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  1. Article ; Online: Mosquito bypassers: infectious sporozoites grown in vitro.

    Rénia, Laurent / Goh, Yun Shan

    Trends in parasitology

    2023  Volume 39, Issue 3, Page(s) 158–159

    Abstract: The whole-sporozoite-based vaccine approach has been limited by the difficulty of mass production of infectious sporozoites from infected mosquitoes. Eappen et al. describe a method for producing a large quantity of sporozoites in vitro, which opens new ... ...

    Abstract The whole-sporozoite-based vaccine approach has been limited by the difficulty of mass production of infectious sporozoites from infected mosquitoes. Eappen et al. describe a method for producing a large quantity of sporozoites in vitro, which opens new areas of investigations in sporozoite biology and large-scale sporozoite production for vaccine development.
    MeSH term(s) Animals ; Malaria ; Sporozoites ; Malaria Vaccines ; Communicable Diseases ; Anopheles
    Chemical Substances Malaria Vaccines
    Language English
    Publishing date 2023-01-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A flow cytometry-based assay for serological detection of anti-spike antibodies in COVID-19 patients.

    Goh, Yun Shan / Ng, Lisa F P / Renia, Laurent

    STAR protocols

    2021  Volume 2, Issue 3, Page(s) 100671

    Abstract: ... refer to Goh et al. (2021). ...

    Abstract One of the key public health strategies in coronavirus 2019 disease (COVID-19) management is the early detection of infected individuals to limit the transmission. As a result, serological assays have been developed to complement PCR-based assays. Here, we report the development of a flow cytometry-based assay to detect antibodies against full-length SARS-CoV-2 spike protein (S protein) in patients with COVID-19. The assay is time-efficient and sensitive, being able to capture the wider repertoire of antibodies against the S protein. For complete details on the use and execution of this protocol, please refer to Goh et al. (2021).
    MeSH term(s) Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Serological Testing/methods ; Enzyme-Linked Immunosorbent Assay/methods ; Flow Cytometry/methods ; Humans ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2021.100671
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  3. Article: Malaria Parasites: The Great Escape.

    Rénia, Laurent / Goh, Yun Shan

    Frontiers in immunology

    2016  Volume 7, Page(s) 463

    Abstract: Parasites of the ... ...

    Abstract Parasites of the genus
    Language English
    Publishing date 2016-11-07
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2016.00463
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  4. Article ; Online: Screening for obstructive sleep apnea (OSA) in children and adolescents with obesity: A scoping review of national and international pediatric obesity and pediatric OSA management guidelines.

    Ng, Nicholas Beng Hui / Lim, Carey Yun Shan / Tan, Sarah Caellainn Hui Lin / Foo, Yu Wah / Tok, Chanel Li Xuan / Lim, Yvonne Yijuan / Goh, Daniel Yam Thiam / Loke, Kah Yin / Lee, Yung Seng

    Obesity reviews : an official journal of the International Association for the Study of Obesity

    2024  Volume 25, Issue 5, Page(s) e13712

    Abstract: Obstructive sleep apnea (OSA) is a prevalent complication that affects up to 60% of children and adolescents with obesity. It is associated with poorer cardiometabolic outcomes and neurocognitive deficits. Appropriate screening and intervention for OSA ... ...

    Abstract Obstructive sleep apnea (OSA) is a prevalent complication that affects up to 60% of children and adolescents with obesity. It is associated with poorer cardiometabolic outcomes and neurocognitive deficits. Appropriate screening and intervention for OSA are crucial in the management of children with obesity. We performed a scoping review of international and national pediatric obesity (n = 30) and pediatric OSA (n = 10) management guidelines to evaluate the recommendations on OSA screening in pediatric obesity. Sixteen (53%) of the pediatric obesity guidelines had incorporated OSA screening to varying extents, with no consistent recommendations on when and how to screen for OSA, and subsequent management of OSA in children with obesity. We provide our recommendations that are based on the strength and certainty of evidence presented. These include a clinical-based screening for OSA in all children with body mass index (BMI) ≥ 85th percentile or those with rapid BMI gain (upward crossing of 2 BMI percentiles) and the use of overnight polysomnography to confirm the diagnosis of OSA in those with high clinical suspicion. We discuss further management of OSA unique to children with obesity. An appropriate screening strategy for OSA would facilitate timely intervention that has been shown to improve cardiometabolic and neurocognitive outcomes.
    MeSH term(s) Adolescent ; Humans ; Child ; Pediatric Obesity/complications ; Pediatric Obesity/diagnosis ; Pediatric Obesity/therapy ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/therapy ; Sleep Apnea, Obstructive/complications ; Body Mass Index ; Polysomnography ; Cardiovascular Diseases/complications
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147980-X
    ISSN 1467-789X ; 1467-7881
    ISSN (online) 1467-789X
    ISSN 1467-7881
    DOI 10.1111/obr.13712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5908: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A flow cytometry-based assay for serological detection of anti-spike antibodies in COVID-19 patients

    Yun Shan Goh / Lisa F.P. Ng / Laurent Renia

    STAR Protocols, Vol 2, Iss 3, Pp 100671- (2021)

    2021  

    Abstract: ... please refer to Goh et al. (2021). ...

    Abstract Summary: One of the key public health strategies in coronavirus 2019 disease (COVID-19) management is the early detection of infected individuals to limit the transmission. As a result, serological assays have been developed to complement PCR-based assays. Here, we report the development of a flow cytometry-based assay to detect antibodies against full-length SARS-CoV-2 spike protein (S protein) in patients with COVID-19. The assay is time-efficient and sensitive, being able to capture the wider repertoire of antibodies against the S protein.For complete details on the use and execution of this protocol, please refer to Goh et al. (2021).
    Keywords Cell Biology ; Flow Cytometry/Mass Cytometry ; Health Sciences ; Immunology ; Molecular Biology ; Antibody ; Science (General) ; Q1-390
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Vaccination With Sporozoites: Models and Correlates of Protection.

    Goh, Yun Shan / McGuire, Daniel / Rénia, Laurent

    Frontiers in immunology

    2019  Volume 10, Page(s) 1227

    Abstract: Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple control interventions need to be in place simultaneously to achieve this goal. In addition to effective control measures, drug therapies and insecticides, ... ...

    Abstract Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple control interventions need to be in place simultaneously to achieve this goal. In addition to effective control measures, drug therapies and insecticides, vaccines are critical to reduce mortality and morbidity. Hence, there are numerous studies investigating various malaria vaccine candidates. Most of the malaria vaccine candidates are subunit vaccines. However, they have shown limited efficacy in Phase II and III studies. To date, only whole parasite formulations have been shown to induce sterile immunity in human. In this article, we review and discuss the recent developments in vaccination with sporozoites and the mechanisms of protection involved.
    MeSH term(s) Animals ; Humans ; Malaria Vaccines/immunology ; Malaria, Falciparum/immunology ; Malaria, Falciparum/prevention & control ; Plasmodium falciparum/immunology ; Sporozoites/immunology ; Vaccination ; Vaccines, Attenuated/immunology ; Vaccines, Subunit/immunology
    Chemical Substances Malaria Vaccines ; Vaccines, Attenuated ; Vaccines, Subunit
    Language English
    Publishing date 2019-06-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Author Correction: Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave.

    Goh, Yun Shan / Fong, Siew-Wai / Tay, Matthew Zirui / Rouers, Angeline / Chang, Zi Wei / Chavatte, Jean-Marc / Hor, Pei Xiang / Loh, Chiew Yee / Huang, Yuling / Tan, Yong Jie / Wang, Bei / Ngoh, Eve Zi Xian / Mohd Salleh, Siti Nazihah / Lee, Raphael Tze Chuen / Lim, Georgina / Maurer-Stroh, Sebastian / Wang, Cheng-I / Leo, Yee-Sin / Lin, Raymond T P /
    Lam, Meng Chon / Lye, David C / Young, Barnaby Edward / Ng, Lisa F P / Renia, Laurent

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1492

    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51484-y
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  8. Article: Neisseria meningitidis

    Necchi, Francesca / Stefanetti, Giuseppe / Alfini, Renzo / Palmieri, Elena / Carducci, Martina / Di Benedetto, Roberta / Schiavo, Fabiola / Aruta, Maria Grazia / Giusti, Fabiola / Ferlenghi, Ilaria / Goh, Yun Shan / Rondini, Simona / Micoli, Francesca

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 6

    Abstract: GMMA, outer membrane vesicles resulting from hyperblebbing mutated bacterial strains, are a versatile vaccine platform for displaying both homologous and heterologous antigens. Periplasmic expression is a popular technique for protein expression in the ... ...

    Abstract GMMA, outer membrane vesicles resulting from hyperblebbing mutated bacterial strains, are a versatile vaccine platform for displaying both homologous and heterologous antigens. Periplasmic expression is a popular technique for protein expression in the lumen of the blebs. However, the ability of internalized antigens to induce antibody responses has not been extensively investigated. Herein, the
    Language English
    Publishing date 2021-06-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10060726
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  9. Article ; Online: The pornography use and its addiction among emerging adults in Malaysia: Perceived realism as a mediator.

    Tan, Soon Aun / Ng, Samantha Hui Li / Hoo, Juliana Ju Yun / Gan, Su Wan / Nainee, Sarvarubini / Yap, Chin Choo / Lee, Ling Khai / Mohd Zaharim, Norzarina / Goh, Yee Shan

    PloS one

    2022  Volume 17, Issue 5, Page(s) e0268724

    Abstract: Past studies have demonstrated a link between pornography use and addiction to pornography, the underlying mechanism of the association is still unclear. This study intended to examine the mediating role of perceived realism of pornography in the ... ...

    Abstract Past studies have demonstrated a link between pornography use and addiction to pornography, the underlying mechanism of the association is still unclear. This study intended to examine the mediating role of perceived realism of pornography in the association between pornography use and addiction among emerging adults in Malaysia. This study recruited 222 self-identified pornography users (M age = 21.05; SD Age = 1.68; 75.1% male respondents) via the purposive sampling method. The correlation results indicated positive associations among pornography use, addiction to pornography, and perceived realism of pornography. Further, the perceived realism of pornography significantly mediated the association between pornography use and addiction to pornography after controlling for gender. Thus, this study has provided a fundamental understanding on the perceived realism role of pornography in explaining the association between its use and addiction. Although it is unlikely to stop illegal pornography use, the results pointed out a need to guide emerging adults in pornography use via media literacy programmes.
    MeSH term(s) Adult ; Behavior, Addictive/epidemiology ; Cross-Sectional Studies ; Erotica ; Female ; Humans ; Infant ; Malaysia/epidemiology ; Male ; Research Design ; Sexual Behavior ; Young Adult
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0268724
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  10. Article: Igg Subclasses Targeting the Flagella of

    Goh, Yun Shan / Armour, Kathryn L / Clark, Michael R / Grant, Andrew J / Mastroeni, Pietro

    Journal of vaccines & vaccination

    2016  Volume 7, Issue 3

    Abstract: Invasive non- ... ...

    Abstract Invasive non-typhoidal
    Language English
    Publishing date 2016-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 2157-7560
    ISSN 2157-7560
    DOI 10.4172/2157-7560.1000322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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