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Article ; Online: Diagnosis and Treatment of Cerebral Venous Thrombosis.

Liberman, Ava L

Continuum (Minneapolis, Minn.)

2023 Volume 29, Issue 2, Page(s) 519–539

Abstract: Objective: Cerebral venous thrombosis (CVT), thrombosis of the dural sinus, cerebral veins, or both, is a rare cerebrovascular disease. Although mortality rates after CVT have declined over time, this condition can result in devastating neurologic ... ...

Abstract	Objective: Cerebral venous thrombosis (CVT), thrombosis of the dural sinus, cerebral veins, or both, is a rare cerebrovascular disease. Although mortality rates after CVT have declined over time, this condition can result in devastating neurologic outcomes. This article reviews the latest literature regarding CVT epidemiology, details new factors associated with the development of CVT, and describes advances in CVT treatment. It also contains a discussion of future directions in the field, including novel diagnostic imaging modalities, and potential strategies to reduce the risks associated with CVT. Latest developments: The incidence of CVT may be as high as 2 per 100,000 adults per year. It remains a difficult condition to diagnose given its variable clinical manifestations and the necessity of neuroimaging for confirmation. The COVID-19 pandemic has revealed a novel CVT trigger, vaccine-induced immune thrombotic thrombocytopenia (VITT), as well as an association between COVID-19 infection and CVT. Although VITT is a very rare event, timely diagnosis and treatment of CVT due to VITT likely improves patient outcomes. Direct oral anticoagulants are currently being used to treat CVT and emerging data suggest that these agents are as safe and effective as vitamin K antagonists. The role of endovascular therapy to treat CVT, despite a recent clinical trial, remains unproven. Essential points: The incidence of CVT has increased, outcomes have improved, and the use of direct oral anticoagulants to treat CVT represents an important advance in the clinical care of these patients. Rates of CVT as a complication of COVID-19 vaccines using adenoviral vectors are very low (<5 per million vaccine doses administered), with the benefits of COVID-19 vaccination far outweighing the risks.
MeSH term(s)	Adult ; Humans ; Anticoagulants/therapeutic use ; COVID-19/complications ; COVID-19/prevention & control ; COVID-19 Testing ; COVID-19 Vaccines/adverse effects ; Intracranial Thrombosis/diagnosis ; Intracranial Thrombosis/drug therapy ; Pandemics ; Venous Thrombosis/therapy ; Venous Thrombosis/drug therapy
Chemical Substances	Anticoagulants ; COVID-19 Vaccines
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Review ; Journal Article
ISSN	1538-6899
ISSN (online)	1538-6899
DOI	10.1212/CON.0000000000001211
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Article ; Online: The development and validation of the Conscious Objectification Questionnaire.

Liberman, Tamar J / Burke, Natasha L

The International journal of eating disorders

2022 Volume 55, Issue 8, Page(s) 1162–1168

Abstract: Objective: Self-objectification is linked to disordered eating (DE) behaviors in women. However, the awareness of objectification by the self and others, not just the objectifying experiences themselves, may be differentially related to DE. The proposed ...

Abstract	Objective: Self-objectification is linked to disordered eating (DE) behaviors in women. However, the awareness of objectification by the self and others, not just the objectifying experiences themselves, may be differentially related to DE. The proposed study examines the development and validity of the Conscious Objectification Questionnaire (COQ), which seeks to evaluate awareness of objectification by others and intentional self-objectification. Method: In Study 1, 24 participants who identify as women (≥18 years) will provide qualitative feedback on COQ items, and survey items will be updated based on participant feedback. In Study 2, separate participants will complete the COQ and questionnaires assessing DE, self-objectification, and mental health correlates. Exploratory factor analyses will be conducted on the COQ, and reliability and convergent and divergent validity will be assessed. Results: Results will clarify whether the COQ is a reliable and valid instrument that measures the distinct construct of awareness of objectification. Discussion: If proven psychometrically sound, the COQ may be useful for future research on the link between awareness of objectification and disordered eating. Public significance: The novel Conscious Objectification Questionnaire (COQ) assesses the degree to which women recognize and act upon being objectified. The COQ will be reviewed by self-objectification experts and pilot participants before being psychometrically evaluated with data from a larger sample. The COQ is expected to differentially relate to disordered eating above and beyond existing self-objectification measures and accurately represent the distinct construct of conscious awareness of societal and self-objectification.
MeSH term(s)	Body Image/psychology ; Feeding and Eating Disorders/diagnosis ; Female ; Humans ; Reproducibility of Results ; Self Concept ; Surveys and Questionnaires
Language	English
Publishing date	2022-06-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603170-5
ISSN	1098-108X ; 0276-3478
ISSN (online)	1098-108X
ISSN	0276-3478
DOI	10.1002/eat.23759
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Article ; Online: OWL2: a molecular beacon-based nanostructure for highly selective detection of single-nucleotide variations in folded nucleic acids.

Mueller, Brittany L / Liberman, Mark J / Kolpashchikov, Dmitry M

Nanoscale

2023 Volume 15, Issue 12, Page(s) 5735–5742

Abstract: Hybridization probes have been used in the detection of specific nucleic acids for the last 50 years. Despite the extensive efforts and the great significance, the challenges of the commonly used probes include (1) low selectivity in detecting single ... ...

Abstract	Hybridization probes have been used in the detection of specific nucleic acids for the last 50 years. Despite the extensive efforts and the great significance, the challenges of the commonly used probes include (1) low selectivity in detecting single nucleotide variations (SNV) at low (
MeSH term(s)	Nucleic Acids ; Nucleic Acid Hybridization ; Nucleotides ; Oligonucleotide Probes/chemistry ; Nanostructures
Chemical Substances	Nucleic Acids ; Nucleotides ; Oligonucleotide Probes
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d2nr05590b
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Article ; Online: Cardiac monitoring: is longer better?

Liberman, Leonardo / Liberman, Nicole / Silver, Eric S

Kardiologia polska

2021 Volume 79, Issue 2, Page(s) 110–111

MeSH term(s)	Arrhythmias, Cardiac ; Child ; Electrocardiography ; Humans ; Monitoring, Physiologic ; Tachycardia
Language	English
Publishing date	2021-02-25
Publishing country	Poland
Document type	Editorial ; Comment
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.15825
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Article: Block Copolymer Adsorption on the Surface of Multi-Walled Carbon Nanotubes for Dispersion in

Levin, Irena / Radulescu, Aurel / Liberman, Lucy / Cohen, Yachin

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 5

Abstract: This research aims to characterize the adsorption morphology of block copolymer dispersants of the styrene-block-4-vinylpyridine family (S4VP) on the surface of multi-walled carbon nanotubes (MWCNT) in a polar organic solvent, ...

Abstract	This research aims to characterize the adsorption morphology of block copolymer dispersants of the styrene-block-4-vinylpyridine family (S4VP) on the surface of multi-walled carbon nanotubes (MWCNT) in a polar organic solvent,
Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13050838
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Article ; Online: Long-Term Follow-Up of Second-Degree Heart Block in Children.

Epstein, Rebecca / Liberman, Leonardo / Silver, Eric S

Pediatric cardiology

2023 Volume 44, Issue 7, Page(s) 1529–1535

Abstract: Little is known about the outcomes of children with second-degree heart block. We aimed to determine whether children with structurally normal hearts and Mobitz 1, 2:1 block or Mobitz 2 are at increased risk for progressing to complete heart block (CHB) ... ...

Abstract	Little is known about the outcomes of children with second-degree heart block. We aimed to determine whether children with structurally normal hearts and Mobitz 1, 2:1 block or Mobitz 2 are at increased risk for progressing to complete heart block (CHB) or requiring a pacemaker (PM) at long-term follow-up. We searched our institutional electrophysiology database for children with potentially concerning second-degree block on ambulatory rhythm monitoring between 2009 and 2021, defined as frequent episodes of Mobitz 1 or 2:1 block, episodes of Mobitz 1 or 2:1 block with additional evidence of conduction disease (i.e. first-degree heart block, bundle branch block), or episodes of Mobitz 2. Ambulatory rhythm monitor, ECG, and demographic data were reviewed. The primary composite outcome was CHB on follow-up rhythm monitor or PM placement. 20 patients were in the final analysis. Six (30%) patients either developed CHB but do not have a PM (4 = 20%) or have a PM (2 = 10%). Median follow-up was 5.8 years (IQR 4.4-7.0). Patients with CHB or PM were more likely to have second-degree block at maximum sinus rate (67% vs. 0%, p = 0.003), a below normal average heart rate (67% vs. 14%, p = 0.04), and 2:1 block on initial ECG (50% vs. 0%, p = 0.02). In this study of children with potentially concerning second-degree block, 30% of patients progressed to CHB or required a PM. Second-degree block at maximum sinus rate, a low average heart, and 2:1 block on initial ECG were associated with increased risk of disease progression.
MeSH term(s)	Humans ; Child ; Follow-Up Studies ; Atrioventricular Block ; Cardiac Conduction System Disease ; Heart ; Bundle-Branch Block/diagnosis ; Bundle-Branch Block/therapy
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-023-03195-w
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Article ; Online: Shared social groups or shared experiences? The effect of shared knowledge on children's perspective-taking.

Anderson, Laura / Liberman, Zoe / Martin, Alia

Journal of experimental child psychology

2023 Volume 234, Page(s) 105707

Abstract: Although the ability to consider others' visual perspectives to interpret ambiguous communication emerges during childhood, people sometimes fail to attend to their partner's perspective. Two studies investigated whether 4- to 6-year-olds show a " ... ...

Abstract	Although the ability to consider others' visual perspectives to interpret ambiguous communication emerges during childhood, people sometimes fail to attend to their partner's perspective. Two studies investigated whether 4- to 6-year-olds show a "closeness-communication bias" in their consideration of a partner's perspective in a communication task. Participants played a game that required them to take their partner's visual perspective in order to interpret an ambiguous instruction. If children, like adults, perform worse when they overestimate the extent to which their perspective is aligned with that of a partner, then they should make more perspective-taking errors when interacting with a socially close partner compared with a more socially distant partner. In Study 1, social closeness was based on belonging to the same social group. In Study 2, social closeness was based on caregiving, a long-standing social relationship with a close kinship bond. Although social group membership did not affect children's consideration of their partner's perspective, children did make more perspective-taking errors when interacting with a close caregiver compared with a novel experimenter. These findings suggest that close personal relationships may be more likely to lead children to overestimate perspective alignment and hinder children's perspective-taking than shared social group membership, and they highlight important questions about the mechanisms underlying the effects of partner characteristics in perspective-taking tasks.
MeSH term(s)	Adult ; Humans ; Child ; Social Group ; Interpersonal Relations ; Communication ; Theory of Mind
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218137-x
ISSN	1096-0457 ; 0022-0965
ISSN (online)	1096-0457
ISSN	0022-0965
DOI	10.1016/j.jecp.2023.105707
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Article ; Online: Haematophagous parasites of some fish species in the Lower Irtysh

Е. L. Liberman

Российский паразитологический журнал, Vol 15, Iss 3, Pp 23-

2021 Volume 31

Abstract: The purpose of the research is study of four fish species infected with haematophagous parasites in the rivers of the Lower Irtysh basin. Materials and methods. The work was performed in the rivers of the Lower Irtysh basin in 2017–2020. A total of 390 ... ...

Abstract	The purpose of the research is study of four fish species infected with haematophagous parasites in the rivers of the Lower Irtysh basin. Materials and methods. The work was performed in the rivers of the Lower Irtysh basin in 2017–2020. A total of 390 fish of different sex and age were examined including 47 roach (Rutilus rutilus lacustris, (Pallas)), 41 ide (Leuciscus idus, (Linnaeus, 1758)), 47 pike (Esox lucius, (Linnaeus, 1758)) and 255 Siberian sterlet (Acipenser ruthenus marsiglii (Brandt, 1833)). We took blood from the tail artery, and examined its fresh drop under a microscope, and prepared a thin smear, then dried it in the air and fixed in a mixture of 70% ethyl alcohol and diethyl ether (1 : 1) for 30 minutes. The fixed smears were dried in the air at room temperature and stained with azure and eosin at a dilution of 1 : 10 for 40 minutes. We identified species of the found parasites and calculated the prevalence of infection with standard error of the mean.Results and discussion. We found representatives of the Coccidea and Kinetoplastea classes parasitizing in fish blood. Trypanoplasma acipenseris and Haemogregarina acipenseris were recorded in the Siberian sterlet. The pike was infected with T. schulmani and H. esoci. T. schulmani was found in the blood of the ide and roach. Piscicola geometra is the main host of flagellates and sporozoans that parasitize in fish blood in the basin of the Lower Irtysh. The roach and the Siberian sterlet become infected with parasitic flagellates from the age of 1+. All examined fish were infected in age groups 2+ – 4+. Haemogregarina parasitize in the pike aged 4+ and 5+, and in the Siberian sterlet aged 1+ – 4+ and 6+ – 7+.
Keywords	infection ; age dynamics ; ide ; roach ; siberian sterlet ; pike ; lower irtysh ; Biology (General) ; QH301-705.5
Subject code	590
Language	Russian
Publishing date	2021-09-01T00:00:00Z
Publisher	Federal Scientific Centre VIEV
Document type	Article ; Online
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Article ; Online: Long-term outcomes of tricuspid valve intervention during stage 2 palliation in patients with a single right ventricle.

Smerling, Jennifer L / Goldstone, Andrew B / Bacha, Emile A / Liberman, Leonardo

The Journal of thoracic and cardiovascular surgery

2023 Volume 166, Issue 4, Page(s) 1200–1209.e3

Abstract: Objectives: In patients with single ventricle physiology and a systemic right ventricle, tricuspid valve regurgitation increases the risk of adverse outcomes, and tricuspid valve intervention at the time of staged palliation further increases that risk ... ...

Abstract	Objectives: In patients with single ventricle physiology and a systemic right ventricle, tricuspid valve regurgitation increases the risk of adverse outcomes, and tricuspid valve intervention at the time of staged palliation further increases that risk in the postoperative period. However, long-term outcomes of valve intervention in patients with significant regurgitation during stage 2 palliation have not been established. The purpose of this study is to evaluate the long-term outcomes after tricuspid valve intervention during stage 2 palliation in patients with right ventricular dominant circulation in a multicenter study. Methods: The study was performed using the Single Ventricle Reconstruction Trial and Single Ventricle Reconstruction Follow-up 2 Trial datasets. Survival analysis was performed to describe the association among valve regurgitation, intervention, and long-term survival. Cox proportional hazards modeling was used to estimate the longitudinal association of tricuspid intervention and transplant-free survival. Results: Patients with tricuspid regurgitation at stage 1 or 2 had worse transplant-free survival (hazard ratio, 1.61; 95% confidence interval, 1.12-2.32; hazard ratio, 2.3; 95% confidence interval 1.39-3.82). Those with regurgitation who underwent concomitant valve intervention at stage 2 were significantly more likely to die or undergo heart transplantation compared with those with regurgitation who did not (hazard ratio, 2.93; confidence interval, 2.16-3.99). Patients with tricuspid regurgitation at the time of the Fontan had favorable outcomes regardless of valve intervention. Conclusions: The risks associated with tricuspid regurgitation in patients with single ventricle physiology do not appear to be mitigated by valve intervention at the time of stage 2 palliation. Patients who underwent valve intervention for tricuspid regurgitation at stage 2 had significantly worse survival compared with patients with tricuspid regurgitation who did not.
MeSH term(s)	Humans ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Tricuspid Valve Insufficiency ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/surgery ; Univentricular Heart ; Heart Transplantation ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2023.05.014
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Article: Continuous Compartment Pressure Monitoring Allows the Early Detection of Compartment Syndrome After Arterial Revascularization.

Schupbach, Drew / Reindl, Rudy / Gill, Heather L / Liberman, A S / Harvey, Edward J

Cureus

2024 Volume 16, Issue 3, Page(s) e55451

Abstract: Compartment syndrome (CS) occurs in several clinical scenarios. Reperfusion injury and tissue swelling are common causes. This can occur after trauma but also is seen post revascularization of extremities. CS is a difficult diagnosis to make in a timely ... ...

Abstract	Compartment syndrome (CS) occurs in several clinical scenarios. Reperfusion injury and tissue swelling are common causes. This can occur after trauma but also is seen post revascularization of extremities. CS is a difficult diagnosis to make in a timely fashion that avoids permanent tissue damage. The treatment for CS is immediate fasciotomy, but fasciotomy is not a complication-free procedure. Previous care pathways usually resulted in fasciotomy being performed in a disproportionate number of normal legs. These false positives and prophylactic releases are costly to the health system because of protracted hospital stays and increased surgery numbers. The desirable tool for surgeons would be one that decreases false positives and negatives while ensuring a diagnosis in a timely fashion with true positives. A new technology that allows continuous pressure monitoring seems to be the best aid to make a diagnosis. We present our experience in decreasing the time to diagnosis in a CS case post revascularization despite the neurological blockade.
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.55451
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