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Article ; Online: Physiological and Environmental Influences on Wingbeat Frequency of Oriental Armyworm, Mythimna separata (Lepidoptera: Noctuidae).

Xu, Rui-Bin / Ge, Shi-Shuai / Yu, Wen-Hua / Li, Xiao-Kang / Wu, Kong-Ming

2022 Volume 52, Issue 1, Page(s) 1–8

Abstract: The oriental armyworm, Mythimna separata (Walker, 1865) (Lepidoptera: Noctuidae), is a serious global migratory insect pest of grain crops. Although its migratory biology has been studied for a long history, the factors affecting wingbeat frequency (WBF), ...

Abstract	The oriental armyworm, Mythimna separata (Walker, 1865) (Lepidoptera: Noctuidae), is a serious global migratory insect pest of grain crops. Although its migratory biology has been studied for a long history, the factors affecting wingbeat frequency (WBF), which is closely related to the flight activity of the insect, remain unclear. In this study, the WBFs of both cultured and migrating moths were tested under different conditions in the laboratory using a stroboscope. The results indicated that age and mating status significantly influenced WBF. One day old adults had the lowest WBF, and unmated females had a significantly higher WBF than that of mated females. In general, the WBF of males was significantly higher than that of female individuals. The WBF decreased gradually with increasing environmental humidity, and WBF had a significant negative binomial regression relationship with temperature change. The WBF of moths that fed on hydromel was much higher than those of the controls that fed on water or without diet. However, wind speed and air pressure had no significant effects on the moth WBF in the test environments. These findings provide a deeper understanding of factors that affect flight ability in M. separata, which will be helpful for developing a regional migratory monitoring and warning system of the pest, such as identifying target insect species based on the WBF from radar observation.
MeSH term(s)	Male ; Female ; Animals ; Spodoptera ; Moths/physiology ; Reproduction ; Humidity
Language	English
Publishing date	2022-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120799-4
ISSN	1938-2936 ; 0046-2268 ; 0046-225X
ISSN (online)	1938-2936
ISSN	0046-2268 ; 0046-225X
DOI	10.1093/ee/nvac101
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Article: Identification of m6a-related signature genes in esophageal squamous cell carcinoma by machine learning method.

Shang, Qi-Xin / Kong, Wei-Li / Huang, Wen-Hua / Xiao, Xin / Hu, Wei-Peng / Yang, Yu-Shang / Zhang, Hanlu / Yang, Lin / Yuan, Yong / Chen, Long-Qi

Frontiers in genetics

2023 Volume 14, Page(s) 1079795

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1079795
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Article ; Online: Detection of SARS-CoV-2 RNA in Medical Wastewater in Wuhan During the COVID-19 Outbreak.

Zhou, Jun-Bo / Kong, Wen-Hua / Wang, Sheng / Long, Yi-Bing / Dong, Lian-Hua / He, Zhen-Yu / Liu, Man-Qing

Virologica Sinica

2021 Volume 36, Issue 5, Page(s) 1077–1079

MeSH term(s)	COVID-19 ; Disease Outbreaks ; Humans ; RNA, Viral/genetics ; SARS-CoV-2 ; Waste Water
Chemical Substances	RNA, Viral ; Waste Water
Language	English
Publishing date	2021-05-03
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1011219-4
ISSN	1995-820X ; 1000-3223 ; 1003-5125
ISSN (online)	1995-820X
ISSN	1000-3223 ; 1003-5125
DOI	10.1007/s12250-021-00373-z
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Article ; Online: Gut microbiota-derived short-chain fatty acids regulate group 3 innate lymphoid cells in HCC.

Hu, Chupeng / Xu, Bingqing / Wang, Xiaodong / Wan, Wen-Hua / Lu, Jinying / Kong, Deyuan / Jin, Yu / You, Wenhua / Sun, Hua / Mu, Xiaoxin / Feng, Dongju / Chen, Yun

Hepatology (Baltimore, Md.)

2022 Volume 77, Issue 1, Page(s) 48–64

Abstract: Background and aims: Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the ... ...

Abstract	Background and aims: Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short-chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3 regulation. Approach and results: We report that Lactobacillus reuteri was markedly reduced in the gut microbiota of mice with HCC, accompanied by decreased SCFA levels, especially acetate. Additionally, transplantation of fecal bacteria from wild-type mice or L. reuteri could promote an anticancer effect, elevate acetate levels, and reduce IL-17A secretion in mice with HCC. Mechanistically, acetate reduced the production of IL-17A in hepatic ILC3s by inhibiting histone deacetylase activity, increasing the acetylation of SRY (sex-determining region Y)-box transcription factor 13 (Sox13) at site K30, and decreasing expression of Sox13. Moreover, the combination of acetate with programmed death 1/programmed death ligand 1 blockade significantly enhanced antitumor immunity. Consistently, tumor-infiltrating ILC3s correlated with negative prognosis in patients with HCC, which could be functionally mediated by acetate. Conclusions: These findings suggested that modifying bacteria, changing SCFAs, reducing IL-17A-producing ILC3 infiltration, and combining with immune checkpoint inhibitors will contribute to the clinical treatment of HCC.
MeSH term(s)	Mice ; Animals ; Gastrointestinal Microbiome ; Interleukin-17 ; Immunity, Innate ; Carcinoma, Hepatocellular/metabolism ; Lymphocytes ; Liver Neoplasms/metabolism ; Fatty Acids, Volatile/metabolism ; Acetates
Chemical Substances	Interleukin-17 ; Fatty Acids, Volatile ; Acetates
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.32449
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Article ; Online: Long-term outcomes of intraoperative chemotherapy with 5-FU for colorectal cancer patients receiving curative resection (IOCCRC): a randomized, multicenter, prospective, phase III trial.

International journal of surgery (London, England)

2024

Abstract: Background: We aimed to compare combined intraoperative chemotherapy and surgical resection with curative surgical resection alone in colorectal cancer patients.: Methods: We performed a multicenter, open-label, randomized, phase III trial. All ... ...

Abstract	Background: We aimed to compare combined intraoperative chemotherapy and surgical resection with curative surgical resection alone in colorectal cancer patients. Methods: We performed a multicenter, open-label, randomized, phase III trial. All eligible patients were randomized and assigned to intraoperative chemotherapy and curative surgical resection or curative surgical resection alone (1:1). Survival actualization after long-term follow-up was performed in patients analyzed on an intention-to-treat basis. Results: From January 2011 to January 2016, 696 colorectal cancer patients were enrolled and randomly assigned to intraoperative chemotherapy and radical surgical resection (n=341) or curative surgical resection alone (n=344). Intraoperative chemotherapy with surgical resection showed no significant survival benefit over surgical resection alone in colorectal cancer patients (3-year DFS: 91.1% vs. 90.0%, P=0.328; 3-year OS: 94.4% vs. 95.9%, P=0.756). However, colon cancer patients benefitted from intraoperative chemotherapy, with a relative 4% reduction in liver and peritoneal metastasis (HR=0.336, 95% CI: 0.148-0.759, P=0.015) and a 6.5% improvement in 3-year DFS (HR=0.579, 95% CI: 0.353-0.949, P=0.032). Meanwhile, patients with colon cancer and abnormal pretreatment CEA levels achieved significant survival benefits from intraoperative chemotherapy (DFS: HR=0.464, 95% CI: 0.233-0.921, P=0.029 and OS: (HR=0.476, 95% CI: 0.223-1.017, P=0.049). Conclusions: Intraoperative chemotherapy showed no significant extra prognostic benefit in total colorectal cancer patients who underwent radical surgical resection; however, in colon cancer patients with abnormal pretreatment serum CEA levels (> 5 ng/ml), intraoperative chemotherapy could improve long-term survival.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000001301
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Article ; Online: Gene Therapy Activates Retinal Pigment Epithelium Cell Proliferation for Age-related Macular Degeneration in a Mouse Model.

Yuan, Yun / Kong, Wen / Liu, Xiao-Mei / Shi, Guo-Hua

Current medical science

2023 Volume 43, Issue 2, Page(s) 384–392

Abstract: Objective: Age-related macular degeneration (AMD) is a degenerative retinal disease. The degeneration or death of retinal pigment epithelium (RPE) cells is implicated in the pathogenesis of AMD. This study aimed to activate the proliferation of RPE ... ...

Abstract	Objective: Age-related macular degeneration (AMD) is a degenerative retinal disease. The degeneration or death of retinal pigment epithelium (RPE) cells is implicated in the pathogenesis of AMD. This study aimed to activate the proliferation of RPE cells in vivo by using an adeno-associated virus (AAV) vector encoding β-catenin to treat AMD in a mouse model. Methods: Mice were intravitreally injected with AAV2/8-Y733F-VMD2-β-catenin for 2 or 4 weeks, and β-catenin expression was measured using immunofluorescence staining, real-time quantitative reverse transcription polymerase chain reaction (PCR), and Western blotting. The function of β-catenin was determined using retinal flat mounts and laser-induced damage models. Finally, the safety of AAV2/8-Y733F-VMD2-β-catenin was evaluated by multiple intravitreal injections. Results: AAV2/8-Y733F-VMD2-β-catenin induced the expression of β-catenin in RPE cells. It activated the proliferation of RPE cells and increased cyclin D1 expression. It was beneficial to the recovery of laser-induced damage by activating the proliferation of RPE cells. Furthermore, it could induce apoptosis of RPE cells by increasing the expression of Trp53, Bax and caspase3 while decreasing the expression of Bcl-2. Conclusion: AAV2/8-Y733F-VMD2-β-catenin increased β-catenin expression in RPE cells, activated RPE cell proliferation, and helped mice heal from laser-induced eye injury. Furthermore, it could induce the apoptosis of RPE cells. Therefore, it may be a safe approach for AMD treatment.
MeSH term(s)	Mice ; Animals ; beta Catenin/genetics ; beta Catenin/metabolism ; Retinal Pigment Epithelium ; Macular Degeneration/genetics ; Macular Degeneration/therapy ; Cell Proliferation/genetics ; Genetic Therapy
Chemical Substances	beta Catenin
Language	English
Publishing date	2023-03-17
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-022-2684-3
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Article ; Online: The effect of Tuina based on the concept of hip-knee-ankle conjugation in patients with chronic ankle instability: study protocol for a randomized controlled trial.

Wen, Zonglin / Lyu, Ruoyun / Wang, Wei / Hua, Xia / Yu, Yifeng / Zeng, Ke / Kong, Lingjun / Wang, JianWei

Frontiers in rehabilitation sciences

2023 Volume 4, Page(s) 1165548

Abstract: Background: Chronic ankle instability (CAI) is a common sports injury disease and characterized by limited mobility, perceived instability and muscle weakness, combined treatment of hip-knee-ankle is a common rehabilitation method. Tuina, as a ... ...

Abstract	Background: Chronic ankle instability (CAI) is a common sports injury disease and characterized by limited mobility, perceived instability and muscle weakness, combined treatment of hip-knee-ankle is a common rehabilitation method. Tuina, as a traditional Chinese manual therapy, is usually used for CAI, but many of them only focus on the local ankle joint rather than the combination of hip and knee joint. Therefore, we have designed a randomized controlled trial (RCT) to investigate the effects of Tuina base on the concept of hip-knee-ankle conjugation on the stability and balance of lower limbs and ankle function in patients with CAI. Methods: We have designed a randomized controlled trial. A total of 72 participants with CAI will be randomly divided into functional training groups and hip-knee-ankle Tuina combined with functional training group in a 1:1 ratio. Participants in control group will receive 8 sessions of functional training (30 min per session, twice a week for 4 weeks). Participants in intervention group will receive 8 sessions of Tuina combined with functional training (twice a week for 4 weeks). The primary outcomes include the Y-Balance Test (YBT) and Cumberland Ankle Instability Tool (CAIT). The Secondary outcomes include the Foot and Ankle Ability Measure (FAAM) and ankle range of motion (ROM). The outcome assessments will be conducted before the first intervention and after the last intervention. Discussion: The aim of this study is to explore a safe and effective manipulation program and serve as reference for clinical treatment of CAI and expect to provide the necessary theoretical and practical support to our future research. Clinical trial registration: Chinese Clinical Trail Registry ChiCTR2300068274.
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6861
ISSN (online)	2673-6861
DOI	10.3389/fresc.2023.1165548
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Article ; Online: P4HA2-induced prolyl hydroxylation of YAP1 restricts vascular smooth muscle cell proliferation and neointima formation.

Wang, Liang / Liu, Ting / Zheng, Yaofu / Zhou, Jiamin / Hua, Hexiang / Kong, Liming / Huang, Weilin / Peng, Xiaoping / Wen, Tong

Life sciences

2023 Volume 330, Page(s) 122002

Abstract: Vascular smooth muscle cell (VSMC) proliferation and neointima formation play significant roles in atherosclerosis development and restenosis following percutaneous coronary intervention. Our team previously discovered that TEA domain transcription ... ...

Abstract	Vascular smooth muscle cell (VSMC) proliferation and neointima formation play significant roles in atherosclerosis development and restenosis following percutaneous coronary intervention. Our team previously discovered that TEA domain transcription factor 1 (TEAD1) promotes vascular smooth muscle differentiation, which is necessary for vascular development. Conversely, aberrant YAP1 activation upregulates the platelet-derived growth factor receptor beta to encourage VSMC proliferation and neointima formation. In this study, we aimed to investigate the molecular mechanisms of YAP1/TEAD signaling during neointima formation. Our research focused on the prolyl 4-hydroxylase alpha 2 (P4HA2) and its downstream target, Yes-associated protein 1 (YAP1), in regulating VSMC differentiation and neointima formation. Our results indicated that P4HA2 reduction leads to VSMC dedifferentiation and promotes neointima formation after injury. Furthermore, we found that P4HA2-induced prolyl hydroxylation of YAP1 restricts its transcriptional activity, which is essential to maintaining VSMC differentiation. These findings suggest that targeting P4HA2-mediated prolyl hydroxylation of YAP1 may be a promising therapeutic approach to prevent injury-induced neointima formation in cardiovascular disease.
MeSH term(s)	Humans ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Hydroxylation ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Neointima/metabolism ; Prolyl Hydroxylases/metabolism ; Transcription Factors/metabolism ; Animals
Chemical Substances	Prolyl Hydroxylases (EC 1.14.11.-) ; Transcription Factors
Language	English
Publishing date	2023-08-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2023.122002
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Article ; Online: Controllable Synthesis of Peapod-like Sb@C and Corn-like C@Sb Nanotubes for Sodium Storage.

Yang, Kaixuan / Tang, Jianfeng / Liu, Yan / Kong, Ming / Zhou, Bin / Shang, Yongchen / Zhang, Wen-Hua

ACS nano

2020 Volume 14, Issue 5, Page(s) 5728–5737

Abstract: Antimony (Sb) is regarded as an attractive anode material for sodium-ion batteries (SIBs) due to its high theoretical capacity of 660 mAh ... ...

Abstract	Antimony (Sb) is regarded as an attractive anode material for sodium-ion batteries (SIBs) due to its high theoretical capacity of 660 mAh g
Language	English
Publishing date	2020-04-28
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.0c00366
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Article ; Online: SARS-CoV-2 detection in patients with influenza-like illness.

Kong, Wen-Hua / Li, Yao / Peng, Ming-Wei / Kong, De-Guang / Yang, Xiao-Bing / Wang, Leyi / Liu, Man-Qing

Nature microbiology

2020 Volume 5, Issue 5, Page(s) 675–678

Abstract: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, Hubei Province, China in late December 2019. We re-analysed 640 throat swabs collected from patients in Wuhan ... ...

Abstract	Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first reported in Wuhan, Hubei Province, China in late December 2019. We re-analysed 640 throat swabs collected from patients in Wuhan with influenza-like-illness from 6 October 2019 to 21 January 2020 and found that 9 of the 640 throat swabs were positive for SARS-CoV-2 RNA by quantitative PCR, suggesting community transmission of SARS-CoV2 in Wuhan in early January 2020.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus/isolation & purification ; COVID-19 ; Child ; Child, Preschool ; China ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Female ; Humans ; Infant ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; RNA, Viral/isolation & purification ; Real-Time Polymerase Chain Reaction ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Young Adult
Chemical Substances	RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-04-07
Publishing country	England
Document type	Journal Article
ISSN	2058-5276
ISSN (online)	2058-5276
DOI	10.1038/s41564-020-0713-1
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