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Article: Asymmetrical Holmes' Tremor Heralding HIV-Associated Neurocognitive Disorder.

Dhamija, Kamakshi / Garg, Divyani / Chaudhry, Neera / Singla, Deepshikha

2023 Volume 26, Issue 2, Page(s) 193–195

Language	English
Publishing date	2023-01-20
Publishing country	India
Document type	Journal Article
ZDB-ID	2240174-X
ISSN	1998-3549 ; 0972-2327
ISSN (online)	1998-3549
ISSN	0972-2327
DOI	10.4103/aian.aian_813_22
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Article: Effect of aerobic exercise training on EEG: event-related potential and neuropsychological functions in depressed elderly with mild cognitive impairment.

Khan, Zainab / Saif, Ashi / Chaudhry, Neera / Parveen, Adila

Dementia & neuropsychologia

2023 Volume 17, Page(s) e20220082

Abstract: Increased depressive severity has been linked to neurocognitive impairment. Aerobic exercise (AE) is an efficient technique for improving cognitive function. However, studies indicating the importance of AE to neurophysiological and neuropsychological ... ...

Abstract	Increased depressive severity has been linked to neurocognitive impairment. Aerobic exercise (AE) is an efficient technique for improving cognitive function. However, studies indicating the importance of AE to neurophysiological and neuropsychological functions in the depressed elderly using event-related potentials (ERPs) are scarce. Objectives: This study aimed to identify the potential benefits of AE on neurophysiological and neuropsychological functions. Methods: A total of 30 depressed older adults (AE group: n=15; control group (CG): n=14) were recruited based on the inclusion and exclusion criteria. The AE group was subjected to an 8-week-period AE program (3 times/week for 30 min per session) at moderate intensity, determined using heart rate maximum (HRmax). The training intensity was set at 50% HRmax and increased by 5% in subsequent weeks. Pre- and post-training measures for neurophysiological function were tested using ERP-P300 (amplitude-μV and latency-ms) and also for neuropsychological functions using the trail making test (TMT), mini mental status examination (MMSE), and everyday cognition questionnaire (ECog). Results: In the experimental group, statistically significant improvements were observed when analyzed for all 3 (group-by-time interaction effect, main effect of time, and main effect of group), in both neurophysiological functions (p<0.001) and neuropsychological functions (p<0.001), except for ECog scores, where the results were insignificant for the main effect of a group. Correlation analysis demonstrated no association between neurophysiological and neuropsychological functions (p>0.05). Conclusion:* Findings showed that 8 weeks of AE training may be a promising approach to improve cognitive functions in depressed older adults. However, considering relatively small number of patients, the question arises for effectiveness in other populations.
Language	English
Publishing date	2023-07-17
Publishing country	Brazil
Document type	Journal Article
ISSN	1980-5764
ISSN	1980-5764
DOI	10.1590/1980-5764-DN-2022-0082
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Article ; Online: Association of impaired cognitive function with balance confidence, static balance, dynamic balance, functional mobility, and risk of falls in older adults with depression.

Khan, Zainab / Saif, Ashi / Chaudhry, Neera / Parveen, Adila

Aging medicine (Milton (N.S.W))

2023 Volume 6, Issue 4, Page(s) 370–378

Abstract: Objectives: Increased depression severity has been linked to cognitive impairment (CI). Importantly, CI is a known risk factor for impaired balance and falls. Therefore, this study aims to explore the relationship between CI and neuromuscular functions ... ...

Abstract	Objectives: Increased depression severity has been linked to cognitive impairment (CI). Importantly, CI is a known risk factor for impaired balance and falls. Therefore, this study aims to explore the relationship between CI and neuromuscular functions and secondarily it aims to find out if CI is a potential predictor for neuromuscular functions deficits in depressed elderly. Methods: Eighty-four depressed elderly participated in the study. Assessment for CI symptoms were done using Mini Mental Status Examination (MMSE) in subjects having confirmed depression. Neuromuscular functions such as balance confidence, static and dynamic balance, functional mobility, and fall risk were subjectively assessed using Activities-specific Balance Confidence (ABC) Scale, Berg Balance Scale (BBS), Timed Up and Go (TUG) Test, and Performance Oriented Mobility Assessment (POMA), respectively. Results: Pearson's analysis revealed that there was moderate positive linear-correlation between MMSE and BBS ( Conclusion: Results of this study points to an impaired CI as a possible factor in development of neuromuscular function impairment in depressed elderly.
Language	English
Publishing date	2023-12-19
Publishing country	Australia
Document type	Journal Article
ISSN	2475-0360
ISSN (online)	2475-0360
DOI	10.1002/agm2.12276
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Article ; Online: Foix-Chavany-Marie syndrome as a heralding feature of acute disseminated encephalomyelitis.

Kathait, Aparna / Dhar, Siddharth / Garg, Divyani / Chaudhry, Neera

Acta neurologica Belgica

2022 Volume 122, Issue 4, Page(s) 1097–1098

MeSH term(s)	Deglutition Disorders ; Dysarthria ; Encephalomyelitis, Acute Disseminated/complications ; Encephalomyelitis, Acute Disseminated/diagnostic imaging ; Facial Paralysis ; Humans
Language	English
Publishing date	2022-05-02
Publishing country	Italy
Document type	Case Reports ; Letter
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-022-01968-3
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Article: Gender differences in quality of life and psychiatric comorbidities among persons with juvenile myoclonic epilepsy: A single-center cross-sectional study.

Laskar, Sanghamitra / Chaudhry, Neera / Choudhury, Cankatika / Garg, Divyani

Journal of neurosciences in rural practice

2023 Volume 14, Issue 3, Page(s) 482–487

Abstract: Objectives: Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized/genetic epilepsy syndrome. Gender differences are known in clinical presentation, with a well-identified female predilection. We aimed to study gender-based ... ...

Abstract	Objectives: Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized/genetic epilepsy syndrome. Gender differences are known in clinical presentation, with a well-identified female predilection. We aimed to study gender-based differences in quality of life (QoL) and psychiatric comorbidities among persons with JME. Materials and methods: This was a cross-sectional study conducted at a teaching hospital in Delhi, India. Persons above 11 years of age with JME diagnosed according to the International League Against Epilepsy criteria established in 2001 were enrolled. QoL assessment was made using Quality of Life in Epilepsy Inventory-Adolescents-48 (QOLIE-AD-48) and Patient-Weighted Quality of Life in Epilepsy Inventory 31 (QOLIE-31-P) for adolescent and adult patients, respectively. For the assessment of psychiatric comorbidities, participants were administered the Mini-International Neuropsychiatric Interview (M.I.N.I). Participants who tested positive for psychiatric comorbidities on M.I.N.I subsequently underwent the Diagnostic and Statistical Manual-5 categorization. Results: We enrolled 50 patients with JME. Eighteen (36%) were male and 32 (64%) were female patients. The median age of males at study enrollment was 23.5 (range 15-38) years. The median age of females was 22 (16-48) years. The median QOLIE-31-P score among males was 68.31 (37.13-91.82) and for females was 66.9 (31.7-99.1). The median overall QoL score for males was 65 (25-87.5), which qualified as "fair" QoL. For females, the median overall QoL score was 62.5 (10-87.5) which also qualified as "fair" QoL. No significant difference was noted between genders in QoL ( Conclusion: Persons with JME do not have gender-stratified differences in terms of psychiatric comorbidities and QoL despite differences in exposure to antiseizure medications and other gender-related factors. All persons with JME should be screened for psychiatric comorbidities, specifically anxiety, and depression.
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2601242-X
ISSN	0976-3155 ; 0976-3147
ISSN (online)	0976-3155
ISSN	0976-3147
DOI	10.25259/JNRP_34_2023
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Article ; Online: Perfusion CT imaging as a diagnostic and prognostic tool for dementia: prospective case-control study.

Dash, Sanket / Agarwal, Yatish / Jain, Swarna / Sharma, Anuradha / Chaudhry, Neera

Postgraduate medical journal

2023 Volume 99, Issue 1170, Page(s) 318–325

Abstract: Background: As functional changes precede structural changes in dementia, we aimed to elucidate changes on cerebral perfusion CT (PCT) for early diagnosis of dementia; and to differentiate Alzheimer's disease (AD) from vascular dementia (VaD). We also ... ...

Abstract	Background: As functional changes precede structural changes in dementia, we aimed to elucidate changes on cerebral perfusion CT (PCT) for early diagnosis of dementia; and to differentiate Alzheimer's disease (AD) from vascular dementia (VaD). We also aimed to study correlation between Montreal Cognitive Assessment (MOCA) score and PCT parameters. Methods: We conducted a prospective case-control study enrolling 25 dementia patients (15 cases of VaD, 10 cases of AD) and 25 age-matched controls. PCT was performed on a 256-slice CT scanner. Using perfusion software, colour maps were generated for cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time and time-to-peak. These colour maps were first visually inspected for any abnormalities. Subsequently, quantitative assessment of perfusion parameters was done using symmetrical freehand region of interests drawn in bilateral frontal, temporal, parietal regions, basal ganglia and hippocampi. Results: Strategic infarcts were present in 93.3% cases and white matter ischaemic changes in 100% cases of VaD. A global reduction in CBF and CBV was also observed in cases of VaD; whereas these parameters were significantly lower mainly in temporoparietal regions and hippocampi of patients with AD. There was significant positive correlation between MOCA score and various perfusion parameters in both forms of dementia. Conclusion: PCT is a reliable imaging modality for early diagnosis of dementia and in differentiating VaD from AD. As perfusion parameters show positive correlation with MOCA score, they could be used as a surrogate marker of cognitive status in the follow-up of patients with dementia.
MeSH term(s)	Humans ; Brain/diagnostic imaging ; Case-Control Studies ; Prognosis ; Tomography, X-Ray Computed/methods ; Alzheimer Disease/diagnostic imaging ; Perfusion
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	80325-x
ISSN	1469-0756 ; 0032-5473
ISSN (online)	1469-0756
ISSN	0032-5473
DOI	10.1136/postgradmedj-2021-141264
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Article: Cranial electrostimulation improves slow wave sleep in collegiate population: a polysomnographic study.

Aseem, Anam / Chaudhry, Neera / Hussain, Mohammed Ejaz

Sleep science (Sao Paulo, Brazil)

2022 Volume 15, Issue 1, Page(s) 88–94

Abstract: Objective: Sleep disturbance is quite prevalent among students, which leads to deleterious consequences on health. Cranial electrostimulation (CES) has been speculated to entrain cortical slow waves; therefore, we investigated the efficacy of cranial ... ...

Abstract	Objective: Sleep disturbance is quite prevalent among students, which leads to deleterious consequences on health. Cranial electrostimulation (CES) has been speculated to entrain cortical slow waves; therefore, we investigated the efficacy of cranial electrostimulation to improve slow wave sleep in collegiates. Methods: Twenty-eight students with Pittsburgh sleep quality index (PSQI) score >5 were randomly assigned into two groups: CES and control. Participants in CES group completed 60 minutes of CES intervention for 12 weeks with 100 µA microcurrent and 0.5 Hz frequency parameters during night. Pre- and post-intervention measures were taken for sleep architecture using over-night polysomnography (PSG) and sleep quality using PSQI. Participants were instructed to report to the laboratory at 10:00 p.m. and PSG was performed with electroencephalograms (EEG), chin electromyography (EMG) and bilateral electrooculogram (EOG) in place. Sleep stages were scored manually in accordance with the new AASM guidelines. PSG variables reported in the present study are sleep latency (SL), total sleep time (TST), percentage of N1, N2, N3, NREM (non-rapid eye movement), REM (rapid eye movement) and sleep efficiency (SE%). Results: After ascertaining the comparability of demographic and sleep variables at baseline for both the groups, a 2X2 mixed model ANOVA was employed. Significant between-group differences were obtained for N1% and N3% such that N1% decreased and N3% increased post CES. However, other PSG variables, along with PSQI score did not demonstrate statistically significant between-group difference. Discussion: The present study demonstrated that 12-weeks of CES improved N3% and reduced N1%. Future researches should be undertaken to build upon the findings of present study.
Language	English
Publishing date	2022-05-31
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2697016-8
ISSN	1984-0063 ; 1984-0659
ISSN (online)	1984-0063
ISSN	1984-0659
DOI	10.5935/1984-0063.20220029
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Article ; Online: Event-related potential and neuropsychological function in depressed older adults with cognitive impairment: A correlational study.

Khan, Zainab / Saif, Ashi / Chaudhry, Neera / Parveen, Adila

Aging medicine (Milton (N.S.W))

2022 Volume 5, Issue 3, Page(s) 174–181

Abstract: Background: Increased depression severity has been linked to cognitive functioning impairment, such as deficits in episodic memory and executive function, causing difficulties in planning strategies, which ultimately lead to impaired decision-making ... ...

Abstract	Background: Increased depression severity has been linked to cognitive functioning impairment, such as deficits in episodic memory and executive function, causing difficulties in planning strategies, which ultimately lead to impaired decision-making functions. There are number of ways to assess cognitive functions, two most important and routinely done tests are neuropsychological test battery (NBT) and event-related potentials (ERPs). Objective: This study examines the relationship between conventional neuropsychological tests assessing various cognitive domains and an ERP-P300 in depressed older adults. Methods: Forty-six depressed elderly subjects participated in the study. NBT (Pennsylvania's Penn Computerized Neurocognitive Battery [Penn CNP]) assessing attention, episodic memory, working memory, social cognition, complex cognition, and sensorimotor speed and ERP-P300 (amplitude μV and latency ms) was recorded using an auditory oddball paradigm. Results: Correlation test was run and Pearson's analysis and revealed that there was a negative statistically significant linear correlation between working memory on NBT and P300 wave amplitude on ERP-P300 ( Conclusion: Therefore, we conclude that neurophysiological measurements cannot be substituted by neuropsychological tests or vice versa; rather, higher brain functions should be estimated by both of the methods.
Language	English
Publishing date	2022-10-02
Publishing country	Australia
Document type	Journal Article
ISSN	2475-0360
ISSN (online)	2475-0360
DOI	10.1002/agm2.12225
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Article: Addressing the Devil Within: Normal Pressure Hydrocephalus—A Narrative Review

Garg, Divyani / Chaudhry, Neera

Indian Journal of Neurosurgery

2022 Volume 11, Issue 03, Page(s) 195–201

Abstract: Normal pressure hydrocephalus (NPH) is the most frequently occurring form of hydrocephalus among adults. It is characterized clinically by the classical triad, called Hakim's triad, comprising gait issues, cognitive impairment, and urinary problems. NPH ... ...

Abstract	Normal pressure hydrocephalus (NPH) is the most frequently occurring form of hydrocephalus among adults. It is characterized clinically by the classical triad, called Hakim's triad, comprising gait issues, cognitive impairment, and urinary problems. NPH may be primary or idiopathic (iNPH) or secondary. Characteristic neuroimaging features occur, which are vital to diagnosis. Diagnostic criteria in the form of Japanese guideline and Congress of Neurological Surgeons 2005 guidelines have been devised, and broadly, are based on a constellation of clinical and neuroimaging features, in association with cerebrospinal fluid (CSF) testing. CSF tap test, extended lumbar drainage, and CSF infusion tests are invasive diagnostic tests. CSF tap test and extended lumbar drainage are used to demonstrate clinical reversibility with CSF drainage, and patients who demonstrate this are candidates for CSF shunting. However, due to the low negative predictive value of these tests, potential response to shunting cannot be negated among patients who do not respond to CSF drainage. Various shunting procedures are used for treatment, including ventriculoperitoneal, lumboperitoneal, and ventriculoatrial shunts. Endoscopic third ventriculostomy has also been attempted with limited success. Among the clinical features, gait abnormalities are most responsive to shunting. Persistent long-term response to shunting has been reported. Patients need to be meticulously followed up after the shunting procedure, to assess clinical and neuroimaging response, and detect possible shunt-related complications, especially CSF over-drainage. Early treatment is associated with better prognosis, and it is crucial to recognize and treat this condition before the development of severe symptoms.
Keywords	hydrocephalus ; CSF tap test ; ventriculoperitoneal shunts ; Evans' index
Language	English
Publishing date	2022-07-10
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2698542-1
ISSN	2277-9167 ; 2277-954X ; 2277-9167
ISSN (online)	2277-9167
ISSN	2277-954X ; 2277-9167
DOI	10.1055/s-0042-1753475
Database	Thieme publisher's database

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Article: Systemic Lupus Erythematosus Presenting as Acute Sensory Axonal Neuropathy (ASAN).

Gyanchandani, Khushboo / Chaudhry, Neera / Choudhury, Cankatika / Sengupta, Ananya

Annals of Indian Academy of Neurology

2020 Volume 24, Issue 2, Page(s) 292–293

Language	English
Publishing date	2020-06-05
Publishing country	India
Document type	Journal Article
ZDB-ID	2240174-X
ISSN	1998-3549 ; 0972-2327
ISSN (online)	1998-3549
ISSN	0972-2327
DOI	10.4103/aian.AIAN_344_19
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