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Article ; Online: Retraction Note: Long noncoding RNA HEIH depletion depresses esophageal carcinoma cell progression by upregulating microRNA-185 and downregulating KLK5.

Wang, Bing / Hao, Xuezhi / Li, Xingkai / Liang, Yicheng / Li, Fang / Yang, Kun / Chen, Hengqi / Lv, Fang / Gao, Yushun

2023 Volume 14, Issue 12, Page(s) 842

Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-023-06365-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: "Shell-Core" Bilayer Nanoparticle as Chemotherapeutic Drug Co-Delivery Platforms Render Synchronized Microenvironment Respond and Enhanced Antitumor Effects.

Zeng, Jia / Sun, Peng / Fang, Xinning / Jiang, Yicheng / Wu, Zhenghong / Qi, Xiaole

International journal of nanomedicine

2023 Volume 18, Page(s) 1521–1536

Abstract: Background: Synergistic chemotherapy has been proved as an effective antitumor means in clinical practice. However, most co-administration treatment often lacks simultaneous control over the release of different chemotherapeutic agents.: Materials and ...

Abstract	Background: Synergistic chemotherapy has been proved as an effective antitumor means in clinical practice. However, most co-administration treatment often lacks simultaneous control over the release of different chemotherapeutic agents. Materials and methods: β Results: These BNs had a spherical structure with the particle size of 299 ± 15.17 nm, while the synchronized release behaviour of those two drugs was proved in the medium with the pH value of 5.5 and 20 mM GSH. The co-delivery of DOX and CUR reduced the IC Conclusion: The designed bilayer nanoparticle could be considered as potential chemotherapeutic co-delivery platform for efficient synchronized microenvironment respond and drug release. Furthermore, the simultaneous and synergistic drug release guaranteed the enhanced antitumor effects during the co-administration treatment.
MeSH term(s)	Mice ; Animals ; Drug Delivery Systems ; Doxorubicin/pharmacology ; Curcumin/pharmacology ; Neoplasms ; Nanoparticles ; Drug Carriers ; Hydrogen-Ion Concentration ; Drug Liberation ; Tumor Microenvironment
Chemical Substances	Doxorubicin (80168379AG) ; Curcumin (IT942ZTH98) ; Drug Carriers
Language	English
Publishing date	2023-03-24
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S401038
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Zs.A 6606: Show issues

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Article ; Online: PAA-PU Janus Hydrogels Stabilized by Janus Particles and its Interfacial Performance During Hemostatic Processing.

Fang, Yan / Zheng, Yanyan / Chi, Chongyi / Jiang, Sai / Qin, Wanbang / Zhang, Yicheng / Liu, Haiqing / Chen, Qinhui

Advanced healthcare materials

2024 , Page(s) e2303802

Abstract: Hydrogel is a very promising dressing for hemostasis and wound healing due to its good adhesion and long-term moist environment. However, secondary injury caused by tissue adhesion due to homogeneous hydrogel cannot be ignored. The obvious interface ... ...

Abstract	Hydrogel is a very promising dressing for hemostasis and wound healing due to its good adhesion and long-term moist environment. However, secondary injury caused by tissue adhesion due to homogeneous hydrogel cannot be ignored. The obvious interface existing in Janus hydrogel will weaken its asymmetric function. Here, a hierarchical adhesive polyacrylic acid-polyurushiol water-oil Janus hydrogel (JPs@PAA-PU) without adhesive layer is fabricated by one-pot method in the stabilization of polystyrene@silica-siliver Janus particles (JPs). The morphological structure, mechanical properties, anisotropic chemical composition, and adhesion performance, in vivo, and in vitro hemostatic properties of Janus hydrogel are investigated. Result shows that the obtained Janus hydrogel possesses obvious compartmentalization in microstructure, functional groups, and chemical elements. Janus hydrogel is provided with asymmetric interfacial toughness with top 52.45 ± 2.29 Kpa and bottom 7.04 ± 0.88 Kpa on porcine liver. The adhesion properties of PAA side to tissue, red blood cells and platelets, promoting effect of PU side on coagulation cascade reaction and its physical battier endow Janus hydrogel with shorter hemostatic time and less blood loss than control group. It also exhibits excellent antibacterial effects against Escherichia coli and Staphylococcus aureus (>90%). Janus hydrogel possesses biosafety, providing safety guarantee for clinical applications in the future.
Language	English
Publishing date	2024-02-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202303802
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Zs.A 6966: Show issues

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Article ; Online: The checkmark association between gamma glutamyl-transpeptidase and body mass index in a large Chinese population.

Mei, Wendan / Fang, Yicheng / Wang, Chenxu / Ren, Xia / Hu, Jian / Su, Fan / Tavengana, Grace / Wu, Huan / Wen, Yufeng

Neuro endocrinology letters

2024 Volume 45, Issue 2

Abstract: Background: Obesity has long been regarded as a risk factor for abnormal liver function, although the quantitative relationship between them is not clear. This study aimed to investigate the relationship between body mass index (BMI) and gamma-glutamyl ... ...

Abstract	Background: Obesity has long been regarded as a risk factor for abnormal liver function, although the quantitative relationship between them is not clear. This study aimed to investigate the relationship between body mass index (BMI) and gamma-glutamyl transpeptidase (GGT) in different gender populations. Methods: The cross-sectional study included 221,934 people aged over 18 years and under 90 years who underwent physical examinations at Yijishan Hospital in Wuhu City from 2011 to 2016. t-test and Chi-square test were used to compare the differences in demographic characteristics and biochemical indexes between men and women. Linear regression model and smooth curve method were used to investigate the relationship between BMI and GGT. Results: The smooth curve shows a checkmark association between GGT and BMI. After adjusting for confounders, the cut-off BMI for the whole population was 19.5 kg/m2. When BMI was less than 19.5 kg/m2, GGT levels decreased with increasing BMI, and when BMI was greater than 19.5 kg/m2, GGT levels increased with increasing BMI. After gender stratification, there was a checkmark association between male and female GGT levels and BMI, but the trend of male GGT levels changing with BMI was more obvious than that of females. Conclusions: Our investigation demonstrated that the GGT level in obese Chinese people is significantly higher than that in non-obese people living in Wuhu City. BMI level can be considered as an early warning index for diseases related to liver function injury in the clinic, although the influence of gender difference should be specifically considered.
Language	English
Publishing date	2024-04-07
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	135951-4
ISSN	2354-4716 ; 0172-780X
ISSN (online)	2354-4716
ISSN	0172-780X
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Zs.B 2384: Show issues

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Article ; Online: Effect of fasting glucose levels on carotid intima-media thickness in premenopausal versus postmenopausal women.

Xia, Ren / Fan, Su / Jian, Hu / Lei, Cao / Wendan, Mei / Chenxu, Wang / Yicheng, Fang / Tavengana, Grace / Mingfei, Jiang / Huan, Wu / Yufeng, Wen

Archives of endocrinology and metabolism

2024 Volume 68, Page(s) e230110

Abstract: Objective: To investigate the relationship between fasting blood glucose (FBG) and carotid intimamedia thickness (IMT) in premenopausal and postmenopausal women.: Subjects and methods: The study enrolled 2,959 women seen at the Maanshan People's ... ...

Abstract	Objective: To investigate the relationship between fasting blood glucose (FBG) and carotid intimamedia thickness (IMT) in premenopausal and postmenopausal women. Subjects and methods: The study enrolled 2,959 women seen at the Maanshan People's Hospital of Anhui Province from December 2013 to December 2018. Carotid IMT was measured using Doppler ultrasound. Linear regression and R smoothing curves were used to analyze the relationship between blood glucose level and carotid IMT in the premenopausal and postmenopausal groups. Results: Postmenopausal compared with premenopausal women had higher mean IMT (mIMT; 0.81 ± 0.23 mm versus 0.70 ± 0.14 mm, respectively, p < 0.001) and maximum IMT (maxIMT; 0.86 ± 0.35 mm versus 0.74 ± 0.16 mm, respectively, p < 0.001) values. On linear regression analysis, mIMT values increased with increasing FBG values when FBG level was ≤ 7 mmol/L, but no significance was found between FBG and maxIMT. After stratification by menopausal status, mIMT and maxIMT increased with increasing FBG when FBG was ≤ 7 mmol/L in the premenopausal group. In the postmenopausal group, mIMT and maxIMT increased with increasing FBG. After adjustment for covariate factors, the relationship between FBG and mIMT remained the same as before the adjustment, but when FBG was ≤ 11 mmol/L, the maxIMT increased with increasing FBG. In the stratification analysis, maxIMT increased with increasing FBG when FBG was ≤ 7 mmol/L in the premenopausal group, while both mIMT and maxIMT increased with increasing FBG when FBG was > 10 mmol/L in the postmenopausal group. Conclusion: Levels of FBG contributed more to increased IMT in postmenopausal than premenopausal women. The influence of FBG was greater on maxIMT than mIMT. Additionally, FBG was helpful in assessing focal thickening of the carotid intima.
MeSH term(s)	Humans ; Female ; Carotid Intima-Media Thickness ; Postmenopause ; Blood Glucose ; Premenopause ; Carotid Arteries/diagnostic imaging ; Fasting
Chemical Substances	Blood Glucose
Language	English
Publishing date	2024-03-08
Publishing country	Brazil
Document type	Journal Article
ISSN	2359-4292
ISSN (online)	2359-4292
DOI	10.20945/2359-4292-2023-0110
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Article ; Online: Spatiotemporal characteristics and natural forces of grassland NDVI changes in Qilian Mountains from a sub-basin perspective

Zhu Wang / Yicheng Wang / Yang Liu / Fang Wang / Wei Deng / Pinzeng Rao

Ecological Indicators, Vol 157, Iss , Pp 111186- (2023)

2023

Abstract: The Qilian Mountains (QLMs) encompass a diverse alpine grassland ecosystem undergoing notable changes due to global climate change. Understanding the driving forces behind these changes is crucial for effective regional vegetation restoration and ... ...

Abstract	The Qilian Mountains (QLMs) encompass a diverse alpine grassland ecosystem undergoing notable changes due to global climate change. Understanding the driving forces behind these changes is crucial for effective regional vegetation restoration and management, particularly given the contrasting climatic conditions between the eastern and western regions of the QLMs. This study investigated the spatiotemporal evolution of grassland NDVI and the influence of 13 variables on NDVI changes in six distinct QLM sub-basins from 1990 to 2019 using Landsat data and the Geodetector model, respectively. Results revealed a consistent greening trend in all sub-basins, albeit with varying slopes. Notably, the Qinghai Lake basin exhibited a recent slowdown in NDVI, highlighting the need for enhanced vegetation restoration efforts, especially in permafrost-covered areas. Environmental factors affecting NDVI differed among basins. In the western QLMs, sunshine duration and relative humidity emerged as key factors influencing NDVI distribution, while in the eastern basins, altitude and air temperature played significant roles. This study underscored the importance of hydrothermal conditions, both horizontally and vertically, in shaping grassland NDVI. Other factors, such as vegetation types, soil characteristics, and permafrost degradation, also influenced NDVI, while slope and slope aspects had a limited impact. Furthermore, the research identified threshold-dependent responses of NDVI to the interaction of these factors. These findings emphasized the need to customize vegetation restoration strategies based on the specific environmental conditions of each basin within the QLMs. This nuanced understanding of the distinct driving characteristics between the eastern and western QLMs enables more effective and targeted approaches to restoring and managing grassland ecosystems in this region.
Keywords	Geodetector model ; Driving forces ; Alpine grassland ; Partitioning discrepancy ; Qilian Mountains ; Ecology ; QH540-549.5
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Regulating the Obesity-Related Tumor Microenvironment to Improve Cancer Immunotherapy.

Fang, Huapan / Wu, Yicheng / Chen, Linfu / Cao, Zhiqin / Deng, Zheng / Zhao, Rui / Zhang, Lin / Yang, Yang / Liu, Zhuang / Chen, Qian

ACS nano

2023 Volume 17, Issue 5, Page(s) 4748–4763

Abstract: Obesity usually induces systemic metabolic disturbances, including in the tumor microenvironment (TME). This is because adaptive metabolism related to obesity in the TME with a low level of prolyl hydroxylase-3 (PHD3) depletes the major fatty acid fuels ... ...

Abstract	Obesity usually induces systemic metabolic disturbances, including in the tumor microenvironment (TME). This is because adaptive metabolism related to obesity in the TME with a low level of prolyl hydroxylase-3 (PHD3) depletes the major fatty acid fuels of CD8
MeSH term(s)	Mice ; Animals ; CD8-Positive T-Lymphocytes ; Tumor Microenvironment ; Mice, Obese ; Immunotherapy ; Neoplasms/therapy ; Cell Line, Tumor
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.2c11159
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: miRNA-27b-3p/TPX2 Axis Regulates Clear Cell Renal Cell Carcinoma Cell Proliferation, Invasion and Migration.

Liu, Nana / Jiang, Yicheng / Chen, Shiyuan / Pan, Fang / Tang, Yao / Tan, Xingping

Critical reviews in eukaryotic gene expression

2023 Volume 34, Issue 1, Page(s) 27–39

Abstract: There is a wide variety of cancer cells that can be linked to the presence of TPX2. However, there is not a lot of evidence regarding its role in the development and maintenance of clear cell renal cell carcinoma (ccRCC). In our study, bioinformatics ... ...

Abstract	There is a wide variety of cancer cells that can be linked to the presence of TPX2. However, there is not a lot of evidence regarding its role in the development and maintenance of clear cell renal cell carcinoma (ccRCC). In our study, bioinformatics analysis was performed to obtain differentially expressed mRNAs and miR-NAs in ccRCC. Survival curves predicted correlation of TPX2 expression with patient survival. The upstream regulatory miRNA of TPX2 was predicted to be miRNA-27b-3p through database, and dual luciferase assay verified the targeted relationship. qRT-PCR and Western blot were employed for examination of TPX2 mRNA and protein expression in ccRCC cells. Proliferation, invasion, migration and cell cycle were detected by CCK-8, colony formation, wound healing, Transwell, and flow cytometry assays. The results showed that TPX2 showed very high expression in ccRCC, and patients with higher TPX2 expression had shorter relative survival. Low miRNA-27b-3p expression was found in ccRCC. Knockdown of TPX2 or forced expression of miRNA-27b-3p in ccRCC cells inhibited cell proliferation, migration, invasion, and arrested cell division in G0/G1 phase. Dual luciferase reporter presented that miRNA-27b-3p targeted TPX2 to inhibit its expression. Rescue experiments demonstrated that the miRNA-27b-3p/ TPX2 axis affected the biological functions of ccRCC cells. Concurrent overexpression of miRNA-27b-3p and TPX2 inhibited the facilitating effect of TPX2 on ccRCC cell growth. The results revealed novel regulatory mechanisms involved in ccRCC progression, hoping that it may spark an insight for later discovery about the new therapeutic targets for ccRCC.
MeSH term(s)	Humans ; Carcinoma ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Luciferases ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Microtubule-Associated Proteins/genetics
Chemical Substances	Cell Cycle Proteins ; Luciferases (EC 1.13.12.-) ; MicroRNAs ; Microtubule-Associated Proteins ; TPX2 protein, human ; MIRN27b microRNA, human
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1071345-1
ISSN	1045-4403
ISSN	1045-4403
DOI	10.1615/CritRevEukaryotGeneExpr.2023048827
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Zs.A 3226: Show issues

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Article ; Online: High-multiplex single-cell imaging analysis reveals tumor immune contexture associated with clinical outcomes after CAR T cell therapy.

Jin, Jin / Lin, Li / Meng, Jiao / Jiang, Lijun / Zhang, Man / Fang, Yuekun / Liu, Wanying / Xin, Xiangke / Long, Xiaolu / Kuang, Dong / Ding, Xilai / Zheng, Miao / Zhang, Yicheng / Xiao, Yi / Chen, Liting

Molecular therapy : the journal of the American Society of Gene Therapy

2024

Abstract: Chimeric antigen receptor (CAR) T cell therapy has made great progress in treating lymphoma, yet patient outcomes still vary greatly. The lymphoma microenvironment may be an important factor in the efficacy of CAR T therapy. In this study, we designed a ... ...

Abstract	Chimeric antigen receptor (CAR) T cell therapy has made great progress in treating lymphoma, yet patient outcomes still vary greatly. The lymphoma microenvironment may be an important factor in the efficacy of CAR T therapy. In this study, we designed a highly multiplexed imaging mass cytometry (IMC) panel to simultaneously quantify 31 biomarkers from 13 patients with relapsed/refractory diffuse large B cell lymphoma (DLBCL) who received CAR19/22 T cell therapy. A total of 20 sections were sampled before CAR T cell infusion or after infusion when relapse occurred. A total of 35 cell clusters were identified, annotated, and subsequently redefined into 10 metaclusters. The CD4
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2024.03.023
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Zs.A 5640: Show issues

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Article ; Online: Efficient 3D imaging and pathological analysis of the human lymphoma tumor microenvironment using light-sheet immunofluorescence microscopy.

Chen, Liting / Meng, Jiao / Zhou, Yao / Zhao, Fang / Ma, Yifan / Feng, Wenyang / Chen, Xingyu / Jin, Jin / Gao, Shimeng / Liu, Jianchao / Zhang, Man / Liu, Aichun / Hong, Zhenya / Tang, Jiang / Kuang, Dong / Huang, Liang / Zhang, Yicheng / Fei, Peng

Theranostics

2024 Volume 14, Issue 1, Page(s) 406–419

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Imaging, Three-Dimensional/methods ; Tumor Microenvironment ; Microscopy, Fluorescence/methods ; Fluorescent Antibody Technique ; Lymphoma, Large B-Cell, Diffuse/pathology ; Solvents
Chemical Substances	Solvents
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.86221
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