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  1. Article ; Online: Adjuvant pembrolizumab for melanoma: update from the EORTC 1325-MG/KEYNOTE-054 trial.

    Indini, Alice / Grossi, Francesco

    The Lancet. Oncology

    2021  Volume 22, Issue 5, Page(s) 573–575

    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Double-Blind Method ; Humans ; Melanoma/drug therapy ; Skin Neoplasms/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
    Language English
    Publishing date 2021-04-12
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(21)00125-X
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    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 460: Show issues

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  2. Article ; Online: Efficacy of Tixagevimab-Cilgavimab as Immunoprophylaxis in Patients With Hematologic Cancer.

    Salvini, Marco / Grossi, Paolo Antonio / Cacioppo, Alessandro / Merli, Michele / Pellegrini, Giacomo / Brociner, Marco / Passamonti, Francesco

    JAMA oncology

    2024  Volume 10, Issue 3, Page(s) 405–407

    MeSH term(s) Humans ; Antibodies, Monoclonal ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/drug therapy ; Patients
    Chemical Substances tixagevimab ; cilgavimab (1KUR4BN70F) ; Antibodies, Monoclonal
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.6446
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  3. Article ; Online: Quality of bladder cancer treatment information on YouTube: May the user's profile affect the quality of results?

    Prontera, Pier Paolo / Prusciano, Francesca Romana / Lattarulo, Marco / Utano, Emanuele / Schiralli, Francesco / Sciorio, Carmine / Romano, Lorenzo / Grossi, Francesco Saverio

    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

    2024  Volume 96, Issue 1, Page(s) 12179

    Abstract: Background: Social media are widely used information tools, including the medical/health field. Unfortunately, the levels of misinformation on these platforms seem to be high, with a medium-low quality of the proposed content, as evidenced by previous ... ...

    Abstract Background: Social media are widely used information tools, including the medical/health field. Unfortunately, the levels of misinformation on these platforms seem to be high, with a medium-low quality of the proposed content, as evidenced by previous studies. You Tube is one of the most important platforms for audio/video content. It shows content to users through a recommendation algorithm system.
    Materials and methods: We have classified in two cohorts the first results obtained by researching "bladder tumor treatment" on You Tube through two different user profiles: "Cohort A" with a not logged-in session in incognito mode (46 videos enrolled) and "Cohort B" with a logged-in session with a physician profile (50 videos enrolled). The videos were evaluated using validated instruments such as DISCERN and PEMAT-AV Furthermore, we used a Likert's scale for the evaluation of levels of misinformation.
    Results: Overall quality of information was moderate to poor (DISCERN 3) in 54% of Cohort A and 24% of Cohort B. Moreover, a high degree of misinformation (Likert score 3) was found in 52% of Cohort A cases and 32% of Cohort B.
    Conclusions: Levels of misinformation in both cohorts are positively correlated to the number of views per month. Globally, the levels of information quality, understandability and actionability are lower for the results obtained from searches performed with anonymous user profile (Cohort A).
    MeSH term(s) Humans ; Social Media ; Urinary Bladder Neoplasms/therapy ; Physicians ; Reproducibility of Results
    Language English
    Publishing date 2024-02-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1153526-x
    ISSN 2282-4197 ; 1120-8538 ; 1124-3562
    ISSN (online) 2282-4197
    ISSN 1120-8538 ; 1124-3562
    DOI 10.4081/aiua.2024.12179
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    Ui VI Zs.182: Show issues Location:
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  4. Article: Current Insights on the Treatment of Anaplastic Lymphoma Kinase-Positive Metastatic Non-Small Cell Lung Cancer: Focus on Brigatinib.

    Rijavec, Erika / Biello, Federica / Indini, Alice / Grossi, Francesco / Genova, Carlo

    Clinical pharmacology : advances and applications

    2022  Volume 14, Page(s) 1–9

    Abstract: Rearrangement of anaplastic lymphoma kinase ( ...

    Abstract Rearrangement of anaplastic lymphoma kinase (
    Language English
    Publishing date 2022-01-20
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2520726-X
    ISSN 1179-1438
    ISSN 1179-1438
    DOI 10.2147/CPAA.S284850
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  5. Article: Difficult Respiratory Weaning after Cardiac Surgery: A Narrative Review.

    Nicolotti, Davide / Grossi, Silvia / Nicolini, Francesco / Gallingani, Alan / Rossi, Sandra

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: Respiratory weaning after cardiac surgery can be difficult or prolonged in up to 22.7% of patients. The inability to wean from a ventilator within the first 48 h after surgery is related to increased short- and long-term morbidity and mortality. Risk ... ...

    Abstract Respiratory weaning after cardiac surgery can be difficult or prolonged in up to 22.7% of patients. The inability to wean from a ventilator within the first 48 h after surgery is related to increased short- and long-term morbidity and mortality. Risk factors are mainly non-modifiable and include preoperative renal failure, New York Heart Association, and Canadian Cardiac Society classes as well as surgery and cardio-pulmonary bypass time. The positive effects of pressure ventilation on the cardiovascular system progressively fade during the progression of weaning, possibly leading to pulmonary oedema and failure of spontaneous breathing trials. To prevent this scenario, some parameters such as pulmonary artery occlusion pressure, echography-assessed diastolic function, brain-derived natriuretic peptide, and extravascular lung water can be monitored during weaning to early detect hemodynamic decompensation. Tracheostomy is considered for patients with difficult and prolonged weaning. In such cases, optimal patient selection, timing, and technique may be important to try to reduce morbidity and mortality in this high-risk population.
    Language English
    Publishing date 2023-01-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020497
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  6. Article ; Online: Gender distribution in the editorial boards of surgical journals: A snapshot from Western Europe.

    Picciariello, Arcangelo / Altomare, Donato Francesco / Gallo, Gaetano / Grossi, Ugo

    Surgery

    2021  Volume 170, Issue 4, Page(s) 1292

    MeSH term(s) Europe ; Humans ; Periodicals as Topic ; Physicians, Women
    Language English
    Publishing date 2021-08-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2021.07.006
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    Uk I Zs.129: Show issues Location:
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  7. Article ; Online: Tumori polmonari non a piccole cellule con istotipo non squamoso. Nuove prospettive nel trattamento di seconda linea.

    Grossi, Francesco

    Recenti progressi in medicina

    2016  Volume 107, Issue 12, Page(s) 641–646

    Abstract: The treatment options for patients with non-squamous non-small cell lung cancer (NSCLC) in second-line have been limited for a long time. Docetaxel, pemetrexed and erlotinib are the standard second-line treatment. Docetaxel is frequently used although it ...

    Title translation New perspectives in second-line treatment in non-squamous non-small cell lung cancer.
    Abstract The treatment options for patients with non-squamous non-small cell lung cancer (NSCLC) in second-line have been limited for a long time. Docetaxel, pemetrexed and erlotinib are the standard second-line treatment. Docetaxel is frequently used although it is associated with an unfavorable safety profile. Recently, the results from the trial CheckMate 057 with nivolumab, an anti-PD-1 inhibitor, has increased the therapeutic options for patients with non-squamous NSCLC in the second-line setting. The results of this randomized phase III trial comparing nivolumab vs docetaxel have deeply changed our current clinical practice. This review explores the recent findings about nivolumab in this setting by analyzing the results of CheckMate 057 trial findings and discussing their implications in clinical practice. Particular attention has been given to efficacy, patients selection, toxicity profile, and quality of life.
    Language Italian
    Publishing date 2016-12
    Publishing country Italy
    Document type Journal Article ; English Abstract
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/2502.26232
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    Zs.B 193: Show issues Location:
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  8. Article ; Online: Immune related adverse events and response to immunotherapy: Focus on corticosteroids.

    Indini, Alice / Rijavec, Erika / Grossi, Francesco

    Lung cancer (Amsterdam, Netherlands)

    2020  Volume 145, Page(s) 225

    MeSH term(s) Adrenal Cortex Hormones ; Humans ; Immunotherapy ; Italy ; Lung Neoplasms ; Nivolumab
    Chemical Substances Adrenal Cortex Hormones ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2020-02-17
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2020.02.009
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    Zs.A 2135: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 423: Show issues

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  9. Article ; Online: Finite-size criticality in fully connected spin models on superconducting quantum hardware.

    Grossi, Michele / Kiss, Oriel / De Luca, Francesco / Zollo, Carlo / Gremese, Ian / Mandarino, Antonio

    Physical review. E

    2023  Volume 107, Issue 2-1, Page(s) 24113

    Abstract: The emergence of a collective behavior in a many-body system is responsible for the quantum criticality separating different phases of matter. Interacting spin systems in a magnetic field offer a tantalizing opportunity to test different approaches to ... ...

    Abstract The emergence of a collective behavior in a many-body system is responsible for the quantum criticality separating different phases of matter. Interacting spin systems in a magnetic field offer a tantalizing opportunity to test different approaches to study quantum phase transitions. In this work, we exploit the new resources offered by quantum algorithms to detect the quantum critical behavior of fully connected spin-1/2 models. We define a suitable Hamiltonian depending on an internal anisotropy parameter γ that allows us to examine three paradigmatic examples of spin models, whose lattice is a fully connected graph. We propose a method based on variational algorithms run on superconducting transmon qubits to detect the critical behavior for systems of finite size. We evaluate the energy gap between the first excited state and the ground state, the magnetization along the easy axis of the system, and the spin-spin correlations. We finally report a discussion about the feasibility of scaling such approach on a real quantum device for a system having a dimension such that classical simulations start requiring significant resources.
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.107.024113
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  10. Book ; Online: Guide de facilitateur sur la gestion des risques climatiques dans le conseil agricole au Sénégal

    List, Geneva / Braun, Melody / Grossi, Amanda / Hansen, James / Trzaska, Sylwia / Fiondella, Francesco

    2023  

    Abstract: Guide de facilitateur sur la gestion des risques climatiques dans le conseil agricole au Sénégal . ...

    Abstract Guide de facilitateur sur la gestion des risques climatiques dans le conseil agricole au Sénégal .
    Keywords climate change ; capacity development ; climate-smart agriculture
    Language French
    Publishing date 2023-06-22T19:40:00Z
    Publisher International Research Institute for Climate and Society
    Publishing country fr
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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