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Article ; Online: Sex differences in the frailty phenotype and mortality in the I-Lan longitudinal aging study cohort.

Lu, Ya-Wen / Chang, Chun-Chin / Chou, Ruey-Hsing / Lee, Wei-Ju / Chen, Liang-Kung / Huang, Po-Hsun / Lin, Shing-Jong

2024 Volume 24, Issue 1, Page(s) 182

Abstract: ... was conducted with data from the I-Lan Longitudinal Aging Study, in which community-dwelling subjects ...

Abstract	Background: Frailty is a common geriatric syndrome related to multiple adverse outcomes. Sex differences in its prevalence and impact on mortality remain incompletely understood. Methods: This study was conducted with data from the I-Lan Longitudinal Aging Study, in which community-dwelling subjects aged > 50 years without coronary artery disease or diabetes were enrolled. Sex disparities in phenotypically defined frailty and sex-morality predictor interactions were evaluated. Sex- and frailty-stratified analyses of mortality were performed. Results: The sample comprised 1371 subjects (51.4% women, median age 61 years). The median follow-up period was 6.3 (interquartile range, 5.8-7.0) years. The frailty prevalence did not differ between men (5.3%) and women (5.8%). Frail individuals were older and less educated and had poorer renal function than did non-frail individuals. Body composition trends differed between sexes, regardless of frailty. Relative to non-frail men, frail men had significantly lower body mass indices (BMIs; 24.5 vs. 23.4 kg/m Conclusion: Frailty reflected poorer health in men than in women in the present cohort. This study revealed sex disparities in the impact of frailty on mortality among relatively healthy community-dwelling older adults.
MeSH term(s)	Aged ; Humans ; Female ; Male ; Frailty ; Frail Elderly ; Sex Characteristics ; Aging ; Phenotype ; Geriatric Assessment
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-024-04785-w
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Article ; Online: Sex difference in the association between pathological albuminuria and subclinical atherosclerosis: insights from the I-Lan longitudinal aging study.

Lu, Ya-Wen / Chang, Chun-Chin / Chou, Ruey-Hsing / Tsai, Yi-Lin / Liu, Li-Kuo / Chen, Liang-Kung / Huang, Po-Hsun / Lin, Shing-Jong

Aging

2022 Volume 14, Issue 19, Page(s) 8001–8012

Abstract: Background: Pathological albuminuria (PAU) (urinary albumin creatinine ratio [UACR] ≥30 mg/g) is an independent risk factor of cardiovascular disease. PAU is more prevalent in men than women. We aimed to compare the association of PAU and the early ... ...

Abstract	Background: Pathological albuminuria (PAU) (urinary albumin creatinine ratio [UACR] ≥30 mg/g) is an independent risk factor of cardiovascular disease. PAU is more prevalent in men than women. We aimed to compare the association of PAU and the early phase of subclinical atherosclerosis (SA) between sexes. Methods: 1228 subjects aged 50-90 years were stratified by sex and UACR (normal or PAU). SA was defined as mean carotid intima-media thickness ≥75th percentile of the cohort. Demographics and SA prevalence were compared between groups. Multivariate logistic regression was performed to assess the relationship between PAU and SA. Results: Both men and women with PAU had increased prevalence of hypertension, anti-hypertensive therapy, and metabolic syndrome than controls. Men with PAU were older and had greater waist circumference and total body fat percentage. Sex disparity was observed in associations between waist-to-height ratio, total body fat, and UACR. After adjusting for traditional risk factors, multivariate logistic regression disclosed that PAU was independently associated with SA in men (adjusted odds ratio 1.867, 95% CI 1.066-3.210) but not in women. Conclusion: The relationship of PAU and SA differed between sexes. This result may highlight the need for sex-specific risk management strategies to prevent atherosclerosis.
MeSH term(s)	Female ; Humans ; Male ; Albuminuria/epidemiology ; Carotid Intima-Media Thickness ; Creatinine ; Sex Characteristics ; Antihypertensive Agents ; Cross-Sectional Studies ; Atherosclerosis/epidemiology ; Atherosclerosis/complications ; Aging ; Risk Factors ; Albumins
Chemical Substances	Creatinine (AYI8EX34EU) ; Antihypertensive Agents ; Albumins
Language	English
Publishing date	2022-10-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204331
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Article: [Gridded Emission Inventories of Major Criteria Air Pollutants and Source Contributions in Lan-Bai Metropolitan Area, Northwest China].

Wang, Wen-Peng / Wang, Zhan-Xiang / Li, Ji-Xiang / Gao, Hong / Huang, Tao / Mao, Xiao-Xuan / Ma, Jian-Min

Huan jing ke xue= Huanjing kexue

2021 Volume 42, Issue 3, Page(s) 1315–1327

Abstract: Lan-Bai Metropolitan Area in Gansu province is an important heavy-industry base with the highest ... criteria air pollutants in the Lan-Bai Metropolitan Area based on emission data and statistical yearbooks ... The results showed that the total annual emissions of seven major criteria air pollutants in the Lan-Bai ...

Abstract	Lan-Bai Metropolitan Area in Gansu province is an important heavy-industry base with the highest level of total air pollutant emissions in Northwest China. It is significant to study the high-resolution pollutant emission inventory to forecast regional air quality and to simulate pollutant emission reduction, as well as provide early warnings and forecasts, and to control air pollution. Taking Lanzhou and Baiyin as the main research areas, this study established the gridded emission inventories of seven major criteria air pollutants in the Lan-Bai Metropolitan Area based on emission data and statistical yearbooks of 2015-2016. The spatial pollution characteristics and emission source contributions were also studied. The results showed that the total annual emissions of seven major criteria air pollutants in the Lan-Bai Metropolitan Area were as followings:NO
Language	Chinese
Publishing date	2021-03-20
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202007131
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Article ; Online: Anti-tumor necrosis factor-α is potentially better than tumor necrosis factor-α as the biomarker for sarcopenia: Results from the I-Lan longitudinal aging study.

Lin, Wei-Ju / Lee, Wei-Ju / Peng, Li-Ning / Huang, Yi-Long / Tung, Chien-Yi / Lin, Chi-Hung / Tsai, Ting-Fen / Chen, Liang-Kung

Experimental gerontology

2022 Volume 172, Page(s) 112053

Abstract: ... alternative as a biomarker of sarcopenia. Data from 484 participants from the I-Lan Longitudinal Aging Study ...

Abstract	Tumor necrosis factor (TNF)-α is a proinflammatory cytokine involved in the pathogenesis of sarcopenia, but its short half-life and inconsistent reproducibility limit the potential of TNF-α to be an ideal sarcopenia biomarker. Anti-TNF-α, a natural consequent autoantibody to TNF-α, is an indicator of relatively prolonged TNF-α exposure, has more stable concentrations than TNF-α and should be a better alternative as a biomarker of sarcopenia. Data from 484 participants from the I-Lan Longitudinal Aging Study were used for this study, and sarcopenia was defined by the Asian Working Group for Sarcopenia 2019 consensus. Plasma levels of anti-TNF-α were determined by a sandwich ELISA approach, and levels of TNF-α were determined by an immunoassay. Compared to nonsarcopenic participants, 43 sarcopenic participants had higher levels of anti-TNF-α (0.73 ± 0.19 vs. 0.79 ± 0.25 OD, p = 0.045). Plasma levels of anti-TNF-α were positively correlated with TNF-α (r = 0.24, p < 0.001), and plasma levels of anti-TNF-α were positively correlated with adiposity (r = 0.16, p < 0.001) and negatively correlated with lean body mass (r = -0.14, p = 0.003). Individuals with increasing levels of anti-TNF-α had higher odds of being sarcopenic (OR 5.4, 95 % CI: 1.1-25.8, p = 0.035), and these associations were stronger among women and younger adults. An association between TNF-α and sarcopenia was noted only in middle-aged adults (OR 6.2, 95 % CI: 1.8-21.7, p = 0.004). Plasma anti-TNF-α levels were positively correlated with TNF-α and were significantly associated with sarcopenia. Anti-TNF-α may be a more appropriate biomarker than TNF-α for sarcopenia, but further investigations are needed to confirm its roles in sarcopenia diagnosis and treatment response evaluation.
MeSH term(s)	Female ; Humans ; Middle Aged ; Aging ; Biomarkers ; Necrosis/complications ; Reproducibility of Results ; Sarcopenia ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha/immunology ; Autoantibodies
Chemical Substances	Biomarkers ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha ; Autoantibodies
Language	English
Publishing date	2022-12-09
Publishing country	England
Document type	Journal Article
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2022.112053
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Article ; Online: Gender difference in the association between TyG index and subclinical atherosclerosis: results from the I-Lan Longitudinal Aging Study.

Lu, Ya-Wen / Chang, Chun-Chin / Chou, Ruey-Hsing / Tsai, Yi-Lin / Liu, Li-Kuo / Chen, Liang-Kung / Huang, Po-Hsun / Lin, Shing-Jong

Cardiovascular diabetology

2021 Volume 20, Issue 1, Page(s) 206

Abstract: ... Methods: The I-Lan Longitudinal Aging Study (ILAS) enrolled 1457 subjects aged 50-80 years ...

Abstract	Background: Insulin resistance (IR) is a known risk factor for cardiovascular disease (CVD) in non-diabetic patients through the association of hyperglycemia or associated metabolic factors. The triglyceride glucose (TyG) index, which was defined by incorporating serum glucose and insulin concentrations, was developed as a surrogate marker of insulin resistance. We aimed to investigate the association between the TyG index and the early phase of subclinical atherosclerosis (SA) between the sexes. Methods: The I-Lan Longitudinal Aging Study (ILAS) enrolled 1457 subjects aged 50-80 years. For each subject, demographic data and the TyG index {ln[fasting triglyceride (mg/dL) × fasting plasma glucose (mg/dL)]/ Results: Patients with a higher TyG index (≥ 8.55) had a higher body mass index (BMI), hypertension (HTN) and diabetes mellitus (DM). They had higher lipid profiles, including total cholesterol (T-Chol) and low-density lipoprotein (LDL), compared to those with a lower TyG index (< 8.55). Gender disparity was observed in non-diabetic women who had a significantly higher prevalence of SA in the high TyG index group than in the low TyG index group. In multivariate logistic regression analysis, a high TyG index was independently associated with SA in non-diabetic women after adjusting for traditional risk factors [adjusted odds ratio (OR): 1.510, 95% CI 1.010-2.257, p = 0.045] but not in non-diabetic men. The TyG index was not associated with the presence of SA in diabetic patients, irrespective of sex. Conclusion: A high TyG index was significantly associated with SA and gender disparity in non-diabetic patients. This result may highlight the need for a sex-specific risk management strategy to prevent atherosclerosis.
MeSH term(s)	Aged ; Aged, 80 and over ; Asymptomatic Diseases ; Biomarkers/blood ; Blood Glucose/metabolism ; Carotid Artery Diseases/blood ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/epidemiology ; China/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Insulin/blood ; Insulin Resistance ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Middle Aged ; Prevalence ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sex Factors ; Triglycerides/blood
Chemical Substances	Biomarkers ; Blood Glucose ; Insulin ; Triglycerides
Language	English
Publishing date	2021-10-13
Publishing country	England
Document type	Comparative Study ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-021-01391-7
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Article ; Online: From East Lynne to Konggu Lan

Xuelei Huang

Transcultural Studies, Vol 3, Iss 2, Pp 48-

Transcultural Tour, Trans-Medial Translation

2012 Volume 84

Abstract: This paper traces the travels of a Victorian best-selling novel entitled East Lynne (1861) and its various translations as serialized novels, stage plays, and films produced in Japan and China in the early twentieth century. The author argues that all ... ...

Abstract	This paper traces the travels of a Victorian best-selling novel entitled East Lynne (1861) and its various translations as serialized novels, stage plays, and films produced in Japan and China in the early twentieth century. The author argues that all versions of the story reflected a global trend for what may be termed “popular consumption of sensation plus sentiment.” The principle agents in the formation of this global trend in the popular spheres are to be found in the development of print capitalism and the cultural industries on the one hand, and in the public’s desires for sensation and sentiment in a time of rapid social changes on the other. As such, this study presents an early example of the global flow of cultural products. It demonstrates that global flows of cultural products along with commodities and concepts not only helped shape imagined communities that were called nations, but also linked people at mental levels across national boundaries.
Keywords	east lynne ; konggu lan ; no no hana ; translation ; adaptation ; Social Sciences ; H
Subject code	950
Language	English
Publishing date	2012-12-01T00:00:00Z
Publisher	Ruprecht-Karls-Universität Heidelberg
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Association Between Serum Activin A Levels and Hypertension in the Elderly: A Cross-Sectional Analysis From I-Lan Longitudinal Aging Study.

Tsai, Yi-Lin / Chang, Chun-Chin / Liu, Li-Kuo / Huang, Po-Hsun / Chen, Liang-Kung / Lin, Shing-Jong

American journal of hypertension

2018 Volume 31, Issue 3, Page(s) 369–374

Abstract: ... A total of 470 participants of I-Lan longitudinal Aging Study (ILAS) were eligible for this study. Serum ...

Abstract	Background: Hypertension is an important risk factor for cardiovascular disease. Activin A, a member of the transforming growth factor-β cytokine family, has been shown to regulate blood pressure through the renin-angiotensin system. However, the relationship between activin A and blood pressure remains uncertain. The objective of this study was to determine whether serum activin A levels are associated with blood pressure. Method: A total of 470 participants of I-Lan longitudinal Aging Study (ILAS) were eligible for this study. Serum levels of activin A were assessed by enzyme-linked immunosorbent assay. Cross-sectional analyses were performed, including comparisons of demographic characteristics, hypertensive status, and activin A levels. Results: Among the study participants (50% men, mean age, 69 years), 236 (50.2%) were hypertensive and 234 (49.8%) were normotensive. Hypertensive patients had significantly higher serum activin A levels than normotensives (normotensive vs. hypertensive: 507 ± 169 vs. 554 ± 176 pg/ml, mean ± SD, P < 0.001). All subjects were divided into 3 tertiles on the basis of serum activin A levels. Increasing tertiles of activin A were associated with higher systolic blood pressure (SBP), diastolic blood pressure and pulse pressure (PP) (all P < 0.001). After adjusting for all the potential confounding factors, serum activin A concentration was still significantly associated with SBP (P = 0.02) and PP (P = 0.03). Conclusions: Serum activin A level was associated with SBP and PP. Further studies are required to assess their causal relationship and the clinical relevance.
MeSH term(s)	Activins/blood ; Age Factors ; Aged ; Aging/blood ; Biomarkers/blood ; Blood Pressure ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Hypertension/blood ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/physiopathology ; Inhibin-beta Subunits/blood ; Longitudinal Studies ; Male ; Middle Aged ; Taiwan/epidemiology ; Up-Regulation
Chemical Substances	Biomarkers ; activin A ; inhibin beta A subunit ; Activins (104625-48-1) ; Inhibin-beta Subunits (93443-12-0)
Language	English
Publishing date	2018-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	639383-4
ISSN	1941-7225 ; 1879-1905 ; 0895-7061
ISSN (online)	1941-7225 ; 1879-1905
ISSN	0895-7061
DOI	10.1093/ajh/hpx185
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Zs.A 2329: Show issues

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Article ; Online: Alleles of the LAN blood group system: molecular and serologic investigations.

Reid, Marion E / Hue-Roye, Kim / Huang, Angela / Velliquette, Randall W / Tani, Yoshihiko / Westhoff, Connie M / Lomas-Francis, Christine / Zelinski, Teresa

Transfusion

2014 Volume 54, Issue 2, Page(s) 398–404

Abstract: Background: Anti-Lan has been implicated in hemolytic transfusion reactions and hemolytic disease ... of the fetus and newborn. The LAN blood group system is encoded by ABCB6, whose gene product, ABCB6, belongs ... serologically defined as Lan-, Lan+(w) /-, or Lan+(w) .: Study design and methods: Genomic DNA was extracted ...

Abstract	Background: Anti-Lan has been implicated in hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. The LAN blood group system is encoded by ABCB6, whose gene product, ABCB6, belongs to the ATP-binding cassette (ABC) efflux transporter superfamily. The purpose of this study was to characterize additional alleles by analyzing DNA from 14 (13 unrelated) subjects whose red blood cells were serologically defined as Lan-, Lan+(w) /-, or Lan+(w) . Study design and methods: Genomic DNA was extracted from blood samples recovered from liquid nitrogen storage. Intronic primers flanking each of the ABCB6 coding exons were used for polymerase chain reaction amplification. Amplicons were sequenced and analyzed by standard methods. Results: Among the study subjects, we identified five alleles (one with a nonsense change, three with frameshifts, one with a missense change) that encode the Lan- phenotype and four alleles (with missense changes) encoding either Lan+(w) or Lan+(w) /- phenotypes. Conclusions: Of the nine alleles we identified, three were novel and six were previously documented in the dbSNP. Of these six, only one allele was previously associated with Lan negativity. To date, 19 ABCB6 alleles that encode Lan- or Lan+(w) /-, or Lan+(w) phenotypes have been described.
MeSH term(s)	ATP-Binding Cassette Transporters/blood ; ATP-Binding Cassette Transporters/genetics ; Adult ; Alleles ; Blood Donors ; Blood Group Antigens/blood ; Blood Group Antigens/genetics ; Codon, Nonsense ; Female ; Frameshift Mutation ; Humans ; Infant, Newborn ; Male ; Mutation, Missense ; Phenotype
Chemical Substances	ABCB6 protein, human ; Blood Group Antigens ; Codon, Nonsense
Language	English
Publishing date	2014-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.12285
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Article ; Online: FNIH-defined Sarcopenia Predicts Adverse Outcomes Among Community-Dwelling Older People in Taiwan: Results From I-Lan Longitudinal Aging Study.

Tang, Ting-Ching / Hwang, An-Chun / Liu, Li-Kuo / Lee, Wei-Ju / Chen, Liang-Yu / Wu, Yi-Hui / Huang, Chung-Yu / Hung, Cheng-Hao / Wang, Chih-Jen / Lin, Ming-Hsien / Peng, Li-Ning / Chen, Liang-Kung

The journals of gerontology. Series A, Biological sciences and medical sciences

2017 Volume 73, Issue 6, Page(s) 828–834

Abstract: ... of the I-Lan Longitudinal Aging Study were obtained for analysis. Overall, 1,839 community-dwelling people aged ...

Abstract	Background: To evaluate the predictive validity of sarcopenia defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project among Asian older adults. Methods: Data of the I-Lan Longitudinal Aging Study were obtained for analysis. Overall, 1,839 community-dwelling people aged 50 years and older, capable of completing a 6-m walk, with life expectancy of more than 6 months, and not institutionalized at time of data collection were enrolled for study. Data for subjects aged 65 years and older were obtained for study. The outcome measures were all-cause mortality and a composite adverse outcome which includes hospitalizations, emergency department visits, institutionalization, and falls. Results: Data of 728 eligible elderly participants (73.4 ± 5.4 years; 52.9% males) were analyzed. The prevalence of FNIH-diagnosed sarcopenia was 9.5%: 11.9% males; 6.7% females. Participants having FNIH-defined sarcopenia were considerably older, frailer, more obese, with poorer physical performance than nonsarcopenic subjects (All p < .001); during mean follow-up of 32.9 ± 8.8 months, they also had 3.8 times higher risk of dying, independent of age, sex, multimorbidity, cognitive function, and nutritional status (hazard ratio = 3.8; 95% confidence interval = 1.26-11.45; p = .018). Moreover, sarcopenia defined by grip strength-BMI ratio (WeakBMI) showed stronger association with composite adverse outcomes than traditional handgrip strength (hazard ratio = 1.99; 95% confidence interval = 1.01-3.93; p = .047 vs hazard ratio = 1.80; 95% confidence interval = 0.89-3.62; p = .102 in fully-adjusted model). Conclusion: Among community-dwelling older people in Taiwan, participants with FNIH-defined sarcopenia had a significantly greater risk of all-cause mortality and composite falls, emergency department visits, institutionalization, and hospitalization.
MeSH term(s)	Aged ; Female ; Geriatric Assessment ; Humans ; Independent Living ; Longitudinal Studies ; Male ; Predictive Value of Tests ; Sarcopenia/epidemiology ; Taiwan/epidemiology
Language	English
Publishing date	2017-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glx148
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Article ; Online: Association between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging Study.

Chang, Chun-Chin / Wu, Cheng-Hsueh / Liu, Li-Kuo / Chou, Ruey-Hsing / Kuo, Chin-Sung / Huang, Po-Hsun / Chen, Liang-Kung / Lin, Shing-Jong

Scientific reports

2018 Volume 8, Issue 1, Page(s) 5234

Abstract: ... level and cardiovascular risk. In total, 973 nonhypertensive and nondiabetic participants in the I-Lan ...

Abstract	Serum uric acid level is a risk factor for cardiovascular disease (CVD). However, whether it is an independent risk factor or not remains controversial. We analyzed the association between serum uric acid level and cardiovascular risk. In total, 973 nonhypertensive and nondiabetic participants in the I-Lan Longitudinal Aging Study were eligible for this study. Subjects were divided into tertiles according to uric acid levels. The 10-year cardiovascular risk was calculated using Framingham risk score (FRS). Study subjects in the highest tertile of serum uric acid level were older, more likely to be male, and had higher systolic blood pressure, body mass index, carotid artery intima-media thickness and serum triglyceride, high-sensitivity C-reactive protein, and low-density lipoprotein cholesterol levels and lower serum high-density lipoprotein cholesterol levels (all p < 0.05). Subjects in the highest tertile had significantly higher FRS (p < 0.001). After adjusting for other risk factors, serum uric acid level remained associated significantly with the FRS (p < 0.05). In binary logistic regression analysis, the serum uric acid level was an independent predictive factor for high (≥20%) FRS (odds ratio 1.33, 95% confidence interval 1.10-1.68). These findings warrant attention to this cardiovascular risk factor in apparently healthy adults.
MeSH term(s)	Age Factors ; Aged ; Aging ; Body Mass Index ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Carotid Intima-Media Thickness ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Risk Factors ; Sex Factors ; Taiwan/epidemiology ; Uric Acid/blood
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2018-03-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-22997-0
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