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  1. Article ; Online: How to Incorporate Religion and Spirituality Into the Medical Curriculum.

    Jain, Raksha / Kassam, Misbah

    Academic medicine : journal of the Association of American Medical Colleges

    2022  Volume 97, Issue 1, Page(s) 8

    MeSH term(s) Curriculum ; Humans ; Religion ; Spiritual Therapies ; Spirituality
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000004456
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    Zs.A 112: Show issues Location:
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  2. Article ; Online: Diagnosing Cystic Fibrosis in Adults: Better Late Than Never.

    Jain, Raksha

    Annals of the American Thoracic Society

    2018  Volume 15, Issue 10, Page(s) 1140–1141

    MeSH term(s) Adult ; Canada ; Cystic Fibrosis ; Humans ; Registries
    Language English
    Publishing date 2018-10-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201806-432ED
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  3. Article ; Online: Cystic Fibrosis: Highly Effective Targeted Therapeutics and the Impact on Sex and Racial Disparities.

    Montemayor, Kristina / Jain, Raksha

    The Medical clinics of North America

    2022  Volume 106, Issue 6, Page(s) 1001–1012

    Abstract: People with Cystic Fibrosis (CF) are living longer and healthier lives due in part to new therapies, called Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulators. However, disparities in outcomes still exist, with females demonstrating a ... ...

    Abstract People with Cystic Fibrosis (CF) are living longer and healthier lives due in part to new therapies, called Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulators. However, disparities in outcomes still exist, with females demonstrating a shorter life expectancy than males; this is opposed to the typical female versus male life expectancy in the general United States population. In addition, minority populations such as those of Hispanic ethnicity and African Americans are less frequently eligible for these new CFTR modulators. The mechanisms driving this difference and the relative contribution of CFTR to the etiology are not yet elucidated.
    MeSH term(s) Male ; Female ; Humans ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis/drug therapy ; Mutation
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215710-x
    ISSN 1557-9859 ; 0025-7125
    ISSN (online) 1557-9859
    ISSN 0025-7125
    DOI 10.1016/j.mcna.2022.07.005
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  4. Article ; Online: Chronic Pancreatitis Associated With a Variant of

    Agarwal, Shubham / Lingvay, Ildiko / Mirfakhraee, Sasan / Jain, Raksha

    AACE clinical case reports

    2023  Volume 9, Issue 3, Page(s) 93–96

    Abstract: Background/objective: Total pancreatectomy is performed for pain relief in chronic pancreatitis. Concomitant autologous islet cell transplantation can be performed to improve glycemic control. We report the case of a patient with chronic pancreatitis ... ...

    Abstract Background/objective: Total pancreatectomy is performed for pain relief in chronic pancreatitis. Concomitant autologous islet cell transplantation can be performed to improve glycemic control. We report the case of a patient with chronic pancreatitis who underwent a total pancreatectomy with autologous islet cell transplantation with increasing insulin requirements and its association with cystic fibrosis transmembrane conductance regulator (CFTR)-related disorder.
    Case report: A 40-year-old woman presented with abdominal pain and had elevated levels of serum lipase. She was treated for acute pancreatitis. In the subsequent 2 years, she had 4 additional episodes of pancreatitis and eventually developed chronic abdominal pain. She underwent total pancreatectomy for pain relief with autologous intrahepatic islet cell transplantation. She experienced repeated episodes of pneumonia and underwent screening for cystic fibrosis, which showed a 7T/7T polymorphic variant at
    Discussion: Chronic pancreatitis can be a manifestation of an undiagnosed CFTR-related disorder, which in this case was followed by total pancreatectomy. Autologous islet cell transplantation was performed with declining postprocedural glycemic control. Interval failure of the transplanted islets is present in up to two thirds of the patients but is not affected by the presence of cystic fibrosis.
    Conclusion: A gradual decline in glycemic control may be expected in patients with autologous islet cell transplantation and can be improved with the use of continuous subcutaneous insulin infusion.
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Case Reports
    ISSN 2376-0605
    ISSN (online) 2376-0605
    DOI 10.1016/j.aace.2023.04.007
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  5. Article ; Online: The modern landscape of fertility, pregnancy, and parenthood in people with cystic fibrosis.

    Jain, Raksha / Kazmerski, Traci M / Taylor-Cousar, Jennifer L

    Current opinion in pulmonary medicine

    2023  Volume 29, Issue 6, Page(s) 595–602

    Abstract: Purpose of review: With improved long-term survival and the expanding availability of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies that treat the underlying genetic defect in cystic fibrosis, more people are interested ... ...

    Abstract Purpose of review: With improved long-term survival and the expanding availability of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies that treat the underlying genetic defect in cystic fibrosis, more people are interested in parenthood. Cystic fibrosis care centers and people with cystic fibrosis need more information to guide decisions related to parenting.
    Recent findings: Here we present currently available data on fertility, pregnancy, and parenthood in the modern era of cystic fibrosis care. Fertility may be improving in female individuals with cystic fibrosis with the use of CFTR modulator therapies, and there is an associated increase in annual pregnancies. Infertility in male individuals with cystic fibrosis remains approximately 97-98% and is unchanged with CFTR modulators in those already born with cystic fibrosis. As more female individuals with cystic fibrosis experience pregnancy, questions remain about the impact of pregnancy on their health and that of their child. Fortunately, there are multiple routes to becoming a parent; however, more work is needed to understand the impact of pregnancy and parenthood in the context of CF as some previous data suggests potential challenges to the health of parents with cystic fibrosis.
    Summary: We encourage cystic fibrosis care teams to have knowledge and resources available to support the reproductive goals of all individuals with cystic fibrosis.
    MeSH term(s) Child ; Pregnancy ; Male ; Humans ; Female ; Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Fertility ; Parents ; Mutation
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000001009
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    Zs.A 4900: Show issues Location:
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  6. Article ; Online: Family Planning and Reproductive Health in Cystic Fibrosis.

    Meiss, Lauren N / Jain, Raksha / Kazmerski, Traci M

    Clinics in chest medicine

    2022  Volume 43, Issue 4, Page(s) 811–820

    Abstract: Family planning in cystic fibrosis (CF) is an increasingly important aspect of care, as improvements in care and outcomes lead to a rise in the number of pregnancies and parenthood in people with CF. This article highlights: (1) Health considerations for ...

    Abstract Family planning in cystic fibrosis (CF) is an increasingly important aspect of care, as improvements in care and outcomes lead to a rise in the number of pregnancies and parenthood in people with CF. This article highlights: (1) Health considerations for people with CF related to pregnancy, contraception, and parenthood. (2) Facets of reproductive planning, fertility, and preconception counseling. (3) Relationship-centered reproductive health discussions.
    MeSH term(s) Pregnancy ; Female ; Humans ; Family Planning Services ; Reproductive Health ; Cystic Fibrosis/complications ; Cystic Fibrosis/therapy
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2022.06.015
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  7. Article ; Online: Menopause in people with cystic fibrosis.

    Prochownik, Katherine / Jain, Raksha / Taylor-Cousar, Jennifer L / Lavage, Daniel R / Stransky, Olivia M / Thomas, Holly N / Kazmerski, Traci M

    Menopause (New York, N.Y.)

    2023  Volume 30, Issue 4, Page(s) 401–405

    MeSH term(s) Female ; Humans ; Cystic Fibrosis/complications ; Menopause ; Hot Flashes
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1205262-0
    ISSN 1530-0374 ; 1072-3714
    ISSN (online) 1530-0374
    ISSN 1072-3714
    DOI 10.1097/GME.0000000000002155
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    Zs.A 4111: Show issues Location:
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  8. Article ; Online: The impact of switching to race-neutral reference equations on FEV

    Rosenfeld, Margaret / Cromwell, Elizabeth A / Schechter, Michael S / Ren, Clement / Flume, Patrick A / Szczesniak, Rhonda D / Morgan, Wayne J / Jain, Raksha

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2024  

    Abstract: Rationale: The American Thoracic Society recommended switching to race-neutral spirometry reference equations, as race is a social construct and to avoid normalizing disparities in lung function due to structural racism. Understanding the impact of the ... ...

    Abstract Rationale: The American Thoracic Society recommended switching to race-neutral spirometry reference equations, as race is a social construct and to avoid normalizing disparities in lung function due to structural racism. Understanding the impact of the race-neutral equations on percent predicted forced expiratory volume in one second (ppFEV
    Objective(s): To quantify the impact of switching from Global Lung Initiative (GLI) 2012 race-specific to GLI 2022 Global race-neutral reference equations on the distribution of ppFEV
    Methods: Cross-sectional analysis of FEV
    Results: With the switch to GLI Global, ppFEV
    Conclusions: Switching from GLI 2012 race-specific reference equations to GLI 2022 Global race-neutral equations will result in larger reductions in ppFEV
    Language English
    Publishing date 2024-03-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2024.03.013
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  9. Article ; Online: Access to Coronavirus Disease 2019 Clinical Trials by English and Non-English Speakers Is Needed.

    Jain, Mamta K / Rollins, Nancy / Jain, Raksha

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 16, Page(s) 2298–2299

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/prevention & control ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa493
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    Zs.MO 480: Show issues

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  10. Article ; Online: The Impact of Highly Effective Cystic Fibrosis Transmembrane Conductance Regulator Modulators on the Health of Female Subjects With Cystic Fibrosis.

    Taylor-Cousar, Jennifer L / Shteinberg, Michal / Cohen-Cymberknoh, Malena / Jain, Raksha

    Clinical therapeutics

    2023  Volume 45, Issue 3, Page(s) 278–289

    Abstract: Cystic fibrosis (CF) is a genetic disorder that occurs in people of all genetic ancestries. CF is caused by variants in the CF transmembrane conductance regulator (CFTR) gene that result in decreased, absent, or nonfunctional CFTR protein at the cell ... ...

    Abstract Cystic fibrosis (CF) is a genetic disorder that occurs in people of all genetic ancestries. CF is caused by variants in the CF transmembrane conductance regulator (CFTR) gene that result in decreased, absent, or nonfunctional CFTR protein at the cell surface of the mucous membranes. Clinical manifestations include chronic respiratory disease, malabsorption, and decreased fertility. Historically, therapies for CF were focused on the signs and symptoms of the disease. However, more recently, CFTR modulators, therapies directed at the basic defect, are improving the quality and duration of the lives of people with CF. The predicted survival of people with CF in the United States is now 53 years of age. With the hope of longer, healthier lives, female individuals with CF (fwCF) are expressing the desire to discuss fertility, pregnancy, and parenthood. Furthermore, pregnancy rates are increasing substantially. Understanding the impact of use or discontinuation of highly effective modulator therapy on the reproductive health of fwCF is critical. Finally, fwCF and their providers must consider preventative cancer screening.
    MeSH term(s) Female ; Humans ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/therapeutic use ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/genetics ; Aminophenols/pharmacology ; Aminophenols/therapeutic use ; Quinolones/therapeutic use ; Mutation
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Aminophenols ; Quinolones
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2023.01.016
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