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  1. Article ; Online: Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration.

    Rey-Gallardo, Angela / Tomlins, Hannah / Joachim, Justin / Rahman, Izajur / Kitscha, Phoebe / Frudd, Karen / Parsons, Maddy / Ivetic, Aleksandar

    Journal of cell science

    2018  Volume 131, Issue 13

    Abstract: Leukocyte transendothelial migration (TEM) is absolutely fundamental to the inflammatory response, and involves initial pseudopod protrusion and subsequent polarised migration across inflamed endothelium. Ezrin/radixin/moesin (ERM) proteins are expressed ...

    Abstract Leukocyte transendothelial migration (TEM) is absolutely fundamental to the inflammatory response, and involves initial pseudopod protrusion and subsequent polarised migration across inflamed endothelium. Ezrin/radixin/moesin (ERM) proteins are expressed in leukocytes and mediate cell shape changes and polarity. The spatio-temporal organisation of ERM proteins with their targets, and their individual contribution to protrusion during TEM, has never been explored. Here, we show that blocking binding of moesin to phosphatidylinositol 4,5-bisphosphate (PIP
    MeSH term(s) Cell Line ; Cell Movement ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Endothelium/cytology ; Endothelium/metabolism ; Humans ; L-Selectin/genetics ; L-Selectin/metabolism ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Monocytes/cytology ; Monocytes/metabolism ; Protein Binding
    Chemical Substances Cytoskeletal Proteins ; Microfilament Proteins ; ezrin ; L-Selectin (126880-86-2) ; moesin (144131-77-1)
    Language English
    Publishing date 2018-07-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.215541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration.

    Newe, Abigail / Rzeniewicz, Karolina / König, Melanie / Schroer, Carsten F E / Joachim, Justin / Rey-Gallardo, Angela / Marrink, Siewert J / Deka, Jürgen / Parsons, Maddy / Ivetic, Aleksandar

    Frontiers in immunology

    2019  Volume 10, Page(s) 2227

    Abstract: The migration of circulating leukocytes toward damaged tissue is absolutely fundamental to the inflammatory response, and transendothelial migration (TEM) describes the first cellular barrier that is breached in this process. Human ... ...

    Abstract The migration of circulating leukocytes toward damaged tissue is absolutely fundamental to the inflammatory response, and transendothelial migration (TEM) describes the first cellular barrier that is breached in this process. Human CD14
    MeSH term(s) Cell Membrane/metabolism ; Cells, Cultured ; Cluster Analysis ; Cytoplasm/metabolism ; Cytoskeletal Proteins/metabolism ; HEK293 Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; L-Selectin/metabolism ; Leukocytes/metabolism ; Membrane Proteins/metabolism ; Microfilament Proteins/metabolism ; Monocytes/metabolism ; Phosphorylation/physiology ; Serine/metabolism ; Signal Transduction/physiology ; THP-1 Cells ; Transendothelial and Transepithelial Migration/physiology
    Chemical Substances Cytoskeletal Proteins ; Membrane Proteins ; Microfilament Proteins ; ezrin ; L-Selectin (126880-86-2) ; moesin (144131-77-1) ; radixin (144517-21-5) ; Serine (452VLY9402)
    Language English
    Publishing date 2019-09-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.02227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Polysialic acid is required for neuropilin-2a/b-mediated control of CCL21-driven chemotaxis of mature dendritic cells and for their migration in vivo

    Rey-Gallardo, Angela / Delgado-Martín, Cristina / Gerardy-Schahn, Rita / Rodríguez-Fernández, José L / Vega, Miguel A

    Glycobiology. 2011 May, v. 21, no. 5

    2011  

    Abstract: Migration of mature dendritic cells (mDCs) to secondary lymphoid organs is required for the development of immunity. Recently, we reported that polysialic acid (PSA) and the transmembrane glycoprotein neuropilin-2 (NRP2) control mDC chemotaxis to CCL21 ... ...

    Abstract Migration of mature dendritic cells (mDCs) to secondary lymphoid organs is required for the development of immunity. Recently, we reported that polysialic acid (PSA) and the transmembrane glycoprotein neuropilin-2 (NRP2) control mDC chemotaxis to CCL21 and that this process is dependent on the C-terminal basic region of the chemokine. Herein, we provide further insight into the molecular components controlling PSA regulated chemotaxis in mDCs. In the present study, we demonstrate that human mDCs express the NRP2 isoforms NRP2a and NRP2b, that both of them are susceptible to polysialylation and that polysialylation is required to specifically enhance chemotaxis toward CCL21 in mDCs. The results presented suggest that PSA attached to NRP2 isoforms acts as a binding module for the CCL21 chemokine, thereby facilitating its presentation to the chemokine receptor CCR7. To investigate the relevance of polysialylation on mDC migration, a xenograft mouse model was used and the migration of human DCs to mouse lymph nodes analyzed. Here, we demonstrate that the depletion of PSA from mDCs results in a drastic reduction in the migration of the cells to draining popliteal lymph nodes. With this finding, we provide first evidence that PSA is a crucial factor for in vivo migration of mDCs to lymph nodes.
    Keywords CCR7 receptor ; animal models ; chemokine CCL21 ; chemotaxis ; dendritic cells ; glycoproteins ; humans ; immunity ; lymph nodes ; mice
    Language English
    Dates of publication 2011-05
    Size p. 655-662.
    Document type Article
    ZDB-ID 1067689-2
    ISSN 1460-2423 ; 0959-6658
    ISSN (online) 1460-2423
    ISSN 0959-6658
    DOI 10.1093/glycob/cwq216
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  4. Article ; Online: Polysialic acid is required for neuropilin-2a/b-mediated control of CCL21-driven chemotaxis of mature dendritic cells and for their migration in vivo.

    Rey-Gallardo, Angela / Delgado-Martín, Cristina / Gerardy-Schahn, Rita / Rodríguez-Fernández, José L / Vega, Miguel A

    Glycobiology

    2011  Volume 21, Issue 5, Page(s) 655–662

    Abstract: Migration of mature dendritic cells (mDCs) to secondary lymphoid organs is required for the development of immunity. Recently, we reported that polysialic acid (PSA) and the transmembrane glycoprotein neuropilin-2 (NRP2) control mDC chemotaxis to CCL21 ... ...

    Abstract Migration of mature dendritic cells (mDCs) to secondary lymphoid organs is required for the development of immunity. Recently, we reported that polysialic acid (PSA) and the transmembrane glycoprotein neuropilin-2 (NRP2) control mDC chemotaxis to CCL21 and that this process is dependent on the C-terminal basic region of the chemokine. Herein, we provide further insight into the molecular components controlling PSA regulated chemotaxis in mDCs. In the present study, we demonstrate that human mDCs express the NRP2 isoforms NRP2a and NRP2b, that both of them are susceptible to polysialylation and that polysialylation is required to specifically enhance chemotaxis toward CCL21 in mDCs. The results presented suggest that PSA attached to NRP2 isoforms acts as a binding module for the CCL21 chemokine, thereby facilitating its presentation to the chemokine receptor CCR7. To investigate the relevance of polysialylation on mDC migration, a xenograft mouse model was used and the migration of human DCs to mouse lymph nodes analyzed. Here, we demonstrate that the depletion of PSA from mDCs results in a drastic reduction in the migration of the cells to draining popliteal lymph nodes. With this finding, we provide first evidence that PSA is a crucial factor for in vivo migration of mDCs to lymph nodes.
    MeSH term(s) Animals ; Cells, Cultured ; Chemokine CCL19/pharmacology ; Chemokine CCL21/pharmacology ; Chemokine CCL21/physiology ; Chemotaxis ; Dendritic Cells/drug effects ; Dendritic Cells/physiology ; Glycosylation ; Humans ; Mice ; Neuropilin-2/chemistry ; Neuropilin-2/metabolism ; Protein Isoforms/chemistry ; Protein Isoforms/metabolism ; Protein Processing, Post-Translational ; Sialic Acids/metabolism
    Chemical Substances Chemokine CCL19 ; Chemokine CCL21 ; Neuropilin-2 ; Protein Isoforms ; Sialic Acids ; polysialic acid
    Language English
    Publishing date 2011-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067689-2
    ISSN 1460-2423 ; 0959-6658
    ISSN (online) 1460-2423
    ISSN 0959-6658
    DOI 10.1093/glycob/cwq216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Polysialylated neuropilin-2 enhances human dendritic cell migration through the basic C-terminal region of CCL21

    Rey-Gallardo, Angela / Escribano, Cristina / Delgado-Martín, Cristina / Rodriguez-Fernández, José L / Gerardy-Schahn, Rita / Rutishauser, Urs / Corbi, Angel L / Vega, Miguel A

    Glycobiology. 2010 Sept., v. 20, no. 9

    2010  

    Abstract: Dendritic cell (DC) migration to secondary lymphoid organs is a critical step to properly exert its role in immunity and predominantly depends on the interaction of the chemokine receptor CCR7 with its ligands CCL21 and CCL19. Polysialic acid (PSA) has ... ...

    Abstract Dendritic cell (DC) migration to secondary lymphoid organs is a critical step to properly exert its role in immunity and predominantly depends on the interaction of the chemokine receptor CCR7 with its ligands CCL21 and CCL19. Polysialic acid (PSA) has been recently reported to control CCL21-directed migration of mature DCs. Here, we first demonstrate that PSA present on human mature monocyte-derived dendritic cells did not enhance chemotactic responses to CCL19. We have also explored the molecular mechanisms underlying the selective enhancing effect of PSA on CCL21-driven chemotaxis of DCs. In this regard, we found out that prevention of DC polysialylation decreased CCL21 activation of JNK and Akt signaling pathways, both associated with CCR7-mediated chemotaxis. We also report that the enhanced PSA-mediated effect on DC migration towards CCL21 relied on the highly basic C-terminal region of this chemokine and depended on the PSA acceptor molecule neuropilin-2 (NRP2) and on the polysialyltransferase ST8SiaIV. Altogether, our data indicate that the CCR7/CCL21/NRP2/ST8SiaIV functional axis constitutes an important guidance clue for DC targeting to lymphoid organs.
    Keywords CCR7 receptor ; cell movement ; chemokine CCL19 ; chemokine CCL21 ; chemotaxis ; dendritic cells ; glycosyltransferases ; humans ; immunity ; ligands ; lymphatic system ; mitogen-activated protein kinase ; signal transduction
    Language English
    Dates of publication 2010-09
    Size p. 1139-1146.
    Document type Article
    ZDB-ID 1067689-2
    ISSN 1460-2423 ; 0959-6658
    ISSN (online) 1460-2423
    ISSN 0959-6658
    DOI 10.1093/glycob/cwq078
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  6. Article ; Online: Polysialylated neuropilin-2 enhances human dendritic cell migration through the basic C-terminal region of CCL21.

    Rey-Gallardo, Angela / Escribano, Cristina / Delgado-Martín, Cristina / Rodriguez-Fernández, José L / Gerardy-Schahn, Rita / Rutishauser, Urs / Corbi, Angel L / Vega, Miguel A

    Glycobiology

    2010  Volume 20, Issue 9, Page(s) 1139–1146

    Abstract: Dendritic cell (DC) migration to secondary lymphoid organs is a critical step to properly exert its role in immunity and predominantly depends on the interaction of the chemokine receptor CCR7 with its ligands CCL21 and CCL19. Polysialic acid (PSA) has ... ...

    Abstract Dendritic cell (DC) migration to secondary lymphoid organs is a critical step to properly exert its role in immunity and predominantly depends on the interaction of the chemokine receptor CCR7 with its ligands CCL21 and CCL19. Polysialic acid (PSA) has been recently reported to control CCL21-directed migration of mature DCs. Here, we first demonstrate that PSA present on human mature monocyte-derived dendritic cells did not enhance chemotactic responses to CCL19. We have also explored the molecular mechanisms underlying the selective enhancing effect of PSA on CCL21-driven chemotaxis of DCs. In this regard, we found out that prevention of DC polysialylation decreased CCL21 activation of JNK and Akt signaling pathways, both associated with CCR7-mediated chemotaxis. We also report that the enhanced PSA-mediated effect on DC migration towards CCL21 relied on the highly basic C-terminal region of this chemokine and depended on the PSA acceptor molecule neuropilin-2 (NRP2) and on the polysialyltransferase ST8SiaIV. Altogether, our data indicate that the CCR7/CCL21/NRP2/ST8SiaIV functional axis constitutes an important guidance clue for DC targeting to lymphoid organs.
    MeSH term(s) Amino Acid Sequence ; Amino Acids, Basic/chemistry ; Amino Acids, Basic/metabolism ; Animals ; COS Cells ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Movement/physiology ; Cells, Cultured ; Cercopithecus aethiops ; Chemokine CCL21/chemistry ; Chemokine CCL21/metabolism ; Chemokine CCL21/pharmacology ; Chemokine CCL21/physiology ; Dendritic Cells/drug effects ; Dendritic Cells/metabolism ; Dendritic Cells/physiology ; Humans ; Models, Biological ; Molecular Sequence Data ; Neuropilin-2/antagonists & inhibitors ; Neuropilin-2/genetics ; Neuropilin-2/metabolism ; Neuropilin-2/physiology ; Protein Interaction Domains and Motifs/drug effects ; Protein Interaction Domains and Motifs/physiology ; Protein Processing, Post-Translational/physiology ; RNA, Small Interfering/pharmacology ; Sequence Homology, Amino Acid ; Sialic Acids/metabolism ; Up-Regulation/drug effects
    Chemical Substances Amino Acids, Basic ; CCL21 protein, human ; Chemokine CCL21 ; Neuropilin-2 ; RNA, Small Interfering ; Sialic Acids ; polysialic acid
    Language English
    Publishing date 2010-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067689-2
    ISSN 1460-2423 ; 0959-6658
    ISSN (online) 1460-2423
    ISSN 0959-6658
    DOI 10.1093/glycob/cwq078
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  7. Article ; Online: L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro.

    Rzeniewicz, Karolina / Newe, Abigail / Rey Gallardo, Angela / Davies, Jessica / Holt, Mark R / Patel, Ashish / Charras, Guillaume T / Stramer, Brian / Molenaar, Chris / Tedder, Thomas F / Parsons, Maddy / Ivetic, Aleksandar

    Proceedings of the National Academy of Sciences of the United States of America

    2015  Volume 112, Issue 12, Page(s) E1461–70

    Abstract: L-selectin is a cell adhesion molecule that tethers free-flowing leukocytes from the blood to luminal vessel walls, facilitating the initial stages of their emigration from the circulation toward an extravascular inflammatory insult. Following shear- ... ...

    Abstract L-selectin is a cell adhesion molecule that tethers free-flowing leukocytes from the blood to luminal vessel walls, facilitating the initial stages of their emigration from the circulation toward an extravascular inflammatory insult. Following shear-resistant adhesion to the vessel wall, L-selectin has frequently been reported to be rapidly cleaved from the plasma membrane (known as ectodomain shedding), with little knowledge of the timing or functional consequence of this event. Using advanced imaging techniques, we observe L-selectin shedding occurring exclusively as primary human monocytes actively engage in transendothelial migration (TEM). Moreover, the shedding was localized to transmigrating pseudopods within the subendothelial space. By capturing monocytes in midtransmigration, we could monitor the subcellular distribution of L-selectin and better understand how ectodomain shedding might contribute to TEM. Mechanistically, L-selectin loses association with calmodulin (CaM; a negative regulator of shedding) specifically within transmigrating pseudopods. In contrast, L-selectin/CaM interaction remained intact in nontransmigrated regions of monocytes. We show phosphorylation of L-selectin at Ser 364 is critical for CaM dissociation, which is also restricted to the transmigrating pseudopod. Pharmacological or genetic inhibition of L-selectin shedding significantly increased pseudopodial extensions in transmigrating monocytes, which potentiated invasive behavior during TEM and prevented the establishment of front/back polarity for directional migration persistence once TEM was complete. We conclude that L-selectin shedding directly regulates polarity in transmigrated monocytes, which affirms an active role for this molecule in driving later stages of the multistep adhesion cascade.
    MeSH term(s) Amino Acid Sequence ; Cell Adhesion ; Cell Movement ; Cell Polarity ; Cytoplasm/metabolism ; Fluorescence Resonance Energy Transfer ; Green Fluorescent Proteins/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Inflammation ; L-Selectin/metabolism ; Leukocytes/metabolism ; Microscopy, Electron, Transmission ; Microscopy, Video ; Molecular Sequence Data ; Monocytes/cytology ; Monocytes/metabolism ; Phosphorylation ; Serine/chemistry
    Chemical Substances L-Selectin (126880-86-2) ; Green Fluorescent Proteins (147336-22-9) ; Serine (452VLY9402)
    Language English
    Publishing date 2015-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1417100112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Recent advances in genitourinary tumors: A review focused on biology and systemic treatment.

    González Del Alba, Aránzazu / Arranz, José Ángel / Puente, Javier / Méndez-Vidal, María José / Gallardo, Enrique / Grande, Enrique / Pérez-Valderrama, Begoña / González-Billalabeitia, Enrique / Lázaro-Quintela, Martín / Pinto, Álvaro / Lainez, Nuria / Piulats, Josep M / Esteban, Emilio / Maroto Rey, José Pablo / García, Jorge A / Suárez, Cristina

    Critical reviews in oncology/hematology

    2017  Volume 113, Page(s) 171–190

    Abstract: Updated information published up to 2016 regarding major advances in renal cancer, bladder cancer, and prostate cancer is here presented. Based on an ever better understanding of the genetic and molecular alterations that govern the initial pathogenic ... ...

    Abstract Updated information published up to 2016 regarding major advances in renal cancer, bladder cancer, and prostate cancer is here presented. Based on an ever better understanding of the genetic and molecular alterations that govern the initial pathogenic mechanisms of tumor oncogenesis, an improvement in the characterization and treatment of urologic tumors has been achieved in the past year. According to the Cancer Genome Atlas (ATLAS) project, alterations in the MET pathway are characteristics of type 1 papillary renal cell carcinomas, and activation of NRF2-ARE pathway is associated with the biologically distinct type 2. While sunitinib and pazopanib continue to be the standard first-line treatment in metastatic renal cell carcinoma of clear cell histology, nivolumab and cabozantinib are now the agents of choice in the second-line setting. In relation to urothelial bladder carcinoma, new potential molecular targets such as FGFR3, PI3K/AKT, RTK/RAS, CDKN2A, ARIDIA, ERBB2 have been identified. Response to adjuvant cisplatin-based chemotherapy appears to be related to basal, luminal, and p53-like intrinsic subtypes. A phase II study with eribulin and a maintenance phase II trial with vinflunine have shown promising results. Similarly, the use of the check point inhibitors in advanced disease is likely to revolutionize the management of patients who have progressed after cisplatin-based chemotherapy. In prostate cancer, seven mutually exclusive molecular subtypes have been identified by the TCGA project. Chemotherapy has been consolidated as a key treatment for castration-sensitive metastatic prostate cancer, and abiraterone, enzalutamide, cabazitaxel, and radium-223 remain standard therapeutic options for men with metastatic castration-resistant prostate cancer. All this progress will undoubtedly contribute to the development of new treatments and therapeutic strategies that will improve the survival and quality of life of our patients.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Humans ; Male ; Urogenital Neoplasms/drug therapy ; Urogenital Neoplasms/metabolism ; Urogenital Neoplasms/pathology
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2017-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2017.03.010
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  9. Article ; Online: Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state

    Rodríguez-Baño, Jesús / Pachón, Jerónimo / Carratalà, Jordi / Ryan, Pablo / Jarrín, Inmaculada / Yllescas, María / Arribas, José Ramón / Berenguer, Juan / Aznar Muñoz, Esther / Gil Divasson, Pedro / González Muñiz, Patricia / Muñoz Aguirre, Clara / Díaz Menéndez, Marta / de la Calle Prieto, Fernando / Arsuaga Vicente, Marta / Trigo Esteban, Elena / Pérez Valero, Ignacio / de Miguel Buckley, Rosa / Cadiñaños Loidi, Julen /
    Diaz Pollan, Beatriz / Martín Carbonero, Luz / Ramos Ramos, Juan Carlos / Loeches Yagüe, Belén / Montejano Sánchez, Rocío / González García, Juan / García Rodríguez, Julio / Ramírez, Margarita / Gutiérrez, Isabel / Tejerina, Francisco / Aldámiz-Echevarría, Teresa / Díez, Cristina / Fanciulli, Chiara / Pérez-Latorre, Leire / Pinilla, Blanca / López, Juan Carlos / Such Diaz, Ana / Álvaro Alonso, Elena / Torres Macho, Juan / Cuevas Tascon, Guillermo / Jiménez González de Buitrago, Eva / Brañas Baztán, Fátima / Valencia de la Rosa, Jorge / Pérez Butragueño, Mario / Fernández Jiménez, Inés / Muñiz Nicolás, Gemma / Sepúlveda Berrocal, Antonia / Gato Díez, Alberto / Toledano Sierra, María Pilar / García Butenegro, María Paz / Peláez Ballesta, Ana Isabel / Morcillo Rodríguez, Elena / Fernández Romero, Isidoro / Peláez Ballesta, Cristina / Guirado Torrecillas, María Isabel / Goikoetxea Agirre, Josune / Bereciartua Bastarrica, Elena / Guio Carrión, Laura / Rodríguez Álvarez, Regino / Ibarrola Hierro, Marta / Pérez Hernández, Isabel A. / Pérez Zapata, Inés / Román Soto, Sergio / Kallouchi, Mohamed / Domínguez Vicent, Juan Ramón / Silvariño Fernández, Rafae / Ugalde Espiñeira, Jon / Sanjuan López, Ainhoa / García Martínez, Silvia / Temprano Gogenola, Mikel / Asensi, Víctor / Suárez, Silvia / Suárez, Lucia / Yllera, Carmen / Rivas-Carmenado, María / Romero-Palacios, Alberto / Ruiz Aragón, Jesús / Jiménez Aguilar, Patricia / Fernández Ávila, Ma Luisa / Castilla Ortiz, Rosario / Alende Castro, Vanesa / Pérez García, Cristina / Fernández Morales, Marta / Valle Feijoo Begoña Rodríguez Ferreira, María Lorena María / Gómez-Junyent, Joan / Villar-García, Judit / López-Montesinos, Inmaculada / Arrieta-Aldea, Itziar / Rial-Villavecchia, Abora / García Vázquez, Elisa / Roura Piloto, Aychel Elena / Moral Escudero, Encarnación / Hernández Torres, Alicia / Albendín Iglesias, Helena / Vinuesa García, David / Martínez Montes, Clara / De la Hera Fernández, Francisco Javier / Anguita Santos, Francisco / Ruiz Sancho, Andrés / Díaz de Brito Fernández, Vicens / Sanmarti Vilamala, Montserrat / España Cueto, Sergio / Molina Morant, Daniel / González-Cuevas, Araceli / Chara Cervantes, Joel Elías / Policarpo Torres, Guillem / Ortega Montoliu, Meritxell / Angerri Nadal, Mònica / De Genover Gil, Ariadna / Patera, Eleni / Godoy Lorenzo, Rita / Zioga, Evangelia Anna María / Isern Fernández, Virginia / Sabbagh Fajardo, Carlos Enrique / Ferrer Ribera, Ana / Bea Serrano, Carlos / Oltra Sempere, Rosa / Vela Bernal, Sara / Albiol Viñals, Paloma / Pedromingo Kus, Miguel / Garcinuño, María Ángeles / Fiorante, Silvana / Pérez Pinto, Sergio / de la Vega, Alexandra / Fariñas Álvarez, María Carmen / González Rico, Claudia / Arnaiz de las Revillas, Francisco / Giménez, Teresa / Calvo, Jorge / Meije Castillo, Yolanda / Duarte Borges, Alejandra / Pareja Coca, Júlia / Clemente Presas, Mercedes / Sanz Salvador, Xavier / Pérez Rodríguez, Ma Teresa / Sousa, Adrián / Pérez González, Alexandre / Longueira, Rebeca / Araujo, Alejandro / Alonso Martínez, Blanca / García Escudero, Laura / Lidia Kamel Rey, Sara / Roa Alonso, David / Avilés Parra, Juan Pablo / Pelegrín Senent, Iván / Rouco Esteves Marques, Rosana / Raich Montiu, Laia / Souto Higueras, Jessica / Gálvez Bobadilla, Manuel Alejandro / Parra Ruiz, Jorge / Ramos Sesma, Violeta / Velasco Fuentes, Sara / García Pereña, Laura / Lluna Carrascosa, Alfonso / Gilaberte Reyzábal, Sergio / Liébana Gómez, Mónica / Salillas Hernando, Juan / Serrano Martínez, Alberto / Torralba González de Suso, Miguel / Martínez Martín, Patricia / Rábago Lorite, Isabel / González-Ruano Pérez, Patricia / Pérez-Monte Mínguez, Beatriz / García Flores, Ángeles / Comas Casanova, Pere / Martín Plata, Andrea / Santana Báez, Sergio Manuel / Sanz Peláez, Oscar / Mohamed Ramírez, Karim / Robaina Bordón, José María / Vílchez Rueda, Helem Haydeé / Riera Jaume, Melchor / Mut Ramon, Gemma / Gavalda Manso, Meritxell / Planas Bibiloni, Lluis / Castelo Corral, Laura / Ramos Merino, Lucía / Sánchez Vidal, Efrén / Rodríguez Mayo, María / Míguez Rey, Enrique / García de Lomas Guerrero, José M. / De la Torre Lima, Javier / Correa Ruiz, Ana / Fernández Sánchez, Fernando / Jiménez-García, Nicolás / Sierra-Monzón, José Luis / Gracia-Tello, Borja / Hernández-Bonaga, María / Pellejero, Galadriel / Asín-Corrochano, Marta / Boix Palop, Lucia / Calbo, Esther / Badía, Cristina / Dietl, Beatriz / Lucía, Gómez / Domínguez-Castellano, Ángel / Ríos-Villegas, María José / del Toro, María D. / Palacios Baena, Zaira R. / Salamanca-Rivera, Elena / Marín, Elena / Almadana, Virginia / Pérez-Galera, Salvador / González-Iglesias, Luisa / Abelenda-Alonso, Gabriela / Álvarez-Pouso, Claudia / Escrihuela, Francesc / Gudiol, Carlota / Lorenzo-Esteller, Laia / Niubó, Jordi / Podzamczer, Daniel / Pujol, Miquel / Rombauts, Alexander / Salvert Lletí, Miguel / Gil Sánchez, Ricardo / Jiménez Escrig, Marta / Parra Gómez, Laura / Tasias Pitarch, Mariona / Navarro Vilasaró, Marta / Machado Sicilia, María Luisa / Gomila Grange, Aina / Calzado Isbert, Sonia / Carrasco Antón, Nerea / Petkova-Saiz, Elizabet / Cabello Úbeda, Alfonso / Górgolas Hernández-Mora, Miguel / Sánchez-Pernaute, Olga / Dueñas Gutiérrez, Carlos / Martin Guerra, Javier / Castrodeza Sanz, José Javier / Fernández Espinilla, Virginia / Rodríguez Fernández, Laura / González-Moreno, Juan / Villoslada Gelabert, Aroa / Ribot Sanso, María Antonia / Fernández-Baca, María Victoria / Hernández Milian, Almudena / Morán Rodríguez, Miguel Ángel / Ortiz de Zárate Ibarra, Zuriñe / Portu Zapirain, José Joaquin / Saez de Adana Arroniz, Ester / Gainzarain Arana, Juan Carlos / Meca Birlanga, Olga / del Amor Espín, Ma Jesús / Viqueira González, Montserrat / García García, Josefina / Martínez Madrid, Onofre / Bernal Morell, Enrique / Alcaraz, Antonia / Muñoz, Ángeles / Pina, Ignacio / de la Rosa, Vicente / Caínzos Romero, Tamara / Sánchez Trigo, Sabela / Mariño Callejo, Ana Isabel / Álvarez Díaz, Hortensia / Valcarce Pardeiro, Nieves / Sánchez Serrano, Adriana / Piñar Cabezos, Diana / García Villalba, Eva Pilar / Aguayo Jiménez, Carmen / Ruíz Campuzano, María / Naranjo Velasco, Virginia / Santos Peña, Marta / Mora Delgado, Juan / Sevilla Moreno, Israel / Lojo Cruz, Cristina / Kortajarena Urkola, Xabier / Iribarren Loyarte, José Antonio / Bustinduy Odriozola, María Jesús / Ibarguren Pinilla, Maialen / Álvarez Rodríguez, Ignacio / Martínez Marcos, Francisco Javier / Rodríguez Gómez, Francisco Javier / Asschert Agüero, Isabel / Muñoz Beamud, Francisco / Ruiz Reina, Antonio José / Llenas-García, Jara / González-Cuello, Inmaculada / Hellín-Valiente, Elena / Martínez Birlanga, Esther / Tafalla Torres, José Manuel / Calderón Parra, Jorge / Escudero López, Gabriela / Gutiérrez Martín, Isabel / Andrés Eisenhofer, Ane / García Prieto, Sonia / Álvarez Franco, Raquel / Roger Zapata, Daniel / Martínez Cifre, Blanca / Aranda Rife, Elena / Martín Rubio, Irene / Barbosa Ventura, André / Garrido, Javier / Gonzalo, Concepción / Piñero, Iván / de la Cruz Felipe, Nieves / Talavera García, Eva / Lamata Subero, Marta / Mendoza Roy, Paula / García de Carlos, María Soledad / Lajusticia Aisa, Justo / Arteche Eguizabal, Lorea / Urrutia Losada, Ainhoa / Domingo Echaburu, Saioa / Cuadros Tito, Pedro Ángel / Orbe Narváez, Gurutz / Liébana Martos, Ma del Carmen / Roldán Fontana, Carolina / Herrero Rodríguez, Carmen / Duro Ruiz, Gaspar / Pérez Parra, Santiago / Mera Fidalgo, Arantzazu / Hortos Alsina, Miquel / Alberich Conesa, Ana / Bladé Vidal, Lourdes / Merchante Gutiérrez, Nicolás / León Jiménez, Eva / Espíndola Gómez, Reinaldo / Erostarbe Gallardo, María / Martínez Pérez-Crespo, Pedro / Cisneros, José Miguel / Aguilar-Guisado, Manuela / Aldabó, Teresa / Bueno, Claudio / Cordero-Matía, Elisa / Escoresca, Ana / Infante, Carmen / Guillermo, Martín / Salto, Sonsoles / Gioia, Francesca / Vizcarra, Pilar / Fortún Abete, Jesús / Martín Dávila, Pilar / Moreno Guillén, Santiago / Oteo Revuelta, José A. / García-García, Concepción / Santibañez Sáenz, Paula / Cervera Acedo, Cristina / Azcona Gutiérrez, José M. / Reguera Iglesias, José María / Plata Ciezar, Antonio / Valiente de Santis, Lucia / Sobrino Diaz, Beatriz / Ruiz Mesa, Juan Diego

    Clinical Microbiology and Infection ; ISSN 1198-743X

    a multicentre cohort study (SAM-COVID-19)

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.cmi.2020.08.010
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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