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  1. Article ; Online: Uninformed Reform: The Attempt to Abolish the Hospital Managers' Section 23 Discharge Power Under the Mental Health Act 1983.

    Webb, Thomas E

    Medical law review

    2018  Volume 27, Issue 1, Page(s) 79–107

    Abstract: Under section 23 of the Mental Health Act 1983 a person can be discharged by the managers of the hospital from compulsory care. The limited evidence indicates that the section 23 power is normally delegated to a specially appointed panel who hold a ... ...

    Abstract Under section 23 of the Mental Health Act 1983 a person can be discharged by the managers of the hospital from compulsory care. The limited evidence indicates that the section 23 power is normally delegated to a specially appointed panel who hold a hearing. Unfortunately, notwithstanding the implications for the liberty, autonomy, and dignity of the compelled person, very little is known about how this process operates. Nonetheless, since 1996 there has been a sustained effort to abolish the power. In view of this, the proposal to reform the 1983 Act contained in the Queen's Speech January 2017, and the subsequent establishment of the Independent Review of the Mental Health Act in October 2017, I critique the claims made in the abolition debate, and establish the conceptual gaps therein. I argue that a much more developed understanding of the power is required before any change is made to the law in this area.
    MeSH term(s) Health Care Reform/history ; Health Care Reform/legislation & jurisprudence ; Health Facility Administrators/legislation & jurisprudence ; History, 20th Century ; History, 21st Century ; Humans ; Mental Health Services ; Patient Discharge/legislation & jurisprudence ; United Kingdom
    Language English
    Publishing date 2018-04-24
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 1197078-9
    ISSN 1464-3790 ; 0967-0742
    ISSN (online) 1464-3790
    ISSN 0967-0742
    DOI 10.1093/medlaw/fwy008
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  2. Article ; Online: Eukaryotic (translation) initiation factor 4A (eIF4A) inhibition may be used to treat Huntington's disease by decreasing the expression of huntingtin.

    Webb, Thomas E

    Medical hypotheses

    2017  Volume 114, Page(s) 28

    MeSH term(s) 5' Untranslated Regions ; Cell Line, Tumor ; Codon, Initiator ; Eukaryotic Initiation Factor-4A/antagonists & inhibitors ; Humans ; Huntingtin Protein/biosynthesis ; Huntington Disease/drug therapy ; Mutation ; Neuroblastoma/drug therapy ; Open Reading Frames ; Protein Binding ; Protein Biosynthesis ; Protein Structure, Secondary ; RNA, Messenger/metabolism
    Chemical Substances 5' Untranslated Regions ; Codon, Initiator ; HTT protein, human ; Huntingtin Protein ; RNA, Messenger ; Eukaryotic Initiation Factor-4A (EC 2.7.7.-)
    Language English
    Publishing date 2017-10-31
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2017.10.028
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  3. Article ; Online: Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1'-phosphatase.

    Webb, Thomas E / Saad, Ramy

    Immunology letters

    2020  Volume 224, Page(s) 38–39

    MeSH term(s) Amino Acid Sequence ; Animals ; Betacoronavirus/enzymology ; Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/enzymology ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Host-Pathogen Interactions ; Humans ; Macrophage Activation ; Macrophages/enzymology ; Macrophages/immunology ; Macrophages/virology ; Pandemics ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Poly(ADP-ribose) Polymerases/chemistry ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Pyrophosphatases/chemistry ; Pyrophosphatases/genetics ; Pyrophosphatases/metabolism ; SARS-CoV-2 ; Sequence Homology ; T-Lymphocytes, Helper-Inducer/enzymology ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/virology ; Th1-Th2 Balance ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism
    Chemical Substances Viral Proteins ; PARP14 protein, human (EC 2.4.2.30) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; ADP-ribose pyrophosphatase I (EC 3.6.1.-) ; Pyrophosphatases (EC 3.6.1.-)
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2020.05.008
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  4. Article ; Online: Revealing uncertainty in the status of biodiversity change.

    Johnson, T F / Beckerman, A P / Childs, D Z / Webb, T J / Evans, K L / Griffiths, C A / Capdevila, P / Clements, C F / Besson, M / Gregory, R D / Thomas, G H / Delmas, E / Freckleton, R P

    Nature

    2024  Volume 628, Issue 8009, Page(s) 788–794

    Abstract: Biodiversity faces unprecedented threats from rapid global ... ...

    Abstract Biodiversity faces unprecedented threats from rapid global change
    MeSH term(s) Biodiversity ; Uncertainty ; Phylogeny ; Animals ; Conservation of Natural Resources/trends ; Datasets as Topic ; Time Factors ; Spatio-Temporal Analysis
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07236-z
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  6. Article ; Online: Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1’-phosphatase

    Webb, Thomas E. / Saad, Ramy

    Immunology Letters

    2020  Volume 224, Page(s) 38–39

    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2020.05.008
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  7. Article ; Online: Assessing resilience of a health system is difficult but necessary to prepare for the next crisis.

    Sagan, Anna / Thomas, Steve / Webb, Erin / McKee, Martin

    BMJ (Clinical research ed.)

    2023  Volume 382, Page(s) e073721

    MeSH term(s) Humans ; Delivery of Health Care ; Government Programs
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2022-073721
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  8. Article ; Online: Longitudinal clustering of health behaviours and their association with multimorbidity in older adults in England: A latent class analysis.

    Suhag, Alisha / Webb, Thomas L / Holmes, John

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0297422

    Abstract: ... to cluster (i.e. occur in specific combinations within distinct subpopulations). However, little is known ...

    Abstract Background: Health-risk behaviours such as smoking, unhealthy nutrition, alcohol consumption, and physical inactivity (termed SNAP behaviours) are leading risk factors for multimorbidity and tend to cluster (i.e. occur in specific combinations within distinct subpopulations). However, little is known about how these clusters change with age in older adults, and whether and how cluster membership is associated with multimorbidity.
    Methods: Repeated measures latent class analysis using data from Waves 4-8 of the English Longitudinal Study of Ageing (ELSA; n = 4759) identified clusters of respondents with common patterns of SNAP behaviours over time. Disease status (from Wave 9) was used to assess disorders of eight body systems, multimorbidity, and complex multimorbidity. Multinomial and binomial logistic regressions were used to examine how clusters were associated with socio-demographic characteristics and disease status.
    Findings: Seven clusters were identified: Low-risk (13.4%), Low-risk yet inactive (16.8%), Low-risk yet heavy drinkers (11.4%), Abstainer yet inactive (20.0%), Poor diet and inactive (12.9%), Inactive, heavy drinkers (14.5%), and High-risk smokers (10.9%). There was little evidence that these clusters changed with age. People in the clusters characterised by physical inactivity (in combination with other risky behaviours) had lower levels of education and wealth. People in the heavy drinking clusters were predominantly male. Compared to other clusters, people in the Low-risk and Low-risk yet heavy drinkers had a lower prevalence of all health conditions studied. In contrast, the Abstainer but inactive cluster comprised mostly women and had the highest prevalence of multimorbidity, complex multimorbidity, and endocrine disorders. High-risk smokers were most likely to have respiratory disorders.
    Conclusions: Health-risk behaviours tend to be stable as people age and so ought to be addressed early. We identified seven clusters of older adults with distinct patterns of behaviour, socio-demographic characteristics and multimorbidity prevalence. Intervention developers could use this information to identify high-risk subpopulations and tailor interventions to their behaviour patterns and socio-demographic profiles.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Health Behavior ; Latent Class Analysis ; Multimorbidity ; Longitudinal Studies ; Cluster Analysis ; Alcoholic Intoxication
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297422
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  9. Article: Is urologist burnout different on the other side of the pond? A European perspective.

    Pang, Karl H / Webb, Thomas E / Esperto, Francesco / Osman, Nadir I

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2021  Volume 15, Issue 6 Suppl 1, Page(s) S25–S30

    Abstract: The rate of burnout among physicians appears to be on the rise and urologist are no exception. In fact, urology appears to be one of the specialties most affected, with European urologists reporting burnout rates of up to 54% and those working in the ... ...

    Abstract The rate of burnout among physicians appears to be on the rise and urologist are no exception. In fact, urology appears to be one of the specialties most affected, with European urologists reporting burnout rates of up to 54% and those working in the United States up to 68%.Herein, we review the relatively few studies looking at burnout in European urologists to estimate its prevalence and discuss what could be done to reverse the trend. A total of seven studies were identified assessing burnout in urologists in Europe and Turkey. While the rates vary (9.3-68%), they indicate that burnout is prevalent within urology, with data from other studies suggesting there is a rising trend. Although the topic has been studied for many years, with an increased focus in the last decade, little seems to have been done to improve the situation.
    Language English
    Publishing date 2021-08-18
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.7227
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  10. Article ; Online: Subjective Causes for Failure to Return to Sport After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis.

    Yensen, Katie / Mayfield, Cory K / Bolia, Ioanna K / Palmer, Ryan A / Brown, Michael / Kim, Daniel R / Abu-Zahra, Maya S / Kotlier, Jacob L / Webb, Thomas / Cleary, Emmett / Saboori, Nima / Petrigliano, Frank A / Weber, Alexander E

    Sports health

    2024  , Page(s) 19417381241231631

    Abstract: Context: While current literature has explored the outcomes of athletes who return to sport (RTS) after anterior cruciate ligament (ACL) injuries, less is known about the outcomes of those who are unsuccessful in returning to sport.: Objective: To ... ...

    Abstract Context: While current literature has explored the outcomes of athletes who return to sport (RTS) after anterior cruciate ligament (ACL) injuries, less is known about the outcomes of those who are unsuccessful in returning to sport.
    Objective: To determine the rate of athletes who did not RTS after primary ACL reconstruction (ACLR) and to identify the specific subjective reasons for failure to RTS.
    Data sources: A comprehensive search of the PubMed/MEDLINE, Scopus, and Web of Science databases was conducted through April 2021.
    Study selection: Eligible studies included those explicitly reporting the rate of failure for RTS after ACLR as well as providing details on reasons for athletes' inability to return; 31 studies met the inclusion criteria.
    Study design: Systematic review and meta-analysis.
    Level of evidence: Level 2 to 4.
    Data extraction: The reasons for failure to RTS referred to in our study are derived from those established previously in the studies included. Data were collected on the number of athletes, mean age, mean follow-up time, type of sport played, failure to RTS rate, and specific reasons for failure to return.
    Results: The weighted rate of failure to RTS after ACLR was 25.5% (95% CI, 19.88-31.66). The estimated proportion of psychosocial-related reasons cited for failure to RTS was significantly greater than knee-related reasons for failure RTS (55.4% vs 44.6%,
    Conclusion: This study estimates the rate of failure to RTS after ACLR to be 25.5%, with the majority of athletes citing fear of reinjury as the major deterrent for returning to sports. We highlight how factors independent of surgical outcomes may impact an athlete's ability to return to play given that the predominant reason for no RTS after ACLR was unrelated to the knee.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2508802-6
    ISSN 1941-0921 ; 1941-7381
    ISSN (online) 1941-0921
    ISSN 1941-7381
    DOI 10.1177/19417381241231631
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