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  1. Book ; Online ; E-Book: Neuropathology

    Kovacs, Gabor Geza / Alafuzoff, Irina

    (Handbook of clinical neurology ; volume 145)

    2018  

    Author's details volume editors Gabor G. Kovacs and Irina Alafuzoff
    Series title Handbook of clinical neurology ; volume 145
    Collection
    Keywords Nervous System Diseases / pathology ; Nervous System / pathology ; Neuropathology ; Nervous system/Diseases ; Nervous system/Pathophysiology
    Subject code 616.8047
    Language English
    Size 1 Online-Ressource (xvii, 619 Seiten), Illustrationen
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019667519
    ISBN 978-0-12-802615-1 ; 9780128023952 ; 0-12-802615-4 ; 0128023953
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Neuropathology of neurodegenerative diseases

    Kovacs, Gabor G.

    a practical guide

    (Cambridge medicine)

    2015  

    Author's details ed. by Gabor G. Kovacs
    Series title Cambridge medicine
    Keywords Neurodegenerative Diseases / pathology
    Subject code 616.8/3
    Language English
    Size VII, 309 S. : Ill., graph. Darst.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT018493510
    ISBN 978-1-107-44242-9 ; 978-1-107-67420-2 ; 9781107588660 ; 1-107-44242-7 ; 1-107-67420-4 ; 1107588669
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 4747 available for loan (reading room) Lesesaal EG
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Article ; Online: The Irony of Iron: The Element with Diverse Influence on Neurodegenerative Diseases.

    Lee, Seojin / Kovacs, Gabor G

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Iron accumulation in the brain is a common feature of many neurodegenerative diseases. Its involvement spans across the main proteinopathies involving tau, amyloid-beta, alpha-synuclein, and TDP-43. Accumulating evidence supports the contribution of iron ...

    Abstract Iron accumulation in the brain is a common feature of many neurodegenerative diseases. Its involvement spans across the main proteinopathies involving tau, amyloid-beta, alpha-synuclein, and TDP-43. Accumulating evidence supports the contribution of iron in disease pathologies, but the delineation of its pathogenic role is yet challenged by the complex involvement of iron in multiple neurotoxicity mechanisms and evidence supporting a reciprocal influence between accumulation of iron and protein pathology. Here, we review the major proteinopathy-specific observations supporting four distinct hypotheses: (1) iron deposition is a consequence of protein pathology; (2) iron promotes protein pathology; (3) iron protects from or hinders protein pathology; and (4) deposition of iron and protein pathology contribute parallelly to pathogenesis. Iron is an essential element for physiological brain function, requiring a fine balance of its levels. Understanding of disease-related iron accumulation at a more intricate and systemic level is critical for advancements in iron chelation therapies.
    MeSH term(s) Humans ; Iron/metabolism ; Neurodegenerative Diseases/metabolism ; Animals ; tau Proteins/metabolism ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Brain/pathology ; alpha-Synuclein/metabolism ; DNA-Binding Proteins/metabolism ; Iron Chelating Agents/therapeutic use
    Chemical Substances Iron (E1UOL152H7) ; tau Proteins ; Amyloid beta-Peptides ; alpha-Synuclein ; DNA-Binding Proteins ; Iron Chelating Agents
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mycology: Rediscovery of a lost model fungus highlights the origin of mycorrhizal symbioses.

    Nagy, László G / Kovács, Gábor M

    Current biology : CB

    2021  Volume 31, Issue 7, Page(s) R342–R344

    Abstract: Arbuscular mycorrhizae (AM) are the most frequent symbioses of land plants. By reisolating a long-lost fungus from nature, a new study cracks the genomics of an enigmatic fungal-cyanobacterial partnership and reestablishes a valuable model for ... ...

    Abstract Arbuscular mycorrhizae (AM) are the most frequent symbioses of land plants. By reisolating a long-lost fungus from nature, a new study cracks the genomics of an enigmatic fungal-cyanobacterial partnership and reestablishes a valuable model for understanding the AM symbiosis.
    MeSH term(s) Mycology ; Mycorrhizae ; Symbiosis
    Language English
    Publishing date 2021-04-12
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Astroglia and Tau: New Perspectives.

    Kovacs, Gabor G

    Frontiers in aging neuroscience

    2020  Volume 12, Page(s) 96

    Abstract: Astrocytes contribute to the pathogenesis of neurodegenerative proteinopathies as influencing neuronal degeneration or neuroprotection, and also act as potential mediators of the propagation or elimination of disease-associated proteins. Protein ... ...

    Abstract Astrocytes contribute to the pathogenesis of neurodegenerative proteinopathies as influencing neuronal degeneration or neuroprotection, and also act as potential mediators of the propagation or elimination of disease-associated proteins. Protein astrogliopathies can be observed in different forms of neurodegenerative conditions. Morphological characterization of astrogliopathy is used only for the classification of tauopathies. Currently, at least six types of astrocytic tau pathologies are distinguished. Astrocytic plaques (AP), tufted astrocytes (TAs), ramified astrocytes (RA), and globular astroglial inclusions are seen predominantly in primary tauopathies, while thorn-shaped astrocytes (TSA) and granular/fuzzy astrocytes (GFA) are evaluated in aging-related tau astrogliopathy (ARTAG). ARTAG can be seen in the white and gray matter and subpial, subependymal, and perivascular locations. Some of these overlap with the features of tau pathology seen in Chronic traumatic encephalopathy (CTE). Furthermore, gray matter ARTAG shares features with primary tauopathy-related astrocytic tau pathology. Sequential distribution patterns have been described for tau astrogliopathies. Importantly, astrocytic tau pathology in primary tauopathies can be observed in brain areas without neuronal tau deposition. The various morphologies of tau astrogliopathy might reflect a role in the propagation of pathological tau protein, an early response to a yet unidentified neurodegeneration-inducing event, or, particularly for ARTAG, a response to a repeated or prolonged pathogenic process such as blood-brain barrier dysfunction or local mechanical impact. The concept of tau astrogliopathies and ARTAG facilitated communication among research disciplines and triggered the investigation of the significance of astrocytic lesions in neurodegenerative conditions.
    Language English
    Publishing date 2020-04-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2020.00096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Different Pathways for Synthesis of WO₃ and Vertically Aligned Carbon Nanotube-Based Nanostructures.

    Szabó, Anna / Kovács, Gábor / Kovács, Anita / Hernadi, Klara

    Journal of nanoscience and nanotechnology

    2021  Volume 21, Issue 4, Page(s) 2388–2393

    Abstract: ... gaining more-and-more interest among scientists due to their specific properties (e.g., electrical ...

    Abstract The synthesis and investigation of vertically aligned carbon nanotube (VACNT) based materials are gaining more-and-more interest among scientists due to their specific properties (e.g., electrical, optical, mechanical). Therefore, our interest for the present research has focused on synthesis of WO₃/VACNT based nanostructures (using carbon nanotube forests obtained by catalytic chemical vapor deposition-CCVD method on aluminum substrate) using different synthesis pathways and WO₃ precursors. The obtained composites were investigated by scanning electron microscopy (SEM), Raman spectroscopy, while the obtained crystal structures were characterized by X-ray diffraction (XRD). Results have shown that depending on the synthesis method, and using as template the carbonaceous structure, we can successfully obtain non-stochiometric tungsten oxide (W
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1533-4899
    ISSN (online) 1533-4899
    DOI 10.1166/jnn.2021.18964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Astrocytic-Neuronal Teamwork Against External Iron Attacks: Does It Always Work?

    Lee, Seojin / Kovacs, Gabor G

    Function (Oxford, England)

    2021  Volume 2, Issue 2, Page(s) zqab009

    MeSH term(s) Humans ; Neurons ; Astrocytes ; Iatrogenic Disease
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqab009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Effects of Machining Parameters and Tool Reconditioning on Cutting Force, Tool Wear, Surface Roughness and Burr Formation in Nickel-Based Alloy Milling.

    Kónya, Gábor / Kovács, Zsolt F

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 22

    Abstract: Nickel-based superalloys are among the most difficult materials to machine because they have high thermal strength, they are prone to hardening, carbides severely abrade the tool, and they have very poor thermal conductivity. Slot milling is a specific ... ...

    Abstract Nickel-based superalloys are among the most difficult materials to machine because they have high thermal strength, they are prone to hardening, carbides severely abrade the tool, and they have very poor thermal conductivity. Slot milling is a specific issue as it is characterized by rapid tool wear and frequent tool breakages. This is why reconditioned tools are frequently employed in industrial environments, as they can considerably decrease the expenses associated with tools. The chosen machining strategy also plays a crucial role in the tool's lifespan and the quality of the machined surface, making it essential to select the appropriate strategy. Hence, the authors have opted for two conventional trochoidal strategies, namely the circular and swinging toolpath, along with a contemporary toolpath known as the Autodesk Inventor HSM Adaptive strategy. The authors investigated the effects of technological parameters and toolpaths on cutting forces, tool wear, surface roughness and burr formation on machined edges. The results show that lower cutting parameters and adaptive strategies lead to the smallest tool loads, tool wear, the best quality of surface roughness and burr formation on machined edges.
    Language English
    Publishing date 2023-11-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16227140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: POINT: Did the World Symposium on Pulmonary Hypertension Get It Right in Redefining Abnormal Pulmonary Arterial Pressure? Yes.

    Kovacs, Gabor

    Chest

    2022  Volume 161, Issue 2, Page(s) 311–312

    MeSH term(s) Arterial Pressure ; Congresses as Topic ; Humans ; Hypertension, Pulmonary/physiopathology ; Pulmonary Artery/physiopathology ; Vital Signs
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.07.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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  10. Article ; Online: Rebuttal From Dr Kovacs.

    Kovacs, Gabor

    Chest

    2022  Volume 161, Issue 2, Page(s) 315–316

    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.07.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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