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Article ; Online: Amomum tsao-ko

Liu, Ju-Zhao / Lyu, Hong-Chang / Fu, Yu-Jie / Cui, Qi

Arabian journal of chemistry

2022 Volume 15, Issue 7, Page(s) 103916

Abstract: Since the outbreak of COVID-19, this virus has been constantly mutating. The latest mutant Omicron has been identified as VOC by WHO. The main reason for its concern is the mutation of 46 amino acids in spike protein, which has brought the global ... ...

Abstract	Since the outbreak of COVID-19, this virus has been constantly mutating. The latest mutant Omicron has been identified as VOC by WHO. The main reason for its concern is the mutation of 46 amino acids in spike protein, which has brought the global epidemic prevention into another difficulty. Herbal aromatic plant
Language	English
Publishing date	2022-04-18
Publishing country	Saudi Arabia
Document type	Journal Article
ISSN	1878-5379
ISSN (online)	1878-5379
DOI	10.1016/j.arabjc.2022.103916
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: High-throughput base editing KO screening of cellular factors for enhanced GBE.

Yang, Jie / Zhao, Dongdong / Zhu, Xiagu / Yang, Yuanzhao / Li, Bo / Li, Siwei / Bi, Chang-Hao / Zhang, Xue-Li

Journal of genetics and genomics = Yi chuan xue bao

2023 Volume 50, Issue 8, Page(s) 611–614

MeSH term(s)	Gene Editing
Language	English
Publishing date	2023-05-25
Publishing country	China
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2374568-X
ISSN	1873-5533 ; 1673-8527
ISSN (online)	1873-5533
ISSN	1673-8527
DOI	10.1016/j.jgg.2023.05.007
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Article ; Online: Exoasota pursatensis Ko amp; Bae, new genus and species of the Spilomelinae (Lepidoptera: Pyraloidea: Crambidae) from Indochina.

Ko, Jae-Ho / Bayarsaikhan, Ulziijargal / Park, Bo-Sun / Lee, Tak-Gi / Cha, Yeong-Bin / Jang, Chang-Moon / Lee, Jong Koo / Bae, Yang-Seop

Zootaxa

2020 Volume 4838, Issue 1, Page(s) zootaxa.4838.1.6

Abstract: Exoasota pursatensis Ko Bae, gen. nov. sp. nov. (Lepidoptera: Pyraloidea: Crambidae) is described ...

Abstract	Exoasota pursatensis Ko Bae, gen. nov. sp. nov. (Lepidoptera: Pyraloidea: Crambidae) is described from Indochina (Cambodia, Thailand, Vietnam, Myanmar). The new genus Exoasota is assigned to Spilomelinae on the basis of the morphological evidence, including the tympanal organs and genitalia. In addition, we provide comparisons with genera Epiparbattia Caradja (Crambidae, Pyraustinae) and Asota Hübner (Erebidae, Aganainae). Illustrations of adults, genitalia, and tympanal characters are provided.
MeSH term(s)	Animals ; Indochina ; Lepidoptera
Language	English
Publishing date	2020-08-25
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4838.1.6
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Article ; Online: Amomum tsao-ko essential oil, a novel anti-COVID-19 Omicron spike protein natural products

Ju-Zhao Liu / Hong-Chang Lyu / Yu-Jie Fu / Qi Cui

Arabian Journal of Chemistry, Vol 15, Iss 7, Pp 103916- (2022)

A computational study

2022

Abstract: ... aromatic plant Amomum tsao-ko was excavated from formula 1 and 2 for the treatment of COVID-19 in China, and ... A. tsao-ko essential oil (AEO) and RBDOmicron. The AEO components were analyzed and identified by GC/Q-TOF ...

Abstract	Since the outbreak of COVID-19, this virus has been constantly mutating. The latest mutant Omicron has been identified as VOC by WHO. The main reason for its concern is the mutation of 46 amino acids in spike protein, which has brought the global epidemic prevention into another difficulty. Herbal aromatic plant Amomum tsao-ko was excavated from formula 1 and 2 for the treatment of COVID-19 in China, and its active components were extracted and identified. Molecular dynamics simulation and Fpocket were applied to find the key sites on RBDOmicron, and molecular docking was also used to reveal the interaction between A. tsao-ko essential oil (AEO) and RBDOmicron. The AEO components were analyzed and identified by GC/Q-TOF MS. There were 20 kinds of AEO with a relative area percentage of more than 1%, and they were related to the three active centres of RBDOmicron. In this study, virtual screening was used to mine the essential oil components of medicinal plants, and it was found that the components could interact with the spike protein RBD in aerosol to block the interaction of RBD and hACE2, thus cutting off the transmission route and protecting the host. This study has certain guiding significance in the modernization of Traditional Chinese medicine and the prevention of COVID-19.
Keywords	Amomum tsao-ko essential oil ; SARS-CoV-2 ; Omicron ; RBD ; Molecular dynamics ; Molecular docking ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Tsaokopyranols A-M, 2,6-epoxydiarylheptanoids from Amomum tsao-ko and their α-glucosidase inhibitory activity.

He, Xiao-Feng / Zhang, Xu-Ke / Geng, Chang-An / Hu, Jing / Zhang, Xue-Mei / Guo, Yuan-Qiang / Chen, Ji-Jun

Bioorganic chemistry

2020 Volume 96, Page(s) 103638

Abstract: The dried fruits of Amomum tsao-ko are well-known dietary spices and traditional Chinese medicines ... The random screen revealed that 50% ethanol-water extract of A. tsao-ko demonstrated significant α ...

Abstract	The dried fruits of Amomum tsao-ko are well-known dietary spices and traditional Chinese medicines. The random screen revealed that 50% ethanol-water extract of A. tsao-ko demonstrated significant α-glucosidase inhibitory activity with an IC
MeSH term(s)	Amomum/chemistry ; Diabetes Mellitus/drug therapy ; Diarylheptanoids/chemistry ; Diarylheptanoids/isolation & purification ; Diarylheptanoids/pharmacology ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Fruit/chemistry ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/isolation & purification ; Glycoside Hydrolase Inhibitors/pharmacology ; Humans ; Kinetics ; alpha-Glucosidases/metabolism
Chemical Substances	Diarylheptanoids ; Drugs, Chinese Herbal ; Glycoside Hydrolase Inhibitors ; alpha-Glucosidases (EC 3.2.1.20)
Language	English
Publishing date	2020-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2020.103638
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Article ; Online: Amomutsaokols A-K, diarylheptanoids from Amomum tsao-ko and their α-glucosidase inhibitory activity.

He, Xiao-Feng / Wang, Hui-Mei / Geng, Chang-An / Hu, Jing / Zhang, Xue-Mei / Guo, Yuan-Qiang / Chen, Ji-Jun

Phytochemistry

2020 Volume 177, Page(s) 112418

Abstract: ... were isolated from the active fraction of the fruits of Amomum tsao-ko. The structures ...

Abstract	Eleven undescribed diarylheptanoids, amomutsaokols A‒K (1-11), together with 13 known ones (13-24), were isolated from the active fraction of the fruits of Amomum tsao-ko. The structures of the undescribed compounds were determined by extensive 1D and 2D NMR, HRESIMS and ECD calculations. Compounds 3-5, 7, 8, 12, 14 and 19 showed obviously α-glucosidase inhibitory activity with IC
MeSH term(s)	Amomum ; Diarylheptanoids ; Glycoside Hydrolase Inhibitors ; Kinetics ; alpha-Glucosidases
Chemical Substances	Diarylheptanoids ; Glycoside Hydrolase Inhibitors ; alpha-Glucosidases (EC 3.2.1.20)
Language	English
Publishing date	2020-07-15
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2020.112418
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Article: The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and α-glucosidase dual inhibitors

He, Xiao-Feng / Chen, Ji-Jun / Huang, Xiao-Yan / Hu, Jing / Zhang, Xu-Ke / Guo, Yuan-Qiang / Zhang, Xue-Mei / Geng, Chang-An

Industrial crops and products. 2021 Feb., v. 160

2021

Abstract: Amomum tsao-ko is an important crop widely cultivated in China, whose dried fruits are popularly ... consumed as foods and medicines. In this study, the EtOH extract of the fruits of A. tsao-ko was first ... conjugates, amomutsaokins A–H (1-8), together with ten known phenolics (9-18), were isolated from A. tsao-ko ...

Abstract	Amomum tsao-ko is an important crop widely cultivated in China, whose dried fruits are popularly consumed as foods and medicines. In this study, the EtOH extract of the fruits of A. tsao-ko was first revealed with PTP1B selective inhibition. Under the guidance of bioassay, eight rare flavanol-menthane conjugates, amomutsaokins A–H (1-8), together with ten known phenolics (9-18), were isolated from A. tsao-ko. Their structures including absolute configurations were elucidated by extensive spectroscopic data (1D and 2D NMR, HRESIMS, IR and UV) and ECD calculations. Their antidiabetic potency against three diabetes-related proteins (PTP1B, TCPTP, and α-glucosidase) was evaluated, of which compounds 2, 3, 6, 14, and 16 exhibited PTP1B selective inhibition with IC₅₀ values of 201.45–317.51 μM, and compounds 1-3, 5-8, 10, and 16-18 displayed α-glucosidase inhibitory activity with IC₅₀ values ranging from 3.73 to 76.23 μM. Compounds 1 and 6 were demonstrated to be α-glucosidase mixed-type inhibitors with Kᵢ values of 36.2 and 24.4 μM, respectively. Molecular docking suggested that compounds 1 and 6 were well located into the active site of α-glucosidase by interacting with W1355, W1369, K1460, F1559, H1584, and D1279 residues. This study enlightens the therapeutic potential of A. tsao-ko for the treatment of diabetes, as well as searching for new antidiabetic candidates from natural sources.
Keywords	Amomum tsao-ko ; active sites ; bioassays ; diabetes ; flavanols ; phenolic compounds ; spectral analysis ; therapeutics ; China
Language	English
Dates of publication	2021-02
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2020.112908
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds.

Morris, Aaron H / Stamer, Danielle K / Kunkemoeller, Britta / Chang, Julie / Xing, Hao / Kyriakides, Themis R

Biomaterials

2018 Volume 169, Page(s) 61–71

Abstract: ... Specifically, we utilized skin from thrombospondin (TSP)-2 KO mice to derive various decellularized products ... Scanning electron microscopy and mechanical testing showed that TSP-2 KO ADM exhibited an altered structure and a reduction ... in elastic modulus and ultimate tensile strength, respectively. When a powdered form of KO ADM was implanted ...

Abstract	Decellularized biologic scaffolds are gaining popularity over synthetic biomaterials as naturally derived materials capable of promoting improved healing. Nevertheless, the most widely used biologic material - acellular dermal matrix (ADM) - exhibits slow repopulation and remodeling, which prevents integration. Additionally, engineering control of these materials is limited because they require a natural source for their production. In the current report, we demonstrate the feasibility of using genetically engineered animals to create decellularized biologic scaffolds with favorable extracellular matrix (ECM) properties. Specifically, we utilized skin from thrombospondin (TSP)-2 KO mice to derive various decellularized products. Scanning electron microscopy and mechanical testing showed that TSP-2 KO ADM exhibited an altered structure and a reduction in elastic modulus and ultimate tensile strength, respectively. When a powdered form of KO ADM was implanted subcutaneously, it was able to promote enhanced vascularization over WT. Additionally, when implanted subcutaneously, intact slabs of KO ADM were populated by higher number of host cells when compared to WT. In vitro studies confirmed the promigratory properties of KO ADM. Specifically, degradation products released by pepsin digestion of KO ADM induced greater cell migration than WT. Moreover, cell-derived ECM from TSP-2 null fibroblasts was more permissive to fibroblast migration. Finally, ADMs were implanted in a diabetic wound model to examine their ability to accelerate wound healing. KO ADM exhibited enhanced remodeling and vascular maturation, indicative of efficient integration. Overall, we demonstrate that genetic manipulation enables engineered ECM-based materials with increased regenerative potential.
MeSH term(s)	3T3 Cells ; Acellular Dermis/metabolism ; Animals ; Diabetes Mellitus, Experimental/physiopathology ; Gene Knockdown Techniques ; Mice ; Neovascularization, Pathologic ; Thrombospondins/genetics ; Thrombospondins/metabolism ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry ; Wound Healing
Chemical Substances	Thrombospondins ; thrombospondin 2
Keywords	covid19
Language	English
Publishing date	2018-03-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2018.03.049
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Article: Amomutsaokols A–K, diarylheptanoids from Amomum tsao-ko and their α-glucosidase inhibitory activity

He, Xiao-Feng / Wang, Hui-Mei / Geng, Chang-An / Hu, Jing / Zhang, Xue-Mei / Guo, Yuan-Qiang / Chen, Ji-Jun

Phytochemistry. 2020 Sept., v. 177

2020

Abstract: ... were isolated from the active fraction of the fruits of Amomum tsao-ko. The structures ... diarylheptanoids as the active constituents of A. tsao-ko with α-glucosidase inhibitory effects. ...

Abstract	Eleven undescribed diarylheptanoids, amomutsaokols A‒K (1–11), together with 13 known ones (13–24), were isolated from the active fraction of the fruits of Amomum tsao-ko. The structures of the undescribed compounds were determined by extensive 1D and 2D NMR, HRESIMS and ECD calculations. Compounds 3–5, 7, 8, 12, 14 and 19 showed obviously α-glucosidase inhibitory activity with IC₅₀ values ranging from 12.9 to 48.8 μM. An enzyme kinetic analysis indicated that compounds 8 and 9 were α-glucosidase noncompetitive inhibitors with Kᵢ values of 18.5 and 213.0 μM, respectively. This study supported diarylheptanoids as the active constituents of A. tsao-ko with α-glucosidase inhibitory effects.
Keywords	Amomum tsao-ko ; enzyme kinetics ; fruits ; kinetics ; plant biochemistry
Language	English
Dates of publication	2020-09
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-light
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2020.112418
Database	NAL-Catalogue (AGRICOLA)

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Article: Nineteen New Flavanol–Fatty Alcohol Hybrids with α-Glucosidase and PTP1B Dual Inhibition: One Unusual Type of Antidiabetic Constituent from Amomum tsao-ko

He, Xiao-Feng / Chen, Ji-Jun / Li, Tian-Ze / Zhang, Xu-Ke / Guo, Yuan-Qiang / Zhang, Xue-Mei / Hu, Jing / Geng, Chang-An

Journal of agricultural and food chemistry. 2020 Sept. 23, v. 68, no. 41

2020

Abstract: The dried fruits of Amomum tsao-ko were first revealed to have hypoglycemic effects on db/db mice ...

Abstract	The dried fruits of Amomum tsao-ko were first revealed to have hypoglycemic effects on db/db mice at a concentration of 200 mg/kg. In order to clarify the antidiabetic constituents, 19 new flavanol–fatty alcohol hybrids, tsaokoflavanols A–S (1–19), were isolated and determined by extensive spectroscopic data and ECD calculations. Most of the compounds showed α-glucosidase and PTP1B dual inhibition, among which 1, 2, 6, 11, and 18 exhibited obvious activity against α-glucosidase with IC₅₀ values of 5.2–9.0 μM, 20–35 times stronger than that of acarbose (IC₅₀, 180.0 μM); meanwhile, 6, 10–12, and 19 were PTP1B/TCPTP-selective inhibitors with IC₅₀ values of 56.4–80.4 μM, 2–4 times stronger than that of suramin sodium (IC₅₀, 200.5 μM). Enzyme kinetics study indicated that compounds 1, 2, 6, and 11 were α-glucosidase and PTP1B mixed-type inhibitors with Kᵢ values of 13.0, 11.7, 2.9, and 5.3 μM and 142.3, 88.9, 39.2, and 40.8 μM, respectively. Docking simulations proved the importance of hemiacetal hydroxy, the orientation of 3,4-dihydroxyphenyl, and the length of alkyl in binding with α-glucosidase and PTP1B.
Keywords	Amomum tsao-ko ; acarbose ; alcohols ; enzyme kinetics ; food chemistry ; sodium ; spectral analysis ; suramin
Language	English
Dates of publication	2020-0923
Size	p. 11434-11448.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.0c04615
Database	NAL-Catalogue (AGRICOLA)

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