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  1. Article ; Online: Intravenous Fluids-A Test Case for Learning Health Systems.

    Semler, Matthew W

    JAMA network open

    2022  Volume 5, Issue 5, Page(s) e2210054

    MeSH term(s) Fluid Therapy ; Humans ; Infusions, Intravenous ; Learning Health System
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.10054
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  2. Article ; Online: Cefepime vs Piperacillin-Tazobactam for Acute Infection in Hospitalized Adults-Reply.

    Qian, Edward T / Semler, Matthew W / Rice, Todd W

    JAMA

    2024  Volume 331, Issue 8, Page(s) 709–710

    MeSH term(s) Adult ; Humans ; Cefepime/therapeutic use ; Infections/drug therapy ; Piperacillin, Tazobactam Drug Combination/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Hospitalization ; Acute Disease
    Chemical Substances Cefepime (807PW4VQE3) ; Piperacillin, Tazobactam Drug Combination (157044-21-8) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.27891
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  3. Article ; Online: Progressing from "Whether to" to "How to" Conduct Pragmatic Trials.

    Casey, Jonathan D / Rice, Todd W / Semler, Matthew W

    The American journal of bioethics : AJOB

    2023  Volume 23, Issue 8, Page(s) 33–36

    MeSH term(s) Humans ; Patient Selection ; Research Design ; Research Personnel
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2023.2217123
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  4. Article ; Online: Oxygen-Saturation Targets for Adults Receiving Mechanical Ventilation. Reply.

    Semler, Matthew W / Wilkins, Consuelo H / Rice, Todd W

    The New England journal of medicine

    2023  Volume 388, Issue 6, Page(s) 574–575

    MeSH term(s) Humans ; Adult ; Respiration, Artificial ; Critical Illness ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2216088
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  5. Article ; Online: Back to BaSICS: Early Treatments Matter in Critical Illness.

    Seitz, Kevin P / Semler, Matthew W

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 12, Page(s) 1372–1374

    MeSH term(s) Critical Illness/therapy ; Crystalloid Solutions ; Hospitalization ; Humans
    Chemical Substances Crystalloid Solutions
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202203-0611ED
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  6. Article ; Online: Advances in Sepsis Care.

    Jackson, Karen E / Semler, Matthew W

    Clinics in chest medicine

    2022  Volume 43, Issue 3, Page(s) 489–498

    Abstract: This review article summarizes current scientific evidence regarding the treatment of sepsis. We highlight recent advances in sepsis management with a focus on antibiotics, fluids, vasopressors, and adjunctive therapies such as corticosteroids and renal ... ...

    Abstract This review article summarizes current scientific evidence regarding the treatment of sepsis. We highlight recent advances in sepsis management with a focus on antibiotics, fluids, vasopressors, and adjunctive therapies such as corticosteroids and renal replacement therapy.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Combined Modality Therapy ; Humans ; Renal Replacement Therapy ; Sepsis/therapy
    Chemical Substances Adrenal Cortex Hormones ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-09-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2022.05.003
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  7. Article ; Online: Fluid Therapy for Critically Ill Adults With Sepsis: A Review.

    Zampieri, Fernando G / Bagshaw, Sean M / Semler, Matthew W

    JAMA

    2023  Volume 329, Issue 22, Page(s) 1967–1980

    Abstract: Importance: Approximately 20% to 30% of patients admitted to an intensive care unit have sepsis. While fluid therapy typically begins in the emergency department, intravenous fluids in the intensive care unit are an essential component of therapy for ... ...

    Abstract Importance: Approximately 20% to 30% of patients admitted to an intensive care unit have sepsis. While fluid therapy typically begins in the emergency department, intravenous fluids in the intensive care unit are an essential component of therapy for sepsis.
    Observations: For patients with sepsis, intravenous fluid can increase cardiac output and blood pressure, maintain or increase intravascular fluid volume, and deliver medications. Fluid therapy can be conceptualized as 4 overlapping phases from early illness through resolution of sepsis: resuscitation (rapid fluid administered to restore perfusion); optimization (the risks and benefits of additional fluids to treat shock and ensure organ perfusion are evaluated); stabilization (fluid therapy is used only when there is a signal of fluid responsiveness); and evacuation (excess fluid accumulated during treatment of critical illness is eliminated). Among 3723 patients with sepsis who received 1 to 2 L of fluid, 3 randomized clinical trials (RCTs) reported that goal-directed therapy administering fluid boluses to attain a central venous pressure of 8 to 12 mm Hg, vasopressors to attain a mean arterial blood pressure of 65 to 90 mm Hg, and red blood cell transfusions or inotropes to attain a central venous oxygen saturation of at least 70% did not decrease mortality compared with unstructured clinical care (24.9% vs 25.4%; P = .68). Among 1563 patients with sepsis and hypotension who received 1 L of fluid, an RCT reported that favoring vasopressor treatment did not improve mortality compared with further fluid administration (14.0% vs 14.9%; P = .61). Another RCT reported that among 1554 patients in the intensive care unit with septic shock treated with at least 1 L of fluid compared with more liberal fluid administration, restricting fluid administration in the absence of severe hypoperfusion did not reduce mortality (42.3% vs 42.1%; P = .96). An RCT of 1000 patients with acute respiratory distress during the evacuation phase reported that limiting fluid administration and administering diuretics improved the number of days alive without mechanical ventilation compared with fluid treatment to attain higher intracardiac pressure (14.6 vs 12.1 days; P < .001), and it reported that hydroxyethyl starch significantly increased the incidence of kidney replacement therapy compared with saline (7.0% vs 5.8%; P = .04), Ringer lactate, or Ringer acetate.
    Conclusions and relevance: Fluids are an important component of treating patients who are critically ill with sepsis. Although optimal fluid management in patients with sepsis remains uncertain, clinicians should consider the risks and benefits of fluid administration in each phase of critical illness, avoid use of hydroxyethyl starch, and facilitate fluid removal for patients recovering from acute respiratory distress syndrome.
    MeSH term(s) Adult ; Humans ; Critical Illness/therapy ; Fluid Therapy/adverse effects ; Fluid Therapy/methods ; Sepsis/complications ; Sepsis/therapy ; Shock, Septic/therapy ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.7560
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  8. Article ; Online: Fluid Bolus Administration and Cardiovascular Collapse in Critically Ill Patients Undergoing Tracheal Intubation-Reply.

    Russell, Derek W / Casey, Jonathan D / Semler, Matthew W

    JAMA

    2022  Volume 328, Issue 20, Page(s) 2071–2072

    MeSH term(s) Humans ; Critical Illness/therapy ; Intubation, Intratracheal ; Shock/etiology ; Shock/therapy ; Fluid Therapy/methods
    Language English
    Publishing date 2022-11-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.17508
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  9. Article ; Online: Oxygen Targets and the Future of Critical Care Clinical Research.

    DeMasi, Stephanie C / Self, Wesley H / Semler, Matthew W

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 7, Page(s) 746–748

    MeSH term(s) Humans ; Critical Care ; Oxygen ; Respiratory Physiological Phenomena ; Intensive Care Units
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202308-1417ED
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  10. Article ; Online: Authors response: "Etomidate as an induction agent for endotracheal intubation in critically ill patients: A meta-analysis of randomized trials".

    Kotani, Yuki / Semler, Matthew W / Lee, Todd C / Landoni, Giovanni

    Journal of critical care

    2023  Volume 79, Page(s) 154411

    MeSH term(s) Humans ; Etomidate ; Critical Illness/therapy ; Randomized Controlled Trials as Topic ; Anesthetics, Intravenous ; Intubation, Intratracheal
    Chemical Substances Etomidate (Z22628B598) ; Anesthetics, Intravenous
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Meta-Analysis ; Letter ; Comment
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2023.154411
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