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Book ; Online ; E-Book: Alternative Splicing and Cancer

Macha, Muzafar Ahmad / Batra, Surinder K. / Bhat, Ajaz A.

2024

Abstract: This book "Alternative Splicing and Cancer" explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. ...

Author's details	edited by Muzafar A. Macha, Ajaz A. Bhat, and Surinder Kumar Batra
Abstract	This book "Alternative Splicing and Cancer" explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer.
Keywords	Genetic engineering ; Tumors/Genetics
Subject code	660.65
Language	English
Size	1 online resource (211 pages) ;, illustrations (some color)
Edition	First edition.
Publisher	CRC Press
Publishing place	Boca Raton, FL
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-003-26039-X ; 1-04-003068-8 ; 9781032196596 ; 978-1-003-26039-4 ; 978-1-04-003068-4 ; 1032196599
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Immuno-oncology crosstalk and metabolism

Macha, Muzafar Ahmad / Bhat, Ajaz Ahmad / Wani, Nissar Ahmad

2022

Author's details	Muzafar Ahmad Macha, Ajaz Ahmad Bhat, and Nissar Ahmad Wani, editors
Keywords	Cancer/Treatment ; Cell metabolism/Mathematical models
Subject code	616.99406
Language	English
Size	1 online resource (223 pages)
Publisher	Springer
Publishing place	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	981-16-6226-6 ; 981-16-6225-8 ; 978-981-16-6225-6 ; 978-981-16-6226-3
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A micelle-mediated approach enables facile access to bridged oxabicyclo[

Wani, Mohmad Muzafar / Rashid, Auqib / Bhat, Bilal A

Organic & biomolecular chemistry

2023 Volume 21, Issue 30, Page(s) 6151–6159

Abstract: Oxabicyclo[ ...

Abstract	Oxabicyclo[
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob00918a
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Article ; Online: Taqashure Jild: Its similarities and differences with psoriasis.

Bhat, Muzafar Din Ahmad

Clinics in dermatology

2021 Volume 39, Issue 3, Page(s) 545–550

Abstract: Taqashure jild (TJ) is an Arabic word for scaling or sloughing of the skin. There are numerous skin diseases included in the Unani system of medicine; several of these diseases may resemble psoriasis, with TJ being the most likely candidate. The classic ... ...

Abstract	Taqashure jild (TJ) is an Arabic word for scaling or sloughing of the skin. There are numerous skin diseases included in the Unani system of medicine; several of these diseases may resemble psoriasis, with TJ being the most likely candidate. The classic literature of the Unani system of medicine, including The Canon of Medicine (Al-Qanun Fittib), Continens Liber (Kitabul Hawi), Hippocratic Treatments (Moalajat Buqratiya), and The Complete Book of the Medical Art (Kamil-u-Sana), have described TJ as a disease characterized by scaling, roughness, and increased thickness due to abnormal melancholic humor (Sawda Ghayr Tabiiyya).
MeSH term(s)	Humans ; Medicine ; Psoriasis/drug therapy ; Skin
Language	English
Publishing date	2021-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1064149-x
ISSN	1879-1131 ; 0738-081X
ISSN (online)	1879-1131
ISSN	0738-081X
DOI	10.1016/j.clindermatol.2021.05.013
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Article ; Online: Efficacy of Aristolochia rotunda Linn in hyperuricemia: A randomised standard controlled study.

Wani, Shabnum Khursheed / Bhat, Muzafar Din Ahmad / Malik, Rabia

Clinical nutrition ESPEN

2023 Volume 57, Page(s) 764–769

Abstract: Introduction: Hyperuricemia (HU) is a health risk that may go undiagnosed and is on the rise in both developed and developing countries. Gout, the most common inflammatory arthritis characterized by painful, disabling acute attack, is widely known to be ...

Abstract	Introduction: Hyperuricemia (HU) is a health risk that may go undiagnosed and is on the rise in both developed and developing countries. Gout, the most common inflammatory arthritis characterized by painful, disabling acute attack, is widely known to be caused by hyperuricemia. Its prevalence ranges from 2.6% to 36% in different populations. The commonly used drugs for alleviating uric acid and gout have obvious side effects, so herbal therapeutic drugs are in high demand. The aim of the present study was to evaluate the efficacy and safety of Aristolochia rotunda Linn in Hyperuricemia. Methods: Present study was designed as a single-blind randomized standard controlled trial with 20 patients in each group. Participants in the test group were administered A. rotunda Linn 4 gms in two divided doses in capsule form and the control group was given Febuxostat 40 mg once daily after meals for 28 days. Participants were asked to follow up weekly for the assessment of subjective parameters. The objective parameter was assessed pre- and post-trial. The results were analysed statistically. Results: After the intervention, the test and control groups showed a statistically significant reduction in serum uric acid p = 0.021 and p < 0.01 respectively, while the reduction in the control group was found to be more statistically significant than the test group (p = 0.009). Subjective parameters also showed statistical significance at the end of the trial. Conclusion: This study shows that the A. rotunda Linn in a dose of 4 gm for 28 days effectively lowers serum uric acid. The trial was registered in the clinical trial registry of India under CTRI No. CTRI//2020/02/031587.
MeSH term(s)	Humans ; Hyperuricemia/drug therapy ; Aristolochia ; Uric Acid ; Single-Blind Method ; Gout/complications ; Gout/drug therapy
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2023-09-02
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2023.08.024
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Article: Deep learning-based identification of esophageal cancer subtypes through analysis of high-resolution histopathology images.

Aalam, Syed Wajid / Ahanger, Abdul Basit / Masoodi, Tariq A / Bhat, Ajaz A / Akil, Ammira S Al-Shabeeb / Khan, Meraj Alam / Assad, Assif / Macha, Muzafar A / Bhat, Muzafar Rasool

Frontiers in molecular biosciences

2024 Volume 11, Page(s) 1346242

Abstract: Esophageal cancer (EC) remains a significant health challenge globally, with increasing incidence and high mortality rates. Despite advances in treatment, there remains a need for improved diagnostic methods and understanding of disease progression. This ...

Abstract	Esophageal cancer (EC) remains a significant health challenge globally, with increasing incidence and high mortality rates. Despite advances in treatment, there remains a need for improved diagnostic methods and understanding of disease progression. This study addresses the significant challenges in the automatic classification of EC, particularly in distinguishing its primary subtypes: adenocarcinoma and squamous cell carcinoma, using histopathology images. Traditional histopathological diagnosis, while being the gold standard, is subject to subjectivity and human error and imposes a substantial burden on pathologists. This study proposes a binary class classification system for detecting EC subtypes in response to these challenges. The system leverages deep learning techniques and tissue-level labels for enhanced accuracy. We utilized 59 high-resolution histopathological images from The Cancer Genome Atlas (TCGA) Esophageal Carcinoma dataset (TCGA-ESCA). These images were preprocessed, segmented into patches, and analyzed using a pre-trained ResNet101 model for feature extraction. For classification, we employed five machine learning classifiers: Support Vector Classifier (SVC), Logistic Regression (LR), Decision Tree (DT), AdaBoost (AD), Random Forest (RF), and a Feed-Forward Neural Network (FFNN). The classifiers were evaluated based on their prediction accuracy on the test dataset, yielding results of 0.88 (SVC and LR), 0.64 (DT and AD), 0.82 (RF), and 0.94 (FFNN). Notably, the FFNN classifier achieved the highest Area Under the Curve (AUC) score of 0.92, indicating its superior performance, followed closely by SVC and LR, with a score of 0.87. This suggested approach holds promising potential as a decision-support tool for pathologists, particularly in regions with limited resources and expertise. The timely and precise detection of EC subtypes through this system can substantially enhance the likelihood of successful treatment, ultimately leading to reduced mortality rates in patients with this aggressive cancer.
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2024.1346242
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Article ; Online: Micelle-guided Morita-Baylis-Hillman reaction of ketones in water.

Wani, Mohmad Muzafar / Dar, Aijaz Ahmad / Bhat, Bilal A

Organic & biomolecular chemistry

2022 Volume 20, Issue 24, Page(s) 4888–4893

Abstract: A novel Morita-Baylis-Hillman reaction employing electron-deficient alkenes like acrylonitrile with a wide range of aryl and aliphatic ketones using cooperative catalysis in micellar media has been delineated. This transformation executed in water under ... ...

Abstract	A novel Morita-Baylis-Hillman reaction employing electron-deficient alkenes like acrylonitrile with a wide range of aryl and aliphatic ketones using cooperative catalysis in micellar media has been delineated. This transformation executed in water under mild reaction conditions in a confined environment of micelles is aligned to the ideas of sustainable and green chemistry. The site of the reaction was established by incisive proton NMR studies in the palisade region of the micellar assembly. This study is expected to encourage the use of micellar catalysis for energetically less favorable chemical reactions.
MeSH term(s)	Acrylonitrile ; Catalysis ; Ketones/chemistry ; Micelles ; Water
Chemical Substances	Ketones ; Micelles ; Water (059QF0KO0R) ; Acrylonitrile (MP1U0D42PE)
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob00638c
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Article ; Online: Outcomes after primary intramedullary nail fixation of open tibial and femoral fractures in low resource settings.

Gani, Muhammad Haseeb / Liang, Kaifeng / Muzafar, Khalid / Dev, Bias / Bhat, Khurshid A / Ghani, Abdul

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

2022 Volume 33, Issue 5, Page(s) 1663–1673

Abstract: Introduction: Open fractures are unique in the urgency they impart to the injury and the therapeutic challenge they pose. Non-union and infection are among the major concerns. Open tibial and femoral shaft fractures are among the commonest orthopaedic ... ...

Abstract	Introduction: Open fractures are unique in the urgency they impart to the injury and the therapeutic challenge they pose. Non-union and infection are among the major concerns. Open tibial and femoral shaft fractures are among the commonest orthopaedic urgencies. Primary intramedullary (IM) nailing requires a skillset and knowledge of the principles of open fracture management and also a well-equipped operating room with the necessary implants and instruments. In a low resource setting, one or more of these prerequisites may not be met, and the outcome may thus be affected similarly. The objective of this study was to study these outcomes. Methods: We prospectively studied primary IM nailing of open 1, 2 and 3A tibial and femoral fractures done in our hospital, in a simple non-modular operating room without an image intensifier. Results: There were 106 fractures in 104 patients: 93 tibial and 13 femoral. The mean time from injury to surgical debridement was 19.6 h. Mean duration of antibiotics therapy was 4.3 days, and the mean duration of hospital stay was 4.1 days. All patients were followed up to union. Mean time to radiographic union was 6.1 months for the tibia and 5.7 months for the femur. Non-union was seen in 4 tibial and 1 femoral fractures. There were 3 superficial infections but no deep infection. Conclusion: The outcomes were comparable to, and in some cases better than, those found in existing literature. We conclude that primary IM nailing in open long bone fractures can be performed in austere environments with good success, in expert hands if the principles are adhered to.
MeSH term(s)	Humans ; Tibia ; Treatment Outcome ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/surgery ; Fracture Fixation, Intramedullary ; Fracture Healing ; Femoral Fractures/surgery ; Fractures, Open/surgery ; Bone Nails
Language	English
Publishing date	2022-07-12
Publishing country	France
Document type	Journal Article
ZDB-ID	1231084-0
ISSN	1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
ISSN (online)	1432-1068
ISSN	1633-8065 ; 0948-4817 ; 0940-3264
DOI	10.1007/s00590-022-03329-5
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Article ; Online: Primary hyperoxaluria: a case series.

Rather, Jawad Iqbal / Rasheed, Rabiya / Wani, Muzafar Maqsood / Bhat, Mohammad Ashraf / Wani, Imtiyaz Ahmad

Journal of medical case reports

2023 Volume 17, Issue 1, Page(s) 421

Abstract: Background: Primary hyperoxaluria (PH) is a rare genetic disorder characterized by the excessive production and accumulation of oxalate. We present five cases of PH, each exhibiting varying manifestations of the disorder including a case presenting as ... ...

Abstract	Background: Primary hyperoxaluria (PH) is a rare genetic disorder characterized by the excessive production and accumulation of oxalate. We present five cases of PH, each exhibiting varying manifestations of the disorder including a case presenting as postpartum kidney failure. Notably, three of these cases involve a previously unreported mutation. Case presentations: We evaluated five Indian patients who presented with varying manifestations of PH. The first case, a 30 year old woman, presented as post-partum kidney failure and was found to be having oxalate nephropathy precipitated by dietary oxalate overload in the setting of previously undiagnosed PH. Genetic analysis revealed a previously unreported mutation in the alanine-glyoxylate aminotransferase gene. The patient underwent simultaneous kidney liver transplant. The second and third cases, 26 and 28 year old women respectively, were asymptomatic siblings of the first patient, who were diagnosed through screening. The fourth case is a 12 year boy with PH type 1 presenting as nephrolithiasis and rapidly worsening kidney function requiring combined kidney liver kidney transplant. Case 5 is a 6 year old male child with type 2 PH presenting with nephrolithiasis, nephrocalcinosis and normal kidney function. All the patients were born to consanguineous parents. Conclusions: Due to limited clinical suspicion and inadequate diagnostic resources in certain countries with limited resources, it is possible for PH to go undiagnosed. The manifestations of the disease can range from no noticeable symptoms to severe disease. Interestingly, in some individuals with primary hyperoxaluria, the disease may not exhibit any symptoms until it is triggered by a high intake of dietary oxalate.
MeSH term(s)	Male ; Child ; Humans ; Female ; Adult ; Hyperoxaluria, Primary/complications ; Hyperoxaluria, Primary/diagnosis ; Hyperoxaluria, Primary/genetics ; Kidney ; Oxalates ; Kidney Calculi ; Renal Insufficiency
Chemical Substances	Oxalates
Language	English
Publishing date	2023-10-07
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-04129-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Melancholia a Psychiatric Disorder Described in Unani System of Medicine

Muzafar Din Bhat / Asgar Nazir / Husain Ahmad / Shabnum Wani / Firdous Najar

Journal of Research on History of Medicine, Vol 12, Iss 1, Pp 27-

Its Similarities and Differences with Depression

2023 Volume 34

Abstract: Melancholia is a Latin transcription of the Greek word melaina chole, which in ancient Greece mainly meant “biliousness,” and was also used, in medical speech “to signify insane or anxious conduct. In Unani system of medicine, Melancholia is classified ... ...

Abstract	Melancholia is a Latin transcription of the Greek word melaina chole, which in ancient Greece mainly meant “biliousness,” and was also used, in medical speech “to signify insane or anxious conduct. In Unani system of medicine, Melancholia is classified into three categories according to the site affected by the disease. Persian scholars, including Rhazes, Ahmad bin Mohammad Tabri, Haly Abbas, and Avicenna, have given a detailed description of this disorder as a disease. Avicenna, in his treatise, The Canon of Medicine (Al-Qanun Fittib) has defined it as a kind of disorder in which imagination and judgment are so perverted that the victims become very sad and fearful. Some surveys were performed on Unani literature about melancholia and depression. The books consulted were mainly The Canon of Medicine (Al-Qanun Fittib), The Complete Book of the Medical Art (Kamil Sana), College (Kitabbul Kulliyat), Kitabul Umda Fil Jarahat, Tib Akbar. This study is constructed on a scrupulous overview of writings, compositions, and publications on melancholia and depression using internet sources like Web of Science, Scopus, PubMed, Google Scholar, Medline. There are numerous similarities between melancholia, a disease described in Unani system of medicine, and present-day depression, described in the conventional system of medicine. There are also a few differences between the two. Unani scholars were aware of psychiatric disorders and the concept is a collaborative effort of both ancient and conventional systems of medicine.
Keywords	melancholia ; depression ; unani system of medicine ; medicatrix naturae ; anxiety ; Medicine ; R ; History of medicine. Medical expeditions ; R131-687
Subject code	001
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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