disease primers

    2023  Volume 9, Issue 1, Page(s) 39

    Abstract: Lung disease encompasses acute, infectious processes and chronic, non-infectious processes such as chronic obstructive pulmonary disease, asthma and lung cancer. People living with HIV are at increased risk of both acute and chronic lung diseases. ... ...

    Abstract Lung disease encompasses acute, infectious processes and chronic, non-infectious processes such as chronic obstructive pulmonary disease, asthma and lung cancer. People living with HIV are at increased risk of both acute and chronic lung diseases. Although the use of effective antiretroviral therapy has diminished the burden of infectious lung disease, people living with HIV experience growing morbidity and mortality from chronic lung diseases. A key risk factor for HIV-associated lung disease is cigarette smoking, which is more prevalent in people living with HIV than in uninfected people. Other risk factors include older age, history of bacterial pneumonia, Pneumocystis pneumonia, pulmonary tuberculosis and immunosuppression. Mechanistic investigations support roles for aberrant innate and adaptive immunity, local and systemic inflammation, oxidative stress, altered lung and gut microbiota, and environmental exposures such as biomass fuel burning in the development of HIV-associated lung disease. Assessment, prevention and treatment strategies are largely extrapolated from data from HIV-uninfected people. Smoking cessation is essential. Data on the long-term consequences of HIV-associated lung disease are limited. Efforts to continue quantifying the effects of HIV infection on the lung, especially in low-income and middle-income countries, are essential to advance our knowledge and optimize respiratory care in people living with HIV.
    MeSH term(s) Humans ; HIV Infections/complications ; HIV Infections/epidemiology ; Lung Diseases/complications ; Lung Diseases/epidemiology ; Lung ; Pulmonary Disease, Chronic Obstructive/etiology ; Risk Factors
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2056-676X
    ISSN (online) 2056-676X
    DOI 10.1038/s41572-023-00450-5
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  9. Article ; Online: Rates of overtreatment and deprescribing of antihyperglycemics among long-term care residents in British Columbia.

    Pan, Jeffrey / Tejani, Aaron / Logan, Alixandra / Brodoway, Heather / Shukla, Kruti / Son, Maric / Khosla, Kanika / Moradi, AmirHossein / Drummond, Isla / McCarthy, Lisa M / Lega, Iliana C / McCracken, Rita / Thompson, Wade

    Journal of the American Geriatrics Society

    2023  Volume 71, Issue 8, Page(s) 2657–2661

    MeSH term(s) Humans ; Long-Term Care ; Deprescriptions ; British Columbia ; Hypoglycemic Agents ; Overtreatment
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Letter
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18377
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  10. Article ; Online: Interleukin-17 Reduces βENaC via MAPK Signaling in Vascular Smooth Muscle Cells.

    Duncan, Jeremy W / Granger, Joey P / Ryan, Michael J / Drummond, Heather A

    International journal of molecular sciences

    2020  Volume 21, Issue 8

    Abstract: Degenerin proteins, such as the beta epithelial ... ...

    Abstract Degenerin proteins, such as the beta epithelial Na
    MeSH term(s) Animals ; Cell Line ; Cells, Cultured ; Epithelial Sodium Channels/genetics ; Epithelial Sodium Channels/metabolism ; Gene Expression Regulation/drug effects ; Interleukin-17/metabolism ; Interleukin-17/pharmacology ; MAP Kinase Signaling System/drug effects ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; NF-kappa B/metabolism ; Phosphorylation ; Rats
    Chemical Substances Epithelial Sodium Channels ; Interleukin-17 ; NF-kappa B
    Language English
    Publishing date 2020-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21082953
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