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  1. Article ; Online: Is the Left Ventricle a Backroom Fixer of Left Atrial Thrombus?

    Akao, Masaharu

    Circulation journal : official journal of the Japanese Circulation Society

    2023  Volume 87, Issue 12, Page(s) 1798–1799

    MeSH term(s) Humans ; Atrial Fibrillation ; Heart Ventricles/diagnostic imaging ; Heart Diseases/diagnostic imaging ; Thrombosis/diagnostic imaging ; Thrombosis/etiology ; Echocardiography, Transesophageal ; Atrial Appendage/diagnostic imaging
    Language English
    Publishing date 2023-11-02
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-23-0765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy and Safety of Low-Dose Edoxaban by Body Weight in Very Elderly Patients With Atrial Fibrillation: A Subanalysis of the Randomized ELDERCARE-AF Trial.

    Akao, Masaharu / Yamashita, Takeshi / Fukuzawa, Masayuki / Hayashi, Takuya / Okumura, Ken

    Journal of the American Heart Association

    2024  Volume 13, Issue 3, Page(s) e031506

    Abstract: Background: The ELDERCARE-AF trial showed that low-dose edoxaban benefits elderly patients with nonvalvular atrial fibrillation considered ineligible for standard oral anticoagulants due to high bleeding risk, but whether this applied to patients with ... ...

    Abstract Background: The ELDERCARE-AF trial showed that low-dose edoxaban benefits elderly patients with nonvalvular atrial fibrillation considered ineligible for standard oral anticoagulants due to high bleeding risk, but whether this applied to patients with extremely low body weight was unclear.
    Methods and results: This was a prespecified subanalysis by body weight (≤45, >45 kg) of the phase 3, multicenter, randomized, double-blind, placebo-controlled, event-driven ELDERCARE-AF trial, which compared low-dose edoxaban (15 mg once daily) with placebo in Japanese patients considered ineligible for oral anticoagulants at the recommended therapeutic strength or the approved doses. The primary efficacy and safety end points were stroke or systemic embolism and major bleeding (International Society on Thrombosis and Hemostasis definition), respectively. The ≤45-kg weight group included 374/984 patients (38.0%), and the >45-kg group included 610/984 patients (62.0%). The stroke or systemic embolism rate was lower with edoxaban than placebo in both weight groups (≤45 kg: hazard ratio [HR], 0.36 [95% CI, 0.16-0.80]; >45 kg: HR, 0.31 [95% CI, 0.13-0.73]; interaction
    Conclusions: The benefit of edoxaban 15 mg was consistent in elderly patients with atrial fibrillation and extremely low body weight, though clinicians must remain vigilant about the risk of major bleeding, especially gastrointestinal bleeding.
    Registration information: ClinicalTrials.gov. Identifier: NCT02801669.
    MeSH term(s) Humans ; Aged ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Warfarin ; Factor Xa Inhibitors ; Stroke/prevention & control ; Stroke/complications ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Anticoagulants/therapeutic use ; Embolism/epidemiology ; Embolism/etiology ; Embolism/prevention & control ; Body Weight ; Pyridines ; Thiazoles
    Chemical Substances edoxaban (NDU3J18APO) ; Warfarin (5Q7ZVV76EI) ; Factor Xa Inhibitors ; Anticoagulants ; Pyridines ; Thiazoles
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is Progression From Paroxysmal to Sustained Atrial Fibrillation Bad News?

    Ogawa, Hisashi / Akao, Masaharu

    Circulation journal : official journal of the Japanese Circulation Society

    2021  Volume 86, Issue 2, Page(s) 176–181

    Abstract: Atrial fibrillation (AF) is the most common sustained arrhythmia and associated with increased morbidity and mortality resulting from thromboembolism and heart failure. AF often presents initially as paroxysmal and may progress to a sustained form over ... ...

    Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia and associated with increased morbidity and mortality resulting from thromboembolism and heart failure. AF often presents initially as paroxysmal and may progress to a sustained form over time. Sustained forms of AF may be associated with increased symptoms and cardiovascular morbidity, and AF progression may be associated with increased risk of clinically adverse events and outcomes. The present review discusses the clinical factors of arrhythmia progression and risk stratification available to assess the probability of AF progression. Furthermore, currently available treatment options for preventing AF progression are explored and evaluated.
    MeSH term(s) Atrial Fibrillation/pathology ; Disease Progression ; Heart Failure ; Humans ; Risk Factors ; Thromboembolism
    Language English
    Publishing date 2021-11-25
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-21-0691
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  4. Article ; Online: Corrigendum to "Impact of creatinine clearance on clinical outcomes in elderly atrial fibrillation patients receiving apixaban: J-ELD AF Registry sub-analysis" [Am Heart J, 223 (2020), 23-33].

    Akao, Masaharu / Yamashita, Takeshi / Suzuki, Shinya / Okumura, Ken

    American heart journal

    2021  Volume 233, Page(s) 153

    Language English
    Publishing date 2021-01-09
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2020.12.005
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  5. Article ; Online: Differential response to isometric handgrip depending on the heart failure condition in patients with functional mitral regurgitation: a case report.

    Hamatani, Yasuhiro / Ide, Yuya / Watanabe, Hirotoshi / Akao, Masaharu

    European heart journal. Case reports

    2022  Volume 7, Issue 3, Page(s) ytac489

    Abstract: Background: Functional mitral regurgitation (MR) changes dynamically depending on the loading conditions and can cause acute heart failure (HF). Isometric handgrip is a simple stress test and can be performed during early phase of acute HF for the ... ...

    Abstract Background: Functional mitral regurgitation (MR) changes dynamically depending on the loading conditions and can cause acute heart failure (HF). Isometric handgrip is a simple stress test and can be performed during early phase of acute HF for the evaluation of MR.
    Case summary: A 70-year-old woman with a prior myocardial infarction four months before, and with history of recurrent HF admission with functional MR, who received optimal HF medications, was hospitalized for acute HF. On the following day of the admission, isometric handgrip stress echocardiography was performed to evaluate functional MR. During the handgrip, MR deteriorated from moderate to severe and the tricuspid regurgitation pressure gradient increased from 45 to 60 mmHg. After HF stabilization 2 weeks after admission, repeat handgrip stress echocardiography showed that the degree of MR did not significantly change being moderate and the tricuspid regurgitation pressure gradient was only mildly elevated from 25 to 30 mmHg. She underwent transcatheter edge-to-edge mitral repair, and thereafter she has not experienced the rehospitalization for acute HF.
    Discussion: Exercise stress test is recommended for the evaluation of functional MR in HF patients; however, exercise tests are difficult to perform during the early phase of acute HF. In this regard, handgrip test is an option to investigate the exacerbating impact of functional MR during early-phase acute HF. This case indicated that response to isometric handgrip can vary depending on HF condition, highlighting the importance of taking into account the timing of the handgrip procedure in patients with functional MR and HF.
    Language English
    Publishing date 2022-12-27
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytac489
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  6. Article: Atrial fibrillation and stroke prevention: state of the art-epidemiology and pathophysiology: new risk factors, concepts and controversies.

    Kodani, Eitaro / Akao, Masaharu

    European heart journal supplements : journal of the European Society of Cardiology

    2020  Volume 22, Issue Suppl O, Page(s) O1–O13

    Abstract: Atrial fibrillation (AF) increases the risk of thromboembolism, and risk assessment for thromboembolism is necessary for the management of AF patients. CHADS2 and CHA2DS2-VASc scores have been adopted in international guidelines for AF management, but ... ...

    Abstract Atrial fibrillation (AF) increases the risk of thromboembolism, and risk assessment for thromboembolism is necessary for the management of AF patients. CHADS2 and CHA2DS2-VASc scores have been adopted in international guidelines for AF management, but the significance of each risk factor included in these risk scores are sometimes controversial, and the performance of these scores is only modest. There are several other risk factors not included in the scores such as renal dysfunction, low body weight, type of AF (paroxysmal or non-paroxysmal) as well as echocardiographic parameters and blood biomarkers, and physicians should assess patients risk in an integrated manner.
    Language English
    Publishing date 2020-12-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartj/suaa176
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  7. Article ; Online: Underdosing of Direct Oral Anticoagulants　- Pros or Cons?

    Iguchi, Moritake / Akao, Masaharu

    Circulation journal : official journal of the Japanese Circulation Society

    2019  Volume 83, Issue 4, Page(s) 707–708

    MeSH term(s) Anticoagulants ; Atrial Fibrillation ; Humans ; Japan ; Off-Label Use ; Registries
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2019-02-27
    Publishing country Japan
    Document type Editorial ; Comment
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-19-0069
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  8. Article ; Online: Utility of handgrip stress test in patients with functional mitral regurgitation and exertional dyspnoea.

    Hamatani, Yasuhiro / Minami, Kimihito / Abe, Mitsuru / Akao, Masaharu

    European heart journal. Case reports

    2020  Volume 4, Issue 5, Page(s) 1–2

    Language English
    Publishing date 2020-08-16
    Publishing country England
    Document type Journal Article
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytaa267
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  9. Article ; Online: Predictors for a high apixaban level in elderly patients with atrial fibrillation prescribed reduced dose of apixaban.

    Suzuki, Shinya / Yamashita, Takeshi / Akao, Masaharu / Okumura, Ken

    European journal of clinical pharmacology

    2021  Volume 77, Issue 11, Page(s) 1757–1758

    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Atrial Fibrillation/drug therapy ; Dose-Response Relationship, Drug ; Factor Xa Inhibitors/administration & dosage ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/pharmacokinetics ; Female ; Humans ; Male ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; Pyrazoles/pharmacokinetics ; Pyridones/administration & dosage ; Pyridones/adverse effects ; Pyridones/pharmacokinetics
    Chemical Substances Factor Xa Inhibitors ; Pyrazoles ; Pyridones ; apixaban (3Z9Y7UWC1J)
    Language English
    Publishing date 2021-05-20
    Publishing country Germany
    Document type Letter
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-021-03135-8
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  10. Article ; Online: Author Correction: Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2.

    Shintani, Yasunori / Drexler, Hannes Ca / Kioka, Hidetaka / Terracciano, Cesare Mn / Coppen, Steven R / Imamura, Hiromi / Akao, Masaharu / Nakai, Junichi / Wheeler, Ann P / Higo, Shuichiro / Nakayama, Hiroyuki / Takashima, Seiji / Yashiro, Kenta / Suzuki, Ken

    EMBO reports

    2024  Volume 25, Issue 4, Page(s) 2145

    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.1038/s44319-024-00100-1
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    Zs.MG 41: Show issues

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