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  1. Article ; Online: Serious bradycardia and remdesivir for coronavirus 2019 (COVID-19): a new safety concerns.

    Touafchia, Anthony / Bagheri, Haleh / Carrié, Didier / Durrieu, Geneviève / Sommet, Agnès / Chouchana, Laurent / Montastruc, François

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  

    Abstract: Objectives: In recent clinical trials some cardiac arrhythmias were reported with use of remdesivir for COVID-19. To address this safety concern, we investigated whether use of remdesivir for COVID-19 is associated with an increased risk of bradycardia.! ...

    Abstract Objectives: In recent clinical trials some cardiac arrhythmias were reported with use of remdesivir for COVID-19. To address this safety concern, we investigated whether use of remdesivir for COVID-19 is associated with an increased risk of bradycardia.
    Methods: Using VigiBase®, the World Health Organization Global Individual Case Safety Reports database, we compared the cases of bradycardia reported in COVID-19 patients exposed to remdesivir with those reported in COVID-19 patients exposed to hydroxychloroquine, lopinavir/ritonavir, tocilizumab or glucocorticoids. All reports of patients with COVID-19 registered up to the 23 September 2020 were included. We conducted disproportionality analyses allowing the estimation of reporting odds ratios (RORs) with 95% CI.
    Results: We found 302 cardiac effects including 94 bradycardia (31%) among the 2603 reports with remdesivir prescribed in COVID-19 patients. Most of the 94 reports were serious (75, 80%), and in 16 reports (17%) evolution was fatal. Compared with hydroxychloroquine, lopinavir/ritonavir, tocilizumab or glucocorticoids, the use of remdesivir was associated with an increased risk of reporting bradycardia (ROR 1.65; 95% CI 1.23-2.22). Consistent results were observed in other sensitivity analyses.
    Discussion: This post-marketing study in a real-world setting suggests that the use of remdesivir is significantly associated with an increased risk of reporting bradycardia and serious bradycardia when compared with the use of with hydroxychloroquine, lopinavir/ritonavir, tocilizumab or glucocorticoids. This result is in line with the pharmacodynamic properties of remdesivir.
    Language English
    Publishing date 2021-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cardiovascular adverse effects of anti-IL-5/IL-5Rα therapies: A real-world study.

    Quinta, Jean-Baptiste / Montastruc, François / Sommet, Agnès / Touafchia, Anthony / Galinier, Michel / Reber, Laurent / Rousseau, Vanessa / Guilleminault, Laurent

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 3, Page(s) 1411–1413

    MeSH term(s) Eosinophils ; Humans ; Interleukin-5 ; Receptors, Interleukin-5
    Chemical Substances Interleukin-5 ; Receptors, Interleukin-5
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.12.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cardiogenic shock in adults with congenital heart disease: Insights from the FRENSHOCK registry.

    Karsenty, Clément / Touafchia, Anthony / Ladouceur, Magalie / Roubille, François / Bonnefoy, Eric / Bonello, Laurent / Leurent, Guillaume / Levy, Bruno / Champion, Sébastien / Lim, Pascal / Schneider, Francis / Cariou, Alain / Khachab, Hadi / Bourenne, Jeremy / Seronde, Marie-France / Harbaoui, Brahim / Vanzetto, Gérald / Quentin, Charlotte / Delabranche, Xavier /
    Combaret, Nicolas / Morel, Olivier / Lattuca, Benoit / Leborgne, Laurent / Fillippi, Emmanuelle / Gerbaud, Edouard / Brusq, Clara / Bongard, Vanina / Lamblin, Nicolas / Puymirat, Etienne / Delmas, Clément

    Archives of cardiovascular diseases

    2023  Volume 116, Issue 8-9, Page(s) 390–396

    Abstract: Background: Data on cardiogenic shock in adults with congenital heart disease (ACHD) are scarce.: Aim: We sought to describe cardiogenic shock in ACHD patients in a nationwide cardiogenic shock registry.: Methods: From the multicentric FRENSHOCK ... ...

    Abstract Background: Data on cardiogenic shock in adults with congenital heart disease (ACHD) are scarce.
    Aim: We sought to describe cardiogenic shock in ACHD patients in a nationwide cardiogenic shock registry.
    Methods: From the multicentric FRENSHOCK registry (772 patients with cardiogenic shock from 49 French centres between April and October 2016), ACHD patients were compared with adults without congenital heart disease (non-ACHD). The primary outcome was defined by all-cause mortality, chronic ventricular assist device or heart transplantation at 1year.
    Results: Out of the 772 patients, seven (0.9%) were ACHD, who were younger (median age: 56 vs. 67years), had fewer cardiovascular risk factors, such as hypertension (14.3% vs. 47.5%) and diabetes (14.3% vs. 28.3%), and no previous ischaemic cardiopathy (0 vs. 61.5%). Right heart catheterization (57.1% vs. 15.4%), pacemakers (28.6% vs. 4.6%) and implantable cardioverter-defibrillators (28.6% vs. 4.8%) were indicated more frequently in the management of ACHD patients compared with non-ACHD patients, whereas temporary mechanical circulatory support (0 vs. 18.7%) and invasive mechanical ventilation (14.3% vs. 38.1%) were less likely to be used in ACHD patients. At 1year, the primary outcome occurred in 85.7% (95% confidence interval: 42.1-99.6) ACHD patients and 52.3% (95% confidence interval: 48.7-55.9) non-ACHD patients. Although 1-year mortality was not significantly different between ACHD patients (42.9%) and non-ACHD patients (45.4%), ventricular assist devices and heart transplantation tended to be more frequent in the ACHD group.
    Conclusions: Cardiogenic shock in ACHD patients is rare, accounting for only 0.9% of an unselected cardiogenic shock population. Despite being younger and having fewer co-morbidities, the prognosis of ACHD patients with cardiogenic shock remains severe, and is similar to that of other patients.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/epidemiology ; Shock, Cardiogenic/therapy ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/epidemiology ; Heart Transplantation/adverse effects ; Heart-Assist Devices/adverse effects ; Registries
    Language English
    Publishing date 2023-08-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2408778-6
    ISSN 1875-2128 ; 1875-2136
    ISSN (online) 1875-2128
    ISSN 1875-2136
    DOI 10.1016/j.acvd.2023.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Atropinic (anticholinergic) burden in antipsychotic-treated patients.

    Montastruc, François / Benevent, Justine / Touafchia, Anthony / Chebane, Leila / Araujo, Mélanie / Guitton-Bondon, Emmanuelle / Durrieu, Geneviève / Arbus, Christophe / Schmitt, Laurent / Begaud, Bernard / Montastruc, Jean-Louis

    Fundamental & clinical pharmacology

    2017  Volume 32, Issue 1, Page(s) 114–119

    Abstract: Antipsychotic drugs possess side atropinic (anticholinergic) properties that may induce several adverse drug reactions (ADRs), such as memory loss or cognitive impairment. The aim of this study was to investigate anticholinergic burden in patients ... ...

    Abstract Antipsychotic drugs possess side atropinic (anticholinergic) properties that may induce several adverse drug reactions (ADRs), such as memory loss or cognitive impairment. The aim of this study was to investigate anticholinergic burden in patients treated with antipsychotic drugs. All ADR reports including at least one antipsychotic and registered between 2000 and 2015 in the Midi-Pyrénées PharmacoVigilance Database were extracted and analyzed using the Anticholinergic Duran's list. The primary objective of this cross-sectional study was to calculate anticholinergic burden in antipsychotic-treated patients; the secondary one was to investigate associated factors. Among the 1948 reports, the average number of atropinic drugs per report was 2.4 ± 1.4. At least one atropinic drug was found in 59.4% of reports (1158), in addition to antipsychotic drugs. The mean anticholinergic burden per report was 3.9 ± 2.9. A value ≥3 was found in 61.7% of the reports. A significant association between anticholinergic burden, age, and male gender of patients was found. The mean value of anticholinergic burden remained stable during the study period. This study showed high values of anticholinergic burden in patients receiving antipsychotics. Thus, considering the potential noxious clinical impact of atropinic properties on cognitive functions, an appropriate approach should be used to reduce prescription of antipsychotics with a high anticholinergic burden but also coprescription of other frequently associated atropinic drugs, such as antiparkinsonians, H1 antihistamines, or imipraminic antidepressants in these patients.
    MeSH term(s) Adolescent ; Adult ; Adverse Drug Reaction Reporting Systems ; Aged ; Aged, 80 and over ; Antipsychotic Agents/adverse effects ; Child ; Child, Preschool ; Cholinergic Antagonists/adverse effects ; Cognition/drug effects ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Cross-Sectional Studies ; Databases, Factual ; Drug Interactions ; Drug Utilization Review ; Female ; France ; Humans ; Infant ; Infant, Newborn ; Male ; Memory/drug effects ; Memory Disorders/chemically induced ; Memory Disorders/diagnosis ; Memory Disorders/psychology ; Middle Aged ; Polypharmacy ; Risk Factors ; Time Factors ; Young Adult
    Chemical Substances Antipsychotic Agents ; Cholinergic Antagonists
    Language English
    Publishing date 2017-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 639134-5
    ISSN 1472-8206 ; 0767-3981
    ISSN (online) 1472-8206
    ISSN 0767-3981
    DOI 10.1111/fcp.12321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2247: Show issues Location:
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