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  1. Article ; Online: Reply to Olschewski

    Johnson, Shelsey W / Ventetuolo, Corey E

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 12, Page(s) 1340–1341

    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202310-1770LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prime Time for Proteomics in Pulmonary Arterial Hypertension Risk Assessment?

    Singh, Navneet / Ventetuolo, Corey E

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 9, Page(s) 988–990

    MeSH term(s) Familial Primary Pulmonary Hypertension ; Humans ; Proteome ; Proteomics ; Pulmonary Arterial Hypertension/diagnosis ; Risk Assessment
    Chemical Substances Proteome
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202201-0040ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Critical Care Management of the Patient with Pulmonary Hypertension.

    Mullin, Christopher J / Ventetuolo, Corey E

    Clinics in chest medicine

    2021  Volume 42, Issue 1, Page(s) 155–165

    Abstract: Pulmonary hypertension patients admitted to the intensive care unit have high mortality, and right ventricular failure typically is implicated as cause of or contributor to death. Initial care of critically ill pulmonary hypertension patients includes ... ...

    Abstract Pulmonary hypertension patients admitted to the intensive care unit have high mortality, and right ventricular failure typically is implicated as cause of or contributor to death. Initial care of critically ill pulmonary hypertension patients includes recognition of right ventricular failure, appropriate monitoring, and identification and treatment of any inciting cause. Management centers around optimization of cardiac function, with a multipronged approach aimed at reversing the pathophysiology of right ventricular failure. For patients who remain critically ill or in shock despite medical optimization, mechanical circulatory support can be used as a bridge to recovery or lung transplantation.
    MeSH term(s) Critical Care/methods ; Critical Illness ; Heart Failure/etiology ; Heart Failure/therapy ; Humans ; Hypertension, Pulmonary/therapy ; Intensive Care Units
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2020.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Breathing for Two.

    Rudder, Meghan / Russo, Melissa / Ventetuolo, Corey E

    The New England journal of medicine

    2021  Volume 384, Issue 1, Page(s) 61–68

    MeSH term(s) Adult ; Cardiac Catheterization ; Diagnosis, Differential ; Dyspnea/etiology ; Echocardiography ; Electrocardiography ; Erythema Infectiosum/complications ; Erythema Infectiosum/diagnosis ; Female ; Heart Failure/diagnosis ; Heart Ventricles/diagnostic imaging ; Humans ; Parvovirus B19, Human/isolation & purification ; Pregnancy ; Pregnancy Complications, Cardiovascular/diagnosis ; Pregnancy Complications, Infectious/diagnosis ; Pulmonary Arterial Hypertension/complications ; Pulmonary Arterial Hypertension/diagnosis ; Radiography, Thoracic ; Respiration ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcps2006666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pulmonary Hypertension: A Contemporary Review.

    Johnson, Shelsey / Sommer, Natascha / Cox-Flaherty, Katherine / Weissmann, Norbert / Ventetuolo, Corey E / Maron, Bradley A

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 5, Page(s) 528–548

    Abstract: Major advances in pulmonary arterial hypertension, pulmonary hypertension (PH) associated with lung disease, and chronic thromboembolic PH cast new light on the pathogenetic mechanisms, epidemiology, diagnostic approach, and therapeutic armamentarium for ...

    Abstract Major advances in pulmonary arterial hypertension, pulmonary hypertension (PH) associated with lung disease, and chronic thromboembolic PH cast new light on the pathogenetic mechanisms, epidemiology, diagnostic approach, and therapeutic armamentarium for pulmonary vascular disease. Here, we summarize key basic, translational, and clinical PH reports, emphasizing findings that build on current state-of-the-art research. This review includes cutting-edge progress in translational pulmonary vascular biology, with a guide to the diagnosis of patients in clinical practice, incorporating recent PH definition revisions that continue emphasis on early detection of disease. PH management is reviewed including an overview of the evolving considerations for the approach to treatment of PH in patients with cardiopulmonary comorbidities, as well as a discussion of the groundbreaking sotatercept data for the treatment of pulmonary arterial hypertension.
    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/etiology ; Pulmonary Arterial Hypertension/complications ; Vascular Diseases ; Lung ; Familial Primary Pulmonary Hypertension/complications ; Chronic Disease ; Pulmonary Embolism/complications
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202302-0327SO
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Group 3 Pulmonary Hypertension: From Bench to Bedside.

    Singh, Navneet / Dorfmüller, Peter / Shlobin, Oksana A / Ventetuolo, Corey E

    Circulation research

    2022  Volume 130, Issue 9, Page(s) 1404–1422

    Abstract: Pulmonary hypertension (PH) because of chronic lung disease is categorized as Group 3 PH in the most recent classification system. Prevalence of these diseases is increasing over time, creating a growing need for effective therapeutic options. Recent ... ...

    Abstract Pulmonary hypertension (PH) because of chronic lung disease is categorized as Group 3 PH in the most recent classification system. Prevalence of these diseases is increasing over time, creating a growing need for effective therapeutic options. Recent approval of the first pulmonary arterial hypertension therapy for the treatment of Group 3 PH related to interstitial lung disease represents an encouraging advancement. This review focuses on molecular mechanisms contributing to pulmonary vasculopathy in chronic hypoxia, the pathology and epidemiology of Group 3 PH, the right ventricular dysfunction observed in this population and clinical trial data that inform the use of pulmonary vasodilators in Group 3 PH.
    MeSH term(s) Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/epidemiology ; Lung ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/drug therapy ; Vasodilator Agents ; Ventricular Dysfunction, Right/drug therapy
    Chemical Substances Vasodilator Agents
    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.121.319970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Another Piece in the Estrogen Puzzle of Pulmonary Hypertension.

    Al-Naamani, Nadine / Ventetuolo, Corey E

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 3, Page(s) 274–275

    MeSH term(s) Animals ; Estrogens ; Hypertension, Pulmonary ; Pulmonary Artery ; Rats
    Chemical Substances Estrogens
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201910-1982ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Nothing but a Number? Age and Precision Treatment in Pulmonary Arterial Hypertension.

    Mullin, Christopher J / Ventetuolo, Corey E

    American journal of respiratory and critical care medicine

    2018  Volume 198, Issue 8, Page(s) 986–988

    MeSH term(s) Familial Primary Pulmonary Hypertension ; Humans ; Hypertension, Pulmonary
    Language English
    Publishing date 2018-07-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201806-1075ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Systolic Strain by Speckle-Tracking Echocardiography Is a Feasible and Sensitive Measure of Right Ventricular Dysfunction in Acute Respiratory Failure Patients on Mechanical Ventilation.

    Simmons, James / Haines, Philip / Extein, Jonathan / Bashir, Zubair / Aliotta, Jason / Ventetuolo, Corey E

    Critical care explorations

    2022  Volume 4, Issue 1, Page(s) e0619

    Abstract: Right ventricular (RV) dysfunction is common in acute respiratory failure and associated with worse outcomes, but it can be difficult to detect in the ICU setting. Speckle-tracking echocardiography (STE) can identify early changes in RV systolic function ...

    Abstract Right ventricular (RV) dysfunction is common in acute respiratory failure and associated with worse outcomes, but it can be difficult to detect in the ICU setting. Speckle-tracking echocardiography (STE) can identify early changes in RV systolic function and be quantified as systolic strain. We measured the feasibility of RV global longitudinal systolic strain (RV GLS) in respiratory failure patients and its association with clinical outcomes.
    Design: Retrospective cohort.
    Setting: Two tertiary hospital medical ICUs in Providence, RI, from March 2015 to January 2018.
    Patients: Two hundred twenty-three patients with acute respiratory failure requiring mechanical ventilation (MV) with available echocardiograms.
    Measurements and main results: Clinical data were extracted from medical records. RV GLS was measured via STE (TOMTEC, Chicago, IL), along with standard echocardiographic measurements by two independent readers blinded to outcomes. The average age was 65 years (range, 21-90 yr), 121 (54%) were men, and the most common etiology of respiratory failure was pneumonia (
    Conclusions: The measurement of RV GLS by STE in subjects on MV is feasible, reproducible, and sensitive for the detection of RV dysfunction. RV GLS may predict poor outcomes in acute respiratory failure.
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Selective serotonin reuptake inhibitors and lung function in the multi-ethnic study of atherosclerosis lung study.

    Armstrong, Hilary F / Lederer, David / Lovasi, Gina S / Hiura, Grant / Ventetuolo, Corey E / Barr, RGraham

    Respiratory medicine

    2022  Volume 196, Page(s) 106805

    Abstract: Objective: Depression in patients with Chronic Obstructive Pulmonary Disease (COPD) has been shown to be chronic and potentially increase the burden of symptoms. Selective serotonin reuptake inhibitors (SSRIs) have anti-inflammatory and serotonergic ... ...

    Abstract Objective: Depression in patients with Chronic Obstructive Pulmonary Disease (COPD) has been shown to be chronic and potentially increase the burden of symptoms. Selective serotonin reuptake inhibitors (SSRIs) have anti-inflammatory and serotonergic effects that may improve lung function. We hypothesized that participants taking SSRIs have better lung function than those not taking SSRIs. The dataset was the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. Use of SSRIs was assessed by medication inventory; spirometry was conducted following standard guidelines; dyspnea ratings were self-reported.
    Results: Contrary to our hypothesis, FEV1 was lower, and odds of dyspnea were higher among participants taking SSRIs as compared with those not taking an antidepressant; these differences persisted even with control for potential confounders including depressive symptoms. We found no evidence of a beneficial association between SSRI use and lung function or dyspnea in a large US-based cohort.
    MeSH term(s) Antidepressive Agents/adverse effects ; Atherosclerosis/drug therapy ; Dyspnea ; Humans ; Lung ; Selective Serotonin Reuptake Inhibitors/adverse effects
    Chemical Substances Antidepressive Agents ; Serotonin Uptake Inhibitors
    Language English
    Publishing date 2022-03-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2022.106805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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