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Book: Jo-seon-geun-dae-so-seol-sa

Sim, Gyeong-seob / Han, Chung-mo / Sim, Kyŏng-sŏp

2013

Title variant	Chosŏn kŭndae sosŏlsa
Author's details	[jib-pil Han Jung-mo; Sim Gyeong-seob]
Keywords	Biographical fiction, Korean/History and criticism ; Historycal fiction, Korean/History and criticism ; Korean fiction/History and criticism ; Realism in literature ; Social realism in literature
Language	Korean
Size	191 S.
Publisher	Sa-hoe-gwa-hag-chul-pan-sa
Publishing place	Pyeong-yang
Document type	Book
Note	In korean. Schr.
ISBN	9789946300832 ; 9946300834
Database	Former special subject collection: coastal and deep sea fishing

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Book: Ba u wa eun byeol seon nyeo

Han, Dong sug / Han, Tong-suk

(Geum gang san jeon seol geu lim chaeg ; 1 ; 금강산전설그림책 ; 1)

1991

Title variant	Pauwa ŭnbyŏl sŏnnyŏ
Author's details	[pyeon jib Han Dong sug]
Series title	Geum gang san jeon seol geu lim chaeg ; 1 금강산전설그림책 ; 1
Keywords	Children's stories, Korean
Language	Korean
Size	88 S, überw. Ill
Publisher	Geum seong cheong nyeon chul pan sa
Publishing place	Pyeong yang
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Vascular and metabolic effects of ipragliflozin versus sitagliptin (IVS) in type 2 diabetes treated with sulphonylurea and metformin: IVS study.

Kang, Seon Mee / Yun, Han Mi / Sohn, Minji / Lim, Soo

Diabetes, obesity & metabolism

2023 Volume 25, Issue 7, Page(s) 1922–1931

Abstract: Objective: In patients with type 2 diabetes who were inadequately controlled with metformin and sulphonylurea, we compared the glucose-lowering efficacy, cardiometabolic parameters and safety of two drugs, ipragliflozin, a sodium-glucose cotransporter-2 ...

Abstract	Objective: In patients with type 2 diabetes who were inadequately controlled with metformin and sulphonylurea, we compared the glucose-lowering efficacy, cardiometabolic parameters and safety of two drugs, ipragliflozin, a sodium-glucose cotransporter-2 inhibitor, and sitagliptin, a dipeptidyl peptidase-4 inhibitor. MATERIALS AND METHODS: Patients with 7.5%-9.0% glycated haemoglobin treated with metformin and sulphonylurea were randomly assigned to ipragliflozin (50 mg, n = 70) or sitagliptin (100 mg, n = 70) therapy for 24 weeks. Measures of glycaemic control, fatty liver indices, other metabolic parameters and subclinical atherosclerosis were compared by a paired t-test before and after 24 weeks of treatment. Results: Mean glycated haemoglobin levels decreased from 8.5% to 7.5% in the ipragliflozin group and from 8.5% to 7.8% in the sitagliptin group, resulting in a 0.34% between-group difference (95% confidence interval, 0.10%-0.43%, p = .088). Fasting and postprandial 2-h glucose levels also showed a similar trend, with a greater reduction with ipragliflozin therapy. An increase of over 70% in ketone levels and a decrease in whole body and abdominal fat masses were observed with ipragliflozin treatment. Fatty liver indices also improved with ipragliflozin treatment. Despite no difference in carotid intima-media thickness and ankle-brachial index, ipragliflozin therapy improved flow-mediated vasodilation, reflecting endothelial function, while sitagliptin did not. The safety profile did not differ between the two groups. Conclusions: Ipragliflozin add-on therapy can be a viable option for better glycaemic control with multiple vascular and metabolic benefits in patients with type 2 diabetes who are inadequately controlled with metformin and sulphonylurea.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/metabolism ; Sitagliptin Phosphate/adverse effects ; Metformin/adverse effects ; Glycated Hemoglobin ; Carotid Intima-Media Thickness ; Blood Glucose/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Treatment Outcome ; Hypoglycemic Agents/adverse effects ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Sulfonylurea Compounds/therapeutic use ; Drug Therapy, Combination ; Fatty Liver/drug therapy
Chemical Substances	Sitagliptin Phosphate (TS63EW8X6F) ; Metformin (9100L32L2N) ; ipragliflozin (3N2N8OOR7X) ; Glycated Hemoglobin ; Blood Glucose ; Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents ; Dipeptidyl-Peptidase IV Inhibitors ; Sulfonylurea Compounds
Language	English
Publishing date	2023-04-04
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5442: Show issues

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Article ; Online: Seroprevalence of severe fever with thrombocytopenia syndrome using specimens from the Korea National Health & Nutrition Examination Survey.

Kim, Choon-Mee / Han, Mi Ah / Yun, Na Ra / Bang, Mi-Seon / Lee, You Mi / Lee, Beomgi / Kim, Dong-Min

PLoS neglected tropical diseases

2023 Volume 17, Issue 3, Page(s) e0011097

Abstract: Background: Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile disease caused by bites from ticks infected with the SFTS virus. In Korea, SFTS patients are observed nationwide, including Jeju Island, but there are currently no data ... ...

Abstract	Background: Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile disease caused by bites from ticks infected with the SFTS virus. In Korea, SFTS patients are observed nationwide, including Jeju Island, but there are currently no data regarding the national prevalence of SFTS, including that of residents of 16 cities and provinces. This study aimed to investigate the seroprevalence of SFTS in Korea. Methodology/principal findings: A total of 1500 participants were selected through random sampling from the 2014-2015 Korea National Health and Nutrition Examination Survey (KNHANES). An indirect immunofluorescence antibody assay (IFA) was performed to assess immunoglobulin (Ig) G and IgM antibody titers against SFTS virus. Results: Of the 1500 participants, 55 (3.7%) tested positive for IgG and 1 (0.1%) tested positive for IgM, with antibody titer of ≥ 1:32. Approximately 3.9% and 2.5% of participants in urban and rural areas, respectively, had a positive titer of ≥ 1:32. There was a significant correlation between SFTS incidence per 100,000 population and seroprevalence using an IgG titer ≥ 1:64 as the cut-off value. Conclusion: This is the first study to investigate national SFTS seroprevalence in all 16 cities and provinces representing Korea. Our study will also provide useful guidelines for the development of preventive measures against SFTS.
MeSH term(s)	Humans ; Severe Fever with Thrombocytopenia Syndrome ; Bunyaviridae Infections/epidemiology ; Nutrition Surveys ; Seroepidemiologic Studies ; Antibodies, Viral ; Phlebovirus ; Immunoglobulin G ; Republic of Korea/epidemiology
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011097
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Associations Between Phthalate, Eosinophil, and Aeroallergen Sensitization in Schoolchildren.

Yi, Jeongsik / Shin, Ho-Sang / Han, Man Yong / Choi, Hee Jin / Lee, Mi Seon / Sung, Myongsoon

Journal of Korean medical science

2023 Volume 38, Issue 45, Page(s) e391

Abstract: Background: Phthalates and bisphenol A (BPA) are endocrine-disrupting chemicals and may cause immunological disorders in children. Therefore, according to the region, we investigated urinary phthalates and BPA levels and the relationship between urinary ...

Abstract	Background: Phthalates and bisphenol A (BPA) are endocrine-disrupting chemicals and may cause immunological disorders in children. Therefore, according to the region, we investigated urinary phthalates and BPA levels and the relationship between urinary phthalate, aeroallergen sensitization, and eosinophil count during the coronavirus disease 2019 pandemic. Methods: In total, 203 schoolchildren (134 residential and 69 industrial) aged 7-10 years were enrolled between July 2021 and July 2022. The BPA, metabolites of four high-molecular-weight phthalates (Σ4HMWP) and three low-molecular-weight phthalates (Σ3LMWP), were measured in the urine samples. Total eosinophil count and transepidermal water loss (TEWL) were also measured along with the skin prick test. Results: The two groups had no differences in terms of BPA. The industrial group had significantly more plastic container usage, and there was a difference in the Σ3LMWP ( Conclusion: Exposure to phthalates was significantly associated with eosinophil count but not with aeroallergen sensitization or vitamin D. Therefore, reducing the use of plastic containers may effectively prevent exposure to phthalates and reduce Th2 cell-mediated inflammation in children.
MeSH term(s)	Child ; Humans ; Environmental Pollutants ; Eosinophils/metabolism ; Phthalic Acids/urine ; Vitamin D ; Benzhydryl Compounds/urine ; Environmental Exposure/adverse effects
Chemical Substances	phthalic acid (6O7F7IX66E) ; Environmental Pollutants ; Phthalic Acids ; Vitamin D (1406-16-2) ; bisphenol A (MLT3645I99) ; Benzhydryl Compounds
Language	English
Publishing date	2023-11-20
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2023.38.e391
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Zs.B 3163: Show issues

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Article ; Online: Subversive molecular role of Krüppel-like factor 5 in extracellular matrix degradation and chondrocyte dedifferentiation.

Han, Yohan / Yu, Seon-Mi / Shah, Fahad Hassan / Kim, Song Ja

Functional & integrative genomics

2022 Volume 22, Issue 6, Page(s) 1307–1313

Abstract: Osteoarthritis (OA) is the most common joint disorder worldwide and a leading cause of pain and disability. However, the pathogenesis of osteoarthritis has not been elucidated. Krüppel-like factor (KLF)-5 is involved in several biological processes, ... ...

Abstract	Osteoarthritis (OA) is the most common joint disorder worldwide and a leading cause of pain and disability. However, the pathogenesis of osteoarthritis has not been elucidated. Krüppel-like factor (KLF)-5 is involved in several biological processes, including inflammation and cell differentiation, but its role in OA has not been evaluated. In this study, we investigated the role of KLF-5 in chondrocyte differentiation. KLF-5 overexpression in chondrocytes induced a loss of type II collagen expression and sulfated proteoglycan synthesis at the transcriptional and translational levels. Based on immunofluorescence staining, the ectopic expression of KLF-5 reduced type II collagen expression. In contrast, with KLF-5-transfected cells, KLF-5 siRNA transfection-induced type II expression also blocked dedifferentiation caused by the overexpression of KLF-5. In zebra fish, KLF-5 reduced the sulfated proteoglycan synthesis of ceratobranchial cartilage. Our results suggest that KLF-5 plays a pivotal role in the dedifferentiation of rabbit articular cartilage and zebra fish, providing a basis for therapeutic strategy for osteoarthritis aimed at controlling cartilage destruction.
MeSH term(s)	Animals ; Rabbits ; Chondrocytes ; Collagen Type II/metabolism ; Zebrafish/genetics ; Zebrafish/metabolism ; Osteoarthritis/genetics ; Transcription Factors/metabolism ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Kruppel-Like Transcription Factors/genetics ; Proteoglycans/metabolism ; Proteoglycans/therapeutic use ; Cells, Cultured
Chemical Substances	Collagen Type II ; Transcription Factors ; Kruppel-Like Transcription Factors ; Proteoglycans
Language	English
Publishing date	2022-08-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-022-00892-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The use of the internal transcribed spacer region for phylogenetic analysis of the microsporidian parasite Enterocytozoon hepatopenaei infecting whiteleg shrimp (Penaeus vannamei) and for the development of a nested PCR as its diagnostic tool.

Lee, Ju Hee / Jeon, Hye Jin / Seo, Sangsu / Lee, Chorong / Kim, Bumkeun / Kwak, Dong-Mi / Rhee, Man Hee / Piamsomboon, Patharapol / Nuraini, Yani Lestari / Je, Chang Uook / Park, Seon Young / Kim, Ji Hyung / Han, Jee Eun

Journal of microbiology and biotechnology

2024 Volume 34, Issue 5, Page(s) 1–10

Abstract: The increasing economic losses associated with growth retardation caused ... ...

Abstract	The increasing economic losses associated with growth retardation caused by
Language	English
Publishing date	2024-02-27
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2412195-2
ISSN	1738-8872 ; 1738-8872
ISSN (online)	1738-8872
ISSN	1738-8872
DOI	10.4014/jmb.2401.01010
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Article ; Online: Seroprevalence of varicella-zoster virus as measured by fluorescent antibody to membrane antigen assay and glycoprotein enzyme-linked immunosorbent assay more than 10 years after initiation of a universal vaccination program: An observational study.

Ji, Hye Seon / Kang, Kyu Ri / Kang, Hyun Mi / Choi, Ui Yoon / Lee, Soo Young / Kang, Jin Han

Medicine

2024 Volume 103, Issue 3, Page(s) e36931

Abstract: Universal varicella vaccination (UVV), as a single dose to children aged 12 to 15 months, was introduced in Korea in 2005. A seroprevalence study is required to upgrade this UVV strategy. The fluorescent antibody to membrane antigen (FAMA) assay is the ... ...

Abstract	Universal varicella vaccination (UVV), as a single dose to children aged 12 to 15 months, was introduced in Korea in 2005. A seroprevalence study is required to upgrade this UVV strategy. The fluorescent antibody to membrane antigen (FAMA) assay is the gold standard for varicella-zoster virus (VZV) immunity testing. However, no standard operating procedure (SOP) has been developed for the FAMA assay, in which either glutaraldehyde or acetone may be used for VZV-infected cell fixation. In this observational study, we aimed to investigate the age-specific seroprevalence in Korean children and adults. Additionally, with glycoprotein enzyme-linked immunosorbent assay (gpELISA) as the reference, we evaluated the performance of the FAMA assay using acetone-fixed cells. Four hundred sera were analyzed using the FAMA assay (acetone-fixed cells) and gpELISA, comprising 50 subjects from each age category. In the FAMA assay, the seropositivity rate decreased from 82.0% in the 1 to 4-year-old group to 58.0% in the 5 to 9-year-old group (95% confidence interval [CI]: 69.2-90.2 and 44.2-70.6, respectively; P = .009), while that in the gpELISA decreased from 80.0% to 52.0% (95% CI: 67.0-88.8 and 38.5-65.2, respectively; P = .003). In both methods, the seropositivity rates ranged from 95% to 100% in the population aged ≥ 20 years. We observed a significant correlation between the 2 methods, with a correlation coefficient of 0.795 (P < .001). In receiver operating characteristic analysis using the gpELISA results as a reference, the area under the curve for the FAMA assay was very high at 0.995 (95% CI: 0.990-1.000; P < .001). Compared to the gpELISA, the sensitivity, specificity, and kappa value of the FAMA assay were 99.4%, 79.3%, and 0.84 (nearly perfect), respectively. The seropositivity rate of the 5 to 9-year-old group indicated waning immunity over time and supported implementation of a second dose in the UVV program. The results of the FAMA assay were comparable to those of the gpELISA. Although further study is needed to standardize procedures, our results suggest that the FAMA assay using acetone-fixed cells can be used widely and can be included in a universal FAMA assay SOP.
MeSH term(s)	Adult ; Child ; Humans ; Infant ; Child, Preschool ; Herpesvirus 3, Human ; Seroepidemiologic Studies ; Acetone ; Antibodies, Viral ; Enzyme-Linked Immunosorbent Assay/methods ; Glycoproteins ; Vaccination ; Chickenpox/epidemiology
Chemical Substances	Acetone (1364PS73AF) ; Antibodies, Viral ; Glycoproteins
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036931
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Article ; Online: Distinct Clinical and Laboratory Features of COVID-19 in Children During the Pre-Delta, Delta and Omicron Wave.

Han, Mi Seon / Kim, Kyung Min / Oh, Kyung Jin / Chang, Ju Young / Lee, Seong Yong / Choi, Ji Eun / Shin, Su-Mi / Sun, Jiyu

The Pediatric infectious disease journal

2023 Volume 42, Issue 5, Page(s) 423–428

Abstract: Background: The SARS-CoV-2 variants of concern exhibit distinct features in terms of transmissibility and virulence. This study compared the clinical characteristics of COVID-19 in children during pre-Delta, Delta and Omicron waves.: Methods: Medical ...

Abstract	Background: The SARS-CoV-2 variants of concern exhibit distinct features in terms of transmissibility and virulence. This study compared the clinical characteristics of COVID-19 in children during pre-Delta, Delta and Omicron waves. Methods: Medical records of 1163 children <19 years of age with COVID-19 admitted to a designated hospital in Seoul, South Korea, were analyzed. Clinical and laboratory findings during the pre-Delta (March 1, 2020, to June 30, 2021; 330 children), Delta (July 1, 2021, to December 31, 2021; 527 children) and Omicron (January 1, 2022, to May 10, 2022; 306 children) waves were compared. Results: Children during the Delta wave were older and had a higher proportion of fever ≥5 days and pneumonia than children during the pre-Delta and Omicron waves. The Omicron wave was characterized by younger age and a higher proportion of fever ≥39.0 °C, febrile seizure and croup. More children <2 years of age and adolescents aged 10 to <19 years experienced neutropenia and lymphopenia, respectively, during the Delta wave. Children aged 2 to <10 years had a higher incidence of leukopenia and lymphopenia during the Omicron wave. Conclusions: Distinct features of COVID-19 were observed in children during the Delta and Omicron surges. Continuous scrutiny of the manifestations of variants of concern is needed for appropriate public health response and management.
MeSH term(s)	Adolescent ; Humans ; Child ; Young Adult ; Adult ; Child, Preschool ; COVID-19/epidemiology ; SARS-CoV-2 ; Lymphopenia ; Neutropenia ; Fever
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003872
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Article ; Online: Tuberculous Pericarditis Mimicking a Malignant Pericardial Tumor: A Case Report.

Park, Ji Young / Han, Ji-Yeon / Park, Jinyoung / Shin, Gi Won / Yun, Su Young / Kang, Mi Seon / Kim, Da Som

Journal of the Korean Society of Radiology

2023 Volume 85, Issue 1, Page(s) 197–203

Abstract: Tuberculous pericarditis is an extrapulmonary manifestation of tuberculosis that is most commonly associated with pericardial thickening, effusion, and calcification. We present a case of tuberculous pericarditis mimicking a malignant pericardial tumor ... ...

Abstract	Tuberculous pericarditis is an extrapulmonary manifestation of tuberculosis that is most commonly associated with pericardial thickening, effusion, and calcification. We present a case of tuberculous pericarditis mimicking a malignant pericardial tumor in a 77-year-old male. CT revealed an irregular and nodular pericardial thickening. MRI revealed high signal intensity on T1-weighted fat-suppressed images and peripheral rim enhancement after gadolinium administration. MRI can be helpful in determining the differential diagnoses in cases of tuberculous pericarditis with nonspecific imaging findings.
Language	English
Publishing date	2023-12-09
Publishing country	Korea (South)
Document type	Case Reports
ISSN	2951-0805
ISSN (online)	2951-0805
DOI	10.3348/jksr.2023.0021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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