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Article ; Online: Language in autism: domains, profiles and co-occurring conditions.

Journal of neural transmission (Vienna, Austria : 1996)

2023 Volume 130, Issue 3, Page(s) 433–457

Abstract: This article reviews the current knowledge state on pragmatic and structural language abilities in autism and their potential relation to extralinguistic abilities and autistic traits. The focus is on questions regarding autism language profiles with ... ...

Abstract	This article reviews the current knowledge state on pragmatic and structural language abilities in autism and their potential relation to extralinguistic abilities and autistic traits. The focus is on questions regarding autism language profiles with varying degrees of (selective) impairment and with respect to potential comorbidity of autism and language impairment: Is language impairment in autism the co-occurrence of two distinct conditions (comorbidity), a consequence of autism itself (no comorbidity), or one possible combination from a series of neurodevelopmental properties (dimensional approach)? As for language profiles in autism, three main groups are identified, namely, (i) verbal autistic individuals without structural language impairment, (ii) verbal autistic individuals with structural language impairment, and (iii) minimally verbal autistic individuals. However, this tripartite distinction hides enormous linguistic heterogeneity. Regarding the nature of language impairment in autism, there is currently no model of how language difficulties may interact with autism characteristics and with various extralinguistic cognitive abilities. Building such a model requires carefully designed explorations that address specific aspects of language and extralinguistic cognition. This should lead to a fundamental increase in our understanding of language impairment in autism, thereby paving the way for a substantial contribution to the question of how to best characterize neurodevelopmental disorders.
MeSH term(s)	Humans ; Autistic Disorder/complications ; Autistic Disorder/epidemiology ; Cognition ; Comorbidity ; Language Development Disorders/complications ; Language Development Disorders/epidemiology
Language	English
Publishing date	2023-03-16
Publishing country	Austria
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	184163-4
ISSN	1435-1463 ; 0300-9564
ISSN (online)	1435-1463
ISSN	0300-9564
DOI	10.1007/s00702-023-02592-y
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Article ; Online: Toxicity-related antiretroviral drug treatment modifications in individuals starting therapy: a cohort analysis of time patterns, sex, and other risk factors.

Perović Mihanović, Marta / Haque, Najm S / Rutherford, George W / Zekan, Šime / Begovac, Josip

Medical science monitor : international medical journal of experimental and clinical research

2013 Volume 19, Page(s) 483–492

Abstract: Background: Modifications to combination antiretroviral drug therapy (CART) regimens can occur for a number of reasons, including adverse drug effects. We investigated the frequency of and reasons for antiretroviral drug modifications (ADM) during the ... ...

Abstract	Background: Modifications to combination antiretroviral drug therapy (CART) regimens can occur for a number of reasons, including adverse drug effects. We investigated the frequency of and reasons for antiretroviral drug modifications (ADM) during the first 3 years after initiation of CART, in a closed cohort of CART-naïve adult patients who started treatment in the period 1998-2007 in Croatia. Material and methods: We calculated differential toxicity rates by the Poisson method. In multivariable analysis, we used a discrete-time regression model for repeated events for the outcome of modification due to drug toxicity. Results: Of 321 patients who started CART, median age was 40 years, 19% were women, baseline CD4 was <200 cells/mm3 in 71%, and viral load was ≥100 000 copies/mL in 69%. Overall, 220 (68.5%) patients had an ADM; 124 (56%) of these had ≥1 ADM for toxicity reasons. Only 12.7% of individuals starting CART in the period 1998-2002 and 39.4% in the period 2003-2007 remained on the same regimen after 3 years. The following toxicities caused ADM most often: lipoatrophy (22%), gastrointestinal symptoms (20%), and neuropathy (18%). Only 5% of drug changes were due to virologic failure. Female sex (hazard ratio [HR], 2.42 95%; confidence intervals, 1.39-4.24) and older age (HR, 1.42 per every 10 years) were associated with toxicity-related ADM in the first 3 months of a particular CART regimen, but after 3 months of CART they were not. Conclusions: Less toxic and better-tolerated HIV treatment options should be available and used more frequently in Croatia.
MeSH term(s)	Adult ; Anti-HIV Agents/adverse effects ; Anti-HIV Agents/therapeutic use ; Cohort Studies ; Drug Therapy, Combination ; Female ; HIV Infections/drug therapy ; HIV Infections/virology ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Risk Factors ; Sex Characteristics ; Time Factors ; Treatment Outcome
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2013-06-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.889283
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Article ; Online: Comparison of four international cardiovascular disease prediction models and the prevalence of eligibility for lipid lowering therapy in HIV infected patients on antiretroviral therapy.

Begovac, Josip / Dragović, Gordana / Višković, Klaudija / Kušić, Jovana / Perović Mihanović, Marta / Lukas, Davorka / Jevtović, Đorđe

Croatian medical journal

2015 Volume 56, Issue 1, Page(s) 14–23

Abstract: Aim: To compare four cardiovascular disease (CVD) risk models and to assess the prevalence of eligibility for lipid lowering therapy according to the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines, European AIDS ... ...

Abstract	Aim: To compare four cardiovascular disease (CVD) risk models and to assess the prevalence of eligibility for lipid lowering therapy according to the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines, European AIDS Clinical Society Guidelines (EACS), and European Society of Cardiology and the European Atherosclerosis Society (ESC/EAS) guidelines for CVD prevention in HIV infected patients on antiretroviral therapy. Methods: We performed a cross-sectional analysis of 254 consecutive HIV infected patients aged 40 to 79 years who received antiretroviral therapy for at least 12 months. The patients were examined at the HIV-treatment centers in Belgrade and Zagreb in the period February-April 2011. We compared the following four CVD risk models: the Framingham risk score (FRS), European Systematic Coronary Risk Evaluation Score (SCORE), the Data Collection on Adverse Effects of Anti-HIV Drugs study (DAD), and the Pooled Cohort Atherosclerotic CVD risk (ASCVD) equations. Results: The prevalence of current smoking was 42.9%, hypertension 31.5%, and hypercholesterolemia (>6.2 mmol/L) 35.4%; 33.1% persons were overweight, 11.8% were obese, and 30.3% had metabolic syndrome. A high 5-year DAD CVD risk score (>5%) had substantial agreement with the elevated (≥7.5%) 10-year ASCVD risk equation score (kappa=0.63). 21.3% persons were eligible for statin therapy according to EACS (95% confidence intervals [CI], 16.3% to 27.4%), 25.6% according to ESC/EAS (95% CI, 20.2% to 31.9%), and 37.9% according to ACC/AHA guidelines (95% CI, 31.6 to 44.6%). Conclusion: In our sample, agreement between the high DAD CVD risk score and other CVD high risk scores was not very good. The ACC/AHA guidelines would recommend statins more often than ESC/EAS and EACS guidelines. Current recommendations on treatment of dyslipidemia should be applied with caution in the HIV infected population.
MeSH term(s)	Adult ; Aged ; Anti-HIV Agents/therapeutic use ; Cardiovascular Diseases/prevention & control ; Croatia/epidemiology ; Cross-Sectional Studies ; Dyslipidemias/drug therapy ; Eligibility Determination/statistics & numerical data ; Female ; HIV Infections/drug therapy ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Middle Aged ; Models, Statistical ; Practice Guidelines as Topic ; Prevalence ; Risk Assessment ; Risk Factors ; Serbia/epidemiology ; United States
Chemical Substances	Anti-HIV Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2015-02-28
Publishing country	Croatia
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1157623-6
ISSN	1332-8166 ; 0353-9504
ISSN (online)	1332-8166
ISSN	0353-9504
DOI	10.3325/cmj.2015.56.14
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Article: Sepsa uzrokovana bakterijom Fusobacterium necrophorum (Lemierreov sindrom): rijetka komplikacija akutnog tonzilofaringitisa.

Perović, Marta / Maretić, Tomislav / Begovac, Josip

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti

2006 Volume 60, Issue 5, Page(s) 509–512

Abstract: Lemierre syndrome is defined as an acute pharyngotonsillar infection that has spread into the lateral pharyngeal space causing thrombophlebitis of the internal jugular vein with consecutive metastatic emboli. The syndrome is most often caused by ... ...

Title translation	Sepsis caused by Fusobacterium necrophorum (Lemierre syndrome): a rare complication of acute pharyngotonsilitis.
Abstract	Lemierre syndrome is defined as an acute pharyngotonsillar infection that has spread into the lateral pharyngeal space causing thrombophlebitis of the internal jugular vein with consecutive metastatic emboli. The syndrome is most often caused by Fusobacterium (F.) necrophorum and usually involves young, previously healthy people. We present a healthy 20-year-old man who suddenly developed with high fever and sore throat followed by dyspnea, tachypnea and cough on the third day of illness. His condition worsened despite outpatient intramuscular penicillin therapy (1600 000 IU/day). He was admitted to Dr. Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, on the sixth day of his illness with clinical signs of sepsis. Chest radiograph showed bilateral multiple infiltrates. F. necrophorum was isolated from blood culture. Swelling of the neck was also observed on the fourteenth day of illness, however, thrombophlebitis of the jugular vein was not diagnosed on ultrasound examination. The patient was treated with clindamycin for five weeks and recovered completely.
MeSH term(s)	Acute Disease ; Adult ; Fusobacterium Infections/complications ; Fusobacterium necrophorum ; Humans ; Jugular Veins ; Male ; Pharyngitis/complications ; Pharyngitis/microbiology ; Sepsis/microbiology ; Thrombophlebitis/etiology ; Tonsillitis/complications ; Tonsillitis/microbiology
Language	Croatian
Publishing date	2006-12
Publishing country	Croatia
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1108025-5
ISSN	1330-0164 ; 0375-8338
ISSN	1330-0164 ; 0375-8338
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Zs.A 342: Show issues

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Article ; Online: Meningitis and radiculomyelitis caused by Angiostrongylus cantonensis.

Maretić, Tomislav / Perović, Marta / Vince, Adriana / Lukas, Davorka / Dekumyoy, Paron / Begovac, Josip

Emerging infectious diseases

2009 Volume 15, Issue 6, Page(s) 996–998

MeSH term(s)	Angiostrongylus cantonensis/pathogenicity ; Animals ; Eosinophilia/parasitology ; Female ; Humans ; Male ; Meningitis/parasitology ; Middle Aged ; Myelitis/parasitology ; Radiculopathy/parasitology ; Strongylida Infections/parasitology
Language	English
Publishing date	2009-06-15
Publishing country	United States
Document type	Case Reports ; Letter ; Review
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid1506.081263
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Zs.A 4778: Show issues

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Article ; Online: Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.

Vion, Anne-Clémence / Alt, Silvanus / Klaus-Bergmann, Alexandra / Szymborska, Anna / Zheng, Tuyu / Perovic, Tijana / Hammoutene, Adel / Oliveira, Marta Bastos / Bartels-Klein, Eireen / Hollfinger, Irene / Rautou, Pierre-Emmanuel / Bernabeu, Miguel O / Gerhardt, Holger

The Journal of cell biology

2018 Volume 217, Issue 5, Page(s) 1651–1665

Abstract: Blood flow shapes vascular networks by orchestrating endothelial cell behavior and function. How endothelial cells read and interpret flow-derived signals is poorly understood. Here, we show that endothelial cells in the developing mouse retina form and ... ...

Abstract	Blood flow shapes vascular networks by orchestrating endothelial cell behavior and function. How endothelial cells read and interpret flow-derived signals is poorly understood. Here, we show that endothelial cells in the developing mouse retina form and use luminal primary cilia to stabilize vessel connections selectively in parts of the remodeling vascular plexus experiencing low and intermediate shear stress. Inducible genetic deletion of the essential cilia component intraflagellar transport protein 88 (IFT88) in endothelial cells caused premature and random vessel regression without affecting proliferation, cell cycle progression, or apoptosis. IFT88 mutant cells lacking primary cilia displayed reduced polarization against blood flow, selectively at low and intermediate flow levels, and have a stronger migratory behavior. Molecularly, we identify that primary cilia endow endothelial cells with strongly enhanced sensitivity to bone morphogenic protein 9 (BMP9), selectively under low flow. We propose that BMP9 signaling cooperates with the primary cilia at low flow to keep immature vessels open before high shear stress-mediated remodeling.
MeSH term(s)	Animals ; Blood Vessels/drug effects ; Blood Vessels/physiology ; Bone Morphogenetic Proteins/pharmacology ; Cell Movement/drug effects ; Cell Polarity/drug effects ; Cilia/metabolism ; Embryo, Nonmammalian/drug effects ; Embryo, Nonmammalian/metabolism ; Endothelial Cells/cytology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Mice, Inbred C57BL ; Mice, Knockout ; Stress, Mechanical ; Vascular Remodeling/drug effects ; Zebrafish/embryology
Chemical Substances	Bone Morphogenetic Proteins
Language	English
Publishing date	2018-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.201706151
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Article ; Online: Meningitis and Radiculomyelitis Caused by Angiostrongylus cantonensis

Tomislav Maretić / Marta Perović / Adriana Vince / Davorka Lukas / Paron Dekumyoy / Josip Begovac

Emerging Infectious Diseases, Vol 15, Iss 6, Pp 996-

2009 Volume 998

Keywords	Angiostrongylus cantonensis ; eosinophilic meningitis ; lumbosacral myeloradiculopathy Elsberg syndrome ; parasites ; letter ; Croatia ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2009-06-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Ljudi na društvenoj margini

Stanojlović, Seška / Perović, Suzana

ljudska prava u psihijatrijskim bolnicama (septembar 2006-mart 2007)

(Helsinške sveske ; br. 25)

2007

Institution	Helsinki Committee for Human Rights in Serbia
Author's details	[urednik Seška Stanojlović ; autori Suzana Perović and others]
Series title	Helsinške sveske ; br. 25
MeSH term(s)	Commitment of Mentally Ill/legislation & jurisprudence ; Social Marginalization ; Hospitals, Psychiatric ; Human Rights/legislation & jurisprudence ; Legislation as Topic
Keywords	Serbia
Language	Serbian ; English
Size	160 pages :, illustrations ;, 23 cm.
Publisher	Helsinški odbor za ljudska prava u Srbiji
Publishing place	Beograd
Document type	Book
Note	In Serbian; one article also in English.
ISBN	9788672081329 ; 8672081323
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Smjernice za intervencijske i invazivne postupke u bolesnika s mehanickom krizoboljom.

Kovac, Damir / Rotim, Kresimir / Bozić, Boris / Sajko, Tomislav / Kejla, Zvonimir / Perović, Darko / Kvesić, Drazen / Houra, Karlo / Skoro, Ivan / Ivanec, Zeljko / Borić, Marta / Sesar, Nikolina / Subasić, Ante

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti

2013 Volume 67, Issue 3, Page(s) 225–231

Abstract: Back pain caused primarily by mechanical disorders is the most common type of back pain and it is usually found in young and middle-aged population, i.e. active population. This is why back pain is one of the most important public health problems. ... ...

Title translation	Guidelines for interventional and invasive treatment in patients with mechanical back pain.
Abstract	Back pain caused primarily by mechanical disorders is the most common type of back pain and it is usually found in young and middle-aged population, i.e. active population. This is why back pain is one of the most important public health problems. Treatment of pain syndrome affecting spine depends on a variety of factors and generally includes conservative and invasive methods. Relative indication for interventional and surgical procedures is long lasting back pain, the symptoms of which, predominantly pain, cause significant problems for the patient on performing everyday activities. Invasive/surgical treatment is applied after minimally 3 months of unsuccessful conservative treatment. Invasive and surgical procedures comprise a wide spectrum of interventions, from interventional and semi-interventional procedures, minimally invasive procedures to extensive, invasive operations that include instrumentation. The choice of intervention is based on clinical findings, duration and severity of pain and other symptoms, as well as on diagnostic reports. Despite recommendations based on the results of clinical studies, individual approach to each patient is the main principle of successful treatment.
MeSH term(s)	Decompression, Surgical/methods ; Evidence-Based Medicine ; Female ; Humans ; Low Back Pain/diagnosis ; Low Back Pain/surgery ; Lumbar Vertebrae/surgery ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures/standards ; Practice Guidelines as Topic ; Spinal Fusion/standards
Language	Croatian
Publishing date	2013-06
Publishing country	Croatia
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1108025-5
ISSN	1330-0164 ; 0375-8338
ISSN	1330-0164 ; 0375-8338
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Article ; Online: Prevalence and concordance of high cardiovascular disease scores in HIV/AIDS patients from Croatia and Serbia with four international algorithms

Josip Begovac / Gordana Dragovic / Klaudija Viskovic / Jovana Kusic / Marta Perovic Mihanovic / Davorka Lukas / Djordje Jevtovic

Journal of the International AIDS Society , Vol 17, Iss 4(Suppl 3), Pp 1-

2014 Volume 1

Abstract: Introduction: We evaluated cardiovascular risks in HIV-infected patients from Croatia and Serbia and the eligibility for statin therapy as recommended by the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines, European ... ...

Abstract	Introduction: We evaluated cardiovascular risks in HIV-infected patients from Croatia and Serbia and the eligibility for statin therapy as recommended by the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines, European AIDS Clinical Society (EACS) Guidelines and European Society of Cardiology and the European Atherosclerosis Society (ESC/EAS) guidelines for cardiovascular disease (CVD) prevention [1–3]. Materials and Methods: A cross-sectional analysis of consecutive patients between 40 and 79 years old who had received antiretroviral therapy for at least 12 months was performed. Results: Of 254 (132 from Croatia and 122 from Serbia) persons included in the study, 76% were male; median age was 49 years. Up to 51.6% of persons had a high CVD risk. The prevalence of current smoking was 42.9%, hypertension 31.5% and hypercholesterolaemia (>6.2 mmol/L) 35.4%. Statins would be recommended to 21.3% (95% CI, 16.3% to 27.4%) of persons by the EACS, 25.6% (95% CI, 20.2% to 31.9%) by ESC/EAS and 37.9% (95% CI, 31.6 to 44.6%) by the ACC/AHA guidelines. A high 5-year data collection on adverse effects of anti-HIV drugs study risk score (>5%) had a moderate agreement with the high (≥20%) 10-year CVD Framingham risk score (kappa=0.47) and high (≥5%) 10-year European systematic coronary risk evaluation score algorithm (kappa=0.47), and substantial agreement with the elevated (≥7.5%) 10-year Pooled Cohort Atherosclerotic CVD risk equation score (kappa=0.63). Conclusion: We found a high prevalence of CVD risks in patients from Croatia and Serbia. The ACC/AHA guideline would recommend statins more often than ESC/EAS and EACS guidelines.
Keywords	General Works ; A ; Medicine ; R ; Political science ; J ; Social Sciences ; H ; Immunologic diseases. Allergy ; RC581-607
Subject code	610
Language	English
Publishing date	2014-11-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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